Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MALAT1 | 378938 | metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) | 11 | PRO1073, MALAT-1, NCRNA00047, HCN, NEAT2, LINC00047, mascRNA |
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25025966 | 2014 | Cell line : LoVo, HCT116 Source : - Sample Type : Paraffin-embedded tumour and adjacent normal tissue No. of Sample : Paraffin-embedded tumour and adjacent normal tissue samples from 60 CRC patients Stage : Duke Stage A-D. | real time RT-PCR,RNA-binding protein immunoprecipitation,Immunofluorescence and confocal microscopy ,Protein immunoprecipitation,FISH | Up-regulation | - | MALAT1 might be a potential predictor for tumour metastasis and prognosis. Furthermore, the interaction between MALAT1 and SFPQ could be a novel therapeutic target for CRC. |
| 25031737 | 2014 | Cell line : - Source : Fudan University Shanghai Cancer Hospital in China. Sample Type : CRC tumor No. of Sample : 146 Stage : TNM Stage II,III. | real time RT-PCR,univariate Kaplan-Meier method and the multivariate COX regression model | Up-regulation | - | The expression of MALAT1 is upregulated in CRC tissues, and a higher expression level of MALAT1 might serve as a negative prognostic marker in stage II/III CRC patients. |
| 26254614 | 2015 | Cell line : - Source : PubMed, Embase, Ovid, and Cochrane Library databases. Sample Type : - No. of Sample : - Stage : - | Cell proliferation, invasion and migration assay,genome-wide expression profiling, western blotting | Up-regulation | - | High tissue MALAT1 level was associated with an inferior clinical outcome in various cancers, suggesting that MALAT1 might serve as a potential prognostic biomarker for various cancers. |
Gene Details
| Gene Type | ncRNA |
|---|---|
| Gene Family | Long non-coding RNAs, "-" |
| Description | This gene produces a precursor transcript from which a long non-coding RNA is derived by RNase P cleavage of a tRNA-like small ncRNA (known as mascRNA) from its 3' end. The resultant mature transcript lacks a canonical poly(A) tail but is instead stabilized by a 3' triple helical structure. This transcript is retained in the nucleus where it is thought to form molecular scaffolds for ribonucleoprotein complexes. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer metastasis and cell migration, and it is involved in cell cycle regulation. Its upregulation in multiple cancerous tissues has been associated with the proliferation and metastasis of tumor cells. [provided by RefSeq, Mar 2015] | Chromosome | 11 |
| Location | 11q13.1 |
| Start | 65265224 |
| End | 65273940 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 8717 |
| OMIM ID | 607924 |
| HGNC ID | HGNC:29665 |
| Unigene ID | - |
| Ensembl ID | ENSG00000251562 |
| PharmGKB ID | - |
Protein Information
| Protein ID | |
|---|---|
| Protein Name | metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 0 |
| Uniprot ID | |
| Ensembl Protein ID |
Post-translational Modification Information (Source : HPRD)
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Enzyme Information
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PPi Information
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Pathway Information
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Structure Information
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Domain Information
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Drug Information
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