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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
LIMS1 3987 LIM and senescent cell antigen-like domains 1  2PINCH, PINCH1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21426571   2011Cell line : -

Source : Linkping and Vrinnevi hospitals.

Sample Type : Paraffin-embedded tissue

No. of Sample : 251 primary adenocarcinomas, 149 adjacent normal mucosa, 57 distant normal mucosa and 75 lymph node metastases

Stage : TNM Stage I-IV.

 ImmunohistochemistryUp-regulation- Impact of PINCH on prognosis was dependent on differentiation status.

22199270   2011Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 81

Stage : -

RT-PCRUp-regulation-PINCH mRNA was overexpressed in colorectal cancer and associated with PCNA mRNA, VEGF mRNA and FAS mRNA expression.


Gene Details



NC_000002.11 (109150811..109303702)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]  
Chromosome 2
Location 2q12.3
Start 109150811  
End 109303702  
Strand +  
Gene Sequence

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Length 152892  
OMIM ID 602567   
HGNC ID HGNC:6616   
Unigene ID Hs.597715   
Ensembl ID ENSG00000169756   
PharmGKB ID PA30389   

mRNA Information


mRNA ID NM_005569.3
Exon join(1..161,13457..13556,46028..46163,46858..46967, 47626..47814,49871..49976,50332..50528,53683..53869, 54721..54807,55513..55644,55881..55937,58873..58938, 60267..60441,61189..61244,62888..63045,66034..67817)  
mRNA Sequence

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Length 3701  



CDS Information


   
Location146..2062
CDS Sequence

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CCDS ID CCDS2078.1



Protein Information


      
Protein IDNP_005560.1
Protein NameLIM and senescent cell antigen-like domains 1
Molecular Wt. (Da)0
Protein Sequence

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Length 638  
Uniprot IDQ13428
Ensembl Protein ID ENSP00000325223  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation321

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                         
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
3611ILK3842NP_004508.1in vitro;in vivo;yeast 2-hybrid1   002   292   911   078   730   
5932RBBP84990AAH30590.1yeast 2-hybrid16189514   
7046TGFBR11822NP_004603.1in vivo15761153   
7114TMSB4X2153NP_066932.1in vitro15565145   
9404LPXN5651NP_001137467.1yeast 2-hybrid16189514   
10919EHMT26854NP_006700.3yeast 2-hybrid16189514   
57154SMURF16902NP_065162.1in vivo15761153   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd09331Oct-68  LIM1_PINCH
cl02475Oct-68  LIM superfamily
cd09334191-244  LIM4_PINCH
cl02475191-244  LIM superfamily
cd0933271-122  LIM2_PINCH
cl0247571-122  LIM superfamily
cd09335252-305  LIM5_PINCH
cl02475252-305  LIM superfamily
cd09333135-185  LIM3_PINCH
cl02475135-185  LIM superfamily
cd09336193-244  LIM1_Paxillin_like
cd09405192-245  LIM1_Paxillin
cd09406193-245  LIM1_Leupaxin
pfam00412Oct-67  LIM
cd09337193-244  LIM2_Paxillin_like
cd09338193-244  LIM3_Paxillin_like
pfam00412193-248  LIM
cd08368193-244  LIM
smart00132192-243  LIM
smart00132Oct-62  LIM
cd0836871-122  LIM
pfam0041271-126  LIM
cd09409193-245  LIM3_Paxillin
cd09457193-244  LIM2_ENH
cd09412193-244  LIM4_Leupaxin
cd09349Feb-60  LIM1_Zyxin
cd0936171-122  LIM1_Enigma_like
cd08368252-304  LIM
cd09336252-304  LIM1_Paxillin_like
cd09407193-244  LIM2_Paxillin
smart00132251-303  LIM
smart0013270-121  LIM
cd09362193-244  LIM2_Enigma_like
cd0945371-122  LIM1_ENH
cd09411193-242  LIM4_Paxillin
cd08368Oct-63  LIM
cd09392193-244  LIM2_Lrg1p_like
cd09339193-241  LIM4_Paxillin_like
cd0933671-122  LIM1_Paxillin_like
cd09361193-244  LIM1_Enigma_like
cd0935571-109  LIM2_Ajuba_like
cd09410193-245  LIM3_Leupaxin
cd09456193-244  LIM2_Enigma
cd0933828-60  LIM3_Paxillin_like
pfam00412135-188  LIM
cd0945271-122  LIM1_Enigma
cd09331193-248  LIM1_PINCH
cd09408193-240  LIM2_Leupaxin
cd0940671-118  LIM1_Leupaxin
cd09349193-244  LIM1_Zyxin
cd0945471-122  LIM1_ZASP_Cypher
cd09455193-241  LIM1_Enigma_like_1
cd0940871-119  LIM2_Leupaxin
cd0933971-122  LIM4_Paxillin_like
cd09361252-304  LIM1_Enigma_like
cd09341191-240  LIM2_Testin_like
cd09453193-244  LIM1_ENH
cd0933771-119  LIM2_Paxillin_like
cd0939171-105  LIM1_Lrg1p_like
cd09364193-244  LIM1_LIMK
cd0934571-122  LIM2_FHL
cd09364252-304  LIM1_LIMK
pfam00412252-306  LIM
cd0940930-64  LIM3_Paxillin
cd0940571-118  LIM1_Paxillin
cd0933721-63  LIM2_Paxillin_like
cd0941271-122  LIM4_Leupaxin
cd09452193-244  LIM1_Enigma
cd0932871-121  LIM2_abLIM
cd0941031-63  LIM3_Leupaxin
cd09396193-239  LIM_DA1
cd09462189-244  LIM1_LIMK1
cd09328193-226  LIM2_abLIM
cd09345Oct-59  LIM2_FHL
cd09454193-244  LIM1_ZASP_Cypher
cd0937271-109  LIM2_FBLP-1
cd09400Sep-59  LIM_like_1
cd09352Oct-63  LIM1_Ajuba_like
cd09360193-243  LIM_ALP_like
cd09334251-281  LIM4_PINCH
cd09431193-248  LIM3_Fhl2
cd0940771-119  LIM2_Paxillin
cd0942671-125  LIM2_FHL2
cd0933871-118  LIM3_Paxillin_like
cd0939671-122  LIM_DA1
cd0945571-121  LIM1_Enigma_like_1
cd0940620-63  LIM1_Leupaxin
cd0941071-118  LIM3_Leupaxin
cd09362252-304  LIM2_Enigma_like
cd0935371-127  LIM2_Zyxin
cd0933071-106  LIM4_abLIM
cd0935671-117  LIM2_TRIP6
cd09328249-303  LIM2_abLIM
cd09405251-304  LIM1_Paxillin
cd09456252-304  LIM2_Enigma
cd09392252-304  LIM2_Lrg1p_like
cd0933469-101  LIM4_PINCH
cd09430252-304  LIM5_LIMPETin
cd09329193-244  LIM3_abLIM
cd09391193-225  LIM1_Lrg1p_like
cd09387Oct-63  LIM2_LMO4
cd09441Oct-67  LIM2_SF3
cd09336Aug-64  LIM1_Paxillin_like
cd0936571-106  LIM2_LIMK
cd09405Oct-64  LIM1_Paxillin
cd09840Oct-60  LIM2_CRP2
cd0940171-122  LIM_TLP_like
cd0945171-109  LIM_RIL
cd09454252-304  LIM1_ZASP_Cypher
cd09418191-240  LIM2_Prickle
cd09457252-304  LIM2_ENH
cd0936071-109  LIM_ALP_like
cd0945071-118  LIM_ALP
cd09461193-243  LIM3_Enigma_like_1
cd09346252-304  LIM3_FHL
cd0938471-119  LIM1_LMO2
cd09455252-304  LIM1_Enigma_like_1
cd08368135-185  LIM
cd09397193-244  LIM1_UF1
cd09375Oct-63  LIM2_Lhx1_Lhx5
cd09328Oct-58  LIM2_abLIM
cd0940971-118  LIM3_Paxillin
cd0936470-119  LIM1_LIMK


Ontology Information


   
HPRD ID3251
Molecular ClassAdapter molecule
Molecular FunctionDNA repair protein (GO:0003685)
Biological ProcessDNA repair (GO:0006281)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO