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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26418031 | 2015 | Cell line : Caco 2, HT-29 , HCT-116, Ovcar-3 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Western-blotting,Wound-healing assay,Invasion assay,Cell viability analysis,Apoptosis and survival assay,Cell cycle analysis,Immunofluorescence,Luciferase assay ,Expression Chip array | Up-regulation | - | LPA increases the proliferative potential of colon adenocarcinoma HCT-116 cells through a mechanism involving cooperation between the Rho-ROCK and STAT3 pathways involved in cell cycle control. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009] | Chromosome | 6 |
| Location | 6q25-q26 |
| Start | 160952506 |
| End | 161097478 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 144973 |
| OMIM ID | 152200 |
| HGNC ID | HGNC:6667 |
| Unigene ID | - |
| Ensembl ID | ENSG00000198670 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_005577.2 |
|---|---|
| Exon | join(1..75,2117..2210,15879..16038,19981..20162, 21370..21529,25528..25709,26917..27076,31072..31253, 32464..32623,36621..36802,38010..38169,42165..42346, 43554..43713,47711..47892,49100..49259,53263..53444, 54655..54814,59718..59899,61171..61330,65278..65459, 66717..66876,70841..71022,72259..72418,75275..75432, 76664..76823,79746..79927,81171..81330,87672..87853, 89081..89240,108805..108986,110192..110351,117717..117898, 118439..118587,120843..120936,123568..123688, 125195..125269,126193..126333,128415..128521, 133727..133845,134486..134893) | mRNA Sequence | Download Select all |
| Length | 6489 |
Protein Information
| Protein ID | NP_005568.2 |
|---|---|
| Protein Name | lipoprotein, Lp(a) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 2040 |
| Uniprot ID | |
| Ensembl Protein ID |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| I | Proteolytic Cleavage | 1031 |
| I | Proteolytic Cleavage | 1031 |
| T | Proteolytic Cleavage | 1357 |
| I | Proteolytic Cleavage | 1707 |
| N | Proteolytic Cleavage | 1029 |
Enzyme Information
No matching records could be found.
PPi Information
No STRING Network could be found.
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 821 | CANX | 252 | NP_001737.1 | in vitro;in vivo | 971 772 312 562 843 |
| 2244 | FGB | 620 | NP_005132.2 | in vitro;in vivo | 10980194 |
| 2335 | FN1 | 626 | NP_997647.1 | in vitro;in vivo | 2531657 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
No matching records could be found.
Ontology Information
| HPRD ID | 128 |
|---|---|
| Molecular Class | Transport/cargo protein |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Development (GO:0007275); Apoptosis (GO:0006915); Cell differentiation (GO:0030154); Regulation of gene expression, epigenetic (GO:0040029) |
Drug Information
No matching records could be found.