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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
- Pathway
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- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24845032 | 2014 | Cell line : - Source : - Sample Type : Population based case Control study No. of Sample : 5,679 cases and 7,443 controls Stage : - | Meta analysis | Polymorhpism | - | LEP A19G (rs2167270) genetic polymorphism may decrease the susceptibility to cancers in colorectal cancer and non-Hodgkin's lymphoma. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008] | Chromosome | 7 |
| Location | 7q31 |
| Start | 127881241 |
| End | 127897682 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 16442 |
| OMIM ID | 164160 |
| HGNC ID | HGNC:6553 |
| Unigene ID | Hs.194236 |
| Ensembl ID | ENSG00000174697 |
| PharmGKB ID | PA228 |
mRNA Information
| mRNA ID | XM_005250340.3 |
|---|---|
| Exon | join(1..105,10790..10961,13206..16427) | mRNA Sequence | Download Select all |
| Length | 3499 |
Protein Information
| Protein ID | XP_005250397.1 |
|---|---|
| Protein Name | leptin |
| Molecular Wt. (Da) | 14123 |
| Protein Sequence | Download Select all |
| Length | 166 |
| Uniprot ID | P35680 |
| Ensembl Protein ID | ENSP00000484591 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2 | A2M | 72 | NP_000005.2 | in vitro | 9724081 |
| 1401 | CRP | 422 | NP_000558.2 | in vitro;in vivo | 16582918 |
| 3101 | HK3 | 806 | NP_002106.2 | in vitro;yeast 2-hybrid | 11068878 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Adipocytokine signaling pathway | hsa04920 |
| AMPK signaling pathway | hsa04152 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Jak-STAT signaling pathway | hsa04630 |
| Neuroactive ligand-receptor interaction | hsa04080 |
| Non-alcoholic fatty liver disease (NAFLD) | hsa04932 |
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 1797 |
|---|---|
| Molecular Class | Cytokine |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.