Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
MAD1L1 8379 MAD1 mitotic arrest deficient-like 1 (yeast)  7HsMAD1, TXBP181, MAD1, PIG9, TP53I9 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
26183163   2015Cell line : -

Source : -

Sample Type : Population based case-control study

No. of Sample : 710 CRC cases and 735 controls

Stage : -

Meta analysisPolymorhpism-The study emphasized that MAD1L1 Arg558His and MAD2L1 Leu84Met can significantly interact with smoking to enhance CRC risk.


Gene Details



NC_000007.13 (1855428..2272583, complement)

View Larger Image
   
Gene Type protein coding
Gene Family -
Description MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]  
Chromosome 7
Location 7p22
Start 1855428  
End 2272583  
Strand -  
Gene Sequence

   Download   Select all

Length 417156  
OMIM ID 602686   
HGNC ID HGNC:6762   
Unigene ID Hs.654838   
Ensembl ID ENSG00000002822   
PharmGKB ID PA372   

mRNA Information


mRNA ID ?NM_001013836.1
Exon join(1..77,10195..10374,11927..12065,13493..13617, 14906..14987,16662..16792,16950..17064,19676..19737, 83711..83797,163611..163755,218307..218447,230828..230884, 252408..252496,275230..275320,296052..296262, 334559..334749,416721..417157)  
mRNA Sequence

   Download   Select all

Length 2376  



CDS Information


   
Location202..2082
CDS Sequence

   Download   Select all

CCDS ID CCDS43539.1



Protein Information


      
Protein IDNP_001013858.1
Protein NameMAD1 mitotic arrest deficient-like 1 (yeast)
Molecular Wt. (Da)42001
Protein Sequence

   Download   Select all

Length 718  
Uniprot IDO00574
Ensembl Protein ID ENSP00000304414  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation427
YPhosphorylation427
YPhosphorylation427
SPhosphorylation214;-
SPhosphorylation214;-
SPhosphorylation214;-
SPhosphorylation16
SPhosphorylation16
SPhosphorylation16
SPhosphorylation428
SPhosphorylation428
SPhosphorylation428
KAcetylation61
KAcetylation61
KAcetylation61
SPhosphorylation490
SPhosphorylation490
SPhosphorylation490
SPhosphorylation485
SPhosphorylation485
SPhosphorylation485
SPhosphorylation12
SPhosphorylation12
SPhosphorylation12
TPhosphorylation323
TPhosphorylation323
TPhosphorylation323
SPhosphorylation594
SPhosphorylation594
SPhosphorylation594
TPhosphorylation550
TPhosphorylation550
TPhosphorylation550

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                       
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
4085MAD2L13274NP_002349.1in vitro11459826   
4149MAX1113NP_002373.3in vitro10229200   
4751NEK24953NP_002488.1in vitro;in vivo;yeast 2-hybrid14978040   
7343UBTF2814NP_055048.1in vitro;in vivo15282543   
22981NINL11120NP_079452.3yeast 2-hybrid16189514   
23650TRIM2910280NP_036233.2yeast 2-hybrid16189514   
27229TUBGCP410616NP_055259.2yeast 2-hybrid16189514   
51421AMOTL216485NP_057285.3yeast 2-hybrid16189514   
348487FAM131C8779NP_872429.2yeast 2-hybrid16189514   


Pathway Information


                  
Pathway Name Pathway ID
Cell cycle hsa04110
Progesterone-mediated oocyte maturation hsa04914
Viral carcinogenesis hsa05203


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam055572-716  MAD
TIGR0216846-631  SMC_prok_B
PRK0391894-617  PRK03918
COG119640-620  Smc
COG1196110-478  Smc
TIGR0216948-408  SMC_prok_A
COG1196104-417  Smc
TIGR0216840-322  SMC_prok_B
COG1196234-529  Smc
TIGR0216850-613  SMC_prok_B
TIGR02168347-627  SMC_prok_B
COG119650-409  Smc
TIGR0216987-441  SMC_prok_A
COG119650-376  Smc
COG119641-580  Smc
COG041968-541  SbcC
TIGR02168204-527  SMC_prok_B
TIGR02169152-474  SMC_prok_A
TIGR02169176-528  SMC_prok_A
TIGR0452350-386  Mplasa_alph_rch
COG041946-527  SbcC
TIGR0216951-301  SMC_prok_A
TIGR0216950-401  SMC_prok_A
COG041941-482  SbcC
COG3264103-293  MscK
PTZ0012142-570  PTZ00121
TIGR0452399-509  Mplasa_alph_rch
pfam0788829-391  CALCOCO1
PRK10246114-572  PRK10246
PRK1270579-219  PRK12705
TIGR0060673-643  rad50
TIGR02169340-629  SMC_prok_A
COG437250-269  COG4372
TIGR0216946-581  SMC_prok_A
PRK0391851-527  PRK03918
PRK0222450-399  PRK02224
TIGR02168367-632  SMC_prok_B
TIGR0061898-527  sbcc
COG494237-296  EnvC
COG041946-318  SbcC
COG1196362-580  Smc
pfam12128104-617  DUF3584
PRK0222451-292  PRK02224
pfam0972636-248  Macoilin
pfam1212847-630  DUF3584
PRK0486379-375  mukB
TIGR0061846-564  sbcc
COG041942-415  SbcC
PRK0222496-537  PRK02224
PHA02562364-527  46
COG0497103-401  RecN
PRK02224164-620  PRK02224
COG320679-302  GumC
COG119650-528  Smc
COG502241-352  COG5022
pfam02463203-559  SMC_N
COG4942202-399  EnvC
TIGR0268051-395  TIGR02680
pfam06785104-261  UPF0242
TIGR02169340-619  SMC_prok_A
TIGR0061836-521  sbcc
TIGR0331997-248  RNase_Y
COG502239-308  COG5022
PRK0222442-574  PRK02224
pfam15066162-295  CAGE1
COG4372430-619  COG4372
pfam01576146-572  Myosin_tail_1
TIGR0268053-234  TIGR02680
COG3096174-543  MukB
PRK0222497-325  PRK02224
PRK1270450-248  PRK12704
pfam1351446-579  AAA_27
PRK0486385-528  mukB
PRK1024629-240  PRK10246
TIGR00634180-397  recN
TIGR04211222-310  SH3_and_anchor
pfam01496224-473  V_ATPase_I
PLN0318855-231  PLN03188
PHA02562120-193  46
PLN0293938-391  PLN02939
PRK00286104-251  xseA
TIGR04211101-197  SH3_and_anchor
pfam05622105-238  HOOK
PRK10929329-489  PRK10929
PRK04863187-571  mukB
COG1579136-290  COG1579
PRK05771420-528  PRK05771
PRK0040970-242  PRK00409
PRK05636181-242  PRK05636
PRK0486341-304  mukB
TIGR04211111-216  SH3_and_anchor


Ontology Information


   
HPRD ID2245
Molecular ClassTranscription regulatory protein
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessBiological_process unknown (GO:0000004)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO