Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| LPAR1 | 1902 | Endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 | 9 | EDG2; LPA1; VZG1; GPR26; edg-2; vzg-1; Gpcr26; Mrec1.3; rec.1.3 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15220934 | 2004 | Cell line : - Source : Department of Surgical Oncology of the University of Tokyo. Sample Type : - No. of Sample : - Stage : - | RT-PCR, Immunohistochemistry, Western blot analysis. | Down-regulation | - | In colorectal cancers expressed LPA1 mRNA at a significantly lower level as compared with normal tissues. LPA receptor expression might be an important event in the development of colorectal cancer. 26 colorectal cancers and 16 corresponding normal tissue samples were included. |
| 15728708 | 2005 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | RT-PCR, Hybridization of the cancer profiling array,In vitro interaction assays, Immunoprecipitation | Down-regulation | - | Found that expression of LPA2 was elevated, whereas expression of LPA1 downregulated in several types of cancers, including ovarian and colon cancer. Caco2 and SW480 cell line were used. |
| 20890765 | 2010 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | RT-PCR, Bisulfite sequencing analyses,PCR-single-strand conformation polymorphism method. | Unknown | - | LPA1, LPA2, and LPA4 genes were expressed in DLD1, SW480, HCT116, CaCo-2, SW48, and LoVo cells. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class A : Lysophospholipid receptors : Lysophosphatidic acid |
| Description | The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants encoding the same protein have been identified for this gene [provided by RefSeq, Jul 2008] | Chromosome | 9 |
| Location | 9q31.3 |
| Start | 110873261 |
| End | 111039243 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 165983 |
| OMIM ID | 602282 |
| HGNC ID | HGNC:3166 |
| Unigene ID | Hs.126667 |
| Ensembl ID | ENSG00000198121 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_005251781.2 |
|---|---|
| Exon | join(1..374,65686..65763,67024..67171,97076..97823, 163522..165983) | mRNA Sequence | Download Select all |
| Length | 3104 |
CDS Information
| Location | join(67127..67171,97076..97823,163522..163823) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS6777.1 |
Protein Information
| Protein ID | NP_001392.2 |
|---|---|
| Protein Name | Endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 |
| Molecular Wt. (Da) | 40978 |
| Protein Sequence | Download Select all |
| Length | 364 |
| Uniprot ID | Q99728 |
| Ensembl Protein ID | ENSP00000260947 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2773 | GNAI3 | 765 | NP_006487.1 | in vitro | 9600933 |
| 9826 | ARHGEF11 | 9302 | NP_937879.1 | in vitro;in vivo | 15755723 |
| 23365 | ARHGEF12 | 9207 | NP_056128.1 | in vitro;in vivo | 15755723 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Gap junction | hsa04540 |
| Neuroactive ligand-receptor interaction | hsa04080 |
| Pathways in cancer | hsa05200 |
| Phospholipase D signaling pathway | hsa04072 |
| PI3K-Akt signaling pathway | hsa04151 |
| Rap1 signaling pathway | hsa04015 |
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 3354 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.