Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| LIFR | 3977 | leukemia inhibitory factor receptor alpha | 5 | CD118 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21617854 | 2011 | Cell line : HCT116,SW480, DLD1, HT29, Widr, SW48, RKO Source : - Sample Type : - No. of Sample : - Stage : - | Bisulfite-sequencing,Methylation-specific PCR,Immunohistochemistry,real time RT-PCR | Down-regulation | - | Down-regulated LIFR protein expression was observed in primary tumors. |
| 23579219 | 2013 | Cell line : - Source : Asan Medical Center (Seoul, Korea) Sample Type : CRC Tumor No. of Sample : 170 Stage : - | Genotyping, pyrosequencing | Polymorhpism | - | LIFR rs3729740 and possibly ANXA11 rs1049550 may be useful as biomarkers for predicting whether mCRC patients are sensitive to relevant target regimens. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, "Fibronectin type III domain containing" |
| Description | This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] | Chromosome | 5 |
| Location | 5p13-p12 |
| Start | 38475065 |
| End | 38595507 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 120443 |
| OMIM ID | 151443 |
| HGNC ID | HGNC:6597 |
| Unigene ID | Hs.133421 |
| Ensembl ID | ENSG00000113594 |
| PharmGKB ID | PA30371 |
mRNA Information
| mRNA ID | NM_002310.5 |
|---|---|
| Exon | join(1..145,64740..64900,66566..66680,68112..68251, 71824..71987,83442..83616,84688..84942,88774..88903, 89332..89501,91285..91430,92607..92769,95823..95893, 98811..99024,101621..101800,105115..105216,106161..106328, 109426..109587,110538..110631,112739..112817, 113188..120443) | mRNA Sequence | Download Select all |
| Length | 10107 |
Protein Information
| Protein ID | NP_002301.1 |
|---|---|
| Protein Name | leukemia inhibitory factor receptor alpha |
| Molecular Wt. (Da) | 103840 |
| Protein Sequence | Download Select all |
| Length | 1097 |
| Uniprot ID | P37275 |
| Ensembl Protein ID | ENSP00000319248 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 1044 |
| S | Phosphorylation | 927 |
| Y | Phosphorylation | 807 |
| T | Phosphorylation | 530 |
| T | Phosphorylation | 531 |
| S | Phosphorylation | 534 |
| S | Phosphorylation | 1077 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1270 | CNTF | 347 | NP_000605.1 | in vitro | 1 264 327 416 051 220 |
| 1271 | CNTFR | 348 | NP_001833.1 | in vitro | 112 852 331 194 315 000 000 000 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytokine-cytokine receptor interaction | hsa04060 |
| Jak-STAT signaling pathway | hsa04630 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00063 | 433-530 | FN3 |
| cl21522 | 433-530 | FN3 superfamily |
| cd00063 | 729-821 | FN3 |
| cl21522 | 729-821 | FN3 superfamily |
| cd00063 | 541-623 | FN3 |
| cl21522 | 541-623 | FN3 superfamily |
| pfam00041 | 436-520 | fn3 |
| smart00060 | 433-514 | FN3 |
| pfam06278 | 896-1004 | DUF1032 |
| cl09405 | 896-1004 | DUF1032 superfamily |
| smart00060 | 724-820 | FN3 |
| pfam00041 | 556-619 | fn3 |
| smart00060 | 541-616 | FN3 |
Ontology Information
| HPRD ID | 4493 |
|---|---|
| Molecular Class | Cytokine receptor |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.