CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
LASP1	3927	LIM and SH3 protein 1	17	MLN50; Lasp-1

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
20660701	2010	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	Immunohistochemistry, 2-D DIGE,	Up-regulation	-	Overexpression of LASP-1 was found in metastatic CRC tissues (p=0.002), and its expression level was closely correlated with overall survival of patients with CRC. LASP-1 might be a promising target in the treatment of patients with CRC with growth and metastasis of CRC. SW620 CRC cells were used.
20812987	2010	Cell line : - Source : Nanfang Hospital tumour tissue bank. Sample Type : - No. of Sample : - Stage : -	2-D Gel electrophoresis, and mass spectrometry,Western blotting, Immunohistochemistry	Up-regulation	-	This gene differentially expressed in between normal colorectal tissue and colorectal cancer tissue experiment done by 2-D Gel eclectrophotesis In total, 150 patients were involved in the study.
21215099	2010	Cell line : SW480 Source : - Sample Type : - No. of Sample : - Stage : -	RT-PCR , Western blotting, MTT	Up-regulation	-	LASP-1 gene expression enhances proliferation of colorectal cancer cells and may serve as a useful marker for colorectal cancer progression.
20089989	2010	Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : -	Biochemical isolation to nano-LC-MS/MS analysis	Up-regulation	-	This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue.

