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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25778303 | 2015 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 75 Stage : - | Immunohistochemistry | Up-regulation | - | LEPR expression in colorectal carcinoma significantly corresponded to proliferation index of tumor cells and neoangiogenesis, which could have significant therapeutic and prognostic implications. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, "Immunoglobulin superfamily / Immunoglobulin-like domain containing" |
| Description | The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010] | Chromosome | 1 |
| Location | 1p31 |
| Start | 65886335 |
| End | 66103176 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 216842 |
| OMIM ID | 601007 |
| HGNC ID | HGNC:6554 |
| Unigene ID | Hs.23581 |
| Ensembl ID | ENSG00000116678 |
| PharmGKB ID | PA229 |
mRNA Information
| mRNA ID | NM_017526.4 |
|---|---|
| Exon | join(<1..89,4652..4727,9211..9397,11152..15356) | mRNA Sequence | Download Select all |
| Length | 4777 |
Protein Information
| Protein ID | NP_059996.1 |
|---|---|
| Protein Name | leptin receptor |
| Molecular Wt. (Da) | 20977 |
| Protein Sequence | Download Select all |
| Length | 131 |
| Uniprot ID | P15923 |
| Ensembl Protein ID | ENSP00000262965 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 1141 |
| C | Disulfide Bridge | 131;142 |
| C | Disulfide Bridge | 186;196 |
| N | Glycosylation | 187 |
| C | Disulfide Bridge | 188;193 |
| C | Disulfide Bridge | 352;412 |
| C | Disulfide Bridge | 37;90 |
| N | Glycosylation | 397 |
| C | Disulfide Bridge | 413;418 |
| N | Glycosylation | 41 |
| C | Disulfide Bridge | 473;528 |
| C | Disulfide Bridge | 488;498 |
| N | Glycosylation | 624 |
| N | Glycosylation | 81 |
| C | Disulfide Bridge | 89;99 |
| Y | Phosphorylation | 986 |
| N | Glycosylation | 98 |
| C | Disulfide Bridge | 131;142 |
| C | Disulfide Bridge | 186;196 |
| N | Glycosylation | 187 |
| C | Disulfide Bridge | 188;193 |
| C | Disulfide Bridge | 352;412 |
| C | Disulfide Bridge | 37;90 |
| N | Glycosylation | 397 |
| C | Disulfide Bridge | 413;418 |
| N | Glycosylation | 41 |
| C | Disulfide Bridge | 473;528 |
| C | Disulfide Bridge | 488;498 |
| N | Glycosylation | 624 |
| N | Glycosylation | 81 |
| C | Disulfide Bridge | 89;99 |
| N | Glycosylation | 98 |
| C | Disulfide Bridge | 131;142 |
| C | Disulfide Bridge | 186;196 |
| N | Glycosylation | 187 |
| C | Disulfide Bridge | 188;193 |
| C | Disulfide Bridge | 352;412 |
| N | Glycosylation | 397 |
| C | Disulfide Bridge | 413;418 |
| N | Glycosylation | 41 |
| C | Disulfide Bridge | 473;528 |
| C | Disulfide Bridge | 488;498 |
| N | Glycosylation | 624 |
| N | Glycosylation | 81 |
| C | Disulfide Bridge | 89;99 |
| N | Glycosylation | 98 |
| K | Ubiquitination | 879 |
| K | Ubiquitination | 891 |
| K | Ubiquitination | 879 |
| K | Ubiquitination | 879 |
| T | Phosphorylation | 208 |
| T | Phosphorylation | 208 |
| T | Phosphorylation | 208 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 347 | APOD | 134 | NP_001638.1 | in vitro;in vivo;yeast 2-hybrid | 11344130 |
| 3717 | JAK2 | 993 | NP_004963.1 | in vitro | 8608603 |
| 3952 | LEP | 1249 | NP_000221.1 | in vivo | 8608603 |
| 5300 | PIN1 | 3031 | NP_006212.1 | yeast 2-hybrid | 16169070 |
| 5781 | PTPN11 | 1470 | NP_002825.3 | in vivo | 11018044 |
| 6774 | STAT3 | 26 | NP_644805.1 | in vivo | 8608603 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Adipocytokine signaling pathway | hsa04920 |
| AMPK signaling pathway | hsa04152 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Jak-STAT signaling pathway | hsa04630 |
| Neuroactive ligand-receptor interaction | hsa04080 |
| Non-alcoholic fatty liver disease (NAFLD) | hsa04932 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00063 | 237-330 | FN3 |
| cl21522 | 237-330 | FN3 superfamily |
| cd00063 | 741-822 | FN3 |
| cl21522 | 741-822 | FN3 superfamily |
| cd00063 | 537-627 | FN3 |
| cl21522 | 537-627 | FN3 superfamily |
| pfam06328 | 336-422 | Lep_receptor_Ig |
| cl05692 | 336-422 | Lep_receptor_Ig superfamily |
| smart00060 | 237-317 | FN3 |
| pfam00041 | 238-320 | fn3 |
| pfam00041 | 741-812 | fn3 |
| smart00060 | 741-820 | FN3 |
Ontology Information
| HPRD ID | 3751 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P48357 | DB09046 | Metreleptin | BiotechDrug |