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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
LMNB1 4001 lamin B1  5- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20846378   2010Cell line : -

Source : Conducted in Malaysia, evaluated in a North American population

Sample Type : Blood samples

No. of Sample : 210 (99 CRC and 111 controls)

Stage : -

real time RT-PCR Up-regulation--


Gene Details



NC_000005.9 (126112315..126172712)

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Gene Type protein coding
Gene Family Intermediate filaments type V, lamins
Description This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]  
Chromosome 5
Location 5q23.2
Start 126112315  
End 126172712  
Strand +  
Gene Sequence

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Length 60398  
OMIM ID 150340   
HGNC ID HGNC:6637   
Unigene ID Hs.89497   
Ensembl ID ENSG00000113368   
PharmGKB ID PA30403   

mRNA Information


mRNA ID NM_005573.3
Exon join(1..1245,28154..28310,28949..29074,33558..33728, 35151..35276,42300..42520,44288..44513,46159..46263, 49366..49485,56072..56179,59601..60398)  
mRNA Sequence

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Length 3420  



CDS Information


   
Location887..2647
CDS Sequence

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CCDS ID CCDS4140.1



Protein Information


      
Protein IDNP_005564.1
Protein Namelamin B1
Molecular Wt. (Da)17566
Protein Sequence

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Length 586  
Uniprot IDP13385
Ensembl Protein ID ENSP00000296145  



Post-translational Modification Information (Source : HPRD)


Residue Type site
CMethylation583
SPhosphorylation23
RProteolytic Cleavage402
RProteolytic Cleavage402
SPhosphorylation395
SPhosphorylation405
SPhosphorylation393
SPhosphorylation391
TPhosphorylation20
YProteolytic Cleavage377
SPhosphorylation23;-
TPhosphorylation19;-
TPhosphorylation25;-
SPhosphorylation28;-
SPhosphorylation200;-
TPhosphorylation575;-
SPhosphorylation404;-
SPhosphorylation284
TPhosphorylation5
SPhosphorylation579
SPhosphorylation278
SPhosphorylation279
KAcetylation33
KAcetylation271
KAcetylation157
KAcetylation483
KAcetylation181
KAcetylation123
SPhosphorylation375
TPhosphorylation3
SPhosphorylation232
SPhosphorylation158
SPhosphorylation210
SPhosphorylation396

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
4000LMNA1035CAA27173.1in vitro;yeast 2-hybrid11792809   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam00932439-549  LTD
cl20210439-549  LTD superfamily
pfam0003831-387  Filament
TIGR0216812-349  SMC_prok_B
COG1196125-386  Smc
TIGR0216831-327  SMC_prok_B
COG119683-392  Smc
COG119633-327  Smc
TIGR0216870-389  SMC_prok_B
pfam0157625-384  Myosin_tail_1
TIGR0216831-359  SMC_prok_B
COG119695-389  Smc
TIGR0216980-389  SMC_prok_A
COG119633-353  Smc
COG119631-213  Smc
PRK0222434-354  PRK02224
TIGR0216989-386  SMC_prok_A
TIGR0216930-389  SMC_prok_A
TIGR0216933-327  SMC_prok_A
TIGR0216912-390  SMC_prok_A
TIGR02168127-389  SMC_prok_B
COG041928-389  SbcC
PRK0222428-387  PRK02224
TIGR0216933-186  SMC_prok_A
TIGR04320120-205  Surf_Exclu_PgrA
PRK0391828-389  PRK03918
COG041989-389  SbcC
PRK11281171-383  PRK11281
TIGR02168165-389  SMC_prok_B
pfam0711147-369  HCR
pfam10186246-362  Atg14
pfam0548346-390  SCP-1
pfam1212831-365  DUF3584
COG494277-345  EnvC
COG309684-388  MukB
pfam07888103-388  CALCOCO1
COG041949-360  SbcC
COG491388-363  COG4913
COG0544120-349  Tig
pfam09726123-338  Macoilin
TIGR0432083-185  Surf_Exclu_PgrA
pfam0562217-373  HOOK
PRK03918234-398  PRK03918
TIGR0100032-233  bacteriocin_acc
pfam0157648-386  Myosin_tail_1
TIGR0300739-214  pepcterm_ChnLen
PRK0222428-387  PRK02224
COG1196131-389  Smc
TIGR0452399-389  Mplasa_alph_rch
pfam1017483-389  Cast
pfam09731150-325  Mitofilin
TIGR0184320-150  type_I_hlyD
PRK0359861-190  PRK03598
pfam04849123-358  HAP1_N
PRK03918106-381  PRK03918
COG1195135-241  RecF
pfam1212834-389  DUF3584
pfam0555731-389  MAD
PRK12704207-362  PRK12704
TIGR03007213-393  pepcterm_ChnLen
TIGR04320120-186  Surf_Exclu_PgrA
pfam12128152-390  DUF3584
PRK0391820-334  PRK03918
PRK0903967-201  PRK09039
COG4942121-397  EnvC
pfam1316621-177  AAA_13


Ontology Information


   
HPRD ID1802
Molecular ClassStructural protein
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO