Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| LGALS3BP | 3959 | Lectin, galactoside-binding, soluble, 3 binding protein | 17 | 90K; BTBD17B; MAC-2-BP; TANGO10B |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20581239 | 2010 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Cell cultures, in vitro assays, and immunohistochemistry. | Down-regulation | - | 90K, a tumour-associated glycoprotein, interacts with galectins and has roles in host defence. 90K itself has antitumour activity in CRC cells via suppression of Wnt signalling with a novel mechanism of ISGylation-dependent ubiquitination of beta-catenin when it interacts with CD9/CD82. |
| 21515679 | 2011 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | ELISA, Affinity Chromatography, Mass Spectrometry, Immunoprecipitation, Immunoblotting, Histochemistry | Expression Change | - | Mac-2BP was detected as a predominant DC-SIGN ligand expressed on some primary colorectal cancer tissues from certain parts of patients in comparison with CEA from other parts, suggesting that DC-SIGN-binding Mac-2BP bearing tumor-associated Le glycans may become a novel potential colorectal cancer biomarker for some patients instead of CEA. |
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis | Unknown | - | This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue. |
| 19686089 | 2010 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | 90K is able to modulate the immune reaction against tumors and viruses and its level increases in sera of several neoplastic diseases.
|
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | BTB/POZ domain containing |
| Description | The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. [provided by RefSeq, Jul 2008] | Chromosome | 17 |
| Location | 17q25 |
| Start | 78971253 |
| End | 78979979 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 8727 |
| OMIM ID | 600626 |
| HGNC ID | HGNC:6564 |
| Unigene ID | Hs.514535 |
| Ensembl ID | ENSG00000108679 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_005567.3 |
|---|---|
| Exon | join(1..156,2766..2840,3824..4015,5161..5292,6758..7010, 7276..8727) | mRNA Sequence | Download Select all |
| Length | 2277 |
CDS Information
| Location | join(2789..2840,3824..4015,5161..5292,6758..7010, 7276..8404) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS11759.1 |
Protein Information
| Protein ID | NP_005558.1 |
|---|---|
| Protein Name | Lectin, galactoside-binding, soluble, 3 binding protein |
| Molecular Wt. (Da) | 63277 |
| Protein Sequence | Download Select all |
| Length | 585 |
| Uniprot ID | P12830 |
| Ensembl Protein ID | ENSP00000261769 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 69 |
| N | Glycosylation | 125 |
| N | Glycosylation | 398 |
| N | Glycosylation | 192 |
| N | Glycosylation | 551 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 929 | CD14 | 1151 | NP_000582.1 | in vitro | 7583357 |
| 1289 | COL5A1 | 368 | NP_000084.3 | in vitro;in vivo | 9501082 |
| 1291 | COL6A1 | 370 | NP_001839.2 | in vitro;in vivo | 9501082 |
| 2335 | FN1 | 626 | NP_997647.1 | in vitro | 9501082 |
| 3688 | ITGB1 | 628 | NP_391987.1 | in vitro;in vivo | 9501082 |
| 3956 | LGALS1 | 1040 | NP_002296.1 | in vitro;in vivo | 11146440 |
| 3958 | LGALS3 | 1090 | NP_002297.2 | in vitro;in vivo | 881 315 283 909 861 000 000 |
| 4811 | NID1 | 574 | NP_002499.2 | in vitro;in vivo | 9501082 |
| 5480 | PPIC | 459 | NP_000934.1 | in vitro | 10077627 |
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 1BY2 |
|---|---|
| Resolution | 2 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | MAC-2 BINDING PROTEIN |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00202 | 24-124 | SR |
| cl02509 | 24-124 | SRCR superfamily |
| pfam00530 | 27-124 | SRCR |
| smart00875 | 261-358 | BACK |
| cl06652 | 261-358 | BACK_like superfamily |
| pfam07707 | 261-358 | BACK |
Ontology Information
| HPRD ID | 5187 |
|---|---|
| Molecular Class | Unknown |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.