Gene Details

Chromosome: 17; NC_000017.10 (37026112..37078023)
View Larger Image

Gene Type	protein coding
Gene Family	-
Description	This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]
Chromosome	17
Location	17q11-q21.
Start	38869859
End	38921770
Strand	+
Gene Sequence	>gi\|568815581:38869859-38921770 Homo sapiens chromosome 17, GRCh38.p2 Primary Assembly GCAGTCAGCCTGAGAGCGCTGAGGCGCCAGCACCGCGGGCCCCGCCGTCCCCCCAGGAACCCGCCCCCGC GCAGCCCCACGTCGCCCGGAGAGCGCGCCTCGCTGCGCGTGCCCTTGCCCGCGCCCGAGGCGCGTGCCCG CCCCAGTGCAGCCCCTCCTCCCCGCTGTGTTTATTAGGGGAAGGAGGGCGGAGGCGGAGGCCAGTTCCCC AGCTCCAGCCGCCGTCGCTGCTGCCTGTGTAGTTGCAGCCGCGGCCGCCTCCCGCCAGCTCGCCTCGGGG AACAGGACGCGCGTGAGCTCAGGCGTCCCCGCCCCAGCTTTTCTCGGAACCATGAACCCCAACTGCGCCC GGTGCGGCAAGATCGTGTATCCCACGGAGAAGGTGAACTGTCTGGATAAGGTGAGCCCGGGACCGGGAGA CGCGTCTTTGCAATCCCCCGCAGTGCTCCGAATCCAGGGAGGAGAGAAGGGCCGGGTCTTTGCCGCCTTA TCCCCGCGATCCCAGGAGAATGGAGGGAGGGCGAGCGGGCGGTGTCATGGGGTGTGGGGACACATCCCAG TCTGAAAACCAGGAGATCTGGGGCGAGGCGGGAAGTCCACGCGTAGCGGGCAGCCGCTGCTGGAGAGGGG TGGGCTCTGTGTCCCGGGGTTGGGAGGACGGGAGAGGAGCAGGGAAGTCAGGCGCCGGGGTGTGTTGGGG GAAGGTTAGGGGTGCAGTCCCGCCCCCTACGGCCTGGAGAGTGAGAAGAGACGGCCGCTCCCTCTCCGCT CTGCGCCGAGCGCCAAGTAGGCGGAAGCGCGGGGCGCTGGTGGAGGGGGCGGGGGGGCGGGGCAGAGGCT GGGGGGCCCTGCAAAACCGTCCGCTCCGGCGGGGGTGGCCTGGCTTCCTGGCCTGGCGGGGCGGGGGCTA TCAGCCTGCGAGTGTGTGGCATCTGATGCGGGGGGTTTTGGGTAAGGACCCGGGCTCTGCCGCAAGAGCC CCGTTTTTGAACGACCTGCACCCCCTTGGATTCAGTCGTTAAAGGACTCGCAGACCTCCTCCACAGCTTC CCAACCCCCACCTCCAATTAAAAGCCAACTCCCGGTGCTGGGCCGTCCAGCCTGAGCCGGGTGGGGTTGG GTGGCAGAGTAGGGTGGGTGGAGGGTGCTTAGCTGAGATCTCCTGAAATTGTGCTCAGAGCCAGGAGACC GTGTGGAAGAACAAAGAGCTAACTTTTCAAAGCAGGTTTCTCCAATGGAGGGTGGGGTTGGCTGAGTTCT GGGGAAGCCGAGGAAAGGGGGAGGTATTGGGGGGAGGGGAGGGTGGCCTTGTGGAGATTCAGTGTCCCCT GGGGGCCCTGTCTCCCCAATGCTGGACTTGTTCATCTGGTTGCCATTAGACTTTTGGAGGGGGGTTGGAG AGTAGAACTGGGTGTTTCCCGTACAGTTTAGGGTAGGATCCTGTTCTCTTGTAAGCTCCGTAAGATCCTA AGGTAAAACCTGCCCCTCTGCATCCCCTCCCCAGTCTGGAGGGGAGGCCTCTGTGATTTTGTGCCCTTCC TCACCGCGTCTTTCATCCACCACCCAAAGCTGGCTCCAAGTCCAAGTATTCTGTCCTTTCCATCTGAACT GGGAGGGCTGGGAGGACTGGATGGAAGAGAGGTGCAAGGGTGGGAACACTAGATGAAAGAGGGGTATAGA GCCCTGGGGCCAAGTTCATTACTGACCTGGAGCCAGGTTTTGTTCAGGAGAGGATAGTTTATTGGACACC TTATCTCTCCCCTCCCCCTTGGTGTGTGAGCTTCCTCAGTGACCTTTGGCCTCTGAGTCAGCGTGAGGAG GTGGGGTTGGAGGTTCTGAAAGATATTTGAACTTGCTCTTGGGGAGTGTGGGCATATGGGGCCGCTGCTG TGTCACTGTTCCTCCTGGTCCTGGGCTTGACTGGGCAGGAGGAGAGGAGGGGGTATATTGTGGGCACGAG GAAAGTTGTTGATCTCCCCATGACCATGCCAGCCGCTGTTGGGCAGGACTTGAGCTTAGAGCTATCAGAT AATGAAGTCTCCCCTTGAGAATGTACCTGTCCTTGCACACTGGGGTTTCGCCCGCCCCTCGTGGCAGAGA TTTTGGCCTCTGCATCTTGAGTTCCCTGTGGTCCCCTTCTTCTCCACAGTCATGAATTGGGAAGAGGCAG TGGGCACTTGACCCGTATAAGGAAAAAGCAAAACATGAAGGCAGGATTGCCACTCCAGGAGTTGGGAAAC TGGGTCCTTGTTCCAGGTCTGCTCCCACCAGTTTTATGAATGTCTCTAGGCCTCAGTATTCACCATCTGT CAGATGGGTATGATGATGTCATTTCCTTAAAGGTGGGGCAGTGCACTAAAGTCCCTGAGTGCTAAAGAGG GTGCTGTATAGACTATGCCCTCCCTACCTCTCTGGGATGCTCTGTTCAGCTCCACACCACTCCCCTTGGA AAGACCTTCAGTGCCGTGTACCCGAGGGGAGGGGAGCAGGGATGGGCAGGGTGCCCTCCCCAGTTCTCTT ACCCTAGCTGGAAGAGGACGTTCAAGTGGGGGTTGCCCAGGGAAGTGGGAGTTGGTGATTCCTTCCTCTT TTTAGAACTCTCCCTATAGGAAGTGGCCCTGGAGAGACCTCGCCCCCTGTACTGAGCAGGAGACCTGAAA TATCCAGGTATCAGACCTATTCCTCTCCACCTGCTCCAGGCAGTAAGGATAGGACCAGGAATGGGGAGCC AGTGCCTGGAGGATGCTGGGCTGTGACCAGGGAGGAGGGGAAACCTTCAGTCCCATAGGCAGCTTCAGTC CCATAGTTGCTAACCAACTTCCCAAGGCCTCCCATTTACAGCAAAAGAGTCAAATTAGACTCACCCGTTT CTCTACAATCCCCCATGGTACTCAGCCCACTACGTGGCCCAAAGCACAGGGTGTGTCCTTGGTTTCAGCC TTTTCTCCTCCCTGAGCCTTATCTCCCAAAGGCATAGGTGGGTAAAAACCTTGTCACCTCTGAAGGCCAC CCTGCCCCCAACCTGCAGTACCCAGCATGCTTTGCAAGCTGGATAAATATGTATTGCTGATGACAGTGTT TGAGGAAGGAGGTCGAGATTTGCTTCTCCAGAGGACTTCTGGGATTAGAGCTGGGGGAGAAACAGGGTGA CCTCATTTGCTCATTCAACAAATATTTATTGAGCACCTACTTTGTGCACCTGCTTTGTATCTAGGGAGCT GTGTTGTCAAGAACCTCGCCACGTCCCTCTTTCCTGGCTTGCTTCCCCAGGTTTCTGAAAACAGGTGGAG GTAGAGGATTGGTCTGCTGCCAGTTCCCCTGGAATCCCCTGTTAGGGTGGGCTCTCTGCCTCTGCTTGTC TCAGCGCTCCCTCCCCACTCGAGGGGGTTGAAGTCCTCACAGCTGTGGTGCCCCGTTTTGCTAGCTGAAG CTTAGAGTACCCCACCATCATCTTGTGACCATCCCTTCATAATAGCTACTAGTTATCACGATATGCTGGG CTCAGTCTTCACAGCAGCCTCACAAAGTAGGTGTATTCGCTCTTGTAAACGATGCACTCCATAAATGGAG GCTCAGGTAGCCCATGTGGCTCATCTCCCTCTCTTAGAGCTGAAATTCACATCCACAGTTCTTTCTGCTC AGCTCTTCTGCCAGTGTGTTTGCAGAAAGTACTTTTATTTATACATATTTATATTTTATTTACATCTCAT TTGTGCCAAAAGTAGGTCCCATCCCTTCCTGACCCTATCTGGAGGAATGCTCTGGGCCTGGGGTCTTGTA TGGGGGCGTGGGGCCACTGGGAATAATCCTGTCCTCCTCGGAATTTGTGGAGGTGCAGCAAAGATCTATG CCTTTAAGCCAGCGGGTCAGGTGGCCAACCAAGCTAGGCTGGTGCCCCGGCCAGGGTGGGGCTGGCATTG CCTCTGCAGGAGGGAGAAACTGTAACCCTGGGCAACAGGAAGGGAAGAGATGGTCTCATAATCCATCCCT GAGTCATGGCCACCCCAGGTAGCCTGGGTTCAGAGGCCAAGGTGCCAGGCTGCAGGCACAGTGACACGAA GCTTGCCACATCCCCCCCAACCCAGAGCCACAGAGGGACAGGCTGTCCCAAGTGAGGGGTATCCTTGCAG GCTTCTGCCCCTACCAGCCTGTTTACCTTTCTTTAGAGTGGGTTGCAGGTAGGCAAGGGAAGATCAAGAT GACCCTGCCTTGGAGCCTCGGATCCAGGCTGAGAGGCCTCTAACAGGCAGCAGAGGTAGGGTCTGTCTGG TTTCTGTGAACAGGGAAGCCATGGACTTTGCAGGCAGCAGGAAGGGGCAGAGGTGCATGCCTCGAGGTGC AGTTTCCTTGAGTCCTGAGGCCCAGGAATGCTTCGCTGAAATCATCTTGCCTGGGGCCTTTAAAAGAGGG GGGCTCTTGCTCTGGGACAGAGCCCATGGGGCAGGGCAGAGGCAGACGGGGTCACTGTGGGGTCCTCTGG ACATATTTCCCTGACAGTGTCCTTCCCCAGACCCCATTGAGACAAGGCAGGAGTTCTTTCATCTTAGGGT CCAGGCTTGGCTCACAGCGGTTGTGGAGGGACTGGCCATTTTCTGCCTCCCCTCCCCACAATTTTCCTAC CCCAAAAAGGACACAGTGGAAGGAGCTGGTGGGTTTTCTTGAACCTTGGGGCCTTCCTCCAGAGAGGGTA GGGGAGTCGCCTGAAGCTGCTGGAGGTGCCAAGCATTAGGGGTGGAACGGCCTCCTCTCCTGACCTTCCA GCACTCTGGGAGACAGTGGCTGCAGCTCCACTTGACACTTGTGCTTCATAGTAACTGGTTTCCATGTTTC TGCTCAGAGCCCCCTGCAGGGGGACAGGCGACCACCCTCCTCTGCCCCACCCTTGGGTGTCTGGATGAGA GTGTGGGGCCTGTGAGGGAGGTGGGAAGGAGCTACTGATAGAAATAGGTGCCATCCCCTAGAAGAGGGGC TCTGCTTCCTCCGCGTGGCAGCCTGGAGGGGTCTTTGGAACCACTGGGTCCAGTGTTGGCCCTGTGCCCC CTGCCTGCTCAGTACACCCCACCCTCCTTCTCCAAGGGGCTTGGCTCCGGGTGCAGGCCTGGCCATCTGG AGTAGGGGTCTCTCTCCCTTTGTCTCCCCAACGTCAATCAGGAGGCAGCCTTGGAGGTCCGTGGTCCTAG GACAGTGTGTAGCCCTTCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAGAAAGTGGGTCATGGTCT GGATTCTGGAGAATGTTTTTCCTGGCAGGCCCCTGTGGGGGTAGGGGGAGGCAGGGGCCCAGGCAGGGGC CTAGGCAGGGGCCTGTGCAGCTAAGTAGGCAGAGGCCAGCAGACTGGGTGGTGACCAGGCTGGGGCACCC TGCCAATGCCTCCCAGTTACTCGGGGAGGGAGTGGGGCTGTCACTTCAGGGGCCTGTGGGGGCAGGGACC AGCCTGTCTTAGTGTCCCTGGTGGGTTCTGTGTGTTGGGGTATGCACCACTTCAGGGGCCTGTGGGGGCA GGGACCAGTCTGTCTTAGTGTCCCGGTGGGTTCTGTCTATTGGGTTATGCACCAGAAGGAGTCTTTAAGT TGCCTCATAGGAGTTTGGGGGCCCTGGGTCACTGGGATAGGCCCAGGTTGGGGAGGGGGCCAAGCTTAGA CCCGCCACTTCTTTGCTTCCAGACTTCCGGCTGGCCGTCCTCCCCAAGAGTGGTTCTCCTAGCATTCTGT TTAATATTCCACCATTAGGTTTTTCCTTTGGGTCTTCTTGATAGGGAACCAGTACCCTATTAGAAGGTGA TTTCCCCCTGAAATTACCCTGGGGGTCTCTGGTTGAAGTGGGCCATGGTAGGGAGGTTGAATCCCAGATT CTCAGCCTTCTTTCTGCTATCCCCTCCTCCCAGTGTCTCAGAAGCACCTCTCCCTCCGGGGGTTTGGAGA CAACATTTTGAAAAGCATCGCCTTGGGGGAATTCCTTGACAAATGGCCAAGAACCAGCTCTGTGGCTGGG CTCCTTCAAAAGTCCCCCTGGGCCTGCCTCCTGGCCTCCTTCTTTTGGAATGGGGAATGTCTCCCTTGAC TACTGGGAAATGGGGCAGGGACAGGCCAGCCAGGTCACTCAGGTGGCCTGGATTATTCTGGGGTCCTGGC AGTGGACCCCTGTTTGGTGGTGATCCAGCACATCATCCTGGGCTTCTGGGGGTGAATTTAGATCCTGTTG TCATGGGTTTGCCTAAGCATCAATACTTCTCAGGGGTTCCACAAAGACCCCTCCAGGCTGCCACGTGGAG CCTGTTAGATCGTTTCTCTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTGCTCTGTCACCCAGGCTGG AGTGCAGTGGCACAATCTTGGCTCACTGCAACCTCCACCTCCTGGGTTTAAGTGATTCTTTTGCCTCAGC CTCCCAAGTAGCTGGAATTACAGGCATGCGCCACCATACCCGGCCTATTTATTTATTTATTTATTTATTT ATTTATTTTTGAGATTAAGTCTCGCTCTATACCCCAGGCTGGAGTGCAGTGGCATGATCTCAGCTCACCG CAATCTCTGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACG CCGTCACTGCACCCGGCTAATTTTTTTGTATTTTTAGTAGATACGGGGTTTCACCATGTTGGCCAGGCTG GTCTTGAACTCCCAACCTCCAGTAATCCGCCTGCCACAGCCTCCCGAAGTGCTCGGATTATAGGCGTGAG CCACCGCTCCCGGCTAGATCTGTTCTCTTTCTGTCATCACTCTCTTCCCTCCGTCGGCCACCCTGGATGG GCCCTGTGTCCCACATTCTCTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCACCCAGACTGGAGTGCA GTGGCCTGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACCCGCCACCA CGCCTGGCTAATTTTTTTGTCTTTTTAGTAGAGATGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATC TCTTGACCTCATGATCCGCCCGCCTCGGCCTCCCAAAGTGCGGGATTACAGGCGTGAGCCACCGTGCCCG GCCGTGTCCCACATTCTCACACGCATGAATGGATTGGAGCTGTGGTTGGCACAGTGAAGCCCCTCTGCAC CCCAACACACACAATCTCCAGTGTGAGCCCTGACCCCCTCGGCTAAGGTTCACACCTGCTGTGCCCAGCA CCTGACATCTGAGTGCTCAGAGGTGCCAAGTGCTGTGCTGAGGGCTTTGAAGGTGATTTCTCCTCAGTCC TGGACAATCCCAGGAGGGCCAGGTGTTATTACATCCATTGTACACACCAGGAAGTGGGCTCCTCTGAGGT GCAGGGCCCCGCCCAAGGCCATACAGTTAGTGGGGTAGAGCTTTGATGTCCACTATAGGGGTGTCCACCT TCAAGGCTTTGAAGTAGAGCCCTTCAGTGCCTCAGTGGGAGACCCGCTGCCGGGTGCTCTCCTGCCCTCC TCCTGGGGTGGGAGAGGATGAGGGAAGGGTAGAAAGGATGTGTTGTGTTGACAGAGCCTGGGACACCCAG CCCACTCCTCTGGCCAGGCATCCCACAGGAAGTGGGAGGTATCGGAGCTGTAGCACCACCTGGGGCTCAT GTGGGGCTGGTGGGTGTGCTGGGCCCTGGTACAGGAGCTAGGAGCACCTGGGTTCTGGGCCTGGGTGTGT GGGGGCTGGGCCTTCCTCTTCTGAGGCCTTGGTGCCACCAGAGGAGCTGCTCCTTCATGTTCAGCGGCTG CTCCCTAGCAACCCAGCGCAGCTTTGCATAAGCAATGAGGCCTCGCCAGCTCTGGGCAGGAGGGGTTCCC TGGGGAGGGTGGAGCTGACTTGGGGGCTGCTGCCACTGCTATAACTGGGCTCTTCCCCCCTGTCCTTCAT GCCTGCCTGTCTCTTCCTCCTGGGTTCAAATGGCCCATTGGTGGAGGATGAGGAAGGAGAGAGGGGAGGG GAGTGCCAAAGCCTGTGACCTGAAATGCCCCCAGCTCACCTGGGATGATTCCATGTTCTCCCCACAGCCA TGGGCCTAGGACAGTCCCAGCAGCTCCTGAGTGCCCCTTCCTAGGGCCTGAGCCCCTTTTTCAGAAGTCC TGGTATCTGATGTATGTCCTCCTGTCTCCATCCCCAGTTCTGGCATAAAGCATGCTTCCATTGCGAGACC TGCAAGATGACACTGAACATGAAGAACTACAAGGGCTACGAGAAGAAGCCCTACTGCAACGCGTGAGTCC TGTTCTGGGCAGGGGGCTGGGTGGGCACCTTGGCTCCCTCCCCGAGTGAGTTCTTCCTTTCCTTCCAATA ACCGCAAGGTGACATTGGCGAACACTTCCATCCCCTACTTGAACATCACAGTTTGTCCTCACAACAGCTG AATGAAGCAAGCACTTTTTATCCCCATTTAAAGTGCTTTTATCCCCCATTTAAAGTGCATTTAAAGTACA GATGAGGAAACTGGGGCTTAGGGAAGGGAAGAGACTCTCAAGGTGGGATGGCTAGGGCAAGACAGGCTCT AACCCAATTTCGGGCAGTAAGGCGAGCACGTTTCTTTCCACTGTCCCCTGCTACAAAAGAGGGGGCTTTC CTCGTGGTCTTTCAAGAATGAGTGACGTGTCTGTTGTATTTGGGGTTGAGGACTTTGTTCTGTTTACCTT CCCTTATTTCTCTCCTCAAAATCGACAGTTTCCTTCTCTCACCTGGGTACTTCTAGGCTTTGGGGGCTCC TTCCTCCAGTGGTTCCTTCAAGAAAACTCTCTGGAAGCCTCATGCCAGCCCTTTTGGTGTTCATTTTTTG AGAATGGGCAGGGGTGCATAAAGGGTGTTGCCTGGGCCAGATAGATCTCTTCCCTGCCTGGTGAGGGAGG CTGTGGAGACTGTTTCTTTTGAGTATAGTCATCTTGAGTATAGTGCAGCTCTGTTCCTTCTGCACTGGGA CCTGCAGCAGCTGACGGTAGGGAGGGAGTATAGAGGTGGGGTCCCCCATCCCAGAGCCTGGAGGAATACC TCCCCTCCCATCCCATCCCATCCCATCCCATGCAATCCCAGAAAGTACAGCAATTTTCCATCTTCCAATT GACCTTGTGAGTAGCAAGTACAAACTCAGTGTTGGGGCCTCACAGCCGCCTCCACCTGCGAGGTGGAGGC TTTGGAAGGTCAAGTCACTTATAAGTAATGATGTAATGATAATTTCTTTTTCTTTTAATTTGCTTTTTTT TTTTTTTTTGAGTCAGAGGACTCATCACCCAGGTTGGAGTGCAGTGGCGCGATCTTGGCTCACTGCAACC TCCGCCTCTTGGATTCAAGCGATTCTTGTACCTAAGCCTCCTGAGTAGCTGGGATTACAGATGCATGCTA CCATGCCCAGCTAATTTTTGTATTTTTTAGTAGAGACCGGGGTTTCACCGTGTTGGCCAGGCTGGTCTCG AACTCCTGACCTCAAGTGATGCACCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTATAAGCCACCTC GCCCAGCCTTAATTCGATTTTTTTTTTAATTTTAACTTTTTTTTTTTTAACTTCAACCAACTCAAGTAAT GGTAATTTCAGTGTTCACATGAATTTAGGATCTGACTTGAGTCCAGTTTTTTTTTTTTTTCTCTTAATTC TCAGTCAGGAGGCTCTTTGCAGCTGAAGTTCACCCAGGGAAAAAAAAATTTGGGACTTGTCTAAAAAGGG GGCTTAAACCTCCAGCCTTACCCCTAACCTTACCCCAAACCTTCCTTGCTTCCTTACCCCCTCCCGTTCC CTGGCTAAGACCACTCTTTCATCTTTTTAGGGGCTCGCTCATTCAGCAGACATTTATTGCCTGCCTGCTG CTATAATACATACTAACCTGCACCAGGTGCTGGGAAAACAGATTCCTGATAAAAATCTCAAGCCCAAGAA GCAACATGAAGTTGTCCCTTCTGGAAGAAGGAGGGCACTGGGCAGGTTATCTGGGTAAAGGAAGGGTTGC AGCTCTGTCCTGGCCCCTCCTTCAGCTGCCCCTTCTCTTCTATTAATTTCTACTGTTCCTCTTCCCCCTA CCAACCCCTCCCACCCCCACAAGGGAAATGGGACATTCTTCGAATTCTTAAGGGCTCACACAAGCCCTGG TTCTCTGCCACTTCCTCCCTCCATTGGGTAGTGGGGTGGGGTTCAGAGAAGCCAGGGCAGTTAACCCCTC CGTTGCTGGACCACCTCAGGCTAGATTCTGAGCCTCCGCCCCAGCACGCAGAAGTCTGACCGAGCCTTGG AGCCCAGTGACTCAAGCAGCCTAGAATTCAGTGAGCACTGGGAGCTGGAGAAAAATCAGAGGCTTGTCCT TGTTTTCTCTGCGTTTTATCAGCCTCATCCAAAGTTCCAGCTTACTGTTTTTACTGTCTTCTTGGGAAGC TGCCACAAGGTTGGGTGGAGGGCTCCTGCAGGGACTGGGGGAGCCAGAAGAGGCAGATCAAGGTTTCTTC TCTGGGTGATGCTTCCAACTTGCAGAGGCAGAGGTTCCCCTGTCTCCCTCCTGGCCTCCAGCCAAAAGAA GCAGGTTGGCCTCTCCATGTTTCCTCCAGCTTTTGTAGCCCTAGCCTCTGCCATGCCTCATTGACCTTTG GCCCAGTTGGGATGTTTCCTGGGAAGGAGCCTAGTGAGAGAGACCTGGGGGCTTTGTGACCCAGCTGTGT TTCACTTTAGCTGTAGTAGCACCTCCTCGCCCAAGGCAGTCATTCTCCCTCCCCTGCATCCACTGGGCCA AGAAGTTACCCGTGGGGATTCTGGGATGAACCAGGTGTGGCGCCCGCTTGCAAGGAGTGCTCTCTGGACG TGTCTGAGCCTTGGTTTCCCCATGGTTAAAAATTCCTGCCCAGGAGGCCTGGCATAGTGGCTCACGCCTG TAATCCCAGCACTTTGGGAGGCTGAAGCAGGTGGATCACTTAAGGTCAGGAGTTCTATCAGCCTGGCCAA CATGGTGAAACTCGTCTCTACTAAAAATACAAACATTAGCCAGATGTGGTGGTGGGCACCTATAATCCCA GCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCCAGGGCTGCAGTGAGCCAAGATTG CCTCTGCACTTCAGTCTGAGCGACAGAGCGAGACTCCATCTCAAAACAAACAAACAAACAAACTAAAGAT AAAAAAAAATTCCTGCCCAGGGATGTTGGACCCTAGACCAAAGAGGATTTATTGAGCTCTTGCTATGTGC CAGACGCTAGGCCGAGTGTTTGCTGTCATTCCCTCCTGCTTTCTTACTTTTTTTGTTTTTATTTTGCTTT GGTTTTTTGGAGACAAGGTCTCCAAAAAAACTTCGTCCTGCTCAGTCACCCAGGCTGGAGTGCAGTGGAG TGATCATGGCTCACTGCAGCCTCCACCTCCTGGGTTTAAGTGATCCTCCTGCCTCAGCCTCCCTAGTAGC TGGGACCACAGGCATGTGGCGCCATGCTAATTTTTAAGTTTTTTGTAGAGAGGAGGGCTTGTCATACTCT TGGCCTCAGGTGATCTACCTGCTTTAGCCCAGCCTCCTCGTGTTTTCTTCCTGCCTCTGGTCTTATCCTT GAGTGACATTCAGGTTCCTGAATCCTGGGTTTACCAGGGTACAGCTTTCTGCCATTTCTGTTCTGGTCTT GCTTTGTGGACCACAGGCCTGGCTTCCTTCTCTGAAGCATCACGTGCTCCATGCTGGGCCAAGCCCAGTG CAGGACCCGTAGGGGCACGTGGTTTCTTCTGGCACTTTGCCAGGGAGTTGGGCCCACCCAGTGAGTGTGT GAGTTTGGTGTGCAGGGAGGCCTCTATGTTCTGCCTGTCTCTGGCTAGTCTCTGAGGGGAGCTAGGATCT TGCAGGGGGCTGGTCAAGAAAGAAGAAAGCTATCTTTCCCTGTGGTTTCTCAAGATTCAGATTTAAGCTC TAGAAAGTGACTGTAAAGTAGGCAGTGAAAAGGCCTCTTCTGTTTCTGTCCTTGCATCAGACTTGTTTGG GGGAGAGGCAGGGGAGAGAACATAGGCCAGAGCTCACTGCCAGCCCACCTGGTGTGGCGGACCCCCACAT GCGTGCAGTTACACACATGCCTGGTGTGTAGGCAGACACCCACGCCGGTGCTGGGGCGGGGGAGGAGGAC TTGGGAGCTGGACTGAATGGGCTGTGTTTGTGTTTCCACCTTCAGGACTGCAGCCATGCAGCCAATGCTG TGGCAAGGTTGAGGGTGCACTCCCGGCTTCTGCACAATAGCCAGTGGTGGAGGAAGAACTGCTAATAGAA TTCTTTTTGTTTGTTTTTTTTGAGACGGAGTCTCTGTCGCTCAGGCTGGAGTGCAGTGGTGCGATCTCCG CTCACTACAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTAC AGGCACCTGCCACCATGCCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTTTCCATGTTGGCCAG GCTGATCTGGAACTCTTGACCTCAGGTGATCCACTCGCCTCGGCCTCCCAAAGTGCTGGGATTATAGGCA TGAGCCACTGCCCGGCCCGAATTCTTTCTTGAAGCTTCTGGGTGGGTGGAGTGAGCCTGCTCTTGGTGAG AGAGATATTTAAGAGAGATATTTATGCCCTCCATTACTTGTTTTGTAAACTGGATTTTCCAAAAGTGGGG CAGATCAGTCCACACGCCCAGGCTTAGCATAAACCTGCATCGTTGTCTCCCTGCAGATAGTCTAGAGTAC TGCCTGTTCCCTCCTCTTTAGGGCCCTACTGACAGGAGGCAGGGTTGCCAGCCAGGGAAACCAGCTTGTG AGGTGTCAAGTGGGAGGTGGGCATGGGCTGGGGAAGGAAAATTGGGGGACTTGGTTGCACCTTTCCCCTC TTCTCTGACTGCACATATTTGGGGTTCATTCTCCAGTTTCCTTGAGCTGTGGGGTAAGGACTGAGGAGGG TAAAGATGTCCCTGATTCTGGGGAGCCAGGAACTATGTTTCTGCCCCTTCCCTTAGGCATCAGATGGGAG TAGGGTGTGGTCTGTGTCAGACAAGGCTGGGTGCTTAAGTGTCTCTGGATTCTAGCAAACTGTCTTTAAT CCCAGCTGCTTTTAAAAGGTGGGGCAGGGTTGGGTGCAGTGGTTTATGCCTGTAATCCCAGCACTTTGGG AGACTGAGGAGGGTGGATCGCTTGAGGCCAGGAGTTCAAGACCAGCCTCATCTCTACAAAAAATGAAATA AATTAGCCGAGTGTGGTGGTGTGGGCCTGTGGTCCCAGTTACTTGGGAGGCTGAGGCAGGAGGATTACTT GAGTCTGGGAGGTTGAGGCTGTAGTGAGCCCTGATTGCACCACAGCACTCCAGCCTGGCAACAGAGGGAC ACTCTGTCTCTAAAAAATGTAAAAATGAAAATAAAAATAGGTGGAGCAGGAGTAGGCAAACCCCGCACTG GGGCCCAGGGCTTTCCCTCCTTCCCAAAATTGTCTGCCTCTAACTGGAAAAATGGGGACTAGGGATGACA GTGTGGGGGAGGGCAAGTGCAAATGGCCAGCCCAAGTAGCCAAATGTGGCCTCCAGGTAGCCCTCCCACC TCACTTACCCCCAAATCCCTGTCCTTCAGGCCTCCTGGAGCCTGAGGGATCACTTTGCTTCCTAACACCT ACGTTTTACAGATGAGGAAACAGGCCCGCGTTTCCATGCCTTACTCAACTTGCAGAATTGTTTCTCTTCT ATATTACCGACAGGGGCAGGCTTTTTTTTTTTTTTTTTTCTTTTCATTTTGTGTGCAATCTGATGGCTGG TAAGTTCTTCCTCAAGTCTAGCCTTGATCTTTTTGACTGCTCTTTTTTTTCCTCTGATTGAACAATGCCT CCTTGTTGCTTCCTATCGCCACCACTTCAGCCCCTTAGGCCTGAGGGGATGGACGGGTGAGAAACTGGGT TAGCAGGGAGCCCTCCCTTCCCGCCTGTGGGCAGCCTTCCCAGTAGGGGCTTTTGGAATCCGCAGCTCTT TCTAGAGGCAGGATGTGGGGGCTGTTTTTTTTTTTTCCTTTTGGTAAAACCAAAAGCTCCTTGTTGCTTT TGTTGATGTCTTTTTGTTCCTCCTTGAACACAAAGCTGTGGTTTTTGAAGAGATCCAAGCCTGGAACGGG CGAGGCTCTGTGTAGAAAGGGCGCTGGGCTTTCGGGTTCGCTATCCTGTTCTTCTGACCCTGGAGTGTGG CTGATGGCAGGACTGGAGAGTGAGGCTGGTGGCTGACAAGCTGTCCCTGTCACCTGTGAGCCCGGAAACC TTGCCCCTGTAGTCCCACCAAGCAGGAAGGCCACCCAGAGGTCCTCACAGATAACCCCTCTCCTGGGACA CAGGGCCTCTTCAGTATCATATCCTTTTTTTTTTTTTTTTTTAATTTTTATTTTTTGAGACAGAGTTTCG CTCTTGTTGCCCAGGCTGGAGTGCAATGGCGCAATCTTGGCTCACTGCAACCTCTGCCTCCTGGGTTCAA GCGGTTCTCCCGCCTCAGCCTCCCAAGTAGCGGGGATTACAGGAGGCCGCTACCATGCCTGGCTAATTTT TTTGTATTTTTAGTAGAGACGGTGTTTCACCATGTTGTCCAGGCTGGTGTCAAACTCCTGACCTCAAGTG ATCCGCCCACCTCAGCCTCCTAAAGTGCTAGGATTACAGCGTGAGCCACCACGTCCGGCTTTTTTTTTTT TTTTTTTTTTGAGATGGGGTCTCTCTCTGTCTCCCAGGTGGAAGTGCAGAGGTGTGATCTCGGCTCACTA CAACCTCCGCTTCCCGGGTTCAAGGGATTTTCCTGCCTCAGCCTCCTGGGTAGCTGGGACTACAGGCGTG TGTCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTTGCCACGTTGGCCAGACTGGTC TTGAACTCCTGACCTCAGATGATCCGCCCGCTTCGGCCTCCCAAAGTGCTGGCATTTCGTGCCCGACCTG TATCATATACCTTTGAAAAGTTCAGAGGGATAGGCAGCTCCTAAGCAGGTGTGGCTGAGAGGCCCCAGAA TATCTCTCATAATGGCCGAGCTTGGAAACGAGTTGGGTTTGAAGGATGAAGTGCTTTGTTTTGCACCCAA CCTGCCAAGCACATCTTTCCCCAGAACTGAGTGCTGGAGGTGGCTGGGGTCCATCTGGCCTCCCCTTCGC TGTCTGGGCAGCTGTGGTGTAGAGGAGAATGCCTTGGGCAAGGTCTCTGTCCTTGACACTGGACCTCAGT TTCTTCATCTGTAAAACGGCACAATGAGAATGCCAGCCTAAAGCTGTGTGGTGGGTTTTGAGAGAGAATG TGCACAGGACTCAGTGTGCCAAGATGTTGCTTTGTGTCTCTGTAAATTGTCCTGAAGCCCGAGGCTGCTG CCAATAGCTGCCTGTTTGCCCTGCCCTATCCCTGTCCAGTCCCTGTTCCTGCCCCGCTTCTTCCTGTCCT ACATGCCTCTCCCTGCAAACTCCCCAGAGCAGCTGATAGCAGGGAGGAAGGGTGGGTGGGGCACCTGCAG AGAGCCCACCACCCACTTGGAATGATTAACAAGGGGCCAGTACAGGCTGGCCTATGGGACAAAGGACAGC TGTGCTCTGGACTCTGCCCTGCACCCAGCTGATCACCTGTCCCTCATTCCTCGCCATGGCCCAGTCTGTC ATGGGGTTGGGTTCCAGCGGAGTCACCAGCTGGGACGGGTGGCCCCTGGTCTGTCTTAGCACCCATGTTG GCATGCACACATTTCCAGCCATCCCTGCTGGGATCTAGGGGTAATGGATGGGATGGGCAGGAAGGGAAAA GGTAGAATTCCCAAAAATTGTTTCTGGAGGGAGGTCAAATCAGTTGGAGCTTTCTTTGAAGCCCGGCATG CTGGTGGGGGGAGGGGTGCAGCACTGATGTTCTCATGCCTTTGCTTCTAGAAACAAACCCGTGACACTTG TCCTCCTCACCTAAATTATCCAGAAAGATCCTATAGACACAGTCTCCTGACTTTGCCCTCATGGGCTTCT CCTTAGTTGAGGACCCCCTTGCTGTCTGTGCCTCTTCCTCAACCCCCGTAGACCTCTCTCTCTCTCTCAC TCATTCTCTCTCACTCGCTCTCTCACTCTCACTCTCTCTCTCTCTCTCTCTGTCTCGCTCTCGCTCTCTC CTCACTCTCTCTCTCACTGTTGCTGCTCTCCTGCCTGGAGCTGAAGATGAGGTTGCCATGGAAACCTGAA GCGTAGTGAGCCGGGAGAGGGAAAGGCAGAGTCGTCTCGCCAGGGCTGGGGGCTGGGGACTGGGGACTGT GGGCTGTGGGGAGGGGACAGGGTTGACCCAGCAAGAGGAATATAGCCCAAGCTGTCTGCCTGCCTTCCTC TGCCTGGGGTTGGGCTTAGTGGGCAGGGGAAGGAGCTTGGAGGCTCTGGAGTGCCTCTTTAATCTAGTTA ATCTGATGCAGGATTAAAATCCTCCCTCACTCCTGCCAAATTAAGCTGAGCTCACATCTGGGCTGGCTCA CCCCCACTTCCCTTCTGATGGGATTAGCACTCCAGCTGTCGGGGGCTGAGACTAGGGGGAAGGGTGCTTC TGAAGAGGATGAAGTACCTGCCAACCCCACCCAAGGTGCCTGCTGCATGTTGGAGGGGCTCCCGAGACCG TCTGGTGGGTGTAGGGTGAGCAGAGGGACACAGTGTGGGGTGCAGGGGGTGTGTGGACATGGCCTCAATG CAGCTGCTGCCTGGGTGTCTTGGAGGCGCCCATCGGTGCAGAGGGCACATCTATATATTCATCGTGTGTG AGGCACAGTGCAGTGTGTGTAGGAACTTCAGACTGTGGAATGGGTGGGGCACGTCAGGTGCACCTGTCTG GCGGTCTTTGGGCACTGGAGCTGGCCTCTGTTTTATTTATTTATTTAATAAAAACAGGCTCTCGCTCTGT AGCTCAGGCTGGTCTCAAACTCCTGGCTCAAGAAATCTGCCCTCCTTGGCCTCCCAAACTGCTGGGATTA CAGGCGTGAGCCACTGCACCCAGCCTGGCCTGTTTTAACCCTGTGCATTCTGGCCAATGAGAAACCCCAG GGTTTTGCAGACCGGGTCTGGAGGATGTGTTTGCCCTGCTTGCCTCTAGCCCTCCCCATCAAATGCTAAC CAGCCTCATCTTCTCAGAATTGAGTCTTCGAGTGCTGGGCCAGAGCTGCCCGGAGGTCTCCTCTCCCCCA CCCTGCTTTTGCCACATGTGCCTCTACTTCCATGTGCTTGCCTCACCACAGCCCCTGCCCATACAGTCTG CAGAATGGCTCTGATGTTGGGAGGAGGGTCGTCTCGTCTCTGAAGCGCTCCCTCTTAGGGCCTCAGGGCC TGCCAGCCCTGCTAGAGATCTTCCCTTTCTGGTCTCTAGGAACAGACTCGTGGTTGATCATCCCTTGGCC TGGAATTGTACAGGAACTTTGAAGGGAGCTCCTCAGCTGTGGGTGGCCCTGGCTGCACGGGGACGACCCC AGACTTGGCCACGTATTCATCACAGGCCACGTCTGTTGCCAGCTGCGGACACCTGTGTTTGCCTTTCCTC ATCTTCCCTTCCTCTGCTGGAGGAACTGCGAGTCTGGGCTGACCTGGGTGGCCAGGACCCAGGTGAGGGC TGGGGGACGGGCACCGCTAGGATCATCTGGATCCGGGACAGTGAAACTGGCCCAAGGGAAAAAGGATTTG CCAAGGTCACCCAGTAAGTCAGTGGCAGGGCCAGAGCCCTGCACTGGGCCCTGTCAAGTTATGCTCCTTT GATTGAGGTCTCCAAATCCTGAGCCCTGCCCTTCACAAGTGGTGGCCTCAGGGGAAGTCGCCTGTTTACA GGTAGCTCTGATGCACGGCCATGTGGGCGGCAGGAGAACATGCCGAGCAGAGGGGCAGCTCGTTCTTAGC TCTCGAGTGTGTCAGTTTTGGGTGGAACGTGCCTAGGAAGAGGTCCCAGGAGGCCATCTATGGCTTACCT GGGTGCAGCCTGTGAGTCAGGGATCTGCAGGGGTCATAGCTGTGGTGGGCTGTGGTCACCCAGGGCTAAA AATGGCCTGACGGGCTCCGGCTTGGAGAAGCCACCCACCAGTCCCTGAAGTAATTGGGGCCCATGCAGAC CCCCAGACATTTCTCATAGCAGCACATACACACAAACCACATGGCTCAGAGCTGCCTGTCTCTCCTGCAG CTGGTTTGCTAGGGGACCTTGTGATGAGAGAGGGATGGAGAAGGGCTGAGTTCTAGTCCTGCACCAGCTT CAATTCCTGGCGTGACTTTTTTTTTTTTTTGAGATAGAGTCTTGCTCTCGCCCAGACTAGAGTACAGTGG CGGATCTTGGCTCACTGCAAGCTCCACCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAG CTGGGATTACAGCTATGCGCCACGGTGCCCGGCTAATTTTTGTATTTTTAATAGAAACAGGATTTCGCCA TGTTAGCCAGGCTGGTCTCGAACTCCTGGCCTCAAGTGATCCACCTGCTTTGGCCTCCCAAAGTGTTGGG ATTATAGGCGTGAGCCACCATGCCCAGCCTGACATTTGTTTATTCAACAAATATTTACTGAGCATCGCCT ACTATTCTAGGAACTTGAGATAAATCAATGAACAAAAGAGACCCCAAAATCCCTCCCTTCATAGAGAAGT AGTGGAGAGAGAAGACAATACATTGATGTGATAAATAAGTTAATTATGAAGACTGCTAAGGGAGAAGTGC CTGGTGCCAGCACACCGTTTCCTCCTCTGAAATGAGGGAGTTGGACCAGAGTCTTCTGGAGGTCTCTGCA GGCTCTGAGGGTTGCCGTGGCTTCGGCTGCCTCCAAGCCAGGCCCTCTTCCTGGGGACCAGGCTGTGCTG GGCCTGGAAATTGGCGGCTAAGTTCAGCATGAACTGAAGAAATCGTCTGGGCGCAAATCTGGATCCCTGT GTGTCTTGGCCATGTTGTTTAACCTCTCTGGCCTCAGTTCTCCCATCTGTCAAAGGGGTACGCTGAATAC CAGTCACACAGGTGGCTGTGAGAATTCGGTGAACTAGGGCACATAAGCCCTTAGCACAGGGAGAACATTC ACTGTTTGTTTTTTTTTGTTTTGTTTTGTTTTTTCTTTTTGAGACGTAGTCTGGCTCTGTCACATAGGCT GGAGTGCAATGGCAGGATCTTGGCTCAGTGCAACCTCTGCCTCCTGAGTTCAAGCGATTCTCCTGCCTCA GCCTCCTGAGTAGCTGGGACTATAGGCGCACGCCATCACACCCGGCTAATTTTTGTATTTTTAGTGGAGA CCGGGGTTTCAGCATATTGACCAGGCTAGTCTTGAACTCCTGACCTCGTGATCTGCCCGCCTCGGCCTCC CAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCTAATTCACTGTTGTTACTATAGATTGAGC AGCCCTAATCCAAAAATCCAGAGTCTGAAGAGCTCCAAGATGCAAAGCTTTGAGTGCCGACGTGATGCCA CAAGGGAAAATTCCACACCTGGCCTCATGTGATAGGTCATAGGTCAAAAAGCAGTCAATAATTTTGTTTC ATGCATAAAATTATTTAAAATATTGTATAAAATTACCTTCAGGCCATGTGTATGAGGTATATAGGAAATG GTCCCATCCCCAAGATGTCTCAGTATGGATATTCAAATATTCTAAAATCTGAGAAAAAATCCAAAATCTG AAACACGTCTGGTCCTGAGCATTTCCAATAAGGGATACTCAACCTGTATTTTACCTGTCACCCTCAGGTG ACCTCCTTTTTTGTCCTCAAGCTGGCCTTCCCACCTACCCTCCAGTTAGGTTGGACCTTGTTAACCGTTT GAAATACCACTTTAACCGTGTGTTTTCTCTCTCACCACTTCCTCCAGGAAGTCCCCCTGGATATGTGTGT CCCTTTGTTTTTCTGTCTCCCCCTTGCTCTCCTCTGCATGGTCGGTCTCCACTTCTGGTCTTAGCTGAAA GCTTAGTCCTGACTCACCTGTGCCCATCTTCCCCCAGCCGGGCCCAGTTGCCTCGACCTCCATGTGTGGT AGGCACAAGGCATGGATTATCCCCAAACAAGGGTAACCTTCAACCCTCAGAGAGTGGCCCAGTGGCCATC CTTTCGCTCAGGACAGTTCTCCTTGGCTGGCCCATCACTGATGCCTGCTGCGTCTTCCCAGGTCAGCCAG TCCCAGCTGAGTCTGAGAAACGCTTGTCTCCCCTCGGCCTTGGTGGTGGACACTGAAGTCCTCCTGTGGG GCCGGGCCAGGGCGTGCCCAAGCATAGGACGAAGTTCCCAGGAGGGCATGCTCTGTGAGAAGCCCAGAGG CTCCTGCCCCTCCCCCAGAGTCACCCCCACTCTGTTTTTTCTGTCCTGCAGACACTACCCCAAGCAGTCC TTCACCATGGTGGCGGACACCCCGGAAAACCTTCGCCTCAAGCAACAGAGTGAGCTCCAGAGTCAGGTGA GGGGCTGGGCGGTGCTGGGGCCTGGCAGGGAGGGATGCTGGGGAGGGAAGTTGTAAGGTCGGCATTTGGC AAGAGTACCTTCCCCTGCGGTTACTCTGCAAGGCCAAGGTGCTGAAATCCTAGCATTGCCTTTAATCTTG ACCCCACCCCTGACTTTATCAAAGGAGCAGGGTAGAGCGTTCTCCCACTTCCTACCTAGAGGGGGTTGGA GAGGTGTGGGTGTCTATTTGAGCCCGCTCTGGGGCTCCCTAAAGCCTACCTCCTCCAGGAAGCCACTCTC CCCTCCCTCTTCCCCATTCACACTCACCCACAAAGGAGGGGTTTGGGGAGGACCAGGGAATTTGCCCCTC CAGGTCATGCCAGTCTGAGGCTGGGCAACCAACCCTCTATAGCCGCGTCCCAAACCTCCACCCACTGAAG GGCAAGGTGTGAAGGGGGCCCTGCCATGGGGGCACAGGATAGGGGGCTGTTCCGCCTCTGTCTCCTTTGG CTTGACTTTCCAGAACACTGCTGAGTGGGAGGTATGTGCCCCTGTAGGAGGGGAGGACGGGTTCCAGGCC TAGGGAGAACTTGGTCTTTAGGGGACACGGAGGAATAAGCAAAGGGTCTGGAGTCCTGAGAACAGAACAG CTGACCCACCCTGCCTGGGGGTGCGAGGGCTCCTGGGACAAACCTGGCCAGTGATGAGGTGGGGTGGGGT GGGGCGGGGCTTCAGCCGATGAAGGATTAGGCGCGAGAATACATGTAGGGGAATTTACCACGTGGGCAGC GCGCCCAGGACCCACTCAGGATCGGGAGAAGACTGCAGAGGTTCCACCCGGGCCACAGAGGGGATCTCTC CCAGTTCCTCCAGAGGGGACTCCTGCTGCCTGATCTTGATGTGACTGCCCGGGTCCATCAGGGAGAACCG ACCCTGCCTTTTGTCAGGCTTTCCATGCACCCTCTCTCAGCATCCTCCCAGCAGCCCTGTGAGGAAGGTG CTATCTTCCCCATTGTTACAGATGAGGCGACTGAGGCCCAGCGACTTTGAGGGACTAGCTGAGGTCCTGC GGGTAGGAGAGGCAATAATAATATTCACAGCTGACGATGGAGGGCTCAGTGCTCCCGGCGTGTGAGCTCG TTTAATCCTCACCCAGCCCTGTGCAGCTGTAGCATCACTTCACTTCAGAGAAGAGGAAATAGACACTGGC AGCTTTGAATGTAGGTTTGTCTAACCCAGGGACTATCCACTCCCCAAGAAACAGTCTCTACCTTAATAAT AAACATGATAGTTCCTTATGCTGTTGAGAAGTTTTGTAGTTTAGGGCTGGGAGCCATGGCTCACGCCTGT AATCCCTGTGCTCTGGGAGGCCAAGGTAAGAGGATCACTTGAGCCCAGGAGTTCGAGACCAGCTGGGGCA ACATAGCAATACCTGGTCCCTAAAAAAAAAAACGAGCAGAGATGGTGGTGTGCACCTGTGGTCGTAGCTA CTTGGGAGTTTGAGGCGGGAGTATCACTTGAGCTGAGGAGTTGGAGGCTGCAGTGAGCCATGATCGCACC ACTACACTCCAGCCTGGGTGATGGGGTGAGACCCTGTCTCTAAAAAAAGGAAAAGCAAGAAATTGTGTAG TTCAGCAAGTGCCTTTAGTTAGTTCCCCTGTTTATCCTTGACTGGGTTCTGGGAGAAGGTAAAAGACCCA GCGTCTCTGTCTTACAGATAGGGGAACCGAGTGAGTGAATGCGGATCCAGGATTTGGGCCCTGGTCTTGT CACTCCCAAGTCTGGGGCCCTTGATGCTGCACAGCCCTGGTAGGGCCTGAGGCTCACAGAGGAAGAGAGC AGCAGCTCACACCTGCCACCCACCCACCTGCGGCACAGAAGCTGAAGTTACTAGGAAGCAGGGAACACCA CAGCCTGCCTGGCCATATTTTACAGATTCTAGCCAGGCCCTGACTCCTGCCTTCAATTCCCTGCCCTGTG GAAGGGCCATGGGGGCCAGAGGTGGAGGGGCTCAGAAGGACCTCGGAGAAGAGGTGCTGGGAGCAGATAG CAGGTCTTTGGAGACACACACACACACACACACACACACACACACACACACACCCTTCTCAGGGGAGAAA TTCAAACCCCTCAGCCTTTGTCAGTTCCACAAAAGCGTGGCTGCAGCTCTTTTTGCCCCGGCACCCTATC CCCGAGGGGTGGGGTTTGAGGAGGAAGCACCTCCACGTTGTTCCCCCTGCCCAGGATGGGCAGCAAGTGG GCAGGGCATGCTGTTGGCAGGGGCTGCTTCTGCCCCCCACAGGGGAAGCCAGCACCACGCTCTGGGTTTG GGGGCTCCTGTCCCTGGCCTGTGCCCCCTGCTTCCCAGGGTCATAGCCTGCTGGGTTCCCGGGGGGGCCT CTTGGGAGATGAAAATGGCGGTCACTCTTCATTAGGGCCTCACTGAGGGCCAGAGCGTGTCCGTGTGTGT ATGTGTGTGTGTGTGCGTGTGCACGCATGCACGCGTGTATGTGTGTGTGTGTGTGTGCAAGCATGCACGC ATGTATGCGTGTATGCCTGACTTTGTTTAATCCTTACAGCCACCTGATGAAAGAGGGGCTCTTATTATCC CCATCATACAGATAGGGAAACTGAGGTTTACAGAGGCTGCCCTGCTTGTGCAGAGCCCAGGGACAGGGGC AGACATCAAGTCCCATGACCTGGCCCTGGAGCCCGTTGCTCTGAACAGTGCTGATGGCACAGGCACCGAG CCCTGTGCTCCCACCCTGCAGGATGCACCAGTCAGCAGCAAGTAGGATGGGCTTGTTGGAATGCAGATTC CTAGGCCCCACCCAAGGGACTTCTGCTTGGCAGCTCTGGGTGAGGCCCAAGAATCTGCATTTTGACTCCC CCGTGATTCTGATAAGGACTTTTGGCCCCACTTTAAGAAGCTTAGAGATGGGTCCATGGGCAGGAGTGTA CCGACCCTGTTTGTATGCTCTGAGGGGTGCCACATTAGGGTAGGGCTTTGCACTAAGGGCACGGCTCTGT TCCCCTGAGGTGGGGGTCCTCGGGGGTTGGGGGCTGAGGGCAGGATAGGCAGGGGAGGAAAGGGTACTGC CCTTTTTGCAGGCCTGTTCTGTCTCCCTTCCCACCGCCCACCAGCTGTGTGGTCTGAGACTGGCCTCAGA CTGTCTTTCCTCTCATAGCTTTGCTTCCTCACCAGTAAAATGAGGACAGCAAACCCAGTTGCCTCAAGCT GGGGGCTGGGCCTGATGCTTTGAGGCTTGGAAGGGCTGAGCCGGCCAGGCTGGAGCAGTGACGGGTTCTG GTTCCTGTGGCTGCCGTGGGGGCAGAGCTGGAGAGAGCTGCCTGCGGCTAGCAGGAAGGGAAGGGGGAGC CTCTTCTGCTCACCCAGCTTCACCCCACGGGGTCAGCTGGCTTCTCTCCATGCCCCTTCTGGGCCTGCCT TGCCCTTCCCTGTCTCTGGGAAGCTGCCCAGGCTATTTCAGCTTTATTTATTTTCCCATCTCTATATTGG TCTCCAAAATGGCACTTTGGGTGTCTGGGACACCTGGAGCCTCCCCTGTGGAGGAGGTAACCACAGAACT GTCCAGAAATGACCCTCTCGGTGGTCCTGCCCAGGCCTGGCTGAGGCAGGGGGCTGGCAGCTGGACCCCC AGCCCCCCTTCTCACTTGCTGCTCCTATCCCACCCCCAGGCTGAGCAGAGGCAGTGGCTTTGGGGTGGGA CTGAGCTGGAGGTGTCTGTATGGCCCTGAGCCCAGGCAGAAGTGCCAAGTGCCAGTAGACTGTTCTTCCA TTTTTTCCTTCATCAACTCACCTTGATGGGGTCATGGGAAATTACAGGGGGGTTTCTATCCTCCTCGGAT CTTGTAAGCAGCACGGGTGGTAGAGTATCACTCTTACCCGAACTAGCTGGCCTGAGATTGAATCTCGCAT CTGCTGCCACCAGCTGTGTGACCTTGGGCAAGTTGCTTAACCTCTGTGCACAGTGCCTTCGTCTGAATAA TGTGGATTACCTCTCTCCAGAGGGTGGTGTGAGATAGGAGGATATGTTAAGCATTTAAAGATTCCTGACG TGGAGTCAGCATTCAGTGTTTGCTACTACTGTTCTCCCGGAAAGGAGAGGAAATGGAACTTGGACATGAA GAAGCTGGGAAATACACACAGCAACCTTTTGACCATGACTTCCAGCCCCGGCCCTTTCCATCAGCTCTCC TCTCCATCTGTGTGTGTCTAATTTTTTTTTTAAATTTGTATTTTTTTGAGACAGGGTCTCTCTCTGTCTC CCAGGCTGGAATGCAGTGGCGTGATCTTGGCTCATTGCAGCCTTGACTTCCCAGACTCAAGCGATTTTCT CGCCTCCACCTCCTGAATAGCTGGGACTACAGGCGTGCATCACCATGCCCGGCTAATTTTTGTATTTTTA GTAGAGACAGGGTTTCGTCATGTTGCCCAGGCTTGTTTCAAACTCCTGACCTCAAGTGATCTGCCCACCT CAGCCTCCCAAAGTGCTGGGATTACAGGTGTCAGCCACCGCGCCCTGCCTAAATTTTAAAAACTAGTGTT TCTTTTTTGTTAGAAGGGGATGGGTTACAAAGTATGTTGGCCCAACACATGGTAGGCACATAATAGTGGA AATTGTATTTCGCTCAATAAATTTTGTATTTTTTTAGAGATTTTTATTAATTTTTTTTTTTTTTAAATAG AGATGGGGTACTATGTTCCCAGGCTGGTCTCGAACTCCTGGGCTCGAGTGATCCACCTGTCTTGGCCTCC TAGACTGCTGGGATTACAGACATGAGCCATTTTGTTTTTTAAGTCCAGCCTAATTTTTGTGTTTTTTTTT TAGACGGAGTTTTACTCTGTCGCCCAGCCTGGAGTACAGTGTCACCATCTCAGCTCACTGCAACCTCCGG CTCCCAGGTTCAAGGAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACGCCCACCACGCCCGGCT AACTTTTTTTGTATTTTTTTTAGTAGAGATGGGGTTTCAGCATGTTAGGCTGGTCATGAACTCCTGACCT CAGGTGATCCACCCACCTCTGCCTCCCAAAGTGGTGGGATTACAGGCGTGAGCCACCGTGCCTGGCATAA TTTTTGTTTTTAAGTAATGATCCTTCTTCTTATATTGGGTCATCAAGGCAGTTGTTTTCCCAATTATGCT GCTTTGTTTGGAGATTACGTGTCTGCATTCAATTCATTCATGATCCAACAAATGTTGATCTGCACCTCCT GTCTGCTGGGATGAGAAGCAAGATAGATCCAGGGAGAACAACTAAGAACTGACAGAAAAATTAGAGTTTC ACGGATGGTGGTTGTTTGGGTGTCAGGAGCCTCAGATGTCAGTCAGTCCTGGGCCTGACAGCAGAGTTTC CAAAATGGGAGCCCAGGTATCTCCCAGGAGTGGGGTCCTCTGGGAGCCCAGGCATCTCCCAGAAGTGGGG TCCTCTGACCGAAGCGCTGAGTTGCATCCTGGCCTGAGCGACAACTGGGTTGTGACCTTGGGCAGGTCCC TTCCTCCACAGGGACCCCCACAGCACCCTGGTGAGCCATCCTAGACAACAGGGGCAAGCACTCCTGCCAG GGCAAGAAGGGAGCCCTGAAGAGGGGCTCTGGGCTGGGCCCTCCCTACACCCCTGGCCCCCCACCCTTCA CTTCTGCCACCCCTTCCATACCCAAAGACCTTTCAAAGAGCCTCCCTGTCTTGATTATCCATAGTCAGGG TCTGAAGGTGCTTTAAAATGGTCACAGACTCCAAATGGGAGGGATTTTAGAGATCAGCTAGCCAGCTCCC TTCAGGGGACCCAGAGAGGGGAACTGACTTGCTTAGAAACACACAGCAAGGTGGTGCTGATCCCAGGCTC CCTCCCTTCTCAGCCCCTACCCCTCACCCCTACCCTCTGTGGGCCTCCTATGTTAGCAGTGAAATGAATG ATCCTTCCCCAACAGGGAGGGGGAGGCAGAAGCAGTTCCCGATCCTGGGAACCTGCTGATGTCATTGCAG CGTCGCCATGGCGATTATTCCCCTGGATTAGGGGCCTGACCCTTGCAAAGCCAGGAAGCAGGGGACGGAG TGGGGGACTGGCACTCGTTCAGCACTTCATTGCTGACAGAGCACTTTCACACTGGCCCTCCACAGTGCGC TGCTGCTTTAGAGCCACTGTCTGTATCGTGGGTTGGAGTGACTGGCGTTATGGTCCCCATTTTACAGATG TGGGAACTGAGTCTTGAGATGTGAAGTCGTTGGCCCAAGATCACTCAGAAGTGGGAGACTGAGCCTGCGT TAGTGCTAGCTCCGCCTGGCTTTGTGCCCAGACTTGGTGATAAGAAGCCCCCTCCCCATATTATACCTGA TTTCTGTCACAACTCTTTTACAGATGAAGAAACCGAGGCCAGGGGCTTGAGATGCAGGGCTTCTGTATCT GGAGCTACATTTCTCTGCCTCTGAGTGCCCTACCTTCCCCGATGCCCGCTTCCCAAAGGGCCTCCCACTA AGAGTCACCGTGCTGGCCCAGGGCTTCCAGGACTGAGGAAGAGCTGGTGCTAGGCAGGTTCTGGACTCTT GGGGTGGGTTGGTGCCTCTATCCACTGCATTCACTTCTGAACTAATGGGGAACAGCACATCCAAGCCCTT CTTGTCTGGATCAGAACAGAGAAGGAGAGGGAACCACATGGATGAGTGACTGGGGGCTTCAGGAGACAAA CAAGGACTCTGACCCCCACAGGCATGTGCAGAGGACCTGACAGGTGTGGCCGTGGCTGCATGCGCATGCG CAGTCGCTCCAGTCCAAGCACAGCTCGGTGCTGCTGCCAGATGATTCCCTGCCAGGGAACTGCCTGGGTT TGTGTCCTGGGCTGACCTGTGTCCAGGACAGTGCAGCCCCCGTGGAGGAAATCCAAGCAGCTGGTGGGGT CTGGAACAGATGGCTGATGAGGTGGACAGTGAAGTCTCTGGAAGCCAAGGAATAGTTTCCTGTTCCATGA GTTTTCTCAGCCTCATTCTGTTCTTCAAAACCCTCAGGGGAGGACAAGCTGTTCCTCATATTTCAATTCC TTTCGTGCCAGGGAAGTCCTTTCTGATGTCTGACTTGAGTCCCTCTAGTACTGTGGTGGGGTGGAAGGGT TCTTCCCTGGAGCTTGGAGACCTGCTGAGATGCTGTCTGACCCCCGCTGCTTTCCTCCCCTCCTATGGCG GTGGCCTCTGAAGCCATCCCGGCAGGCTCCCAGAATCCGCGGGGCCTGTCAAAGGCGCACTGATGGAGCC TTCCCTGGGGCTGTCTCACCACCCTCCTTTCTGGGCACCAACTCTGTCCTTTGGCACAGCCCTCACTCAG CTGGTTGCTGAAAAGCTCCCCCAGGCGTAGTGGGCAGGGCCACATCCTGGCTAACATGAGGGCTGGGGCC ACCCTGGGAGCCCTGGAAAGAACCTTTTTCCTATAAGCTTCCAGACAGGATGGGCAGGGAGTGAAGGGTC AAGAGTCAGGCAGATGAGGGTTTGCACTCTGGTAGTGCCGGACATTGACTGCTAAGCTCTGTGACCTTGG GCAGGGGACTTTGCCTTTCTGTGGCTCCGTTTCCTGATCCGTAAATTGGAGCTGTTAATTGCGTGGCTAT ATGTATGGTGGGATCTAAATGAGATGGTTCATGTAAGGCCCTGGACTCTGTGCCTGCCATTCACTGTGCA CCAAAGACTTGGTAGTGGCTTATTATTACGAGTCTAACACCTTTTGGCTGAGGCCTCTGCTTTGAGTTGG GGACTTCTGATCAGGGTCTTTCTGCTGACTCCCTGTCCCTGTCTCCTGACTGGTTGCTGCCTCAGAGGGG CCCCAAGCCGAGGCCCTTTCGGCTCCTGGCCTGACTCCAATCCCTCTTCCTCCCCTCCTGCAGGTGCGCT ACAAGGAGGAGTTTGAGAAGAACAAGGGCAAAGGTTTCAGCGTAGTGGCAGACACGCCCGAGCTCCAGAG AATCAAGAAGACCCAGGACCAGATCAGTAACGTGAGCTCTTGCCCTGCCCTGCGGCATCCCTGCTGCCCT CTGTTTGGTCCCCTTCCTGCCAGCCTGGCAGACGCAAGCCTGGCAGATGTGAATGAGGCCAGTGCCTCCA CTACCCCTGCCCTCCAGGGTGGGCCTGGGGAAGAGCTTGGGGTTCCCAGATGCCTCTTCTCTGTGTACCC CCAGACCACCAGCACGCATAGCATTTTCTTCTTGAAGGGACTGTATTCTGTGGGGGCCTGTGTGCTAAAT CAGCCCCCACTCTCTCTGACTGTTGTTCTTTTTTCTGGATATCGTGGGTATCGGTGAAGACTGCATGTCT CATCTTAGCACAAAGGTCAAAACTGGGGGGCGGGGAGCACCTGGCCTCCCCTGGTCTGCGCCTGGGTGCT GACATTGCAGTCATTTCCGCCCTTCCTTGGCCTCCTCCCCCACATCAGCCTGCTCTTCCTTCCTGTGTAA AAACCCCAGCCAGCTTCACCCGCCAGCCCTGCACCCCCTGGCTCACACCCCCCGCCTCCCTGATGGTCAG TGGCATCTGGCTGTGGCAGGGGTGGGCATGGAGAGTGGGCAGGGGATCAACTGTCCCCAGCATCGTGTGC CCTCCATGGCACCTGTGGCCAGAGAACAGGCCTCAGTTTCCTGCTTGGCAGAGCCACAGGCAAGCAGCCT GTGTGGCTTTAGGCATGCGGGGGCAGGGCACTGCGGTGAGCAGCAACCATGGGGGATGCGCACACAGAAC TGCAGGGGCTGCCCAGCCAGCCTGGCCTAGGAGGTCCTGCCAGGGAGGGTTTAGGCAGGCAGCTGTCTTC GTGTCTGGAACAGGAAGGGATCAGTGAGCTGCCCATTGTTGCTCTGGGCTGAGGAACTGGGGATAGAGAT TGCCGGGGGAGCCTGGCTTTCCGGTGGTCTCAGCACCCACTCCCTGGGCTCCACATCCCTTCCTACCCTC CACCTGGCCACCTCAGCAGGGCGCTCCTTTAAGAGCTTGGCTGGGCCGTGCATAGAGTGGGCTGCAGTGG TGGGTCAGGTGGATTTCAGAAGCACAGGCAGCCCACAGACAGCAGAACCAGCCATGCCCAAAATGGTGGC TTTCAAACTCTGACTTCAGCCTACAGTAAAATATACATTGTACGTCTTGACCCATCTGACAGGCATACAT TTATGTAGAGGGAAAACAGAATGGAAGCTTTCATGAATGAGTACTTCCTACTTAGAGGGCGTTCAGATCT TTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTTGCTCAGGCTGGAGTGCAGTGGTGCTCCGCCTCCAG GGTTCAAGTGATTCTCCTGCCTTAGCCTCCCAAGTGGAGTAGCTGGGATTACAGGTGCACACCACCACCC CCGGCCAATTTTTGTATTTTTGGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACACCTG ACCTCAGGTGATGTGCCCGCCTTGGCCTCCCAAAGTGCTAAGATTACAGGTGTGAGCCACCGCACCCGGC CACATTCAGATCTTTTCTAAAGATGCTGGTTGCAGGCCCCTATACACCCTCACATAATACAGCCCCTTTG AGGACTGTATTCCCAACACTTTGGGAGACTGAGGTGGGAGGATTGCTTGAGCCCAGGAGTTTGAGACTAG CCTGGGCAACATAGCAAAACTGTTTCTACAAAAAAAAAAAAAAAAAAAAAAAAATACAAAAACTAGCCAG GCATGATAGCACACGCCTGTGGTCCTAGCTATTCAGGAGGCTGAAGTGGGAGGATCACCTGAGCCCAGAG GTTTGAGGTTATAGTGAGCCGTAATTGCACCACTGCATTCCAGCCTGGGAAACCGAGTGAGACCCTGTTT CCAAAAAAAAAAAGGACCAGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGAGAGGCTGAGGTGGG CGGATCATGAGGTCAAGAGATCGAGACCATCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATAC AAAAATTAGCTGGGCGTGGTGGCGTGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGACAGAAGAACCG CTTGAACTCGGGAGGCAGAGGTTGCAGTGAGTCGAGATCGGGCCACTGCACTCCAGCCTGGCGACAGAGC AAGACTCCATCTCAAAAAAAAACCAAAAAGATGCTGGTTGCAGACTTACTGTGAATGGGTTTTGCAACTG GACTGTTGACCTGCAGTTTGAAGTTGGTGGCCTGAGGAAATGGCATGCTTCCCTTTGGCTAGCAGGGGAT GCCTAGGGCGGGCACTCTAATCCTCCTTCCCCTCCAACTTCCAGAGGCCTGTCACAGTTGACTCTTTATA TGCTAGGGCCTGGCCTCACGCCCTGGAGCTTCCCTTTGGCTCAGACCCTGCAAAGGGTAAGACCCTTAGG TCTGTGTTTCAGAGCTCTCGGCTTGGAAAGTGGGGGAGGGGGAAGATGGTCTTAGATTATGGGGAAAACC CGGAATGGTTCACAGAACTGGAATGTCGGCTCTTCAGCCTCTGCGGCTTTTCATGTAGAGGCTCTAGTCT TTTATCAGTGACACTTGCTCCCAATGTGCAACCCCAGCTCCCTGGCTGTTCACTCATTGCTTCACCCTGT GGGTTTTGGAGGAGGGGAGACAAGCCCAGTCATCCCTGCTTCCCTTTCTGGAAGGCTTCCAGAACACTCC ACACTCAGCCTAAGCCACCTCCTCTTCTTCCCTCCCCCAGTTAGAGGTGTTAATATCCTAGTGACAAAAC TCACCACCCTGGCCAAGCCATCCGCATCTCAGGAGATAACCATCTTTTACCCTTCTCGCGGTGCTGCAGT GAGCTAATGGTCCTCTGCAGGAGCTGGGGGAAGGGATCGACCCCGACCTGCTAGCTGCTTTTGCAGCTTT AGCAGAGACCTGTAGGGTGTGAATGCAAAGCCTGGAGACTCTTGGTTTTAATGAAAGCAATTACAGTCTG TCGGATATGGGCCTCCAGACAGCTGTAGCACAGTCACCTGTAGGGTTGACTGAAAATGCAGACTCACAGG CCTTCTCCCCTGGCTGCCAGAATCAGCGTCTCTGGGAGTGGGGCCCAGGAATCAGCATGTTAGACACATT CCCTGGGTTTCTGTGGTGCTCTCTGAAGTTTGAGAGCCACCACCTAAAAGTCTGAAAAAGCTTCACCAAC CCCTAAGTCAGAGGGTGCCAGATCAGGCTGTACCTCAGAACCCCAGGGGAGCTTTATTTTTATTTTTATT TTTTTGAGACGGAGCCTTGGTTTATCACCCAGGCTGGAGTGCAGTGGCGCAATCTCGGCTCACTGCAACC TCCGCCTCCCGGGTTCACGCCATTCTGCTGCCTCAGCCTCGTGAGTAGCTGGGACTACAGGCGCCCGCCA CCACGCCCGGCTAATAGTTTTTGTATTTTTAGTAGAGATGGGGTTTCGCCGTGTTAGCCAGGATGATCTT GATCTCCTGACCTTGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGACACCGA GCCCAGCCTATTTTTATTTTTGAGACAGGGTTTCGCTCCGTCATCCGGGCTGGAGTGCGGTGGTGTGTTC ACGGCTCAGTGCAGCCTGAATCTTCTGGGATCAAGCCATTCTCCCACCTCAGACTCCGAGTAGCTGGGAC CACAGGTGTGCACCACCATGCCCAGCTAATTTTTCTTTTTTTTGCAGAGACACTATCTTGCTATGTTGCC CAGGCTGGTCTCAAACTCCTGGATTCAAGTTATCCTCCCGCCTCAGCCTCCTAAAGTGCTGGGATTATAG GGGTGAGCCACCTCACCTGGCCTCCCAGGGGAGCTTTTTTTTTTTTTTTTTTTTTTTAATCAGAGACAGG GTCTCACTATGTTGTCTTAAACTCCTGGACTTAAGTGATCCGCCCACCTCGGCCTCCCAAAGTTCTGGGA CTACTACAGGCATGAGCCACTGCGCCTGGGAGCTTTAAACCACACATAAAACCATTGCTAAGTTGTCCCA ACCTCCTGAAGTGTTTTGGAAAATAGGGTGTTTAGAGCCACACCTTTTGTTTTGTATCCAAAATAGCATT CCTGTTCCTGTATGTAGCTTGTTGCTTTGCTTCCCAGATTAGCACCAAATGACTCCAGTTACTTTATTTA TTTATTTTTAATTTTAGTTTTATTTTATTTTTGAGATAGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCA GTGGCGTGATCTTGGCTCACTGCAACCTCTGCCTCCCGGGTTGAAGCGATTCTTCTGCCTCAGCCTTCTG AGTAGCTAGGACTATAGGCACATGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGACACAGGGTTT TGCCATATTGGCTCGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCTGCCTTGGCCTCCCAAGGTG CTGGGATTACAGGTGTGAGCCACTGTGCCCAGCTGACTCCAGTTATTTCTAAAGGTCAGGCCATCTTACA AAAGAATGAGGATATGCTTCCTTGGAGGGATATGCTGCAGACTAGGGCTTTTTACCAGCCAGAGCATTTT AAAAACAAGTGTCTGATCTCCTCTGGGGTGTCTGCTTTGGATAAGTGCAGTCTGTCTTCAGTCTTGCTAA GTGGTGAGACAGTGAGGTAGGAAGAGATGGTAAGGGCCCAGATCCTAGCTTCTGTCATTCTGGGGCCAGG CAGGGCTCTTTGAGCCTCAGTTTCCTCATTTGTAAAAATGGGACAGTAGGCCCTACTTTGACAGGTGGTT GCAAGGAACATGCCAAGTGCTTGGCATGGGATAAATGATATCACTCTTATTATCATCATTATTATTTTTG AGACAAGATTGCCCAGGCTGGAGTACAGTGGCACGATCATAGGTCACTGCAGCCTCGAACTCTTGGGCAC AAGTGGTCCTCTCCCGTCAACCTCCTGAGTAGCTGGTACTACAGGCATATAGCACCATGCCCAGCTAATT GTTATTTTTTTTGTAGAGAGAGGGTCTTGCTATGCTGCCCAGGCTGGAGTGTAGTCACGTGATCACAGCT CACTGCAGCCTTGAACTCCTGGGTTTAAGTGAACCCTGGCCTAAGACTCCCAGGTTGCTGGGATTACAGG CACACGCCATCACACCCAGTTATGTTGTCAATGTTATCAATACTTTAAAGGCACACTTGTCTGCTTTCTA CACTGTTGCCGGAGAAGGGTCATAAAGTGAAGTTTGGCAGAAAAGTTTGGCCATTGTCTAGTACTGAGAA TGTGTGGAAGTGAGGAAAGGGGCCAGTATATTACACATCTATGGTGAGTAGTTGTGTCATCATTAAAGGC ATTTGAAGAGTTGCCTTTTGATGGGTCCATGCTATGGGATAAAGGTTACATGTTAGGAATCCTGGCCTTT TGTCATGAGCTCTAGCAGTGTTCAAGTATGGAAAACTTTAGTCACTTTACTGGAGCCTCTTCTTTTATTT ACTTACATATTGATTTTCTGTATACAATTTTGTGTCCTTAAAACTTTTTTTATGTGTGAAATATGACACA TAGTAACATATACAATAAACACCTGTTTCACCAGGCAGGTATACCATACATTGTATTACTGTATGCCTGT CAAGAGCCCAGTGTTCACAGTGTTAAAAATATAACTCCCATGTAGTAAGTACTTATCATATCTTTATTTA ATTATGAGGGAACCAGCTAGAGATTAAAACTGGGGAATATGAGAGGCAGAGGTAAATGCTAGTCTGTGAA AGAAAGTGCTGGGGCCGGGCGAGGTGGCTCATATCTGTAACCCCAGCACTTTGGGAGGCCGAAGCGGGCA GATCACCTGAGGTCTGGAGTTCAAGACCAGCCTGGCCAGCATGGTGAAACCCTGTCTCTACTAAAAATAC AAAAATTAGCCAGGTGTGGTGGTGCACACCTGTAGTCCCAGTTACTTGGGAAGCTGAGGCAGGACAATTG CTTGAACCCGGGAAGTGGAGGTTGCAGTGAGCTGAGACTACACCACTGCACTCCAGCCTGGGCAACAGAG CAAGACTCCGTCTCAAAAATAAAAAAAAAAAAAGGAAAAAAGAGAGTACTGGATACATTTAGCTACAGAA ATGGTTAAGGGCCTACCATTAGTTACACATTGGCTATTGTCCTACAGGAAAATAAAACCATAAACTTTGA AGATATCTTTGCTGCAGGCAGAAATGCTTTGCATCTCAGTTGGCCAGAAATAATGAGCATTTTATACTCT GTAATGAGCTTCAGTCTTTAGAGTCTGGGCCTAATCAATAGTAAATAGTCAAACAAAGTTTTGTCCCCAG AGTAAAATACTCTGAAGGCAGGTTTGTTGGACAATCCTCTAGTTTGATTTTGAAAGCATGTATTTTTCAT TATAATTTTAGTATGTAATTATGTATTCTTAAACACTATAGTTTTGCTTTTCCTGATTTTGAACACAGAG TAATTTTGTGTATCTTGCTTCTCTTACACACCATTGGGTTTAAAGATTCATCCATATGTTTGTGTGTAGC GGTAGTACATCCTTTTTCATTGCTATATAGTATTCCATTGTTTGTTTATACCACATTTTATTGATTCTGT TGCTGGTGGACATTTGTACTGTTTCCAGTTGCTATGGACATTTTTGTACATATCTCCTGAGGTCTATGTA CATTGGAACTGCTGCATCTTAGAATGTGTGCTCCTTGGGCCGGGCCGTGGTGGTTCACACCTGTAATCCC AGCACTTTGGGAGACCGAAGTGGGTGGATCATGAGGTCAAGAGATCAAGACCATCCTGGCTAACACAGTG AAACCCCGTCTCAACTAAAAATACAAAAAATTAGCCGGGTGTGGTGGCGCACTCGGTGGCGCAATCCCAG CTGCTCTGGAGGCTGAGGCAGGAGAATCACTGAACCTGGGAGGCAGAGGATGCAGTGAGTTGAGATCGCA CCACTGCATTCCAGCCTGGGCGACAGAGTGAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAGTGTGCTC CTTCAACTTTACGAGATAATGCGGAACTATTTTCCAAGTGGCTGCACTGATTTACCCTCCCACCAGCAGA GATGAGTTTCATTTGCTCCATGTGCTCAGATATGTTCACTTTAGCATTTTGATCGTGTAGAGTGTGATAG CCGATGGTTTTAGATTGCATTTCTGTGATTACTAATGAAGTTGAGTACAGACTTTTGTTTGTTTTAAAAA TAAAATACTGGGGCATGGTGGGCTCACGCCTGTATCCTAACAGTTTGGGAGGCTGTGGTGGGAGGATTGC TTGAGGCCAGGAGTTTAAGACTTGCCTGGGCAACATAGCAAGATACCATCTCTACAAAAAAAAGAAAGAA AATTAGCCGTGCATGGTGGCATCCACCTGTAGTCCCAGCTACTCGAGCGGCTGAGGTGGTAAGATTGCTT GAGCCCAGGAGTTTGAGGCTGCAGTGAGCCATGATCACGCCACCGCACTCCAGCCTTGGTGACAGAGCGA GACCCTGTCTCTAAAAAATAAATAAATAAAATATTGTGAGTCTCTGATGGGGAGCAGTATTGCATGGTGG TTGAGAACTGAGGCTCTGATGTTAGAACTGGATTCTGACTTAACCCACTGTTTGCCCACATCTTGAGCCT TGGTTTCCCTATCTGTAAAATGGCAGTATTCTCGGGCTGGCTGAGGAAAGGAAATGAGGCCAGGCGCGGT GGCTCAGGCCTGTAATCCCAGCACTTTGGCAGGCTGAGGCAGGTGGATGATTTGAGGCCAGGAGTTTGAG ATCAGCCTGACCAACATGGCAAACCCCCGCGTCCACTAAAAATAGAAAAAAATAGCTGGGCATGGTGGTG CACCCCTGTAGTCTCAGCTACTTGGGAGACAGAAGCAGGAGAATTGGTTGAACTTGGAAGGTGGAGGTTG CAGTGAGCTGAGATCGCACCACTGCACTCCATCCTGGGCGACAGAGCAAGACTGTCTCAAAATAAATAAA TAAATAAATAAATAAAGTTAAAAAAGAAAAGGAAATGAGTAATGCATGTAAGGGCACCCAAAAAAAGACC CTAGCTGGTGAGCTGATGATTCCACCCAGAGCCTGCTGTTCCCTCGTTCACTGTGATGTATAATCATGTG AGGAGCACCGTATGGAGAGTCAGACTTTTATTTTCCACCACAGTTGGGAGAGCAGGGGGGTCAGAAAACA GAACATCAGCTAGCAGAGCTTTGTCATGGACCCTAACTTGTCATCCTGGAGTCCCAGCTAGTAGGGTCCT GGCTGAGTCGGGAGGGTCCTTAGGCCTGGACCCCTGAACCCACATGTACTTGGACCTCATGGGCACAGGT AGAGTGTGGCCTGTGTCCACAGAGGCCCAGGACAGCTTCCAGGCTGGGGGCTGTGCTGACATGTCTGGGC TTAGGGCGCTCCTCACTCAGGGCTCTCTGAAGGCCAGAACTTTGCAGAGCTTGGAGCAGGGATGAGCCAG GCCCTTGGAAGCTGGGAAATGTTTCCTTGCCTTCTGAATGTGCTAACATCCCCCTCATGTGCCTATTTGC TTAACAAACCAGTAGGTGGGTCAGGAAAGTAATAACACAATTTCCTCATTTGCTGGCGAGGGGAAGGAGA GGAAGCTGAGGGTTTGGAAATTTTATCCAAGTGGGCCCAGGCTGGAAGGAGCTGAGCCTCACTTTTTCTC AGCCCATTTAGCCGCTCTGTGCCGCCTGTCCTGAGTTGCATGCCTGGTGTCCCTCTCTCTCGAGTTAGGG TGACTTTCTGATTATCATTCTTGTTGAGAGTGAAAAGGGGTGCATTGAAATTTATCCCTGAGCAGCAGAC ATGAACTGGGACTTGGGCGTGTGGTCACCCTGCTCCACACCTGTTCTCAGGAAAGGGCCTGTCTAGCTGT GATTTTGTCCTTGTGTCACCAGCCTTGGCTGTTACTGAGCAATGAAAGCTCTGCCTCGGGAAGTCATTTA ATTTCTGAGCCTCATGTTCCTCTTCTGGAAGATGGGAATGAAAGTGTGCGTGTCCGGCCCATTTTTTAGG GCAATGATTGTCAGGGTATGAAGAGCTTGGTCAAGCTGTGTGAAGAGCTGTACAGCTGCAGAGGTTGTTA ACATTGATAGAGCCACCCAGGAAGGGTGTCCTGGGTTCAGGCAGCTACTCCTCCAGCCGTCGGGTCAGCC AGCCGTAACTTTAGATACACTTATCCATGTGTAATGACTTTTTAAGAAGCAAGATCAGTTTCCCCAGCCC TTTATGGGAATACCCATGTGTCCATACTTGCTTTCAGCTTAGAGTTTGCTCAGGTTCCTAGAGCTGGTCA GGGTTTGCAGGACCGCCTGGGAGCAGATGGTACCATGGCCTTATTTACAGATGAGGAAACTGAGACCCAG AGGGGAAAGTGACTCCCAAGGTCATGTAGGTAAGCATACGGCTCCCCTAAGGATGAGGCATTGGTCTGGT GACAGTGCAGCCCATCATAAGGGACTGAGCCTGTGGGGTCCAGACCTGCTCTCCTCCCAGAGGAAAAGGC TCCCTGTCACCCCATCGCTAATGCAGATAGCGTCATGTCCAGGGAAGCTGTCACACATTCATCTGGGCCC CCAACATCAAGGACACCTGTCCCTGCAGGCCCCCTGCTGGCACCTTCGGGGCCCAGGGCAGGCCCCTGTC CATTCCGTGTCTGCACTTCCCTCCCTGGTCACAGGTTCTCAGGGGCAGGCTCTTTTCCTTAGCAGAAAGG AAACAAGGGAAGCTGACCTTTCCCACCTCAGAACAAAAGTTGGAAGGGCAGGTGCCTCGTGAGCCTGGAG GCCTCAGGAGGGGTGTCCCCTTCCCTTGTGCCCTCCCCGCCACCAACACCAGTGGACAGGGATCACTAAG AGAGTGGGGCTCGGGAGACTCACCTTCTGCGCTGGGTCTGTGAGAACATCACCTGGAGTGCCCCTCCCAG CGGATGCTGGGGTCGGTTGGATTTTCAGCCTGGCCAGGGTTGGCTGCCTCACCTCAGGAACAGGCTTAGC CTGTGCTGCCACGTGGGTGCCGGTCCTTGCTCTGGCCTGAAGGGAGGGGGCCGGGAAAGGAGGGACTGAT CCTGACCCAAACCCCTAAGTAAACTGCCCTCTGCGTCCAGACTGGACTCCCCCCAGACTCTGTCCAGGCC CTTACCACTGCCCTCCCTGTGCCCCCAGCCCGGGCTGCAGGAACTATTGGCTGTTCAGCCAGCAGGAGCA GCAACCATGCAGGTGTTTCCAGCTGTTAACGTGTAAGCCCTGCCTGGCCACGTGCTTGCTCTTGCCTTTT GTGCACAGCCAGTGCCAAGGGGGAGAGGAGGCAGCAGAGACGTTGTGCGGAGGGGATGCCCAAAGGGGAC TGCCCAGGCTGGGACAGCCCTGATGGGGCAGGGGCGTTCCAGGAAACAGCAGGTTTTGCCTCTCCTCCTC TTCCCACCCCACTACTCCCACCCCATTTTCCCGGATCAGGAAAAGGCAGGCCAGCATTCTAGGGAACAGG AAGTGAAGTTGGCTTCCAGCTAGGTGCCTGCCAGGGCCTGGAGGAAATTCCTGCAGGCCTGAGCCCGTCT GGGAAGGACCAGTTTCTCTCCTTGTCCTGGTGTCCTGCTTTCTGAGTTTCCCCTGAGGGTGGGGGAGAGC TGTCACTCTCTTCACTCTATGTCCCGCTTCCTCCCCCATCCTCATGGAGCACTCAAACCCTGAACCCTCA CACCTTTCTATGGTTGTACCCGTCCCCACCAGTTTCCTCTCTGGAAAGTGAAGAGGAGGCTGGGCACGGT GGCTCACGGCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCAGATCACAAGGTCAAGAAGTTCAAGA CCAGCCTGGCCAACATGGTAAAAGCCTGTCTCTACTAAAAATACAAAAATTAGCCGGGCGTGGTGGCAGT TGCCTATAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGCATCACTTGAACCCGGGAGGCAGAGGGTGCA GTAAGCCGAGACTGTGTCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCATCTCAAAAAAAAAAAA GAAAGAAAAGTGAAGAGGATAGAGCCCACTAGGGGTCATCAAGGTGTGGGACAGGCAGCATGTTCCTACA GGAAGAAAACTCTAACTCCTGGTTCTGGTTCTTTTTCATCTCATTCATTCATTCATTCATTCATTCATTC ATTTGTTTTGAGATGGACTCACTCTGTCTCCCAGGCTGGAGTACAGTGGCTCGATCTCAGCTCACTGCAA TCTCCGTCTCCTGGGTTCAAGTGATTCTCATGACTCGGCTTCCCAAGTAGCTGGGATTACAGGTGCCCAC CACCATGCCTGATTAAGTTTTGTATTTTCAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTAGTCTTG AACTCCTGACTTCAAGCAATCTGCCAACCTCGACCTCCCAAAGTGCTGGGATTAAAGGTGTGAGCCACCG CACCTGGCCATCTCATACTTTCACAATTCATTCTTTGGTGCAAGTTTTACAATATACATTCTATATTTGT CAAGTGATAACTTCCATGTAACTTATAAAATACACATAATTCAGGAAGATTGTGCTAAAATACATTTAAC CAATAGGAGTATGCCGTCAGAATATTTTGGCAAACAAGGGTCACTAAGTTTTTTCTGTAAAGGGCCAGGT AGGAGGTATCTCAGGCTTTGTGGCCATATGGCCTCTGTGGCAGCAGCTCAGTTCTGCAGTTCTGCCATGA AAGCAGCCACAGATAAGAGGTAATTGAGTGGGTGTGGCTGTGTTCCAATAAAACTTTATTTCTGGAGGCT GAAATTTGAATTTCAGAGAAATTTCATGTGTCATGAAATATTATTCCTCTTTTGGTTCTTCTTCCCCCCC TCCACCGCCCCCTGCCAAGCATTAAAGAATGTGGAACCCGTTCTTAGCAGCCGGCTGTGGGCTGGATTTG GTCCATGGACCATAGATTCCCAGCTTCTGCTCTAGACCACCCGTTCTCAGACTTGAAGCCTGCTTCAGAC TTACCTGGAGAGCTTTTTTCCAAAATGCATATTCCAGAACCCCAGCCCTGATTTTGTAGATTTTCTGGAA GGCCCCAGAACCCGCATTCTAACAAGGAGCCCAGTTGAGTCAGACACAGGTAGTCTGGAGTCCACTTTTT TTTAAACAGAGTCTCAGTCTGTTGCCCAGGATGCAGTGCAATGGCGTGATCTTGGCTCACTGCGACCTCC GCCTCCAAGGTTCAAGCAATTCTCGTGCCTCAGCCTTCCGAGTAGCTGGGATCACAGGTGCCTGCCATCA TGCCCAGCTAATTTTTGTATTTTCAGTAGAGACGGCATTTCACCATGTTGGCCAGGCTGGTCTCAAACTC CTGACCTCAGGTGATCCACCAGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGTCACCGCGCCC GGCCAGGAGACCACATGTTAAGAAGCAAAGCTCAAGGGTCTCCAGGATCCTGGTCTGTTCTCTTCAGCCA GTCCTGAGGCCTGGGGTGTGCAGTGCTGTGGGAGACCCCTGCATCAGAATAACTGGCTCCTTCACTACCT TCCAGGAGCTTCCATCCAGTGGGGGTGGGGGACACCACCCGCCAACAGCACAGCCCAGTCCCAGGTGCTA TGGAAGCCCTGGGTTCAGCCTGGAGCCAGGGCCAGCGTCCCGAGGATGAGGTGCCGAGATGGACCTTGAA GGATGAGAGAAGCCTGGACTGCCCTTGAGTGGCGAGGGTGGGCTGCCTCCAGGTTGACCTTAATCCCTTC CCTCCCTACCACCATGTGTCCAGATGACCTTGGGCAGGTCCCTTAGCCTCTCTGGATATCGGGATATGAC ATTGACTACCTCAGAGACTTGTGGGGAGGATTCGGCGAGCTGATATGCATGAAGTGTATCAACTAGGGCT GCTGGCTGGTATCTCCTTCCCTTGTCTTCCCCCACCACCCCAGCCAGGGGACAGGGTGCTGCTGAGGGAG TGGGCTGGGAGAGTCACTTCTGGCCTTGTCTTAGGGATCTGAGAACAGGGCATGGGCCCCGTGTCTGGGA GTGCCCTGGTGCCCTTCCTAGTGGGGTTGGGCGTGGTCAGTCTGGCCAGGGCTGGCTCCCTCCCCCATAA ATAGGCTCACCTGGAGGTCTTTTCCCATTTGAGGCAATGAGATATGTATGTGAGGCTTTATGACTTGTCT TTTTTTTTTCATTTTGAGACAGAGTCACGGAGTCTCACTCTGTCACCCAGGCTGGAGTATAGTGGCATGA TCTTGGCTCACCGCAACCTCTGCCTCCCAGGTTCAAGCTATCCTTTTGCCTCAGCCTCCCGCGTAGCTGG GATTATAGGCGCCCGTCACCACACCCAGCTAATTTTTGTAGTTTTAGTAGAGACAGGGTTTCACCAAGTT GGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGACCCACCCACCTTGGCCTCCCAAAGTTCTGGGATTA CAGGCGTGATCCACCGTGCTCGGCCTCACCACCCGCCTTTCTTGTGGTGTAGTTCTTGCTGCCTCAAGAA CTACATATATCAGGCCTCAAAACCCACCTGATATATGCGTGCCTGGGAATAGGGACCTTGACTTTTCCCC TGTCCCATATGGGCCCAGGGGCCGGTTCTGGGCTGGCCCAGGTGGGGCTAGAGCAGCTGGATCCAGGCAC ATGAGATGTGAAAGTGTGGGCCTTACGCCGCATGGAGCGGCTGGAGGAAGGAGAGAGGGAGCAAGGGTGC CGCAGGGTCAGATTGCCACAGGGCCAGGGTGCCACAGGGTCAGGGTAGGGCCAGGGTGCCATAGGGTCAG AGTAGGGCCAGGGTGCCACAGGGTCAGGGTAGGGCCAGGGTGCCGCTGGGCCAGGGTGCCGCAGGATCTG GTTGCCACAGGGTCAGGGTGCCGCAAGCACAAGGAGTCACCCGTGATTCTCCAGGGTCTGGCTCTTGGGC TGAGATCCAGGAGACCTTGGCAGGCCTGTCTTTGGGAGTCTGGCACAGCCCCAGAAGGCCATCTGGACAG TTTTCAGACCTGAGAGGAGGAAAGGGCTTGTGTCTGGAGAAGGTGCCATGGGGGATGGGAGGTGGAGGAA GCCTGGGGCCAATCAGGATCTGGATCTAGCAGGGAACACCGAGGCCGGTGTTCTCGTCCCACCATGGGAC TCAGCCTGAAGAAGACAAGGTGAATGAACGACCATTTCTCTCTAACTCAGTTGGCTAAGAGGACTGAGCT GGCGCCGAGGCTCTGGACACAAATGGGCCAGTTGACCCTGAGGTTTCTTTCTGGTAGTGGAGGTGGGGCT TCCTCTGGCTGACCCTGCTTAGGTCTCTGATGGAGGTAGCAGGGGCTCTGGTTCCCCCAAACTGGCCAAG TCCTCCACCATAGCACCCAAGGGGTCTGGGCAGAGTGCAGCTTCCCTCCCCTCCCCAGCTTGGCTTGGTG GGCACCTGCCTCCCCTGCCCTCCTGACCTTGATGGCTAATGCAGCCAGCCCCAGGCAGGCACAGTCACAG CCCTCAAACAACATGAGGCCCAACTCAAGACTCCTGGGTGGTGGTGGTCAAGGTGGGGGACTCTGTAGCC AGTAGAGCACTGTGGGGGCAAGAGACTGACTTGAAGGCTTGGAGCCTCACATGCCCGCCTAGTGGGGTGG TCCTGAGGGATATGACTTCTTTGGGCCTCTCTGCTCATTTTTGGAACCTGACCCGAGAAGGAGCCCATCC AAGACAATGTCCCGCCCTCAGGGAGGGTCTGGCAGTTTTTATCCCTAAAGGCTGGGATTCTCAGCGGAGC ATCCTAGGCTGTAGTACCCACGACATCTTGCACACAAGAGGTGGAATCGCCTGTTGATGAAGAGCAAGGC TCTGGAATCTGTGATCTTGGGCCACTCACTTCACTTATCAATCCCTTCGCTTCCTTCTTGCCTGTTACAT GGGGTCTGCAATCTACCCCTCAGGGGCGCTGACGAGCTCACATGAGCCTGTGACATAAAACACCTAGCAC GGCCCTGGCGCAGTAAGAGCTCAGGAAACGGGCTGCTGCTGTGGTTACTGTGGACCCAGGCGGAAACAGA GCAGCCCCGCCCCTGCCGCAGGCATATAAAAGTGACCACTTGGCCGGTCACGGTGGCTCACGCCTGTAAT CCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGTCAACA TGATGAAACCCTGTCTCTATTAAAATACAAAAAATTAGCTGGGCGTAGTGGCAGGCGCCTGTAATCCCAG CCGCCCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCTGGAGGTGGAGGTTGCGGTGAGCTGAGATCGT ACCATTGCACTCCAGCCTGGGCGACAGAGCCAAACTCCGTCTCGAAAAAAAAAAAAAAAGAAAAGGGACC ACTCACTTTGGTCTGATTCTTCAGTTCTCATGGTCCTTTTACATCGGTCATTTCATTGCATTCTCCAACA GTGTCTGAGGGAGACTGGTGTCTCATTTTGCAGAGGTGAAAACTGAGGCTTGGCAAGATTAGGTAGCTTG TCCAAGGACACACAGCTGGTGCTTCCAGAGCGAGACCTGGCTTTCTGTACCCAAAGCTCTTGGGTAGTCT CTCCCATCCTGGGATCTTGAGGGTCACGGGAAGGAACTGGGTGGTTTGCAGTGGGACCCTTCACCTAGTG CCTTCTGACCTTGCAGATAAAATACCATGAGGAGTTTGAGAAGAGCCGCATGGGCCCTAGCGGGGGCGAG GGCATGGAGCCAGAGCGTCGGGATTCACAGGACGGCAGCAGCTACCGGCGGCCCCTGGAGCAGCAGCAGC CTCACCACATCCCGACCAGTGCCCCGGGTGAGTGCAGGTCCTGTTGGTGCAGATGACCTGAGGCGAGGCC AGTGGGGTGGGGAGGAAGCCAGGAGAAGACAGACAGACAGATACACCTTCCGGAGCCTTGCTCTTAATCA ACAGGCGATTATGCCTCTTGTGTGCAAGAGGGGACCAGAGGACCTGAGGCCGGGCCAGCTGGGGTGGGGA GGAAGTCGGCGAGAGACAGACACACACACACACACACACACACACACACACACACATGCACGCACGCATG CAGGCGAGGAAAAGACTGCTTCCCAAGACCCCAAGTTCCATTCTCATCCAGAATGAGGACGTGAGCACCA GGGTCAGGCCTGTACTGGGCCAAGAGGATTGAAAGGAGAGGCCCCCAGGTCATGGGGCTCAGAGCCCCTG CGTGGGATACAACACACAGGCAAATGTGCACACGTGGACATCAGCCTTTGAGCTGTGGGGCTTGAGCCAG GTTGGGGGCGGGGTGGAAGTGCATGGTATGGACTTCTCGGGAGCTCTGGGAGGGGCTGGGTTTGGCAGGA CAGTTTCCAAGCCCTGTCTCCTCCCATCTTCCAGTTTACCAGCAGCCCCAGCAGCAGCCGGTGGCCCAGT CCTATGGTGGCTACAAGGAGCCTGCAGCCCCAGTCTCCATACAGCGCAGCGCCCCAGGTGGTGGCGGGGT GAGTAACCCTGGCCGGAGGGGAGAGGCCAGAGGCAGGGGGTCCTTCGGGAAGGCTTGGACACAGCTCATG GATTCTCCTGACCTTTGCACCCACCCTCTGTTGTGTGTGATGATAAGGATCTCAGCCTTGTGAGCAGAGA GGAAATTGGTTGGCGTAGTGGGCAGAGGCTGGCTGGGACTGGGGCCCTGCGTTCCAGCCCTGGTGTACCA TGGGCAGGTTGCTCACCCTGCTTTGGGTGGGGTTTCCTTACCCCAGCTACCTGGGAACACACAAGGCAAC TTTCTGCATGGGGCCTTCCAGCACTGGGCGCTGCTCTCCTCGCTTCATGAGGATGGCCCCCACATCCTTC AGCTCTCAGGCTGCCCCTGCCTCTGAGGGGCCTCCCCAGCCATGTCGTGTAAAGCGCATCACCCTGATGC TTTGCATCACTCGACTCCGCTGGCTGCCTTCAGAGCACTTTTTCCAACTAAAAAGAGCTCTTCGTGTTGG TCACCTTCTCTGTGTCCCCTGCTGGGCTGGGGACCCTGGCAGCGTCCGTCTGGTTCACCTACTCTGAGCC AGGCCTAGAGCAAGTGAATAAGCCCAGCAGGAATGGGGTGAGATCAGGCTTCCTGAGCCCTCAGAGCTGA AGTCCCGGCTCTGTAAGTCCTGCCACTCACTCCACCCATGGGTGCCGCTGAGCCACCCTTACCAAGCTCC TGGCAGGCTCAGCGCCTCCAGGCTGGGTGCCTGGGAATTCAAAGTAGCTCACGTAGGAGCAGAACAGATA CTTAGAGAGATAAAATCGCCTGAGATAATGGCTGGCTGGAGTCTGATGCTCTGGGCACACAAACAAAGGG ATGTTAGGACTGCCCAGGGCACTGTGGGCGCAAGAGTTAGTCTGAAGTATAAGGTTCCAGGCAGCCCAGC CAGTCCCTCCCTCCTCAATGGGTCTGTCCTGGATGTGTAGGGTCCATCTCTGAATATAAAGCCACCTCTC TGCCCTCTGGGGGCTTACATTCCAGTCAGGGGGACAAACAAGAAAACAATAAGAAAATAGGTGTATAACA TAAGGTCAGCGGTGACACGCTGTGAAGAGAAAGACAGCAGGGTGAGGGATGGATAGAAAGCAGCTGGATT AAGACATTTGGCCGGGGGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCAGGT CACTTGAGGTCAGGAGTTCGAGATCAGCCTGGCCAACATGGTGAAACCCCCTGTCTACCAAAAATACAAA AATTAGCCAGGTGTGGTGGTGTATGCCTGTAACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGTAGA ATTGCTTGAACCCGAGAGGCAGAGGTTGCAGTGAGCCAAGATTGCACTATTGCACTCCAGCCTGGGTGAC AGAGCAATATCTCCAAAGAAAAAAGACATTTGGCCGGGTGCGATGGCTCACACCTGTAATCCCAGCACTT TGGGAGGCCAAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGTGAAACC CTGTCTCTACTAAAAATATAAAATTAGCTCGGCATGGTGGTGCATGTTCATAATCCCAGCTACTCGGGAG GCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCCGAGATCACGCCATTTGCAC TCCAGCCTGGGCAGCAAGAGCAAAACTCCAGCTAGAAAAAAAAAAAGAAAAAAAAGACGTGACATTTGAG CAAAGTCCTCAATAAAGGAAGGAGTGAGCCGTGCAACGAGGACAGGAAGTGCAAAGGCTCTGAGGCAGGA ATATTCTAGGAAAGTTCAGGGAGCAGCAGGAAGCCCGAATTGACTAGAGTGGGAGAGGGTGGGAGGTCCG ATTATGCAGGGACTTGTGGGCCCCAGGAAGGCCTCTGTGACCTGTGATCTGTGCAGAGCGACATAGGTTT TTGGAAGACCACCCTGGCAGCTGTGTTGAGAAGAGGCAGTGGTTTGAGGGTAGAAGCAGGGAGACCGTCA GGAGGCTGTTGCAGGATATAGGCATGGATGGGAGTGGCTCAGCCCAAGATAGAGGCAGAATTGGTGATGA GAGAGACTGAGGTTACTTCATGGGAGGTGTGACTTCTTATCCCATAGACCTGTTGGTTTCAAACTGTCCT GTGGAGCCTCAGAGACCAGTCAAGGGCAGTGAAGGTCAGGGGAGGTAGAATGTTGTCTATAGCTATAGGA TTTATTTTTCTTTTTTTTTTCCTCTTTCTTTTTTTAAACTCCATCCTGGTAGTAGGTGGCGCTGTAGGTT TTTGTGTGCCTTACTGAACATTACCTAGATCTAGGGCTTAAGCGGCAGATTTTGGCTGAGGCTTGGAAGG TGGAACCTGATAGACTCGTCTTCTGTCCTCTGAAGATTTTTCTCCCAAGGAAAGATCTTTGTCCTGAACT TGGACAGGACTCATCATGGCTTCTAAAAGAAACTACTGGTGCTTATAATCATACAAATAATAGCATACAG GGCATGTTTTTTCTGTTTTTTTTTTCTTTTTTGAGACAGGGTCTTGCTCTGCTGCCCAGGCTGGAGTGCA GCAGTGGTGCAATCACAGCTAGCTCACTGCAGCCTTAACCTCCTGGGTTGAAGCCATCCTCCCACCTCAG CCTCCTGAGTAGCTGAGACTACAGGCATGTACCACTAAGCCTAACTAATTTTTTATTTTTTGTTGAGATG GGCTCACGCTAGTACTTTGGGAGGCCGAGGCGAGCGGATCACTTGAGACCAGGAGTTTGAGACCATCGTA GCCAACATGATGAAACCCTGTCTCTACAAAAAAGTACAAAAATTAGCCGGGCATGGTGGTACACGCTTAT AGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCGGATGTTGCAGTGAGCC AAGATCACACCATTGCACTCCAGCTTGGGTGACAAAGCAAGACTCCATCTCAAAAAAAAAAAAAAAAAGA GGGAGTTGGGGGGTCTTACTGTGTTTCCCAGGCTGATTTCAAACTTCTGGGCTCAAGCAGTTCTCCTGCC TTGGCCTCCCACAGTGCTGGGATTACAGGCGTGAGCCACTGCACCTGGCCTGCATGTCGTATTTTTAGAC ATTACTCTGTCATCATGGCTGGTGGACCTTACTGCAGTCCTGTTCAGGGAGGTGGGGCAGAGCTGATGTG ACCCGGTCCCTGCTCTGCCTCTGGCCCTTAGTAGCTGCCAAAGGTTGTAAAAGATCGATTGCTCTCAGAA AGCAAGACACAGAGGTTAAGAATCTTTGCAGCAGAGCCTGGTGCTCCATTTCTGAGTTCACTGCTCCCCC AGGCTCTGCTCCAGGGTCGTGGAGAGTTAGAAAAAAATGCTCAGACCCAGGTGAGCCGGCATGCAGGGCC CTAGGCTGACCACACTTCCCCCACAGAAGCGGTACCGCGCGGTGTATGACTACAGCGCCGCCGACGAGGA CGAGGTCTCCTTCCAGGACGGGGACACCATCGTCAACGTGCAGCAGATCGACGACGGCTGGATGTACGGG ACGGTGGAGCGCACCGGCGACACGGGGATGCTGCCGGCCAACTACGTGGAGGCCATCTGAACCCGCAGCG CCCCCATCTGTCTTCAGCACATTCCACGGCATCGCATCCGTCCTGGGCGTGACCCGTCCATTCTTCAGTG TCTCTGTTTTTTAAAACCTGCGACAGCTTGTGATTCCTACCCCTCTTCCAGCTTCTTTTGCCAACTGAAG CCTTCTTCTGCCACTTCTGCGGGCTCCCTCCTCTGGCAGGCTTCCCCCTTGATCGACTTCTTGGTTTTCT CTCTGGATGGAACGGGCATGGGCCTCTCTGGGGGAGGCAGGGCTGGAATGGGAGACCTGTTGGCCTGTGG GCCTCACCTGCCCCTCTGTTCTCTCCCCTCACATCCTCCTGCCCAGCTCCTCACATACCCACACATTCCA GGGCTGGGGTGAGCCTGACTGCCAGGACCCCAGGTCAGGGGCTCCCTACATTCCCCAGAGTGGGATCCAC TTCTTGGTTCCTGGGATGGCGATGGGGACTCTGCCGCTGTGTAGGGACCAGTGGGATGGGCTCTACCTCT CTTTCTCAAAGAGGGGGCTCTGCCCACCTGGGGTCTCTCTCCCTACCTCCCTCCTCAGGGGCAACAACAG GAGAATGGGGTTCCTGCTGTGGGGCGAATTCATCCCCTCCCCGCGCGTTCCTTCGCACACTGTGATTTTG CCCTCCTGCCCACGCAGACCTGCAGCGGGCAAAGAGCTCCCGAGGAAGCACAGCTTGGGTCAGGTTCTTG CCTTTCTTAATTTTAGGGACAGCTACCGGAAGGAGGGGAACAAGGAGTTCTCTTCCGCAGCCCCTTTCCC CACGCCCACCCCCAGTCTCCAGGGACCCTTGCCTGCCTCCTAGGCTGGAAGCCATGGTCCCGAAGTGTAG GGCAAGGGTGCCTCAGGACCTTTTGGTCTTCAGCCTCCCTCAGCCCCCAGGATCTGGGTTAGGTGGCCGC TCCTCCCTGCTCCTCATGGGAAGATGTCTCAGAGCCTTCCATGACCTCCCCTCCCCAGCCCAATGCCAAG TGGACTTGGAGCTGCACAAAGTCAGCAGGGACCACTAAATCTCCAAGACCTGGTGTGCGGAGGCAGGAGC ATGTATGTCTGCAGGTGTCTGACACGCAAGTGTGTGAGTGTGAGTGTGAGAGATGGGGCGGGGGTGTGTC TGTAGGTGTCTCTGGGCCTGTGTGTGGGTGGGGTTATGTGAGGGTATGAAGAGCTGTCTTCCCCTGAGAG TTTCCTCAGAACCCACAGTGAGAGGGGAGGGCTCCTGGGGCAGAGAAGTTCCTTAGGTTTTCTTTGGAAT GAAATTCCTCCTTCCCCCCATCTCTGAGTGGAGGAAGCCCACCAATCTGCCCTTTGCAGTGTGCAGGGTG GAAGGTAAGAGGTTGGTGTGGAGTTGGGGCTGCCATAGGGTCTGCAGCCTGCTGGGGCTAAGCGGTGGAG GAAGGCTCTGTCACTCCAGGCATATGTTTCCCCATCTCTGTCTGGGGCTACAGAATAGGGTGGCAGAAGT GTCACCCTGTGGGTGTCTCCCTCGGGGGCTCTTCCCCTAGACCTCCCCCTCACTTACATAAAGCTCCCTT GAAGCAAGAAAGAGGGTCCCAGGGCTGCAAAACTGGAAGCACAGCCTCGGGGATGGGGAGGGAAAGACGG TGCTATATCCAGTTCCTGCTCTCTGCTCATGGGTGGCTGTGACAACCCTGGCCTCACTTGATTCATCTCT GGTTTTCTTGCCACCCTCTGGGAGTCCCCATCCCATTTTCATCCTGAGCCCAACCAGGCCCTGCCATTGG CCTCTTGTCCCTTGGCACACTTGTACCCACAGGTGAGGGGCAGGACCTGAAGGTATTGGCCTGTTCAACA ATCAGTCATCATGGGTGTTTTTGTCAACTGCTTGTTAATTGATTTGGGGATGTTTGCCCCGAATGAGAGG TTGAGGAAAAGACTGTGGGTGGGGAGGCCCTGCCTGACCCATCCCTTTTCCTTTCTGGCCCCAGCCTAGG TGGAGGCAAGTGGAATATCTTATATTGGGCGATTTGGGGGCTCGGGGAGGCAGAGAATCTCTTGGGAGTC TTGGGTGGCGCTGGTGCATTCTGTTTCCTCTTGATCTCAAAGCACAATGTGGATTTGGGGACCAAAGGTC AGGGACACATCCCCTTAGAGGACCTGAGTTTGGGAGAGTGGTGAGTGGAAGGGAGGAGCAGCAAGAAGCA GCCTGTTTTCACTCAGCTTAATTCTCCTTCCCAGATAAGGCAAGCCAGTCATGGAATCTTGCTGCAGGCC CTCCCTCTACTCTTCCTGTCCTAAAAATAGGGGCCGTTTTCTTACACACCCCCAGAGAGAGGAGGGACTG TCACACTGGTGCTGAGTGACCGGGGGCTGCTGGGCGTCTGTTCTTTACCAAAACCATCCATCCCTAGAAG AGCACAGAGCCCTGAGGGGCTGGGCTGGGCTGGGCTGAGCCCCTGGTCTTCTCTACAGTTCACAGAGGTC TTTCAGCTCATTTAATCCCAGGAAAGAGGCATCAAAGCTAGAATGTGAATATAACTTTTGTGGACCAATA CTAAGAATAACAAGAAGCCCAGTGGTGAGGAAAGTGCGTTCTCCCAGCACTGCCTCCTGTTTTCTCCCTC TCATGTCCCTCCAGGGAAAATGACTTTATTGCTTAATTTCTGCCTTTCCCCCCTCACACATGCACTTTTG GGCCTTTTTTTATAGCTGGAAAAAACAAAATACCACCCTACAAACCTGTATTTAAAAAGAAACAGAAATG ACCACGTGAAATTTGCCTCTGTCCAAACATTTCATCCGTGTGTATGTGTATGTGTGTGAGTGTGTGAAGC CGCCAGTTCATCTTTTTATATGGGGTTGTTGTCTCATTTTGGTCTGTTTTGGTCCCCTCCCTCGTGGGCT TGTGCTCGGGATCAAACCTTTCTGGCCTGTTATGATTCTGAACATTTGACTTGAACCACAAGTGAATCTT TCTCCTGGTGACTCAAATAAAAGTATAATTTTTACCTGCGGA Download Select all
Length	51912
OMIM ID	602920
HGNC ID	HGNC:6513
Unigene ID	Hs.741156
Ensembl ID	ENSG00000002834
PharmGKB ID	PA30298

mRNA Information

mRNA ID	NM_006148.3
Exon	join(1..400,8228..8322,20562..20646,28554..28661, 44467..44617,45185..45288,48747..51912)
mRNA Sequence	>3927 GCAGTCAGCCTGAGAGCGCTGAGGCGCCAGCACCGCGGGCCCCGCCGTCCCCCCAGGAACCCGC CCCCGCGCAGCCCCACGTCGCCCGGAGAGCGCGCCTCGCTGCGCGTGCCCTTGCCCGCGCCCGA GGCGCGTGCCCGCCCCAGTGCAGCCCCTCCTCCCCGCTGTGTTTATTAGGGGAAGGAGGGCGGA GGCGGAGGCCAGTTCCCCAGCTCCAGCCGCCGTCGCTGCTGCCTGTGTAGTTGCAGCCGCGGCC GCCTCCCGCCAGCTCGCCTCGGGGAACAGGACGCGCGTGAGCTCAGGCGTCCCCGCCCCAGCTT TTCTCGGAACCATGAACCCCAACTGCGCCCGGTGCGGCAAGATCGTGTATCCCACGGAGAAGGT GAACTGTCTGGATAAGTTCTGGCATAAAGCATGCTTCCATTGCGAGACCTGCAAGATGACACTG AACATGAAGAACTACAAGGGCTACGAGAAGAAGCCCTACTGCAACGCACACTACCCCAAGCAGT CCTTCACCATGGTGGCGGACACCCCGGAAAACCTTCGCCTCAAGCAACAGAGTGAGCTCCAGAG TCAGGTGCGCTACAAGGAGGAGTTTGAGAAGAACAAGGGCAAAGGTTTCAGCGTAGTGGCAGAC ACGCCCGAGCTCCAGAGAATCAAGAAGACCCAGGACCAGATCAGTAACATAAAATACCATGAGG AGTTTGAGAAGAGCCGCATGGGCCCTAGCGGGGGCGAGGGCATGGAGCCAGAGCGTCGGGATTC ACAGGACGGCAGCAGCTACCGGCGGCCCCTGGAGCAGCAGCAGCCTCACCACATCCCGACCAGT GCCCCGGTTTACCAGCAGCCCCAGCAGCAGCCGGTGGCCCAGTCCTATGGTGGCTACAAGGAGC CTGCAGCCCCAGTCTCCATACAGCGCAGCGCCCCAGGTGGTGGCGGGAAGCGGTACCGCGCGGT GTATGACTACAGCGCCGCCGACGAGGACGAGGTCTCCTTCCAGGACGGGGACACCATCGTCAAC GTGCAGCAGATCGACGACGGCTGGATGTACGGGACGGTGGAGCGCACCGGCGACACGGGGATGC TGCCGGCCAACTACGTGGAGGCCATCTGAACCCGCAGCGCCCCCATCTGTCTTCAGCACATTCC ACGGCATCGCATCCGTCCTGGGCGTGACCCGTCCATTCTTCAGTGTCTCTGTTTTTTAAAACCT GCGACAGCTTGTGATTCCTACCCCTCTTCCAGCTTCTTTTGCCAACTGAAGCCTTCTTCTGCCA CTTCTGCGGGCTCCCTCCTCTGGCAGGCTTCCCCCTTGATCGACTTCTTGGTTTTCTCTCTGGA TGGAACGGGCATGGGCCTCTCTGGGGGAGGCAGGGCTGGAATGGGAGACCTGTTGGCCTGTGGG CCTCACCTGCCCCTCTGTTCTCTCCCCTCACATCCTCCTGCCCAGCTCCTCACATACCCACACA TTCCAGGGCTGGGGTGAGCCTGACTGCCAGGACCCCAGGTCAGGGGCTCCCTACATTCCCCAGA GTGGGATCCACTTCTTGGTTCCTGGGATGGCGATGGGGACTCTGCCGCTGTGTAGGGACCAGTG GGATGGGCTCTACCTCTCTTTCTCAAAGAGGGGGCTCTGCCCACCTGGGGTCTCTCTCCCTACC TCCCTCCTCAGGGGCAACAACAGGAGAATGGGGTTCCTGCTGTGGGGCGAATTCATCCCCTCCC CGCGCGTTCCTTCGCACACTGTGATTTTGCCCTCCTGCCCACGCAGACCTGCAGCGGGCAAAGA GCTCCCGAGGAAGCACAGCTTGGGTCAGGTTCTTGCCTTTCTTAATTTTAGGGACAGCTACCGG AAGGAGGGGAACAAGGAGTTCTCTTCCGCAGCCCCTTTCCCCACGCCCACCCCCAGTCTCCAGG GACCCTTGCCTGCCTCCTAGGCTGGAAGCCATGGTCCCGAAGTGTAGGGCAAGGGTGCCTCAGG ACCTTTTGGTCTTCAGCCTCCCTCAGCCCCCAGGATCTGGGTTAGGTGGCCGCTCCTCCCTGCT CCTCATGGGAAGATGTCTCAGAGCCTTCCATGACCTCCCCTCCCCAGCCCAATGCCAAGTGGAC TTGGAGCTGCACAAAGTCAGCAGGGACCACTAAATCTCCAAGACCTGGTGTGCGGAGGCAGGAG CATGTATGTCTGCAGGTGTCTGACACGCAAGTGTGTGAGTGTGAGTGTGAGAGATGGGGCGGGG GTGTGTCTGTAGGTGTCTCTGGGCCTGTGTGTGGGTGGGGTTATGTGAGGGTATGAAGAGCTGT CTTCCCCTGAGAGTTTCCTCAGAACCCACAGTGAGAGGGGAGGGCTCCTGGGGCAGAGAAGTTC CTTAGGTTTTCTTTGGAATGAAATTCCTCCTTCCCCCCATCTCTGAGTGGAGGAAGCCCACCAA TCTGCCCTTTGCAGTGTGCAGGGTGGAAGGTAAGAGGTTGGTGTGGAGTTGGGGCTGCCATAGG GTCTGCAGCCTGCTGGGGCTAAGCGGTGGAGGAAGGCTCTGTCACTCCAGGCATATGTTTCCCC ATCTCTGTCTGGGGCTACAGAATAGGGTGGCAGAAGTGTCACCCTGTGGGTGTCTCCCTCGGGG GCTCTTCCCCTAGACCTCCCCCTCACTTACATAAAGCTCCCTTGAAGCAAGAAAGAGGGTCCCA GGGCTGCAAAACTGGAAGCACAGCCTCGGGGATGGGGAGGGAAAGACGGTGCTATATCCAGTTC CTGCTCTCTGCTCATGGGTGGCTGTGACAACCCTGGCCTCACTTGATTCATCTCTGGTTTTCTT GCCACCCTCTGGGAGTCCCCATCCCATTTTCATCCTGAGCCCAACCAGGCCCTGCCATTGGCCT CTTGTCCCTTGGCACACTTGTACCCACAGGTGAGGGGCAGGACCTGAAGGTATTGGCCTGTTCA ACAATCAGTCATCATGGGTGTTTTTGTCAACTGCTTGTTAATTGATTTGGGGATGTTTGCCCCG AATGAGAGGTTGAGGAAAAGACTGTGGGTGGGGAGGCCCTGCCTGACCCATCCCTTTTCCTTTC TGGCCCCAGCCTAGGTGGAGGCAAGTGGAATATCTTATATTGGGCGATTTGGGGGCTCGGGGAG GCAGAGAATCTCTTGGGAGTCTTGGGTGGCGCTGGTGCATTCTGTTTCCTCTTGATCTCAAAGC ACAATGTGGATTTGGGGACCAAAGGTCAGGGACACATCCCCTTAGAGGACCTGAGTTTGGGAGA GTGGTGAGTGGAAGGGAGGAGCAGCAAGAAGCAGCCTGTTTTCACTCAGCTTAATTCTCCTTCC CAGATAAGGCAAGCCAGTCATGGAATCTTGCTGCAGGCCCTCCCTCTACTCTTCCTGTCCTAAA AATAGGGGCCGTTTTCTTACACACCCCCAGAGAGAGGAGGGACTGTCACACTGGTGCTGAGTGA CCGGGGGCTGCTGGGCGTCTGTTCTTTACCAAAACCATCCATCCCTAGAAGAGCACAGAGCCCT GAGGGGCTGGGCTGGGCTGGGCTGAGCCCCTGGTCTTCTCTACAGTTCACAGAGGTCTTTCAGC TCATTTAATCCCAGGAAAGAGGCATCAAAGCTAGAATGTGAATATAACTTTTGTGGACCAATAC TAAGAATAACAAGAAGCCCAGTGGTGAGGAAAGTGCGTTCTCCCAGCACTGCCTCCTGTTTTCT CCCTCTCATGTCCCTCCAGGGAAAATGACTTTATTGCTTAATTTCTGCCTTTCCCCCCTCACAC ATGCACTTTTGGGCCTTTTTTTATAGCTGGAAAAAACAAAATACCACCCTACAAACCTGTATTT AAAAAGAAACAGAAATGACCACGTGAAATTTGCCTCTGTCCAAACATTTCATCCGTGTGTATGT GTATGTGTGTGAGTGTGTGAAGCCGCCAGTTCATCTTTTTATATGGGGTTGTTGTCTCATTTTG GTCTGTTTTGGTCCCCTCCCTCGTGGGCTTGTGCTCGGGATCAAACCTTTCTGGCCTGTTATGA TTCTGAACATTTGACTTGAACCACAAGTGAATCTTTCTCCTGGTGACTCAAATAAAAGTATAAT TTTTACCTGCGGAAAAAAAAAAAAAAAAAAAAAAAAAAA Download Select all
Length	4135

CDS Information

Location	join(332..400,8228..8322,20562..20646,28554..28661, 44467..44617,45185..45288,48747..48920)
CDS Sequence	>gi\|410110897:332-1117 Homo sapiens LIM and SH3 protein 1 (LASP1), transcript variant 1, mRNA ATGAACCCCAACTGCGCCCGGTGCGGCAAGATCGTGTATCCCACGGAGAAGGTGAACTGTCTGGATAAGT TCTGGCATAAAGCATGCTTCCATTGCGAGACCTGCAAGATGACACTGAACATGAAGAACTACAAGGGCTA CGAGAAGAAGCCCTACTGCAACGCACACTACCCCAAGCAGTCCTTCACCATGGTGGCGGACACCCCGGAA AACCTTCGCCTCAAGCAACAGAGTGAGCTCCAGAGTCAGGTGCGCTACAAGGAGGAGTTTGAGAAGAACA AGGGCAAAGGTTTCAGCGTAGTGGCAGACACGCCCGAGCTCCAGAGAATCAAGAAGACCCAGGACCAGAT CAGTAACATAAAATACCATGAGGAGTTTGAGAAGAGCCGCATGGGCCCTAGCGGGGGCGAGGGCATGGAG CCAGAGCGTCGGGATTCACAGGACGGCAGCAGCTACCGGCGGCCCCTGGAGCAGCAGCAGCCTCACCACA TCCCGACCAGTGCCCCGGTTTACCAGCAGCCCCAGCAGCAGCCGGTGGCCCAGTCCTATGGTGGCTACAA GGAGCCTGCAGCCCCAGTCTCCATACAGCGCAGCGCCCCAGGTGGTGGCGGGAAGCGGTACCGCGCGGTG TATGACTACAGCGCCGCCGACGAGGACGAGGTCTCCTTCCAGGACGGGGACACCATCGTCAACGTGCAGC AGATCGACGACGGCTGGATGTACGGGACGGTGGAGCGCACCGGCGACACGGGGATGCTGCCGGCCAACTA CGTGGAGGCCATCTGA Download Select all
CCDS ID	CCDS11331.1

