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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
LHX4 89884 LIM homeobox 4  1Gsh4 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25034524   2014Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

real time RT-PCR and immunohistochemistryUp-regulation-LHX4 is a commonly activated tumor promoter that activate Wnt/?-catenin signaling in cancer cells of CRC.


Gene Details



NC_000001.10 (180199433..180244188)

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Gene Type protein coding
Gene Family Homeoboxes / LIM class
Description This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4. [provided by RefSeq, Dec 2010]  
Chromosome 1
Location 1q25.3
Start 180199433  
End 180244188  
Strand +  
Gene Sequence

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Length 44756  
OMIM ID 602146   
HGNC ID HGNC:21734   
Unigene ID Hs.658487   
Ensembl ID ENSG00000121454   
PharmGKB ID PA134962876   

mRNA Information


mRNA ID ?NM_033343.3
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS1338.1



Protein Information


      
Protein IDNP_203129.1
Protein NameLIM homeobox 4
Molecular Wt. (Da)0
Protein Sequence

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Length 390  
Uniprot IDQ8N1L9
Ensembl Protein ID ENSP00000301887  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0937689-144  LIM2_Lhx3_Lhx4
cl0247589-144  LIM superfamily
cd0946830-81  LIM1_Lhx4
cl0247530-81  LIM superfamily
cd00086158-216  homeodomain
cl00084158-216  homeodomain superfamily
cd0947389-144  LIM2_Lhx4
cd0946727-81  LIM1_Lhx3b
cd0947288-144  LIM2_Lhx3b
cd0946627-82  LIM1_Lhx3a
cd0936830-81  LIM1_Lhx3_Lhx4
pfam00046158-214  Homeobox
cd0937589-144  LIM2_Lhx1_Lhx5
cd0936730-81  LIM1_Lhx1_Lhx5
smart00389158-213  HOX
cd0937989-144  LIM2_AWH
cd0937889-144  LIM2_Lmx1a_Lmx1b
cd0836830-81  LIM
cd0936930-81  LIM1_Lhx2_Lhx9
cd0937330-81  LIM1_AWH
pfam0041289-148  LIM
cd0937130-81  LIM1_Lmx1b
pfam0041230-85  LIM
cd0937788-144  LIM2_Lhx2_Lhx9
cd0938789-143  LIM2_LMO4
cd0938630-81  LIM1_LMO4
cd0937489-144  LIM2_Isl
smart0013288-143  LIM
cd0936630-81  LIM1_Isl
cd0937030-81  LIM1_Lmx1a
cd0936430-82  LIM1_LIMK
smart0013230-80  LIM
cd0939089-144  LIM2_dLMO
cd0946926-81  LIM1_Lhx2
cd0836889-144  LIM
cd0938830-81  LIM1_LMO1_LMO3
cd0947030-81  LIM1_Lhx9
cd0947189-144  LIM2_Isl2
cd0938130-82  LIM1_Lhx7_Lhx8
cd0938389-144  LIM2_Lhx7_Lhx8
cd0938989-144  LIM2_LMO1_LMO3
cd0946227-82  LIM1_LIMK1
cd0947488-141  LIM2_Lhx2
cd0946330-81  LIM1_LIMK2
cd0932930-81  LIM3_abLIM
cd0938430-82  LIM1_LMO2
cd0947588-135  LIM2_Lhx9
cd0938289-144  LIM2_Lhx6
cd0933730-81  LIM2_Paxillin_like
cd0938030-81  LIM1_Lhx6
cd09327102-144  LIM1_abLIM
cd0934329-79  LIM1_FHL
cd0934730-69  LIM4_FHL
cd0936489-144  LIM1_LIMK
cd0938589-143  LIM2_LMO2
cd0940630-81  LIM1_Leupaxin
cd0946389-144  LIM1_LIMK2
cd0942129-77  LIM3_LIMPETin
cd0934989-144  LIM1_Zyxin
cd0939489-142  LIM1_Rga
cd0945689-144  LIM2_Enigma
cd0945430-78  LIM1_ZASP_Cypher
cd0936130-77  LIM1_Enigma_like
cd0933630-82  LIM1_Paxillin_like
cd0935289-144  LIM1_Ajuba_like
cd0935730-78  LIM3_Zyxin_like
cd0932742-81  LIM1_abLIM
cd0939630-80  LIM_DA1
cd0945630-81  LIM2_Enigma
cd0943830-78  LIM3_Ajuba_like
cd0934089-144  LIM1_Testin_like
cd09351105-144  LIM1_LPP
cd0933230-79  LIM2_PINCH
cd0942385-144  LIM1_FHL3
cd0939130-69  LIM1_Lrg1p_like
cd0940730-81  LIM2_Paxillin
cd0941030-69  LIM3_Leupaxin
cd0933830-60  LIM3_Paxillin_like
cd0946584-140  LIM2_LIMK2
cd0937230-81  LIM2_FBLP-1
cd0940030-79  LIM_like_1
cd0936230-81  LIM2_Enigma_like
cd0945330-78  LIM1_ENH
cd0939189-144  LIM1_Lrg1p_like
cd0946289-144  LIM1_LIMK1
cd0933189-146  LIM1_PINCH
cd0942230-70  LIM1_FHL2
cd0935689-144  LIM2_TRIP6
pfam05920169-209  Homeobox_KN
cd0940130-78  LIM_TLP_like
cd0944550-81  LIM_Mical_like_2
cd0943230-79  LIM6_LIMPETin
cd0943430-69  LIM4_FHL3
cd0940088-140  LIM_like_1
cd0935430-88  LIM2_LPP
cd0937289-144  LIM2_FBLP-1
cd0944389-143  LIM_Ltd-1
cd0933589-145  LIM5_PINCH
cd0937830-81  LIM2_Lmx1a_Lmx1b
cd0948689-144  LIM_Eplin_like_1
cd09350105-144  LIM1_TRIP6
cd0935889-141  LIM_Mical_like
cd0936589-140  LIM2_LIMK
cd0940830-81  LIM2_Leupaxin
cd0944289-144  LIM_Eplin_like
cd0936289-144  LIM2_Enigma_like
cd0945730-81  LIM2_ENH
cd0942030-77  LIM3_Prickle
cd0939530-77  LIM2_Rga
cd0934128-77  LIM2_Testin_like
cd0944088-145  LIM1_SF3
cd0942330-70  LIM1_FHL3
cd0934047-77  LIM1_Testin_like
cd0944730-64  LIM_LASP
cd0948589-144  LIM_Eplin_alpha_beta
cd0932886-128  LIM2_abLIM
cd0946489-144  LIM2_LIMK1
cd0939330-79  LIM3_Lrg1p_like
cd0941489-144  LIM1_LIMPETin
cd0934430-70  LIM1_FHL1
cd0935330-88  LIM2_Zyxin
cd0945189-141  LIM_RIL
COG5576147-217  COG5576


Ontology Information


   
HPRD ID14318
Molecular ClassTranscription regulatory protein
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessBiological_process unknown (GO:0000004)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO