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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21632858 | 2011 | Cell line : - Source : - Sample Type : Paraffin-embedded CRC tumor No. of Sample : 179 Stage : - | Immunohistochemistry | Up-regulation | - | High serum LDH levels were linked with significantly poorer overall survival. |
| 22664478 | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : 85 Stage : - | Laser-capture microdissection,qRT-PCR, univariate analysis | Up-regulation | - | In univariate analyses, elevated mRNA expression of LDHA, GLUT-1, and VEGFR1 were associated with response to FOLFOX4/PTK/ZK. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008] | Chromosome | 11 |
| Location | 11p15.1 |
| Start | 18415936 |
| End | 18429765 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 13830 |
| OMIM ID | 150000 |
| HGNC ID | HGNC:6535 |
| Unigene ID | Hs.2795 |
| Ensembl ID | ENSG00000134333 |
| PharmGKB ID | PA30319 |
mRNA Information
| mRNA ID | NM_005566.3 |
|---|---|
| Exon | join(1..248,2431..2580,5043..5160,6449..6622,8452..8625, 9306..9423,11061..11184,12729..13830) | mRNA Sequence | Download Select all |
| Length | 2226 |
Protein Information
| Protein ID | NP_005557.1 |
|---|---|
| Protein Name | lactate dehydrogenase A |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 332 |
| Uniprot ID | O15119 |
| Ensembl Protein ID | ENSP00000257566 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 239;- |
| Y | Phosphorylation | 239;- |
| K | Acetylation | 81 |
| K | Acetylation | 14 |
| K | Acetylation | 118 |
| K | Acetylation | 5 |
| K | Acetylation | 318 |
| K | Acetylation | 278 |
| K | Acetylation | 126 |
| K | Acetylation | 57 |
| K | Acetylation | 222 |
| Y | Phosphorylation | 10 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Central carbon metabolism in cancer | hsa05230 |
| Cysteine and methionine metabolism | hsa00270 |
| Glucagon signaling pathway | hsa04922 |
| Glycolysis / Gluconeogenesis | hsa00010 |
| HIF-1 signaling pathway | hsa04066 |
| Metabolic pathways | hsa01100 |
| Propanoate metabolism | hsa00640 |
| Pyruvate metabolism | hsa00620 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05293 | 19-329 | LDH_1 |
| cl21454 | 19-329 | NADB_Rossmann superfamily |
| cd00300 | 23-328 | LDH_like |
| cd05292 | 21-330 | LDH_2 |
| cd05291 | 21-323 | HicDH_like |
| cd01339 | 23-323 | LDH-like_MDH |
| cd05290 | 22-323 | LDH_3 |
| cd00650 | 23-324 | LDH_MDH_like |
| pfam00056 | 21-160 | Ldh_1_N |
| cd05294 | 22-330 | LDH-like_MDH_nadp |
| pfam02866 | 164-323 | Ldh_1_C |
| cl15765 | 164-323 | Ldh_1_C superfamily |
| cd01337 | 22-332 | MDH_glyoxysomal_mitochondrial |
| cd00704 | 55-323 | MDH |
| cd01336 | 23-182 | MDH_cytoplasmic_cytosolic |
| cd05197 | 222-300 | GH4_glycoside_hydrolases |
| cd01338 | 47-323 | MDH_choloroplast_like |
| TIGR01771 | 25-324 | L-LDH-NAD |
| PLN02602 | 22-330 | PLN02602 |
| PRK00066 | 20-330 | ldh |
| COG0039 | 21-331 | Mdh |
| PRK06223 | 21-323 | PRK06223 |
| TIGR01763 | 22-330 | MalateDH_bact |
| PTZ00082 | 18-319 | PTZ00082 |
| PTZ00117 | 22-321 | PTZ00117 |
| PTZ00325 | 22-332 | PTZ00325 |
| TIGR01772 | 22-332 | MDH_euk_gproteo |
| TIGR01759 | 102-323 | MalateDH-SF1 |
| PRK05086 | 22-323 | PRK05086 |
| TIGR01758 | 26-292 | MDH_euk_cyt |
| PLN00106 | 16-328 | PLN00106 |
| TIGR01756 | 101-299 | LDH_protist |
| TIGR01757 | 58-329 | Malate-DH_plant |
| PLN00135 | 33-181 | PLN00135 |
Ontology Information
| HPRD ID | 8926 |
|---|---|
| Molecular Class | Enzyme: Dehydrogenase |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P00338 | DB02701 | Nicotinamide | SmallMoleculeDrug |