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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19724858 | 2009 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 104 Stage : - | real-time RT-PCR | Up-regulation | - | Upregulation of LOX, LOXL2 and LOXL4 was significantly correlated with absence of lymphovascular invasion, suggesting that the oxygen tension in or around the tumors may be an important regulator for the differential expression of LOX, LOXL2 and LOXL4 in colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008] | Chromosome | 8 |
| Location | 8p21.3 |
| Start | 23154410 |
| End | 23261722 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 107313 |
| OMIM ID | 606663 |
| HGNC ID | HGNC:6666 |
| Unigene ID | Hs.626637 |
| Ensembl ID | - |
| PharmGKB ID | PA30429 |
mRNA Information
| mRNA ID | NM_002318.2 |
|---|---|
| Exon | join(1..256,35776..36213,43945..44120,63007..63218, 70587..70809,75645..75828,81929..82080,84158..84325, 87096..87261,94299..94542,100813..100928,102047..102183, 105263..105374,106088..107313) | mRNA Sequence | Download Select all |
| Length | 3810 |
Protein Information
| Protein ID | NP_002309.1 |
|---|---|
| Protein Name | lysyl oxidase-like 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 774 |
| Uniprot ID | Q15561 |
| Ensembl Protein ID | ENSP00000380311 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01186 | 548-749 | Lysyl_oxidase |
| cl03127 | 548-749 | Lysyl_oxidase superfamily |
| smart00202 | 58-159 | SR |
| cl02509 | 58-159 | SRCR superfamily |
| smart00202 | 326-425 | SR |
| cl02509 | 326-425 | SRCR superfamily |
| pfam00530 | 67-159 | SRCR |
| pfam00530 | 329-425 | SRCR |
| smart00202 | 435-544 | SR |
| cl02509 | 435-544 | SRCR superfamily |
| pfam00530 | 439-544 | SRCR |
| smart00202 | 196-301 | SR |
| cl02509 | 196-301 | SRCR superfamily |
| pfam00530 | 203-301 | SRCR |
Ontology Information
| HPRD ID | 1754 |
|---|---|
| Molecular Class | Enzyme: Oxidase |
| Molecular Function | RNA-directed DNA polymerase activity (GO:0003964) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.