Protein Information

Protein ID	NP_006139.1
Protein Name	LIM and SH3 protein 1
Molecular Wt. (Da)	29586
Protein Sequence	>3927 MNPNCARCGKIVYPTEKVNCLDKFWHKACFHCETCKMTLNMKNYKGYEKKPYCNAHYPKQSFTM VADTPENLRLKQQSELQSQVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNIKYHEEFEK SRMGPSGGEGMEPERRDSQDGSSYRRPLEQQQPHHIPTSAPVYQQPQQQPVAQSYGGYKEPAAP VSIQRSAPGGGGKRYRAVYDYSAADEDEVSFQDGDTIVNVQQIDDGWMYGTVERTGDTGMLPAN YVEAI Download Select all
Length	261
Uniprot ID	P30304
Ensembl Protein ID	ENSP00000303706

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	146
S	Phosphorylation	146
S	Phosphorylation	99
S	Phosphorylation	99
S	Phosphorylation	146
S	Phosphorylation	146
S	Phosphorylation	61
S	Phosphorylation	146
S	Phosphorylation	146
S	Phosphorylation	61
Y	Phosphorylation	171
Y	Phosphorylation	171
T	Phosphorylation	104;-
T	Phosphorylation	104;-
T	Phosphorylation	68;-
T	Phosphorylation	68;-
Y	Phosphorylation	152
Y	Phosphorylation	152
S	Phosphorylation	151
S	Phosphorylation	151
K	Acetylation	128
K	Acetylation	128
K	Acetylation	42
K	Acetylation	42
S	Phosphorylation	134
S	Phosphorylation	134
Y	Phosphorylation	122
Y	Phosphorylation	122
T	Phosphorylation	63
T	Phosphorylation	63
S	Phosphorylation	118
S	Phosphorylation	118
T	Phosphorylation	38
T	Phosphorylation	38
S	Phosphorylation	150
S	Phosphorylation	150

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
58	ACTA1	30	NP_001091.1	in vitro	12571245
60	ACTB	32	NP_001092.1	in vitro;in vivo	9848085
70	ACTC1	15	NP_005150.1	in vitro;in vivo	9848085
2275	FHL3	9101	NP_004459.2	yeast 2-hybrid	16189514
4188	MDFI	7280	NP_005577.1	yeast 2-hybrid	16189514
5359	PLSCR1	8855	NP_066928.1	yeast 2-hybrid	16189514
7791	ZYX	3592	NP_003452.1	in vitro	15004028
9319	TRIP13	5145	NP_004228.1	yeast 2-hybrid	16189514

Pathway Information

No matching records could be found.

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd11934	203-261	SH3_Lasp1_C
cl17036	203-261	SH3 superfamily
cd09447	May-57	LIM_LASP
cl02475	May-57	LIM superfamily
cd11789	206-260	SH3_Nebulin_family_C
cd09359	May-57	LIM_LASP_like
cd11933	204-261	SH3_Nebulin_C
cd11935	207-261	SH3_Nebulette_C
cd09446	May-56	LIM_N_RAP
cd09358	May-57	LIM_Mical_like
smart00326	203-259	SH3
cd11960	206-259	SH3_Abp1_eu
cd11819	208-259	SH3_Cortactin_like
cd11780	206-260	SH3_Sorbs_3
smart00132	May-56	LIM
cd11959	209-260	SH3_Cortactin
cd00174	206-257	SH3
cd08368	May-57	LIM
pfam00412	May-57	LIM
cd11882	206-259	SH3_GRAF-like
pfam14604	209-259	SH3_9
cd09401	May-57	LIM_TLP_like
cd11961	208-259	SH3_Abp1_fungi_C2
cd11824	206-259	SH3_PSTPIP1
cd11791	207-259	SH3_UBASH3
cd12073	209-259	SH3_HS1
cd09443	May-56	LIM_Ltd-1
cd11803	207-261	SH3_Endophilin_A
cd11918	204-261	SH3_Vinexin_3
cd11877	207-259	SH3_PIX
cd11790	206-261	SH3_Amphiphysin
cd11916	207-261	SH3_Sorbs1_3
cd11826	208-259	SH3_Abi
cd09326	May-57	LIM_CRP_like
cd11823	206-259	SH3_Nostrin
cd11772	207-260	SH3_OSTF1
cd11788	205-261	SH3_RasGAP
pfam00018	208-255	SH3_1
cd11999	204-259	SH3_PACSIN_like
cd09440	May-57	LIM1_SF3
cd11917	202-259	SH3_Sorbs2_3
cd11843	206-259	SH3_PACSIN
cd09445	May-57	LIM_Mical_like_2
cd11873	211-259	SH3_CD2AP-like_1
cd11836	206-260	SH3_Intersectin_1
cd09478	May-54	LIM_CRIP
cd11818	206-257	SH3_Eve1_5
cd09441	May-57	LIM2_SF3
cd11763	206-259	SH3_SNX9_like
cd11972	209-261	SH3_Abi2
cd11998	206-260	SH3_PACSIN1-2
cd11781	208-259	SH3_Sorbs_1
cd11785	206-259	SH3_SH3RF_C
cd09476	May-58	LIM1_TLP
cd11971	209-261	SH3_Abi1
cd11827	206-259	SH3_MyoIe_If_like
cd11997	204-259	SH3_PACSIN3
cd11821	206-257	SH3_ASAP
cd11875	206-259	SH3_CD2AP-like_3
cd11840	208-259	SH3_Intersectin_5
cd09477	May-58	LIM2_TLP
cd11962	210-259	SH3_Abp1_fungi_C1
cd09481	May-57	LIM1_CRP3
cd11779	205-260	SH3_Irsp53_BAIAP2L
cd11874	206-259	SH3_CD2AP-like_2
cd11786	208-259	SH3_SH3RF_1
cd11920	208-261	SH3_Sorbs2_1
cd09840	May-57	LIM2_CRP2
cd11996	209-259	SH3_Intersectin2_5
cd11778	209-257	SH3_Bzz1_2
cd12061	208-261	SH3_betaPIX
cd09482	May-57	LIM2_CRP3
cd11856	207-259	SH3_p47phox_like
cd11964	205-260	SH3_STAM1
cd09402	May-57	LIM1_CRP
cd11864	208-259	SH3_PEX13_eumet
cd11825	208-259	SH3_PLCgamma
cd11849	207-259	SH3_SPIN90
cd11793	209-260	SH3_ephexin1_like
cd12058	207-258	SH3_MLK4
cd11897	206-259	SH3_SNX18
cd11936	208-258	SH3_UBASH3B
cd09442	May-57	LIM_Eplin_like
cd09403	May-57	LIM2_CRP
cd11775	205-259	SH3_Sla1p_3
cd09404	May-53	LIM1_MLP84B_like
cd11988	207-259	SH3_Intersectin2_1
cd11783	206-260	SH3_SH3RF_3
cd11805	206-259	SH3_GRB2_like_C
cd09485	May-57	LIM_Eplin_alpha_beta
cd11845	207-257	SH3_Src_like
cd11926	207-258	SH3_SH3RF1_3
cd12053	211-261	SH3_CD2AP_1
cd11949	208-260	SH3_GRB2_C
cd11817	209-257	SH3_Eve1_4
cd11784	206-258	SH3_SH3RF2_3
cd11896	206-259	SH3_SNX33
smart00227	98-128	NEBU
cl23049	98-128	NEBU superfamily
cd11762	208-259	SH3_FCHSD_2
cd11820	205-260	SH3_STAM
cd11963	205-258	SH3_STAM2
cd11912	208-259	SH3_Bzz1_1
cd09486	May-57	LIM_Eplin_like_1
pfam07653	206-259	SH3_2
pfam00880	67-95	Nebulin
cl23503	67-95	Nebulin superfamily
pfam00880	103-130	Nebulin
cl23503	103-130	Nebulin superfamily
cd11816	206-258	SH3_Eve1_3
cd09479	May-57	LIM1_CRP1
cd11782	208-259	SH3_Sorbs_2
cd11773	207-257	SH3_Sla1p_1
cd12006	207-258	SH3_Fyn_Yrk
cd11855	206-259	SH3_Sho1p
cd11806	207-258	SH3_PRMT2
cd11976	208-259	SH3_VAV1_2
cd11884	208-260	SH3_MYO15
cd11987	207-259	SH3_Intersectin1_1
cd11923	209-261	SH3_Sorbs2_2
cd12060	208-261	SH3_alphaPIX
cd11766	206-259	SH3_Nck_2
cd09480	May-57	LIM1_CRP2
cd12052	211-258	SH3_CIN85_1
cd11925	207-261	SH3_SH3RF3_3
cd09364	May-57	LIM1_LIMK
smart00227	62-92	NEBU
cl23049	62-92	NEBU superfamily
cd11769	209-259	SH3_CSK
cd11937	208-259	SH3_UBASH3A
cd11838	206-258	SH3_Intersectin_3
cd09439	May-57	LIM_Mical
cd11886	207-257	SH3_BOI
cd11812	209-258	SH3_AHI-1
cd09329	May-57	LIM3_abLIM
cd11804	208-258	SH3_GRB2_like_N
cd11887	206-259	SH3_Bbc1
cd11842	208-260	SH3_Ysc84p_like
cd11919	205-261	SH3_Sorbs1_1
cd12055	206-259	SH3_CIN85_2
cd11991	207-258	SH3_Intersectin1_3
cd11950	208-259	SH3_GRAP2_C
cd11948	209-259	SH3_GRAP_N
cd12057	208-259	SH3_CIN85_3
cd11992	207-258	SH3_Intersectin2_3
cd11969	208-261	SH3_PLCgamma2
cd12054	205-261	SH3_CD2AP_2
cd11876	209-258	SH3_MLK
cd12007	207-258	SH3_Yes
cd11928	208-259	SH3_SH3RF3_1
cd09350	May-57	LIM1_TRIP6
cd12076	205-259	SH3_Tks4_2
cd11924	209-259	SH3_Vinexin_2
cd11796	206-258	SH3_DNMBP_N3
cd11970	208-261	SH3_PLCgamma1
cd11938	213-255	SH3_ARHGEF16_26
cd12066	208-259	SH3_GRAF3
cd09351	May-57	LIM1_LPP
cd11889	208-258	SH3_Cyk3p-like
cd09450	May-56	LIM_ALP
cd12022	207-259	SH3_p47phox_2
cd11921	205-261	SH3_Vinexin_1
cd11922	209-261	SH3_Sorbs1_2
cd09414	May-57	LIM1_LIMPETin
cd12059	209-258	SH3_MLK1-3
cd11929	206-259	SH3_SH3RF2_1
cd11951	208-258	SH3_GRAP_C
cd11774	208-258	SH3_Sla1p_2
cd11995	209-259	SH3_Intersectin1_5
cd11837	206-258	SH3_Intersectin_2
cd11915	206-261	SH3_Irsp53
cd12065	208-259	SH3_GRAF2
cd12142	207-259	SH3_D21-like
cd11947	208-259	SH3_GRAP2_N
cd11776	206-261	SH3_PI3K_p85
cd09438	May-42	LIM3_Ajuba_like
cd09456	May-57	LIM2_Enigma
cd11809	209-258	SH3_srGAP
cd09340	May-57	LIM1_Testin_like
cd11870	209-259	SH3_p67phox-like_C
cd11901	211-258	SH3_Nck1_2
cd11869	206-261	SH3_p40phox
cd11927	208-259	SH3_SH3RF1_1
cd11810	206-257	SH3_RUSC1_like
cd09379	May-57	LIM2_AWH
cd12077	205-259	SH3_Tks5_2
cd11885	206-258	SH3_SH3TC
cd11833	207-258	SH3_Stac_1
cd12008	207-258	SH3_Src
cd11758	208-260	SH3_CRK_N
cd12046	209-259	SH3_p67phox_C
cd11914	205-261	SH3_BAIAP2L2
cd11913	205-257	SH3_BAIAP2L1
cd11771	208-259	SH3_Pex13p_fungal
cd12064	205-259	SH3_GRAF
cd12051	209-258	SH3_DOCK1_5_A
cd12074	206-260	SH3_Tks5_1
cd09396	May-52	LIM_DA1
cd11829	206-258	SH3_GAS7
cd11946	209-259	SH3_GRB2_N
cd11828	209-258	SH3_ARHGEF9_like
cd09451	May-56	LIM_RIL
cd12013	206-259	SH3_RIM-BP_3
cd11830	209-259	SH3_VAV_2
cd09346	May-53	LIM3_FHL
cd11807	209-257	SH3_ASPP
cd09462	Mar-57	LIM1_LIMK1
cd11910	204-261	SH3_PI3K_p85alpha
cd09421	May-57	LIM3_LIMPETin
cd11801	207-258	SH3_JIP1_like
cd11945	203-259	SH3_Endophilin_B1
cd11939	210-259	SH3_ephexin1
cd09463	May-57	LIM1_LIMK2
cd11940	213-259	SH3_ARHGEF5_19
cd09349	Feb-57	LIM1_Zyxin
cd11839	208-259	SH3_Intersectin_4
cd11978	209-259	SH3_VAV3_2
cd11944	206-259	SH3_Endophilin_B2
cd09357	May-42	LIM3_Zyxin_like
cd09377	May-57	LIM2_Lhx2_Lhx9
cd11954	209-256	SH3_ASPP1
cd09422	May-60	LIM1_FHL2
cd11952	209-257	SH3_iASPP
cd11878	208-257	SH3_Bem1p_1
cd09362	May-57	LIM2_Enigma_like
cd11858	206-259	SH3_Myosin-I_fungi
cd12139	206-245	SH3_Bin1
cd11965	206-258	SH3_ASAP1
cd11865	209-259	SH3_Nbp2-like
cd09426	May-60	LIM2_FHL2
cd09457	May-57	LIM2_ENH
cd11815	210-259	SH3_Eve1_2
cd12047	206-258	SH3_Noxa1_C
cd09360	May-56	LIM_ALP_like
cd09345	May-54	LIM2_FHL
cd09431	May-53	LIM3_Fhl2
cd09338	May-57	LIM3_Paxillin_like
cd11943	207-257	SH3_JIP1
cd11894	208-259	SH3_FCHSD2_2
cd09343	May-57	LIM1_FHL
cd11847	207-258	SH3_Brk
cd09430	May-53	LIM5_LIMPETin
cd11902	211-258	SH3_Nck2_2
cd11879	211-259	SH3_Bem1p_2
cd11883	208-257	SH3_Sdc25
cd11881	209-258	SH3_MYO7A
cd11898	208-261	SH3_SNX9
cd09341	Mar-53	LIM2_Testin_like
cd11802	206-257	SH3_Endophilin_B
cd11770	206-260	SH3_Nephrocystin
cd09427	Apr-57	LIM2_FHL3
cd11942	207-260	SH3_JIP2
cd09363	May-56	LIM3_Enigma_like
cd09429	May-53	LIM3_FHL1
cd09382	May-57	LIM2_Lhx6
cd11777	208-258	SH3_CIP4_Bzz1_like
cd09418	Mar-53	LIM2_Prickle
cd11866	207-258	SH3_SKAP1-like
cd09413	22-57	LIM1_Testin
cd12016	206-259	SH3_Tks_2
cd09336	May-57	LIM1_Paxillin_like
cd09461	May-56	LIM3_Enigma_like_1
cd09394	May-40	LIM1_Rga
cd11966	206-258	SH3_ASAP2
cd12045	207-258	SH3_SKAP2
cd12021	207-259	SH3_p47phox_1
cd09409	May-57	LIM3_Paxillin
cd12056	208-258	SH3_CD2AP_3
cd09400	May-53	LIM_like_1
cd11795	212-259	SH3_DNMBP_N2
cd09393	May-54	LIM3_Lrg1p_like
cd11761	209-260	SH3_FCHSD_1
cd09383	May-57	LIM2_Lhx7_Lhx8
cd11813	206-259	SH3_SGSM3
cd11841	209-258	SH3_SH3YL1_like
cd11986	207-258	SH3_Stac3_1
cd09334	Mar-57	LIM4_PINCH
cd09367	May-53	LIM1_Lhx1_Lhx5
cd09331	May-53	LIM1_PINCH
cd09428	May-53	LIM2_FHL5
cd12003	208-261	SH3_EFS
cd11977	209-259	SH3_VAV2_2
cd11787	208-257	SH3_SH3RF_2
cd12009	207-258	SH3_Blk
cd11911	208-259	SH3_CIP4-like
cd11797	209-254	SH3_DNMBP_N4
cd11854	207-255	SH3_Fus1p
cd09335	May-57	LIM5_PINCH
cd09458	17-56	LIM3_Enigma
cd09397	25-57	LIM1_UF1
cd11909	206-261	SH3_PI3K_p85beta
cd11857	206-256	SH3_DBS
cd11800	207-257	SH3_DNMBP_C2_like
cd09388	May-39	LIM1_LMO1_LMO3
cd11955	209-258	SH3_srGAP1-3
cd09370	May-57	LIM1_Lmx1a
cd11767	208-259	SH3_Nck_3
cd09412	May-57	LIM4_Leupaxin
cd09444	May-45	LIM_Mical_like_1
cd11844	208-259	SH3_CAS
cd09416	Mar-57	LIM2_Testin
cd09376	May-40	LIM2_Lhx3_Lhx4

Ontology Information

HPRD ID	309
Molecular Class	Cytoskeletal associated protein
Molecular Function	GTPase activity (GO:0003924)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO

CoReCG

Search results:

General Information

Evidence Information

Gene Details

mRNA Information

CDS Information

Protein Information

Post-translational Modification Information (Source : HPRD)

Enzyme Information

PPi Information

Pathway Information

Structure Information

Domain Information

Ontology Information

SNP Information

Drug Information

External Links

Important Information