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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
LGR5 8549 Leucine-rich repeat-containing G protein-coupled receptor 5  12FEX; HG38; GPR49; GPR67; GRP49 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22930170   2012Cell line : KM 12C, KM 12SM, HT 29

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

Microarray analysis,Real time RT-PCR and Flow cytometryDown-regulation-Gene differentially expressed and analysed bye by Microarray.

22937206   2012Cell line : -

Source : Keio University Hospital, Japan,

Sample Type : -

No. of Sample : 395 patients with CRC

Stage : -

Genotyping, ImmunohistochemistryPolymorhpism-Lgr5 allelic variation affect Lgr5 protein expression in colorectal carcinomas. The somatic Lgr5 genotype seems to be relatively stable in primary tumors,but becomes vulnerable during the metastatic process of colorectal cancer. This instability has possibly prognostic importance.

20384634   2010Cell line : -

Source : Department of General Surgery, Chinese Peoples Liberation Army General Hospital.

Sample Type : CRC tumor and normal tissue

No. of Sample : 192 colorectal adenocarcinomas

Stage : TNM Stage I-IV

RT-PCR, Immunohistochemistry,In situ Hybridization.Up-regulation-LGR5 may be a novel prognostic marker and a candidate therapeutic target in CRC.

LGR5, a putative intestinal stem cell marker, was frequently overexpressed in adenomas and CRCs. These results suggest that LGR5 plays important roles, not only in early events, but also in late events (invasion and metastasis) in colorectal tumorigenesis.

23153436   2012Cell line : -

Source : Southern Hospital Trust, Kristiansand, Norway.`

Sample Type : CRC tumor and normal tissue

No. of Sample : 89 CRC patients

Stage : TNM Stage I-IV

Immunohistochemistry, Fluorescent immunocytochemistryUp-regulation-Lgr5 may be a potential new therapeutic target for the treatment of colorectal cancer patients, particularly those with advanced colorectal cancer.

Lgr5 appears to be a relevant candidate marker of colorectal CSCs.

Lgr5 is highly expressed in colorectal cancer cells.

25193236   2014Cell line : -

Source : -

Sample Type : Case control study

No. of Sample : 2139 patients.

Stage : -

Meta-analysisUp-regulation-Lgr5 might serve as an efficient biomarker for prognostic indicator, and could be a new molecular target in colorectal cancer therapy.

Lgr5 participates in the progression of CRC as a putative factor. Overexpression of Lgr5 was distinctly correlated with poor patient survival

24751002   2014Cell line : -

Source : Department of General Surgery, the First Affiliated Hospital of Soochow University

Sample Type : CRC tumor and normal tissue

No. of Sample : 53 CRC patients.

Stage : TNM Stage I-IV

Immunohistochemistry, real time RT-PCRUp-regulation-Elevated Lgr5 expression might contribute to the development and progression of CRC, and it could also be used a potential unfavorable prognostic biomarker for CRC.

A better understanding of molecule mechanisms and the relevance of potential value for Lgr5 in the progression of CRC will help to identify a novel therapeutic strategy for CRC patients.


Gene Details



Chromosome: 12; NC_000012.11 (71833813..71978622)

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Gene Type protein coding
Gene Family GPCR / Class A : Orphans
Description -  
Chromosome 12
Location 12q22-q23
Start 71439162  
End 71586310  
Strand -  
Gene Sequence

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Length 147149  
OMIM ID 606667   
HGNC ID HGNC:4504   
Unigene ID Hs.658889    
Ensembl ID ENSG00000139292   
PharmGKB ID PA28894   

mRNA Information


mRNA ID XM_005269204.3
Exon join(1..158,65453..65524,85245..85316,95954..96025, 113912..114127,117458..117529,120425..120493, 122620..122691,127243..127314,127471..127539, 127680..127751,132353..132418,133689..133760, 138764..138835,139643..139768,141117..141262, 143295..143378,144486..147149)  
mRNA Sequence

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Length 4246  



CDS Information


   
Locationjoin(920..1131,65453..65524,85245..85316,95954..96025, 113912..114127,117458..117529,120425..120493, 122620..122691,127243..127314,127471..127539, 127680..127751,132353..132418,133689..133760, 138764..138835,139643..139768,141117..141262, 143295..143378,144486..145573)
CDS Sequence

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CCDS ID CCDS9000.1



Protein Information


      
Protein IDNP_003658.1
Protein NameLeucine-rich repeat-containing G protein-coupled receptor 5
Molecular Wt. (Da)97819
Protein Sequence

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Length 907  
Uniprot IDQ92838
Ensembl Protein ID ENSP00000340611  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00116131-386  LRR_RI
cl23707131-386  LRR_RI superfamily
cd0011652-269  LRR_RI
pfam12799352-391  LRR_4
cl19302352-391  LRR_4 superfamily
cd0011686-376  LRR_RI
cd0011656-246  LRR_RI
pfam12799329-371  LRR_4
smart0001333-70  LRRNT
cl0242333-70  LRRNT superfamily
pfam0146233-65  LRRNT
cd00116230-464  LRR_RI
pfam12799234-273  LRR_4
pfam12799139-179  LRR_4
pfam12799211-250  LRR_4
pfam1385592-150  LRR_8
pfam13855163-222  LRR_8
pfam13855210-269  LRR_8
pfam13855352-410  LRR_8
pfam13855257-314  LRR_8
pfam13855305-364  LRR_8
PLN0011371-426  PLN00113
PLN0011362-384  PLN00113
COG488651-379  LRR
PRK1537094-399  PRK15370
COG4886132-453  LRR
pfam13855115-174  LRR_8
COG488647-270  LRR
pfam13855186-246  LRR_8
pfam13855138-198  LRR_8
pfam13855329-386  LRR_8
pfam13855375-424  LRR_8
PRK1537057-203  PRK15370
pfam13306139-284  LRR_5
pfam1385569-126  LRR_8
pfam13306201-323  LRR_5
pfam13306102-212  LRR_5
PLN0315067-178  PLN03150
PRK15370167-438  PRK15370
COG4886297-469  LRR
pfam00001635-820  7tm_1
pfam13306257-335  LRR_5
PLN03150185-253  PLN03150
PLN03210208-426  PLN03210
PLN03210302-468  PLN03210


Ontology Information


   
HPRD ID571
Molecular ClassG protein coupled receptor
Molecular FunctionG-protein coupled receptor activity (GO:0004930)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO