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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| LMAN1 | 3998 | lectin, mannose-binding, 1 | 18 | MR60, ERGIC-53, ERGIC53, gp58, MCFD1, FMFD1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19118014 | 2009 | Cell line : - Source : LOCATE database, MySQL database and Human tissues were obtained from the local tissue bank established within the German Collaborative Group on HNPCC. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | real time RT-PCR,Western blotting,Immunohistochemistry, ELISA | Mutation | - | LMAN1 mutational inactivation is a frequent and early event potentially contributing to MSI-H tumorigenesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency. [provided by RefSeq, Jul 2015] | Chromosome | 18 |
| Location | 18q21.3-q2 |
| Start | 56995055 |
| End | 57026508 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 31454 |
| OMIM ID | 601567 |
| HGNC ID | HGNC:6631 |
| Unigene ID | Hs.465295 |
| Ensembl ID | ENSG00000074695 |
| PharmGKB ID | PA30399 |
mRNA Information
| mRNA ID | NM_005570.3 |
|---|---|
| Exon | join(1..246,3619..3773,3857..3964,4697..4758,5976..6075, 10041..10164,11706..11764,13226..13358,20324..20517, 20650..20720,26033..26186,27738..27859,28148..31454) | mRNA Sequence | Download Select all |
| Length | 4848 |
Protein Information
| Protein ID | NP_005561.1 |
|---|---|
| Protein Name | lectin, mannose-binding, 1 |
| Molecular Wt. (Da) | 65004 |
| Protein Sequence | Download Select all |
| Length | 510 |
| Uniprot ID | P17987 |
| Ensembl Protein ID | ENSP00000317334 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 425 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2157 | F8 | 2384 | NP_000123.1 | in vivo | 14629470 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Protein processing in endoplasmic reticulum | hsa04141 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd06902 | 44-268 | lectin_ERGIC-53_ERGL |
| cl14058 | 44-268 | lectin_L-type superfamily |
| pfam03388 | 44-269 | Lectin_leg-like |
| cd07308 | 46-267 | lectin_leg-like |
| cd06901 | 63-267 | lectin_VIP36_VIPL |
| cd01951 | 59-262 | lectin_L-type |
| cd06903 | 50-265 | lectin_EMP46_EMP47 |
| COG2882 | 340-415 | FliJ |
| cl21477 | 340-415 | FliJ superfamily |
| COG1322 | 295-433 | RmuC |
Ontology Information
| HPRD ID | 1757 |
|---|---|
| Molecular Class | Chaperone |
| Molecular Function | Growth factor activity (GO:0008083) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P49257 | DB00025 | Antihemophilic Factor (Recombinant) | BiotechDrug |