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General Information
- Evidence
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22276141 | 2012 | Cell line : - Source : UAB Hospital Sample Type : Formalin-fixed paraffin-embedded tissue sections No. of Sample : 303 CRC patients Stage : Stage III CRCs | Microarray for expression profiling, qNPA, qRT-PCR, and IHC platforms | Down-regulation | - | Of 49 down-regulated genes, LPAR6, PDLIM3, and PLAT, and, of 35 up-regulated genes, TRIM29, FUT3, IQGAP3, and SLC6A8 were confirmed . |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class A : Lysophospholipid receptors : Lysophosphatidic acid |
| Description | The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009] | Chromosome | 13 |
| Location | 13q14 |
| Start | 48985181 |
| End | 49018840 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 33660 |
| OMIM ID | 609239 |
| HGNC ID | HGNC:15520 |
| Unigene ID | Hs.123464 |
| Ensembl ID | ENSG00000139679 |
| PharmGKB ID | PA165505129 |
Protein Information
| Protein ID | NP_001155969.1 |
|---|---|
| Protein Name | lysophosphatidic acid receptor 6 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 344 |
| Uniprot ID | Q9NR99 |
| Ensembl Protein ID | ENSP00000217939 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Neuroactive ligand-receptor interaction | hsa04080 |
| Pathways in cancer | hsa05200 |
| Phospholipase D signaling pathway | hsa04072 |
| PI3K-Akt signaling pathway | hsa04151 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam10328 | 29-142 | 7TM_GPCR_Srx |
| cl21561 | 29-142 | 7tm_4 superfamily |
| pfam00001 | 40-291 | 7tm_1 |
| PHA03087 | 23-295 | PHA03087 |
| PHA02638 | 24-304 | PHA02638 |
| PHA02834 | 23-303 | PHA02834 |
| PHA03235 | 53-293 | PHA03235 |
Ontology Information
| HPRD ID | 15417 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.