Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| LCN2 | 3934 | Lipocalin 2 (oncogene 24p3) | 9 | 24p3; MSFI; NGAL |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19308044 | 2009 | Cell line : - Source : The University of Texas MD AndersonCancer Center, ATCC Sample Type : - No. of Sample : - Stage : - | Cell Culture and Transfection, Cell Adhesion Assay, In Vitro Invasion Assays. | Up-regulation | - | NGAL may be a new target for therapeutic intervention in colorectal carcinoma. Overexpressing NGAL in colon carcinomas is an important regulatory molecule that integrates extracellular environment cues, iron metabolism, and intracellular small GTPase signaling in cancer migration and invasion. |
| 19419554 | 2009 | Cell line : - Source : Department of Oncological Surgery, the First AffiliatedHospital of Wenzhou Medical College. Sample Type : CRC tumor and normal tissue No. of Sample : 100 Stage : TNM Stage I-IV | RT-PCR | Up-regulation | - | NGAL may serve as an attractive therapeutic target. NGAL mRNA expression was elevated in human rectal cancer. NGAL mRNA up-regulation was correlated significantly with tumor progression and MMP-9 mRNA overexpression in rectal cancer, suggesting a more aggressive phenotype. |
| 21420718 | 2011 | Cell line : - Source : Cancer Registry of Modena, Italy, Department of Human Pathology of the University of Messina, Italy. Sample Type : - No. of Sample : - Stage : - | immunostaining | Up-regulation | - | NGAL immunoexpression represents a negative prognostic marker associated with shorter disease-specific survival in stage I colorectal cancer. The inhibition of NGAL expression or function may epresent a target for novel therapeutic strategies to prevent disease progression in NGAL-positive colorectal carcinomas. |
| 21622717 | 2011 | Cell line : - Source : Department ofPathology at Tianjin Medical University Cancer Institute and Hospital. Sample Type : Formalin-fixed, paraffin-embedded colorectal tissue No. of Sample : 526 samples (including 287 carcinomas, 105 adenomas with low-grade dysplasia, 40 adenomas with high-grade dysplasia, and 94 samples normal mucosa Stage : - | Tissue microarray, immunohistochemistry, sandwich ELISA, animal model experiments. | Up-regulation | - | NGAL might be a potential therapeutic target for CRC. NGAL overexpression may promote the tumorigenesis and progression of CRC. Detecting NGAL expression in tumor tissues may be useful for evaluating prognosis of patients with CRC. |
| 22930170 | 2012 | Cell line : KM 12C, KM 12SM , HT 30 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Microarray analysis,Real time RT-PCR and Flow cytometry | Up-regulation | - | Gene differentially expressed and analysed bye by Microarray. |
| 24634297 | 2014 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Meta-analysis | Up-regulation | - | NGAL is a potential biomarker for the diagnosis and prognosis of colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Lipocalins |
| Description | - | Chromosome | 9 |
| Location | 9q34 |
| Start | 128149453 |
| End | 128153455 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 4003 |
| OMIM ID | 600181 |
| HGNC ID | HGNC:6526 |
| Unigene ID | Hs.204238 |
| Ensembl ID | ENSG00000148346 |
| PharmGKB ID | PA30309 |
mRNA Information
| mRNA ID | NM_005564.3 |
|---|---|
| Exon | join(1..211,786..922,2186..2265,2454..2573,2731..2832, 3648..3674,3859..4003) | mRNA Sequence | Download Select all |
| Length | 840 |
CDS Information
| Location | join(74..211,786..922,2186..2265,2454..2573,2731..2832, 3648..3667) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_005555.2 |
|---|---|
| Protein Name | Lipocalin 2 (oncogene 24p3) |
| Molecular Wt. (Da) | 20548 |
| Protein Sequence | Download Select all |
| Length | 198 |
| Uniprot ID | P30305 |
| Ensembl Protein ID | ENSP00000245960 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 85 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4313 | MMP2 | 386 | NP_004521.1 | in vivo | 7683678 |
| 4318 | MMP9 | 387 | NP_004985.2 | in vitro | 103 394 121 281 792 |
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 1DFV |
|---|---|
| Resolution | 2.6 |
| Method | X-RAY DIFFRACTION |
| Chains | A,B |
| Molecule | HUMAN NEUTROPHIL GELATINASE |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00061 | 49-193 | Lipocalin |
| cl21528 | 49-193 | Lipocalin superfamily |
Ontology Information
| HPRD ID | 1885 |
|---|---|
| Molecular Class | Transport/cargo protein |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.