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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
LTBR 4055 lymphotoxin beta receptor (TNFR superfamily, member 3)  12TNFCR, TNFR-RP, TNFR2-RP, TNF-R-III, TNFRSF3 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22470139   2012Cell line : RKO

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Lentivirus-mediated RNA interference,real time RT-PCRDown-regulation- Downregulation of SMAD3, LTBR, BAX and BAK1 in WWTR1 knockdown cells, suggesting that these genes may be involved in the repression of cell proliferation.


Gene Details



NC_000012.11 (6484534..6500737)

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Gene Type protein coding
Gene Family Tumor necrosis factor receptor superfamily
Description This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]  
Chromosome 12
Location 12p13
Start 6484534  
End 6500737  
Strand +  
Gene Sequence

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Length 16204  
OMIM ID 600979   
HGNC ID HGNC:6718   
Unigene ID Hs.1116   
Ensembl ID -   
PharmGKB ID PA30481   

mRNA Information


mRNA ID NM_001159575.1
Exon complement(1885..1990)  
mRNA Sequence

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Length 3216  



CDS Information


   
Location92..2170
CDS Sequence

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CCDS ID CCDS59233.1



Protein Information


      
Protein IDNP_001153047.1
Protein Namelymphotoxin beta receptor (TNFR superfamily, member 3)
Molecular Wt. (Da)32740
Protein Sequence

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Length 692  
Uniprot IDO14746
Ensembl Protein ID ENSP00000309572  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation298
SPhosphorylation323
SPhosphorylation302

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
4049LTA1084NP_000586.2in vivo8171323   
4050LTB2987NP_002332.1in vitro7916655   


Pathway Information


                                    
Pathway Name Pathway ID
Cytokine-cytokine receptor interaction hsa04060
HIF-1 signaling pathway hsa04066
HTLV-I infection hsa05166
Intestinal immune network for IgA production hsa04672
NF-kappa B signaling pathway hsa04064
Viral carcinogenesis hsa05203


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd1057811-168  TNFRSF3
cl2285511-168  TNFRSF superfamily
cd1340758-210  TNFRSF5
cd1057743-210  TNFRSF1B
cd1583539-157  TNFRSF1B_teleost
cd1057556-210  TNFRSF6B
cd1341151-211  TNFRSF11A
cd1058357-210  TNFRSF21
cd0018558-143  TNFRSF
cd1057646-152  TNFRSF1A
cd1342254-210  TNFRSF5_teleost
cd1340653-213  TNFRSF4
cd1340557-151  TNFRSF14_teleost
cd1583658-170  TNFRSF11A_teleost
cd1057947-155  TNFRSF6
cd1341658-210  TNFRSF16
cd1058058-168  TNFRSF10
cd1058258-143  TNFRSF14
cd1342351-148  TNFRSF6_teleost
cd1058150-177  TNFRSF11B
cd1583443-194  TNFRSF1A_teleost
cd1341059-210  TNFRSF9
cd1583756-132  TNFRSF26
cd1583949-170  TNFRSF_viral
cd1341259-151  TNFRSF11B_teleost
cd1341637-124  TNFRSF16
PHA0263733-101  PHA02637
cl2286833-101  PHA02637 superfamily
cd1341799-230  TNFRSF18
cd13419148-210  TNFRSF19L
cl22855148-210  TNFRSF superfamily
cd1342454-210  TNFRSF9_teleost
cd1340930-148  TNFRSF8
pfam0002083-124  TNFR_c6
cd00185148-210  TNFRSF
cd1342058-149  TNFRSF25
smart0020883-124  TNFR
pfam0002046-80  TNFR_c6
smart00208170-210  TNFR
smart0020846-80  TNFR
PRK03427264-342  PRK03427


Ontology Information


   
HPRD ID219
Molecular ClassCytokine receptor
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessBiological_process unknown (GO:0000004)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO