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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
MACF1 23499 microtubule-actin crosslinking factor 1  1KIAA0465, ACF7, ABP620, KIAA1251, MACF, FLJ45612, FLJ46776 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25974029   2015Cell line : -

Source : H. Lee Moffitt Cancer Center.

Sample Type : CRC tumor and normal tissue

No. of Sample : 468

Stage : TNM Stage I-IV

Targeted gene sequencing Mutation--


Gene Details



NC_000001.10 (39549839..39952810)

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Gene Type protein coding
Gene Family EF-hand domain containing
Description This gene encodes a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. The encoded protein is a member of a family of proteins that form bridges between different cytoskeletal elements. This protein facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]  
Chromosome 1
Location 1p32-p31
Start 39549839  
End 39952810  
Strand +  
Gene Sequence

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Length 402972  
OMIM ID 608271   
HGNC ID HGNC:13664   
Unigene ID Hs.472475   
Ensembl ID ENSG00000127603   
PharmGKB ID PA30518   

mRNA Information


mRNA ID ?NM_012090.5
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS435.1



Protein Information


      
Protein IDNP_036222.3
Protein Namemicrotubule-actin crosslinking factor 1
Molecular Wt. (Da)0
Protein Sequence

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Length 7388  
Uniprot IDQ9BSJ6
Ensembl Protein ID ENSP00000250056  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation2956;-
SPhosphorylation2454;-
SPhosphorylation2931;-
SPhosphorylation2429;-
SPhosphorylation4954;-
SPhosphorylation4452;-
SPhosphorylation2362;-
SPhosphorylation1860;-
SPhosphorylation2364;-
SPhosphorylation1862;-
SPhosphorylation5797
SPhosphorylation5801
TPhosphorylation5804
SPhosphorylation5289
SPhosphorylation5293
TPhosphorylation5296
SPhosphorylation5807
SPhosphorylation5299
SPhosphorylation5838
SPhosphorylation5841
SPhosphorylation5330
SPhosphorylation5333
SPhosphorylation5842
SPhosphorylation5334
SPhosphorylation280
SPhosphorylation5880
SPhosphorylation5372
SPhosphorylation5895
SPhosphorylation5900
SPhosphorylation5387
SPhosphorylation5392
SPhosphorylation1376
SPhosphorylation2930
SPhosphorylation2428
TPhosphorylation2933
TPhosphorylation2431
TPhosphorylation2935
TPhosphorylation2433
TPhosphorylation2937
TPhosphorylation2435
SPhosphorylation5511
SPhosphorylation5009
SPhosphorylation5513
SPhosphorylation5011
SPhosphorylation5840
SPhosphorylation5332
SPhosphorylation2576
SPhosphorylation2579
SPhosphorylation2074
SPhosphorylation2077
SPhosphorylation5506
SPhosphorylation5004
KAcetylation4754
KAcetylation4252
KAcetylation90
SPhosphorylation4136
SPhosphorylation3634
TPhosphorylation5846
TPhosphorylation5338
TPhosphorylation212
TPhosphorylation518
SPhosphorylation1367
SPhosphorylation2085
SPhosphorylation1583
SPhosphorylation2174
SPhosphorylation1672
TPhosphorylation5516
TPhosphorylation5014
TPhosphorylation5831
SPhosphorylation5832
TPhosphorylation5323
SPhosphorylation5324
SPhosphorylation4432
SPhosphorylation3930
SPhosphorylation4946
SPhosphorylation4444
SPhosphorylation2369
SPhosphorylation1867

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                          
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
58ACTA130NP_001091.1in vitro;in vivo10   601   340   105   592   300   000   000   
2803GOLGA43941NP_002069.2in vitro;in vivo;yeast 2-hybrid15265687   
4897NRCAM7207NP_001032209.1yeast 2-hybrid12421765   
23129PLXND15046NP_055918.2yeast 2-hybrid12421765   
26047CNTNAP25197NP_054860.1yeast 2-hybrid12421765   
55729ATF7IP9811NP_060649.3yeast 2-hybrid15231748   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd001766225-6441  SPEC
cl024886225-6441  SPEC superfamily
cd001766665-6877  SPEC
cl024886665-6877  SPEC superfamily
cd001766446-6660  SPEC
cl024886446-6660  SPEC superfamily
cd0001479-181  CH
cl0003079-181  CH superfamily
cd001766005-6222  SPEC
cl024886005-6222  SPEC superfamily
cd00014195-298  CH
cl00030195-298  CH superfamily
cd001765348-5561  SPEC
cl024885348-5561  SPEC superfamily
cd001765784-6003  SPEC
cl024885784-6003  SPEC superfamily
cd001764693-4907  SPEC
cl024884693-4907  SPEC superfamily
cd001763883-4111  SPEC
cl024883883-4111  SPEC superfamily
cd00176682-871  SPEC
cl02488682-871  SPEC superfamily
cd001765674-5886  SPEC
cl024885674-5886  SPEC superfamily
cd001764468-4687  SPEC
cl024884468-4687  SPEC superfamily
cd001764328-4575  SPEC
cl024884328-4575  SPEC superfamily
cd000517045-7107  EFh
cl083027045-7107  EFh superfamily
cd001765566-5778  SPEC
cl024885566-5778  SPEC superfamily
cd001764909-5113  SPEC
cl024884909-5113  SPEC superfamily
cd001763491-3727  SPEC
cl024883491-3727  SPEC superfamily
cd001764113-4320  SPEC
cl024884113-4320  SPEC superfamily
pfam021877120-7192  GAS2
cl025247120-7192  GAS2 superfamily
smart002437120-7192  GAS2
cd001766552-6768  SPEC
pfam00307197-298  CH
smart0003382-179  CH
cd001766117-6331  SPEC
pfam0030781-181  CH
smart00033198-293  CH
cd001766770-7014  SPEC
cd001766333-6550  SPEC
cd001765259-5452  SPEC
cd001764801-5013  SPEC
smart001506227-6328  SPEC
cd00176586-784  SPEC
cd001764000-4216  SPEC
cd001765454-5670  SPEC
cd001765940-6112  SPEC
smart001506665-6765  SPEC
smart001506555-6657  SPEC
pfam004356227-6328  Spectrin
pfam006811769-1809  Plectin
cl233641769-1809  Plectin superfamily
cd001764592-4797  SPEC
smart001505348-5449  SPEC
smart001504801-4904  SPEC
smart001506117-6219  SPEC
smart001506446-6547  SPEC
smart001505784-5884  SPEC
pfam004354801-4905  Spectrin
pfam006811577-1621  Plectin
cl233641577-1621  Plectin superfamily
pfam006812501-2544  Plectin
cl233642501-2544  Plectin superfamily
smart001506774-6874  SPEC
pfam004356665-6766  Spectrin
smart001506007-6109  SPEC
pfam004354465-4574  Spectrin
pfam006812686-2730  Plectin
cl233642686-2730  Plectin superfamily
smart001506335-6438  SPEC
pfam138337057-7106  EF-hand_8
smart002501769-1805  PLEC
cl233491769-1805  PLEC superfamily
smart001504468-4573  SPEC
pfam004354000-4108  Spectrin
pfam004355348-5450  Spectrin
cd001765128-5343  SPEC
cl024885128-5343  SPEC superfamily
cd000527048-7107  EH
pfam006812290-2332  Plectin
cl233642290-2332  Plectin superfamily
pfam004356442-6548  Spectrin
pfam004356551-6658  Spectrin
cd001765016-5229  SPEC
smart001506887-7011  SPEC
cl024886887-7011  SPEC superfamily
pfam006811812-1848  Plectin
cl233641812-1848  Plectin superfamily
cd001764222-4464  SPEC
pfam006812367-2410  Plectin
cl233642367-2410  Plectin superfamily
smart00150586-680  SPEC
cl02488586-680  SPEC superfamily
smart001504002-4108  SPEC
smart00150683-775  SPEC
smart001505457-5558  SPEC
pfam004356781-6874  Spectrin
pfam004356004-6110  Spectrin
pfam004356117-6219  Spectrin
pfam004355790-5885  Spectrin
pfam004354908-5012  Spectrin
pfam006811654-1694  Plectin
cl233641654-1694  Plectin superfamily
smart001503885-3995  SPEC
smart002502686-2723  PLEC
cl233492686-2723  PLEC superfamily
smart001504911-5011  SPEC
smart001503620-3725  SPEC
cd001761164-1343  SPEC
cl024881164-1343  SPEC superfamily
