Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| LRAT | 9227 | lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) | 4 | LCA14 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25260806 | 2014 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 167 colorectal tumors, 69 adjacent normal tissue Stage : - | real-time RT-PCR ,quantitative bisulfite PCR/LDR/Universal Array assay. | Hypermethylation | - | LRAT�promoter hypermethylation associates with�LRAT�gene expression in CRC. The higher frequency of�LRAT�hypermethylation in colonic polyps and early-stage CRCs indicates that it may occur early in malignant progression. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene localizes to the endoplasmic reticulum, where it catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester. This reaction is an important step in vitamin A metabolism in the visual system. Mutations in this gene have been associated with early-onset severe retinal dystrophy and Leber congenital amaurosis 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014] | Chromosome | 4 |
| Location | 4q32.1 |
| Start | 155665163 |
| End | 155674270 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 9108 |
| OMIM ID | 604863 |
| HGNC ID | HGNC:6685 |
| Unigene ID | Hs.658427 |
| Ensembl ID | ENSG00000121207 |
| PharmGKB ID | PA30443 |
Protein Information
| Protein ID | NP_001288574.1 |
|---|---|
| Protein Name | lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 230 |
| Uniprot ID | Q9BS26 |
| Ensembl Protein ID | ENSP00000262455 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Retinol metabolism | hsa00830 |
| Vitamin digestion and absorption | hsa04977 |
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 6170 |
|---|---|
| Molecular Class | Enzyme: Acyltransferase |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Transport (GO:0006810) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| O95237 | DB00162 | Vitamin A | SmallMoleculeDrug |