pfam006812405-2437  Plectin
cl233642405-2437  Plectin superfamily
pfam006812581-2612  Plectin
cl233642581-2612  Plectin superfamily
pfam006811855-1886  Plectin
cl233641855-1886  Plectin superfamily
pfam060094638-4731  Laminin_II
cl055154638-4731  Laminin_II superfamily
pfam004355262-5341  Spectrin
pfam11971218-277  CAMSAP_CH
pfam004355457-5562  Spectrin
smart002501812-1843  PLEC
cl233491812-1843  PLEC superfamily
pfam134997051-7106  EF-hand_7
pfam040123694-3926  PspA_IM30
COG506973-297  SAC6
COG11964192-5030  Smc
TIGR021684099-4865  SMC_prok_B
TIGR021684191-5032  SMC_prok_B
TIGR021683586-4350  SMC_prok_B
TIGR021684657-5574  SMC_prok_B
TIGR021684552-5272  SMC_prok_B
TIGR021684882-5703  SMC_prok_B
COG11964045-4899  Smc
TIGR021684254-5074  SMC_prok_B
COG11964455-5243  Smc
pfam059567205-7386  APC_basic
COG11965720-6590  Smc
COG11965377-6131  Smc
COG04194101-4794  SbcC
COG04194691-5247  SbcC
TIGR006184094-4793  sbcc
TIGR021685125-6010  SMC_prok_B
COG11964722-5526  Smc
COG11964430-5148  Smc
COG11963621-4375  Smc
TIGR021684453-5210  SMC_prok_B
COG11964683-5586  Smc
pfam135145268-5996  AAA_27
TIGR021694191-5031  SMC_prok_A
COG04193373-3757  SbcC
TIGR021683975-4840  SMC_prok_B
COG11964942-5794  Smc
pfam135144992-5889  AAA_27
TIGR006184453-5112  sbcc
COG11965042-5981  Smc
COG11965532-6250  Smc
pfam135145787-6335  AAA_27
COG11965552-6389  Smc
TIGR021683383-3755  SMC_prok_B
TIGR021683561-3884  SMC_prok_B
TIGR006183556-4274  sbcc
COG04193369-3910  SbcC
COG51267050-7105  FRQ1
pfam135143586-4379  AAA_27
TIGR021694828-5114  SMC_prok_A
PRK022245313-5879  PRK02224
TIGR021685744-6456  SMC_prok_B
PRK039185775-6008  PRK03918
TIGR021694735-5095  SMC_prok_A
COG04193847-4402  SbcC
COG11965495-5915  Smc
COG04193365-3758  SbcC
TIGR021694447-5104  SMC_prok_A
PRK022244650-5148  PRK02224
COG04193509-4164  SbcC
pfam135144306-5101  AAA_27
TIGR006184762-5441  sbcc
COG30963540-3890  MukB
COG04195010-5574  SbcC
pfam121283366-3886  DUF3584
COG11963539-3755  Smc
pfam015764670-5166  Myosin_tail_1
TIGR021685541-6394  SMC_prok_B
COG32644112-4315  MscK
COG43724619-4850  COG4372
TIGR006185311-5901  sbcc
PRK112813591-3906  PRK11281
COG04195744-6246  SbcC
PRK047785744-5994  PRK04778
TIGR006183385-4136  sbcc
COG30963455-3773  MukB
TIGR021685420-6226  SMC_prok_B
TIGR006183540-4402  sbcc
TIGR021693574-4287  SMC_prok_A
pfam121284616-5237  DUF3584
COG43723695-3906  COG4372
pfam054835752-6187  SCP-1
pfam024633569-4345  SMC_N
TIGR021693446-3745  SMC_prok_A
TIGR021693528-3770  SMC_prok_A
PHA033077245-7386  PHA03307
COG43724007-4243  COG4372
COG04195311-6002  SbcC
pfam121283643-4380  DUF3584
pfam121284045-4773  DUF3584
TIGR006064542-5353  rad50
TIGR045234655-5032  Mplasa_alph_rch
COG43723664-3893  COG4372
pfam039994102-4375  MAP65_ASE1
TIGR031854515-4775  DNA_S_dndD
PRK011564958-5643  PRK01156
TIGR021685319-6125  SMC_prok_B
TIGR006064059-4372  rad50
COG47174505-5166  YhaN
PHA033077180-7388  PHA03307
COG506942-174  SAC6
TIGR021695852-6202  SMC_prok_A
pfam054833405-3904  SCP-1
PRK048634547-4850  mukB
pfam054834626-5042  SCP-1
TIGR006064169-5035  rad50
PHA033077247-7386  PHA03307
pfam121285596-6122  DUF3584
pfam121284299-5063  DUF3584
COG44775744-6025  EzrA
PRK022244626-5075  PRK02224
pfam121285266-5997  DUF3584
PTZ001215404-6025  PTZ00121
TIGR021695527-5881  SMC_prok_A
pfam121284918-5752  DUF3584
COG30965762-5973  MukB
pfam055573594-4064  MAD
pfam104984608-4750  IFT57
COG51854618-4799  HEC1
COG43725330-5495  COG4372
PRK048634616-5066  mukB
COG43724613-4795  COG4372
COG52813560-3890  COG5281
PRK039185339-5935  PRK03918
COG11963586-3908  Smc
COG12893521-3652  YccC
pfam135143864-4913  AAA_27
pfam015763574-3755  Myosin_tail_1
COG11965751-6602  Smc
TIGR021683380-4206  SMC_prok_B


Ontology Information


   
HPRD ID5931
Molecular ClassCytoskeletal associated protein
Molecular FunctionTransferase activity (GO:0016740)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO