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Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
21531130	2011	Cell line : - Source : Japan Sample Type : CRC tumor and normal tissue No. of Sample : 113 Stage : TNM Stage I-III	Peptide Nucleic Acid (PNA)-clamp real time RT-PCR TaqMan assay, Gene expression profiles.	Up-regulation	-	-

Gene Details

Chromosome: 17; NC_000017.10 (43340488..43394414, complement)
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Gene Type	protein coding
Gene Family	Mitogen-activated protein kinase cascade / Kinase kinase kinases
Description	This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]
Chromosome	17
Location	17q21
Start	45263119
End	45317064
Strand	+
Gene Sequence	>gi|568815581:c45317064-45263119 Homo sapiens chromosome 17, GRCh38.p2 Primary Assembly GGGGCGACCACGGGCCGGGAGCTCAGCGGTCGGCGGCCGGCGGCGGGAGATCGCGGGCGAGCGGAGCGCA ACACTCGCTTGGTTGGGGAGATCGGCGCTTGGCCGGTAGGTGACGGGGCGGGACCCTGGGGCCCGGTGCG AGGCGACCAGGGAGCGGCTGGGATGGATCGCCTCTCAGCCCCGGGCTGGGCTGCGGCCTGGCCCCTCGCC CCGGAGCAGTGGGGTCGGCGGCCAGGCCAGCGCAGTCCGACGTACCCCGTCCAACCCACTCGCAGCGGTC CGCGGGCGCGCCCTCGCACGCGCTGCCGGTGCCGCGCTCGCCCCGGGCCTCCAGGCCGCGCACTCCTGCT GGCCACACGCTGGCTCCGAGCGCGCGCAGGGGCCGCCTGCTTCCCCTTCACTAGTGCCCCGCGCCGCCGC CAGGCCCGCCCGCCTGCTCTGCGCCCCAGTGCCCCCAGGATGGAGCTCGCCTGCCGCGGGGCGGACGTGT CTCCTGCAGGAGTGCGCCCTGGCATCTGCCCTGGCGTGAAACCCTCCCGGCCTTTCATGGGAAGTTCTCA GGTCACACCTCAAGGCGGGGAGCAGGAGCTAAGCCTGTCCTCAGCATGCAGCGGGGCAGTGCTGGCCGCC CGCAGCATCCTCCCTCCGCCCTCGGACCCCAGTCCTCCTCTGTAATTCTTCTGGGCTCTCCAACTCGGGA CTTTATCTGTCGGTTCAAATATAACATTCCCATCTTGGAAACCCATCGTGGCCCTGGCATCTTGCAGCCA CTGGGCACCAGGCAGAGAGGGGCCACTTGTACGTACGTTTCCCACCTGCCCGGGAGCCTCCTTAGTGCTG GGTAGCTTCAGAAAAAGTGTTTCCTTCCTAGTCGAGGTTAAAAAGTTGCTCTCGGCCCTAAAGGGTGGAC TGGAGGTATGAATGAGGGAGAGGATAAGTGGTGAAAAGGTACATACATCAGCAAAGTAAATGGTAAAACT ACTTTTGATCGCTGGAGACAATGAACACCAATGACTTAATTAAGGACTTTAAAAGCACATGAAATTAAAT GATTAGAGTGAGGTCATGATATAAAATAGGAGTCTGGAGTTTATTCCAAGAAAAATGTTGGAAACCCCTT GACTAGAAACATGGTCTTTCTGAAAGATTAGAAGGAGACAGTATCTTAACATTAGTGATGTGTTTTTTGC TTAGTGTCTTCATACCTGTGAGCTCCGTTTTCCTTCAGATGGCTGTGTGGTAAGACAGATTGTAGTGTCT TGTTTTATGGGCGAGGCACCTGAGGCAGGTGTGTATGAGGGAGTGGGGGTGGTATATATCTTGCCTGATG CCTCATAGCTGGGACTAAGGATGGGTCTTTCCCAGAATCCTAGATCAGGACCACATTATAGAACTGAGAT GCAGAAAGGAGGGAGAAGTTTTTGGTGTGGTTTTTATGCTCTTAATGTGAGAGGACACTTAAAAAGTGCT TGCCTTACTTTGGTTGTGTTTGGATTTACTCTTGGTGTTTTTTAAGTGATATCAATCAGTTTCTTTGGAG CGATGCCAGACCTCTGAATTTTTCAGACACCTTTCGGACATCCTTATTTATTTTGAAGGGTGTGGAGAAC TTCTCAGAAGATCTCAAAATAAAAGTAATCGTCTCTGACTCTAATTTTAGAGATAAGTACCCAGGTATGT GTACCAGCTCTTTGTGAAATCAGACAGCAAGACGCTGCCAAGCTTCAGGCCATCTTCTGAGTGTTTTCTG ATTATAAGAAGCAGTTCTGAAGGGGGTTTTTTGTCATTGGTATTGTCTGTTAAGAGTTTGTGGGAGCGGC ACCACAGAGACCCTGCCAAATCAGTCTCCCTCTATTAAACAAAAATGTCTGGTTGGGCTGTTTCGCCTCA ACAGATGAAGGTTTGGTTCCTCATTTTGGTTCTCCTGTTGAACACTGACTCCTTTGTGATCTGCCTGGAA TATGTGTATATCATTTACTGCTGAGAAGATGGCTTGCGCTGATTGGTTGTCCAGCCCTCGGCAACTGTTG TGATTTTTTTTTTTTTTTTGGTGATTGATAACAGTTCATCCCTGGCTAGGGTCTGGTGAGAGATCTGCGG AGATGTGAAAGAGATGAAAGCTTTATCCAGGGTTGTTTTCTTCGTTGTTGGCACCCTCTGAACAGTGTTG TATCACTTTGGCCTGTGAAGGCACTTTTAACTTCCTATTTTTTTTCCTGTCTCAATGGACAGCACATGGG CTTTCCTAACAAGCCTGCCTGCCTCGATGAAGAGCTGACAGATTCATATTGGTTGGTTTGACAGATGTTC TTTCTGGGGGGAAAGTTCAGAAATCTTAAAAGCAAAGTCAGTCCTAAGTAAAAAGTCTAAGTCAGCCCAA TACGCATAAAGGCAGCGTACTTCTACTAATGGCTTCCATCATCTCAAGGTTGTTTTTTTTTTTTTCCTGG CAAAAGGTTAAAATGCAACTAAAATTCTGCTTTCGTGATTAATAAGTCACTACCACAGTTGTGTCTGATG CTTCCTGTTTGCCCCATTTTAGTATTTCAGTTAAACTGGAAACATCTGAGCATTATGGGCACTATTGATG GCACCAGTGTGAAATTGGTGGGCCGGGGACAATTCCATGTCAGTGGATTTAGGGAGCTCTAAGGATGTCA GCCCCTCTGGTCTCCACACACCAGGATTCCCTAGTAAGGGAACAGAATGGGGCTGAGCATCTGCAAGAGC TGGGTGGGCATTCAAAGTGATGCATGTGTGAAGGTTTTGCATTTACTCGGTGATGCTGGCTAAAATGCTG AAAGTAGTAGCCCAAAAAGGGAAGGCCAGACGTAGGGCAAATTGTAGGGGAGCATTTCTGTTGAGCTGAG CAGGACATTGAAGTATGAGATTTTTTTGTTCTGGGCTTATGACTGCCTGAATGACAATGCAGAAAAAGTC ATTTTTCTTCAGTGGCCGGTGTGCTCTTTGTATTCTAGTTTAAAGGAGCCTCTTCCCTTCTTGCTTTTCT ACATGTCTTAATCCCTCAGCTCCCTGATAGAAATCCCTTGAAATTATGTGGCATCAAGAATAATTTTATG GCCAGTCTTTGTATTTTCACACCATACTCATGTGAAGAAGGGCAGGGACAAAGATCAGAAAAGTGAAGCC TCATAAGGAGAAACAGACAGGATTGCTCAGAATCTAAACCCCCTTTTCTTGATATCTAGGTCACTGCTTT TTCTACTACCTTGCTCATGAAACGATAAGGATTTTCTTCCCCCAAACATGTCAATTTTGAACATAACGAA ACCAGGGTAGCAGCTTTATTTATTTATTGTACCAATCAATTATTAATTGATATTGATTTTTAATTAATAA AAGGCCAAAAGATGAATAGCCTGCTGCCTGGACAGGTGTGCTTGTGCCCATTTTCCAGATGTAGAAACAA AGGCAGAGAGCCCGTGATTTGTCCAGAGCAACAGAACAAGTCCTTGGTGTCTCCGTGTCACATGTGGTGG CTGAGGCTGTCAGGTCAGAGAGACCTGGGTCAGGTCGAGGTCTGCCACGGCCTGCCTGTGTGCCCGCAAG CAAATCACTTCACTTCTCTAATCATCAGGTGCCTCATCTGTGAATGGGATCAGAAATACTTCATGGGGCT GTTTTGAGTAGAAAATGAGAGGAGATATGTAAAGTGCTGAGCCCAGTGCCCAGCACAGAACATAGAGGCT GTAACTGTTGTTGTTGTTGTTGTTGTTCTTGTTGGTGGTGTTTGGTGGTGGTAGTAATAGTAGTAGTAGT AGTAGTAGTAATAGTAGCAGTAGTAGTTGCCAATTACTGCATTGTGACTAAACCTGTTTTCTGTAAGATG ATGTCAAGAAGGGTCAGACTGCCTGACAGGCCAGAGTCATTTTCTCAGTAGGACCTTTAGGGGGACAGTC CTTCAGTCTAAAAGCTTCAGCTCTCGGGTTCTCCCTGTCTTACACTATATACTGCCCTCACCATACTCCA AATGAGGCTACAAAGGTCCAGGCTCTGCCCAGTTGACAATCCTAACTCTGAGCTGGAGACACAGCTAGGC CTGTCTAGGGGCTTCCTGTGTCCCACACGTGATCAAGTAGGTTCCTGCATTAATCCTGGAGGTGAGGAAA GGGAAAATACTGTATGGCATGTAGATCAGCAAGGACTTGTTCTTTGGGGGAACAGGAGGGAACATTTGGT TCTGTGGGATGAGGTTCCCACTACCACATGGCATCCCCAGCTCACCACCCTTTCCCCCTCGTAAAGATGT CTTTGTCAGCTTCTCTCTGAGACTCTGTCTGGGGGCCCACGATCTGCAGTCAAGGACTTGCAGATTCCCC TTTAAATCTCACAAGAAGCCTGGAATGGTGACGTGTGTTTCTTTAGTCCCAGCTACTTGAGAGGCTGAGG CGGGAGGATCACTTGAGCCCAGGAGGTCAAGTAGCTATGGGCAACATAGCGAGACCCCATCTCTTGAAAG AAAAACGTTTGTTTTAATCTCACAAGGGAAAAAAAAAGTTTCATGTTATATTTTAAAGTCTTTTTTCACC TTAATACAAAACAAAAATATAGGCTCTCACCAGGCTACTGTTCCCTTTAAATAACATTTTGTTTTCTCTT GGGGAAGCTGACTTGATGGCCGAAGAGTCATTTCTAAAGTGAAGCTAGTTTTTAGAAAAAATAGATCACC GGATGTCAAGCCTCATGTGGAGCTCGGTTCAGATGAAAATGAAACCAGCAGGCCTGGCGTGGCAGCTCTG CACTTGACTTCAGGCTGGAGGTGAGAGGCAGAGTGTGCCTGGACCTTGCTCCATAACTGGTTGGCCCCAC AGAGTGCATTTGATAGGTGCCTTAGTCATTTTCCAAGCAGCTTTGCTTAGGTGAGCAGAGCACTTTCTCT GGAAGGTGAGTCACCCATGCAGGGGTGTAGGTGACAGGCGATTTATTCCCCAGCACAGTTGCAGAGAAAG TCCTGAGCAGACCTTCGTGAGGAGCCCTCTGCCACAAATCAGCCTCATCCCAGCCCCAGGGCTATGGAGG CAGGGGGCAGGAGGTAAACAGGAGGCTTCTGGGGCCAGTGGGCTGACAGCGGAGGGGGGATCGTGGACGG GGCACAGAGCCCAGATCAGCAGTGTCACTGACTCCTAAGTCCAGCCACCCTGAGGGTGGAAAATGGCCTG CTTCCAGTGACAGTCAGCAAAGAAGCAGGAGGGGAGCTTTGGCCCTGGGGAGCTGGGAAATCCCTTGGCA GAGAGCAGAGAGACAAGCCCTATTTTGGTGTGAAAAACCTTTTAGGAACGCTTTTCCACCTGCCTCCTTT TCAGCCACCTGAGTTGGAGTCTCTGCAGAGCTCCAGCGATTGTAAAGGCTAGATTAAACCCTGGATTTCA GAAAGCTTTAGGAATCCCAAGCCTGCCACCATCTCAGTTGTCTACACTTCTAGGACCAGGATTTGTACCA AGAAAGAAGCAGCAGGGGGTACTCCTGAGCCATCCCTCCCTCCCAGGTTCTGGTTACTACAGCTTCTCCT GACGCTCTTTCTGCTAAAGCCACTATCAGGTGTCCATTAACGCAGAGATTTTCTTCAGACACTGTTCTGG ACTAGTGCAGTTGGTGTTGAACTTGACCGATTATGGTCAGGGACATCTATAAGCAATGTCCAGGACCAAC TACAAGGAGGGCTTGACTTTAATGAAGCTGCAGCTCTTGCAAATAATCTCGTTCCCTGTCTCTGGCAGAC TACCAACCCAGCCCCTGTACCCATACCCCATCAGTCTGGACCAACCAGTAGTCACCTCCTGCTGGCATGG CTAAATAACCTTAACCTCACTGTCCAGAAAGAGCTGTTAGGATTATAGCCTGGACATGATCATTCACATT TTTTGCAGTGAGAAAATGCAGAAGAGAAAATGGTGGCCCAAGAAAGCCAAGTGGGTTGCCCAAGGCCACA CAGCTAGTTAATGGCAGAGCCTGAACTATAAAACCCAGACTCTTCACTGTACTCTGCTGCCAGGGAACGA AGGAACTAATCCTGAAGCAGGATTTTTTTTTTTAAACTAGCTTCTCCTTTTATTCCCCTACCACAACCCT ATCACTCTCAGCCTTTCTGCAAGCTCTGCCAGGCCTGGGAAGGGTGGAGCCACAGCAGCTGCTGCCCTGG GTCTAAGAAAAAGTAAACAGAAAGCTATTTGTTGGACGCTGTCTTATACCATGAGGTTCATGTAATCAAA AGGAGGTCAAGGTTGATAAGAAAATACAATTACCAGGAAGTCTCAAAGGTTGCCCACACCTTTAGGGCAC TTTCCTACCTAGCCAAGCAGTATCTCACCTAGAGTGGGTATTTAGTAACTTTCAATGATTGATTACAGGG GTCCAAACCCACAGTGCACGAAGCTCTTCTGCATCTTTCTTCTGTGCAGGAGGTGCATGCATACTCTGGG TGTTATCCTAGCTGATCTGCCTGGCTCCTCTCAGTGAGAGGCTCTTCCTTGTGGGTGAAGCATGATGTCA TGATGTCATATCTGGATGGTGGCCCCTGTAAGTGCAAAGAATTATTGTAGCCAAAATCTACCACCCACCT TCTACTGACATTAAAGTTTCCTTTTACTGGGCCAGAATTAAAAGGTAGGTGTTTCTGGTCCATACTAGGG ATAGCCAGGAGGGTTGGGAGGAAAAGGAGGCTTAGCCAGCCTCCAATGAGGATGTGGTTGCCAGTTAAGA TTATAAATGGAGGCTGGGCACGGTGGCTCGTGCCTGTAATCCCAGTGCTTTGGGAGGCTGAGGCGGGCGG ATCACAAGGTCAAGAGATTGAGACCATCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAA AAAGTTAGCTGGGCATGGTGGCACATGCCTGTAATCCCAGCTACTCGGGAGGCTGGGGTAGGAGAATCAC TTGAACCTGGGAGGTGGAGGTTGCAGTGAGCCAAGATCCACCATTGCACTCCAGCCTGGGCGACAAGAGC GAAACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAGATGGACTCCTTTGGCCAAGGGAGTTGATTGGA CCCACCAGACTCCTTGAGTCCTGCCCAACAGTCTCCACTGGCAGATGCTGTGCCTGGAGAGGCAGGAATA GCTTTGTATAGATCAATGTGAAGGACAGAGTCCTGCACCACCTCCCTCTAGCATGTATTAGATACTTGCA AATATATGCAAATCCGAGCCCAGATGGGTGTTGTCCAGTTCAGAAGGGTTATCTTCTCAAGCAATTAGAA GTAATTGGGTCTCTAGGTCAGCATTTAGGAAAGGGGATGGCAGGAGAGGCTCCACAGCCATCTTTCAGGA CACCTGCTTGCTGGGGTGCAGTTAGAATACAGCCACCAAGTTGTGACTCCCTCCCTTCCAGCCTGCCAGG TGATTGGACAGTGTGGACACGTGTCCCTGTCCAGCCAGGCTCTCAGAGCCTGTGGCACTCATTTATTCCT CAGAAGTGTGTCTGTCCTTTCACTCAGGAACATTTGCCAAGTGTGTCAAATGGGCCATGTCTGCTAGGTG CTAGAAAACCAAACACAATTGAGGCACCGCCCTGGAGGACCTCACCAAGACAGGGGTAAGCTGGGCACGA AGGCAGACATCTCACAGGTCAACCCCGGTGCTGGTCAGGAGCCATGACTATAGGAGCTGGAGGGAGCGAG GAGGCCACCATGCGCAGCCCAGTGGCCCTCCTTTTCCAGCCTGAGCCAGCACTGTCAGGCGTAGAGCGTC TCGGATTCTGCAGGTGCCTGGGTGGGAACACCTTGGTATTTCTCTCACCCTGGGGTCTTGTACCACTTGT CAGCTTGGAGCGGGAGCTTGGTAACAGTTGGGCAACTTCAGCACTCTGGGGGAAAGAAGTGCATTTTCAG AAGCGTAGGGACAGTCAGGAGAAATTTGCTCAAATGTTGCTTGGGCACAGTGGCTCATGCCTGTAATCCC AATGACTTGGGAGGCTAAGGCAGGAGGATTGCCTTTTAGGCCAAGAACTGGAGACCAGCCTGGACAACAT AGTGAGATCCACCTCCAAAAAAAAAATTTTTTTAAACTAGCTGGACATTGCCAGGCGCAGTGGCTCACAC CTGTAATCCCAGCACTTCGGGAGGCCAAGACAGGCAGACCACTTGAGGCCAGGAGGTCAAGACCAGCCTG GCCAACATGGTGAGACCCGTCTCTACTAAAAATACAAAAATTAGCCAGGTGTGTTGGTGGGCACTTGTAA TCCCAGCTACTCGGGAGGCTGAGGCACAAGAATCACTTGAACCTGGGAGGCAGAGGTTGCAATGAGCCAT GATCGCACCACTGCACCCCAGCCTGGGCGACAGAGCAAGACTCTGTCAAAAAAAAAAAAAAAAGATTAGC TGGGCATGGTGGTGCTTACCTGTAGTCCAGCTACTTCAGAGGCTGAGGTGGGATGATCACTTGAGCTCAG GAGTTCGAGGCTGTAGTAAGCTATGGTTGTACCACTGCATTCCAGCCTGGGTGACAGAACAAGTCCTCTT CTCAAAAAAGAAAATATAGTTCAAAGTAGAATCAGACAGTGAGTAGCCAGCTAATAAACACATAACTGAC CACCTCCCACCCCTCCAAGTGAGAATTGGGAGGGCAGTGACCACACTGGCACATCCCATAGGCTTGGTGC CACTAGAGAGTTGTAGGCAGGTAGATCAAGGCAGTGCTTCTAGGTAACTGGGTTCAGCATTCCAAGAAGG CCTTTCAAGGGTTTCAACAGAGAAGGCTCTTGGTCATCCTCATATTCCTGCTGGCCAGCACGGTGCCTGA AACATGGTAGCCACTGATTAAATATTTGCTGTTGAGTGAAAGTACAAGACTTGAATCCAAACTCCTCCCG CTAAGCCCTGCTGGCCTCGGGGAGGACGAGAGAGCCGTGGGCTGTTTCATGATTTACCCTCTTTTACCAA AGAATCGTGTGAGATCCTCTGAGAATATTCCTCATCATGCCCCATGTCCCAAGCCCTTTTTTACCTTCCC AAGGGAGGACAAGAATATGACCCCTCATTATAAAGGGACCCCTCTGCCACTCATGTCCTCAAGCTGGTTA CTTGGTCCAGCTTGTCAAAGAGCATGTGGGGCAGCATCTGAAATGAGGCCAGGGTCAAGGTTGCCCCGCC ACAGGGCGGAGCTGGACCTGTGCCTCCTTCCATGCATTGGAAGCCTTCTGTGGAAGCTGAGTTCTTTGGG TTTCTTGTTTATTCTGAAGTTCCTCAAACTAGTTCCTCAATTTCAGAACCAGTCACCAGTGACTACAATG AACTTGAATTCTCCTATACAGGGAGCCTGAGCCTGTCTTTCTTCATCTTTTCTGAACACAGGTAGACGCT GCTTGAAGCCACTCCCACCTCTGAAAACCAGATTTCTAAACCCAGAAAGGAGCGGTGGGTGGTTGTATTT CAGCGAGATTGACCGTAGCCTAGGGAACTTCTTGCTCAGAATCCACCCCAAAAGGTTAAATAAGGAGAGT TGTTTTTCACAACCAAAATGCTGCTTGTAACGATGATCTCAAAGCTTGGCAAGATCACAAAGTACGTTTT GAGTCATCAAAGAAACTGGCTGTGTTTCACATGATTTTAGTGTCAAGGGCAATTATGGCCATCTAATCTT TGGAAATTGGTCATGTTAAGTGGCATACAGGGCAGCCCCCACTTAATCAGAATATTCAGTTACACAAAAT ACCCTAAGTTGCTGATTTCGATGACACTTGAAATTTTTTTAATTAATTAATTAATTAATTTTTTTTTTTA ATTTTTTGAGACAGAGTCTCACTCTGTTGCCTAGGTTGGAGTGCAGTGGCACAATCTCGGCTCACTGCAA CCTCCACCTCCCGGGTTCAAGCGATTCTTGTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACCCAC CACCACACCCAGCTAATTTTTGTATTTCTAGTGGAGGCAGCGTTTTGCCATGTTGGCCAGGCTGGTCTCG ATCTCACAACCTCAGGCAGTCCGCCCGCCTGGGCCTCCCAATGTGCTAGGATTACAGGTGTGAGCCACCA CTCCCGGCCTGAAAAATTTTTTATACAATATACATTAAACATTCCTTGTTGCTTATTGTATAAAATTAAG TACACGTGTGACAGGTTTTTATCTCAATACTACCTTGCCCGACATGTTCTCCTGCATATTGGGTCTTTGT GGATCCATGATGCCCCCTGTGGCGTCTTTTCTATTTGCTGTTGGCTCTCCTTGTGCAAAGGATTTGAAGG TTGAATTGAAAATACCATTGTAATACTTCTCTTTTAAAGCTTATAAAATGCCCTGTATCAGGGCCTGGGG GCAAAAGTACTGATGAAATTTATGAAGATAGCAAATGATGCTCGAGTCTTTGTTATAAAAAGAATGGTAA ATAGGTTCAAGAAGCCTGCAGCCAGGCTTTGTAAAGTGAATGGCAAATTTGCATTTGTCATAGAATTTCT CCTTGGAATGGGCCTGGCTATGTCAGGCCTGGGTGGGCTGAGGAACACAGGCCCACCACAAGTCCAGCTT GGAGTCTTTCTTCCCTGTTGTCATTTTAAAGTTGCTTTTTCCAGAACATAGGCTGGCTGTAGTTCATGCT TCCTAATTAAGGTGCTTCCTCCCAGGCCAGTCCCTGAATTTCTCACTAACCTTTGACTTGTGACAGCTTC TGCATCTCGGTCCCAATTTTTAAAGCTTAGATCATTTGGGAGTAGGAAGAGTGTCATGGTTAAGAGTATG GGCTTTGACATAAAAGTCTCTTGTGCAAATCCTGCCGCTGCCACTTCACTGCTGTGTGGCCTTGGGCAAA TTACTTGGCCTACTGAGGCCCAGTTTCTTCCTCCTTGTAAACGGATAACATTAGTGCCTTGCTCACAGAG TTGTGAGGATTCAAGAAAAAAATGCACGCATTACCTAATACATGGCAGATAATAATAGCTGTCATTATTA TTCATTTGTATGATTACCAACAACCAGCATGTAGTTATGTGTATACAAATAGCAGATTGTTGTAACACTC AAAGATGACCACAGGACAACTAATTTCAGCTTTAGCTGCCAAGGAATTGTGGGTCCCAGTTCATCACGCA GAGCTGAGGCACTGCCAGTGGACACAGAAGCCAGATGGGGTGTGCAGAATGCTCTTCAAAGAACATCTTC ATGGGTTCTTGCCGACCACTCTGTCCCTCTGCTTTCAGGATTGTCCTCCTCCTGCTTTGACCACATCTGT TCCAGACTTTCTGTCTGATGCTAGGGCTGCTGGCTAGAAGCTGTGGGAGGTAGGCTTCAGTGCCTTATAG CAGCAACTTTGAAGCAACTTAACACTTATAGACCATGACTCACATCTGTAATCCTAGCACTTTGGGAGGC TGAGGTGGGCAGATCACTTGAGGCCAGGAGTTTGAGATCAGCCTGGCCAAGATGGCACAATCCCATTTCT ACAAAAAAATAAATAAATGAAATTAGCCATGCGTGGTGGTACATGCCTGTAATCCCAGCCACTTGGGTGG CTGAGGCATAAGAATCGCTTGAATTCGGGAGGTGGAGGTTGCAGTGAGCCAAGATCACACCACTGCACTC CAGCCTGGGTGACAGCAAGACTCTGTCTCACAAAAAAAAAAAAAAAAACGGCCGGGCGCTGTGGCTCACG CCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACGAGGTCAGGAGATCGAGACCATCCTGG CTAACATGGTGAAATCCTGTCTCTACTAAAAATACAAAAAATTAGCTGAGCGTGGTGGCGGGTGCCTGTA GTCCCGCTACTCAGGAGGCTGAGGCTGGAGAATGGTGTAAACCCGGCAGGCAGAGCTTGCAGTGAGCCGA GATTGCGTCACTGCACTCCAGCCTGGGCGACAGAGCAAGACTCCGTCTCAAAAAATAAAAAAAATAAAAA AACATAAAACCAAAAAAAATCTTACACTTCCAGTCATACAAAGGTCTGACTGCTCATCTTGTAGCGGCTT CCATCTCACTGGAGGTTCCACTGATGTTTCCAGAGTGCCCACTGCATGCCAGGCACTGTGCTATGTAATT TAAACTTTGTTCCTTGCATTGAGTCACCGTGTAAAATTCTATCATGTAGGTTTGAGGATCCCTATATTAC AGATAAGACTCCTGAGTCTCAGATTATGTGACCTGCCCATGGTCACACACCAGAGTATTGAGAAACTAAG ATTCAAACTCAGATCTTCTGACTCCAAGGCCATCCTGTCATGTAGCTGAATGGCCATTCCTCAGGATTAG TAAGTAATATGTTGGAAGAAATTACCTCTGAGGGTCTTTCTGATCCTAAGAGCACTTTGATTATTCCTTT ATGATTTATTTATCCATCTACCCATTTTTTCCCCATCTAGACTATAGGCATGTTGAAAGCAAGGATAGCA TCTTCACAGCAAATAAATAATACAATGTTTGGAAACCACCTATCTGATGCTATCTACTTCTCTGACACAT AGAAACAGGAGAAAAGATATAACCCATTAACAAAAGAGTCACCCAGAAATTCCAATCCCAAGAGCTTACC ACCTAGAATTCCTTCTACATGTACACATAAATGTGAATAAGGGTAGAGTTTTTTCCATTATTACGTATAA GTGAAAAATTGGAAACAAAGTTTCCAGGTGGGAAAATGATGATACATCTGTACCTTCCAATCTTATGAAG CCTTAAAAAGAATGAATTAGAGGTCAACCATGGTGGCTCACACCTGTAATCCCAGTACTTTGGGAGGCCA AGGCGGGTGGATTGTTTGAGGTCAGGAGTTCAAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTAC TAAAAATACAAAAATTAGCCGGATGTGGTGGCTGACGCCTGTAACTCGGAAGGTTGAGGCAGGAGGATCA CTTGAACTCGGGAGACGGAGGTTGCAGTGAGCCAAGAATGGGCTGCTGCGCTCCAGCCTGGGCGACAGAG CGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAGAAAAGAAAAGAAATAAATCTAAATGTGCTGAGATG GAATAGTATTCATAGTATCTTAAGTGAAAGATACAATTTGTATGACATTACATGTGTATAATCCATGTTT CTTTTAAAAATAGTCCCAAACTAGGCCAGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGC CGAGGCGGCTGGATCACGAGGTCAGGAGATCAAGACCATCCTAGCTAACACGGTGAAACCCCGTCTCTAC TAAAAATACAAAAAAAAAAAAAAGTCCCAAACTATATGTTTATATATGTATAGTAATTGGAACTAGAAGG ATTTACATGAAACTTAAGTGTTTTTTATGTTGCAGAGAGGACGGGACGGTGCCGGGATTTTTTTTCTATA TACAATTTTGTTTTGTTTACATTTTTACAATGAACAATTATTTTGGTATTGGAAAAAAATTTTTGAGATG GAGTCTCACTCTGTTGCCCAAGCTGGGGTGCAGTGGTGCAATCTCGGCTCATTACAACCTCTACCTCCTG GGCTCAAGTGATTCTCCTGCGTTAGCCTCCAAAGTAGCTGGGATTACAGGTGCCCACCACCACACCCAGC TAATTTTTGTATTTTTAGTAGAGACGAGATTTCCCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTC AAGTGATCCACCCACCTCGGCCTCCCAAGGTGATGGGATTACAGTCATGAGCCACTGCACCTGGCCTGAA AAAAAATTTTTAAGCAAGGTTAAAGATCACATATAAGAAAGGCAGGAGAGGCTAGCTAGGAAAACTGTCC TCCCTTGGGTTTCCCAGACTAGGACTAACCCTGCGATTCCCACCCCTTTGCGCAAGCAGTGGAGGAAGGG CTGGTTTTTTTCTCCCTGGTCCACTTCTGCTGTTTTTCACTCTGGGGGGCCACTCTTGCCCAGGGGCATG TGGTCCATCCAGCACTAGCACGGGCCTGTAACCACGCATGCATTTGCCATTCGATAAATCAAAGCAGGAA ACAGTCCGCATCTTCTGAGCACCTTCCTATTTCTTGAGTCACAACTGATAAAACTCTCAGTCCTCAGCAG AGAACAAGGGAGGGAATGAAATGAAAACCAAAACCAGGAAGGACAAGCTTGCCCATCTCCAGCCTTCTGT TTTGCGGCCCAGCTGCCAGAACTCAGTGAGCAGAACAGAAGAGCCACAGACTTTCTGGTGAAGTTTCCTG CCCACACATGGGTTTGTGCTTGCATGTGTGTGCATGTGCGCGCACACGGTTGGAGAAACCAGCTCATCAC ATATTTATAAAGCCCCAATCTCAAGTGTGGACCTAATGCTTCCTAAATTCTCATCCCATGCCAAGAGATT CTTTTTTAGTTGTTTTCATGATTAAAAAGTAATACTTGGCCGGGCACAGTGGCTCATGCCTGTAATCGCA GCACTTTGGGAGGCCAAGGCAGGCAGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGT GAAACCCGGTCTCTACTAAAAATAGAAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAATCCCAGCTGC TCAGGAGGCTGAGGCAGGAGAATTTCTTGAACCCAAGAGGCGGAAGTTGCAGTAAGCCAAGATCGCACCG TTGCACTCCAGCCTGGGCAATAGAGTGAGACTCCATCTCATAAAAATAATAACAATAATAAAAATGAATA AAAGTAATACCTACAGAGAAAATCAGTAGAGGGAGATACAAGAAACTGTTAACGGGGATCCCCTTATAGG AATGGAGGGAAGGACTCATGCTTTTCAATGGCACCCCTTCTGTATTTTTTTTTTTAACCACTTAGAAACA TTATCTGTTAAAAATGAGAACCAAGGTCGGGCGCAGTGGCTCATGCCTGTAATGCCAGCACTCTGGGAGG CTGAAGCAGGTGAATCTCATGAGCTCAAGAGTTCAAGACCAGCCTGGGCACCATGGCAAAACCCTGTCTC TACCAAAAATACAAAAAATTAGCCAAGCGTGGTGGCACGCACCTGTCCCAGCTACTTGGGAGACTGAAAT GGGAGGATCACTTAAGCCTGGGAGGCAGAGGTTACAGTGAGCTGAGATCGTGTCACTGCAGTCCAGCCAA GGTGACAGAGTGAGACTGCATCTCAAAAAAAAAAAAAAAAAGAGAACTGAGAAAACTAATATGTGCTCAC TGAAAAAGTGGAAAAATTAGAAAGGTATAAAAAGAAATATTAAATCATCCATAAGCCCACCACCAAAAGA GAACCATTGCTATATGTCCTAGGTATCTGCATTTTTATAAATATCATTGTAATATACCGACACATGTATA TAGGGTCGTATTTTAGATATGCTTCTGTATCCTCTTTCTACTAATTTAATATCCCATTTTTCCATATTGT TAAAATGATTTATAAACATTTTTAATGGATGTTCCATGATTTATTTAATAATTATCCTTCCCCTGTAATT AGACTTTTTTGTTCCAGTTTTTTTACTGTTATAGAAATACTGTGAACTTTTTTTTTTTCTTGAGATGGAG TTTCGCTCTTGTTGCCCAGGCTGGAATGCAATGGCATGATCTTAGCTCACTGCAACCTCCGCCTCCCAGG TTCAAGCGATTCTCCTGCCTCAGTCTCCTGAGTAGCTGGGATTACAGGCATGTGCCACCATGCCTGGCTA ATTTTGTATTTTTAGTAGAGACGGGGTTTCTCTGTGTTGGTCAGGCTGGTCTCAAACTCCTGACCTCAGG TGATCTGCCTGCCTCGGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCATGGCACCCGGCTTTTTTTT TTTTTTTGAAACAGGATCTCATTCTGTTGTCCAGGCTGGAGTGCAGTGGCGTAATCATGGCTCACTGCAA CCTTGCACTCCTAGACTAAAGCAATCCTTCCACCTCAGCCTCCTGAGTAGCTAGAACTACAGACACGTGT GACTATGCTCAGCTAAGTTTTGTATTTTTTTGTAAAGATGGGGTCTCACTATATTGCCCAGGCTGGTCTC AAACTCCTGGACTCAAGCAATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGTATTACAGGCATAAGCCACC ATGCTCAGCCCTAAACATTTTTGATTATGCTTTTTTCTGTTTTTTTTAATTTGTTCCCTACTTAGATTGC AATTCTGTGAGTTGTGCACACAAAAAGTGGGTATCTTCACTTGCTATGATGCTTTATTGTTCCCAGAGTT CCTTCATCTACATTGTTTCATTGAATGAGTAAAAGGGAGTGGGGGTGTCAGGACCAGGAGGAGGATGAGG ATAGAGGAGACAAGGTGCTGTGGGCAGGCAGAAAAGGAGGCCGTTGTACAGTGGAGCTGATGGGAGGAAC TTCCTGGGTAGAGGCTGAGCCTTGCCTTTGAAGGACAAGCAGGATGTATGGGGTGGCCCACACAACAGCA TGGCACACATGGGACCTGGAGAGTTGAGTAGCCAAGGGGTTGTAGAGAGATCAGACTGGCCAAAGCCAAA CCCTATGTTTGGGGAAACAATGGCCAAAAAGATTATGGACCACAGAGCTGAGACTGAGCCCATAAGCAGT GCAGAGCCAGCAGATGTCTTTGAGCTTGAGGTTGTCTTAAGTACACGATGTTTCAAGATTAGCTCAGCGC CAGGGTGGGAGGTCAGAGAGAAGCTGGAAGTGGGTAAGACCAATGCCAATAGAATAGATGCGAGGGAATT GCCCTAAACATCTGAAGGGGCCTTATAGACAGTAGTTTCTGCACGGCTAGGGCCGGCCAGCCATCATCAG GCATGTGGTGGTAATTGCAGGACAGTCAGAAACTTTACCCCATAAATTGTATTTACCCTGCAGTTTGACC TGTGGGATTGGCAGCAAGACTGAGTTTTGTTTTTTTGAGATGGAGTCTCGCTCTGTTGCCCAGGCTGGAG TGCAGTGGCGCGATCTCGGCTCACTGCAACCTCCACCTCTAGGTTCAAGCAATTCTCTCATCTCAGCCTC CTGAGTAGCTGGGATTACAGGCACGCGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGG TTTCACTATGTTGCCCAGGCTGGTCTTGAACTCCTGACCTCAACTGATCCACCTGCCTCGGCCTCCGAAA GTGCTGGGATTACAGGCGTGAGCCACCATGCCTGGCCGAGACTGAGTTTTTGAGGGCATGTCAGATTTGT TTCTTTTTAATAATTGATCTGTAAGATTTTAATGATTAATGTACCTTCACATTTCATATCCTCCTTAATG GGAAATGCTTATTCAGAAATTACTCTCCTGGGAAGCAGGCCTCAAGCAGGCCAATGAGTCCAGTTCTGAG GTTCCTCCAGCTGCGTTTCACTCACAGTGCCTGAGTGCAGGCCCCAGTAAGGCCCCTTCCTCCTTCCTCA GACATCTGTTTCTATGTCCCAGGGATCACATGGCCATTCTCCTTCTCCGCCTGAGGGAGAGAGTGAAGCA AGCCTTTCAGAAGCCTGTCACTTGTCAGATTGTTAGCCCAGGCCAGGGTGGGGGTTCTGTACCAATGGCA GGATTTTCTTTTCTTTTTTCTTTTTTTTTATTTTCATAAAGACACAGTCTTGTTATGTTATACATGCTGA TCTCAAACTCCCAGGCTCAAGTGATCCTCTTGCCTCAGCCTCCCAAAATGCTGGGATTACAGGAATGAGG CACTGTGCCTGGCCAGTGCCATCTGCCCCTACTCTGCAGCTTCTGCCATCTGGAACTTTACCCCCAAGAG TCTGGGAGGAATGTGGAATTATACCCCGCTCACTCATCTGAGAATTTAAACCCTGGGGGTATATGAGGAT CAAGCGTGTGTCCATGGTCTGATAGCTGAACTTCATCTGCAGCCTCCTCTCCTGGGACTGCCTGACTTAC GCTTTACTCACTGACAACTTCAAGCTGCTGGTGATTGCTGCATTGACTCACCTCTGTGCCTTACCTTTTG CCATCCCCTCTACCCAGAACACCCTCTCCTTTTTCTTGGGCAGGTCTTGCTCACTGCTTCAGACTCAGCT CAGGCATCACCTCCTGGGCTGGACTAGGTGTCGCTCTGTGTTCCCGTCACATCTGCTGTGTGTCTATCTC TGTCATTGCATCCCTGTATTGTACTGAACTCTTCTGACTTCTTGTCTGTTTCCCCCAGTAGACTGTAAGA TCCTCAAGGGACAGTGTCTTCTTCCTCAGTGTACTGCCAGCACTCAGCACGGGGCCCAACACCCAGCAGA CCTAGTACATGCCCAGGAACTGCCACGCATAAGATCCTTGCTCTGCAGCTAGACAGGACACTCTGGGGCC AAGACCTTACTCAACATAAAGCCTCAGCCTGCCTCCAGTCATTGGATTTGGAGGCTCTTTATCGGGTGCC TAGAAGTGATTATATCTTTTTGTCTTAAGTATTTTGTCTGATACGAATATTACTTCTTTGTGGTTAATAT TGGCCTGGCACATCTCTTTCTATGTCTTTATTTCCAACTTTTCTGGATAATTTTGTTTTGTTTCTTTTAG TCAGCATCTAGCTGGATCTTTTAAAATCCAATCTGGTTTGCTGTTTTGTAATCTACTCACATGTACTGTG GTTAATGACATGCTAATATTTTGCCTTATTTCTGCCATCTTGTGTTTTTATTTTATATTTATTGTCCTTT TTGCTTCTTTTTTCCTCCTTGCCTTGCCTTGTATCAGATTGACAGCATTTTCTATTTTTCCTCCTTTATT CTTCTGGTCTGAATTGTATTTCTATTATTTTAGTCATTACTCTTAAATCAACATACATACTAACTGTAAT TTTTTCTAATAAAATTTAAAAGTTGTTGTACATAAAGTCCCCAAAAAGGCAAGGATCATGTTACTTTTTA CCCATTGAACAACCCATTTCACCCATCTTCCTTATTGTTGGTGTCTAGATTTTCATGTTTTAAAACGATT TAAACTGGCCAGACATGGTGGCTCATGCCTGTAATCCCAGCACTTTAGGAGGCCAAGGCAGGCAGATCAC CTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGGGAAATCCCATCTCTACTAAAAATACAAAAAT TAGCCAGATGTGGTGGCACATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAA CCAGAATGCTGAGGTTGCAGTGAGCCAAGATTGTGCCACTGCACTCTAGCCTGGGCGACAGAGCAAGACT CCATCTCAAAAAAAAAAAAAAAAAAAAAGATTTAAACCAATTTCTCATATTCAACTGTTAATTAAATTGA CCAACATATTGTTTGAGTTCCTGTGCCTACCATTGTTTCTTTTTCCTATTTACTTTTTTCTTTGCAAAGT ACATCCTTCAGTGGTTCTTTCAGTGAAGGCAGTGCCACCTTACCTAGAACTCCTGTTTGTGTATGTGTGT ATTAGATGTGCATTTGTTTGATTGTTTCAAGAAAATGAAACGACCTGTTAAAACCATCAAGTTAAGTCAT AACACATAACATAACAGGATTTAGTGGCGTAACTGAACTAAAAGTCTGACAAATTGATGGCTGATTCAGC CCTGACTTGACAAGACCCCTCATCAGTAAGGGATCTTCGTCTGCTTCCTGTCTACCTGGGCTAAGGAATT ATTACCAACAGTAGATGGGCAGATGCTAGGGGTAGTAATATCCACATGGGTAGTAATACTGCTCAGTTCC TGGATGTTCTAGATGCCTCTGCCAACCAGATTTTATTCTAGGAAGGAACTAGAGATCCTTGGGTCCTAAG AGAATGGGCCAAGAGTGTCCTGGCTTGAGCCCTAACTCCATGTTGGATGCTCTAACTGTATAAATTGAGC CTCATTTATTCCTGTAGGTAATGTACCTCTCTAAGCCTTAATTTCTTCATCTGTAAAATTGGAGATAATA TTGCCAACCTTGCAGGGTTGGTGTGGAATGCATTAACAAGGCAGATAGAGTTCCTGGCACAGTGCCCCAT ACACAGAAGACATTTATGGACGGTAGTGGCTATTACATTCCCTGGCACTTGGGAGACACTCATTGAATGT TTATAGGGTGGATGCAGAAGCCTACCATAAAAGGCTTCATTGAGTAGATAGGCCTTAAAGGATAGGTGAG ATCTGGGCAGACATTGATAAGGGAGGAAGGCAAGCAGCCACTCCCTATGGGAGGAACAGGGTGGGCAGAA GAAGAGAATCAGAGGCTTGCCCAGTGCTGCCCTGCTCGGGCAAGTGAAGGAATCAGTCTGGAACAAACTG GGGGAAGGGCTGTAGGAAGGGCAGAAAGGGTAGAAAGGGGAGTCAGGATGAGCATGTATGGGGACTTCTG AGTCTGCCTCGCCAGATGGCTGTTTTGCCAGGCCAGCTTGCTCTGCCTGATACTTGCCCTTGGTTCCCTC TTTTTTTTTCCCCTCCTTTTCTTTCTTTCTTTATTTTTCCTTTTGAGATGGGGTCTTGCTCTGTTGCCCA GACTGGAGTGCGGTGGTGCAGTCATGGCTCACTGCAGGCTCAAGCAACCCTCCTGCTTCAGGCTCCCAAG TAGCTAGGACTACAGGCGTGTGCCACCATGCCTGGCTAATTTTTTAATTTTTTGTAGAGATGAAGTCTCA CTATGTTGTCCAGGCTGGTGTCAAACTGCTGGTCTCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCT GAGATTACAGGCGTGAGCCACCGCACCCAGCCCAGCCCCGCACTTTGAGTAGGCAGAGGTTTGCCTATTG TGGCCTGGTGGCCAGGCAAGCTGAAGACTTAAAAGAGGAAGTTGGGAGAAGATTGGTTTTCAACCAATAT CTTATTAAGGAAGTTGAGTCATTCTACTTCTGCTATTTATCCCCTCTGGGCATTCAGAGAAGGACAAGTT TTTACTTCCAGATGAAATAGTCATGAGAGGGATTTGCCTTGGCCCCTTGTAGACATTTTCAAGCTGGCCC TGTAAGACAGAGTTTTATTTCCCTTTCGTGTATGGAGAATCAAGGCTCCAAGCATTGCATGAACTAGGTA AGGCTCAAGATACCTTGGCTATATGGTGCTGAAACAGAGAAGTCCCATCTTCTCAGTGATGGCTTTTAGT AGCCTGGTGACAGACAAGGGAATGAACATTCATTTAGCCTCTTCTGTTGGCCAGGCAACCTGATTGGCAT TTCATGTACTCGTCTTCATTCGGTCTTCAAAACAGCTCTGAAGGAGCTAAGAGAAGAAACTCAGAGAAGT TAAAAGAAGTGGCTAGCTCAAGGTTTAGATGTCGGCTTAGGAGGCAGCAGTCTAGGTTCAACCCCACCTC TGCAACCTGCAACTGCGTAACTTTTGGTGTGCTACTACACTTCCCTAAGCCATATCTTCATGTCTGAAAA TGAGATGACAGTAGGTACTTTGTAAGTATCGACAGTTAGTATTCTGAGTTGGAGTTGTCCAGCCCTCAAA GAATCCTGACAGATGGGCTACATTCTCAGAACTAGAAGGAACCTCAAAAGATTTCCTAGGCCGCTGGTTT CCAAACTCTTTTCTTGGAGAACTAGGGATTTTGTAGAGGTCCTCGGTGGATGAAGGGACACTGAGCATGT GGAGCTCCTTCAGCCAGGGCAGCGGGTTCAAATGTGAGTTACATGCCAGTTGCATGCATCTGGTTCTTTT AGTTATTGGGAGATGAGGTATGATTTCATTTGACAAAAATGGTCCCACTGCTCTTCTTAAAAAAAAAAAA ATTGTTAAGGCTAGAACCCATAGCTTCTGGTTCCCAGTCTGGAATTTTTACTATGTTGTACTTGCTAAAA CAGGGAACTGAATGAAATATGATATATTCTAAAAAGGTTATCATCTGTGAAGATTAACATTTAAAACATT GTTTTTGTATCTTCCAGTGAATCAAAAATTTGTTTACTGTAAACCCCATTCCTGCCCCAGAATCCTAGGA ACAGAAATTTTACTGTCAGAGAAAACACCGCTCTCATCACCTCAGAACAGCACTGTCCAATAGAACTTTC TGCAATGCTGGACATGTTCTCTGTCTGCACTGTTGAGTATGGTAGCTAGTGTAACAAGGAAATGATTTTA AAATTTTACCTCATTTTAATTAAATGTAAATAGCCACATGTTGCTAGTGGCTACCATTTTGGACAGTGTC GCCTTGAGTACAGAGCAGGGGTCAGGTGGCAGTCTCTGGCCCTTTGGCATCAGAATCATCCAGAGAACTT GTCAAAAGTACAGATTCTGGGCCTAATGCCCAGTGACTGGTTCAGCAGGCCTAGGAGGAATGCATTTAAA GAACTTATCTGGTTATTCTAATCTGTGGTCAGATTGGAAACTGCTGCATTGGAGAGCTTTTCCTCGGAGT GGAAGAATAGAGCCAGAATCAGGCATTTAGCCCGGCCCTGATTTTCTAGGGAGACTAGAGGAACCTTCTG GGGAATGGCAGATCCTTGGAGAATCTGTTGAAAGCTATGGACCAAGTCTTCCCTGGAAAAATGCAAATTA CATTTTTCTCCCTGAATCCATCCTTGAACCTAGATTAAGAACTCCTCATACAGCTATGCCCAGAGGTTGA TCTGGTACTGTCCAGATCATTCCTATCCCCCAGGCTTCTCCAGGAGGTCACTGAGGCATCACAGAAGAAA GAACCAACAGTGTCTGTGCATCAGGCCTCAAAGAATATGGAGTGAATTCTGCTCCTTTCCTTTCCTCTTC TGATTTCTTGGGCTTATGGGTGAGCCATGTGGGTTTGGCTGTTGCCACTGCTCGTGTCCTCAACTCTTAT GCAGAGAGTAGAGGGCCCAATGCCTTTGGGGCGTGAATAAGCTGAGGAGAGTGTCTAGGCTGAGGAATGA ATCAGGAGTTTGACTTGCCTTCAAAGGCAGAGACATAACTGGCTCCCACTTCGTCCTCCCCACACGCTGC AGGAGGGAGAAGGGGCAAAGTGTTAGGGCCATGAGCTGGGGTGACAGCCAGAGACCAAAGTCCAGGGCTG GGAAGGCCCCCTGGCCAGTAGTCCTGGACTTAGTACAGAACCATGATTTTTGTAGACCAGAGTCCAGATA GAATTAGGAAAGGAGGGAGGGAGCAAGTGCATCCGTATGTGTGTGTGTCTGTGTGTGCATGTGTGTGTGT GCATGTGTGTCTGTGTGGGAGGTGGTGTTTGGGGAGAGCCACTGTCAGGCCAAAGTGTCCCAAGAATAGC CTCTTGAACTTGGAGGCTGTCGGTGAGGGTCTGAGTCATGGTGATGTGGCACAGAAAAGCCAGCCACAGG AGGAGCTTTACAGCTCCCAGGCCGTGATTTGTGCCCCTGAGAGGTGAGGGTCAGCCTGTTTTCCCCATGT CCTTCACAAGTTCAGCTGCCATCTGCTGGGTCAGCTTCTCAACAGCCTCCTTGTTACTGTCTGCCTGCCA GGCTGTTGGATGAGTCATCGGGGAACTGCAAAGGAGTCTCTGAGCGTGGCTGCCTCAGCCTCAGCTTCCA CTTCTCTGGGAAGAGGGGAGCCTGGTGTGCTCACAGAGGGGCGCTGGACAGCTGCCTACCTAACACCAAT ATGAAAGGACAACTCTGGGACTCGGGATGCCCTGCACCCCCTCTGGAGGAGTTCTAGCTCAGGATGACCT ATCCAGAAGCCTCCGTTGGGCCATGCCAGGCGGAGACAGGCTATCAGAGCCCCCACACAGCCAGATCTCT AATAGCCACGTGCCCCTCAGAGCAGCAACTGCACCACCTGGCCTCATTTTTCTCATTCATCAGGCAGGAC TCTCTCTTCCTCCTCAGCATTCGGGATCATCCTGTCTCCAAAGGTTATGGAAAAGCAATCTTTGTCCTTT GAGTCCCTCGTTCAGCCAGCGTCAGTTGCGTGGTCTGTGGCCCCTGTGCTATACACTGGGGAGGCACTGT GTGCAGGGCCCCACCTCTTCCCTCAGGAGCCTGTTGACCAGGGAGGACCTTAGTGTGCCCTCCTGCATTT GCCTGTAACCCAGGAGCTTGGGGAGTGGGCATCATAGCCTAAAGAACCTAGGGTCTGGATCCTGGCCATG TCCTGTCACACGTGGGTTGGGTGACCTTGGGCAAGTCTCCACTGAATTAGGCCTCAGCTTCTTCAAATAG AAATGAGGAGGTCACGCTCACATCGAGCTCCCTGTGAGCATTCCCTACTGCTGTTAGGTTTGGAGACTTT TTGGTCTGTTCTTAAGATCTCATTTCCCCTGGTAAAGAGGCTGAGAACAGTGGGATCGGCTCTGGGCTTA GGTCAGTTTCTTTTTTGGAGGTAGAGTGGGGTGGGGAGGTGTGAGGTGGGATGAAAGTACAGTTACAAGA AGCATAGCCAGCCTTGAAGGGCTTTTGCCTAATTGGATGTCAGAACACCCCTTAGACTTTTTTTTTCTTT TAGAGACAGGGTCTTATTCTGTCACTCAGGCTGGAGAATGCAATGGTGCAATCTCAGCTCACTGCAGCCT CAACCTCCTGGGCTCAAGCATTCCTCCCACCGCAGCCTCTAGAGTAGCTGGGACTACAGGCCAGCTACCC CAGCTAATTTTTTGTATTTTTTTGTAGAGACAGGGTTCCACCATGTTGCCCAGGCTGATCTTGAACTCCT GGGCTCAAGTAATCCTTCTGCCTCAGCCTCCCAAAGTGGTGGGATTACAGGCATGGGCCACCATGTCCGG CCCCCTCAGACTTCTTAAGATCCTCAGGTAACAGTGAGGCCACCCATTCAGCCTCCTCAGCATCTGGCGT TTGGTACCAAATCCAGGCATCCTTGCAGGAAGCTGGAGCTGCTCCAAGTTCAGAGCTAGGAGACCCTTAA AGACAGAGATGCAAGGAACTAATCAATAGTGAACAACAAACCCCACCACACCCGCCAGCCAAGCTGGCAG AGCCTTTCATAGCCATCGAGGTGGGAAGACCAGTGAGGCAGATTCAGAAGGAGGAATGCTTCAACCTAGT ACCTCAGCTTCCCACCATCTCATTCAGTCCTCAGGCCTCACAGGGCAAAAGGCCAGAGGCCTTAGAGTTC AGCTTCAGATGGTGTACCTGTCTGCCCCAGAAGCAGAGAAGTGATCCAGGGTTCACAGAGTTATAGCAAG GAAGATGATTTCTGCTGGTAGCAGCTTTAAGACAAACCTACCATCAGAGAGCAGTTATTAAAAATCTGTC TGCATTTGGGACCTTCTCAGGCTGTTTCTAAAGCAAGTCATGCCTGAGAGGGGCCCTGCCCTTTAAAAAC TCCCAGCCTTTAAAAAGGTTTCCAAATGGTAACAGTCTCAAATCAGTGCTCTTCTCTTTTTTGCCAATTC CAGTCTGCAGGCTGTTTGCACAGATTGTTGGCAACTCTGGGTTGCTCTTCTTTGCAGCTTCCTAGGGCTG GGCAAGACAGAACCCAGAGAGACGTGAATTCTTATGCTTTATTCTTTATTTCTAGAGGTATAGGTTCGTG TTAGGGCCTTGAATATAAATTCTACTCCTGATGTTGCCTGAATGAAAAATGATACCTAGAAGTTTTCAGC CAATGAGTTTGGACATTAGAGGAGGAAGCATGTTAGTTCCTTCTGGAGAGCCACAAACAGACGCATTGGG CAAGGAACCACGTGCTGAGCACCATTTGCATGCTGAGTTTTAGACTTTGTAGGACACACACACACACACA CACACACAGATATCTACCTCCTACTAGGGAACAGAATAGAACCTTGCTTCTCTCCACTTGGAGAAAAGTC GCTGTGGATGGTGTGTGCCAACAGGTCCTCTCCAAAGGCTTATGTGGGGTCAGTGAGGCCATGGTTTTGG AGTCTGGGATTCACCACCCTGTCCTGGGGAAACAAAGTTTGCCATAAAACAACAGAAAAAGATCGAGCCA TCATAAAGGCAAGAAAGAGCCAACCCAGACATTTGTGCCACAGCTCTCCTAGAGGGAGTGGGCTGGCATC CTTGCTGGACACAGTGAAGGAGGCTGTTTATGTTGTGGTACTGGGAGGACCGGGGGACTGTGCCGTGTGG AACGTGTAGCTGTTGAGAGGTGGACTCTGTTACCATTGAGGATGTTTGGAGGATGAGTATGTGTGGCAGA GGCACACATAAACAGGCAGAGACCCTTTGCCCCTGCCTTTCTCCCCCAACCCAAGGCTGACCTGTGTTCT CCCAGGTCTGGGATTCTAAGTGACCTGCTCTGTGTTTGGTCTCTCTCAGGATGAGCACAAGCCTGGGAGA TGGCAGTGATGGAAATGGCCTGCCCAGGTGCCCCTGGCTCAGCAGTGGGGCAGCAGAAGGAACTCCCCAA AGCCAAGGAGAAGACGCCGCCACTGGGGAAGAAACAGAGCTCCGTCTACAAGCTTGAGGCCGTGGAGAAG AGCCCTGTGTTCTGCGGAAAGTGGGAGATCCTGAATGACGTGATTACCAAGGGCACAGCCAAGGAAGGCT CCGAGGCAGGGCCAGCTGCCATCTCTATCATCGCCCAGGCTGAGTGTAGGGGCCTAGGGTTGTTGTGGGC ACGGGGCAGGTGGGTGGGCCTGCAGGTGGGTAGCTGGGCCCAGGGGTTCCCTATGGAGGAGAGAGGTCTG TGTCACTGCTAGATAAGATTCTCATGAGACACAACCAGAGGTCTGTGCCGAGAATCATGGAAAGTGGGGT TGTAAAAGTGCACAGATGGTGGATGTGGCAAGGGGAGACTGTGCCCATCGTGACTGGAGCAGGGGAAGAG AGGTAACAGACGAGCACTCGGGACTCTGCAGAATCATCAAGCAGGCCATCAACCTTCTGCTGTGACCTTG AGCAGCCCCAGTGTCTGGAGAGGCTCCAGACAGGAAAGGCCAGGTCTCCTGGAAAGCCCCACTGGGGCCT GTAGGGCCTTCACCATCTTCCACCTAGAGGTGGCCCCACCCCCAGGAATGAGCACCGTGCTCTTGAGCCT GCTGGGCCAGTCCTGGGGCGGCAGGCTGCTGCAGGGTGAGACCTAGTCTGGTCCTTTCTTCTTCTACTCA TGATACCTTATGATGACTAGTAATGGTGGCTTCCCTTGGAGACAGAAACTCCCACGAGGCCTGGGTAGGG CCGGGAGTCCTCTCTCTCCAACGCCTTCCCTCAACCCGGGAGGCTTCTTGGGGTGGAACCTGGAGAGCTG GACAGCCATGCTGTCATTTCTCCACACGCATACATCCTGCCCTCGTCTCCCACTTCCTCCTGGTTGGTTT TTGAGGAGAGATGAGAGAATAAAAACTAAAATACAGAGAGTGACATAATAATTGTTTTAAAAAAATACAC ATATATCCACACTTATATGTACACACATATATAAATACCTAATAGCTGTTTTTCCTATGAGCCAGGCACT GTGTTGAGCATTTTCTGTAGATCATCTCACTTCAGCTTCATAGGAAGTGAGGCGGGCGCCCTGTGATCCC CATAATATAGGCTTGGCTATTTCAGAGCAGGTGGCTGAGGCCGTGGTCTGCTCTTGACCAGTAAGCTGAG AAGCTGGGGAGAGACAGTGCGGGAAGGAGGCATTGGTGGGGAGGTGACTGCCAGACAGGGGTTGTCTGGA AAGGAGGGGAAGGAGAGGCGCCAGAGGGGATCTCTGTAAAATGTCTCTCCCCTAAGTGCTAAATTCCTAT TTTTTCTCCTCTCTGCTAATCCAACTCCTTTTGCTTTAGGTGAGAATAGCCAAGAGTTCAGCCCCACCTT TTCAGAACGCATTTTCATCGCTGGGTCCAAACAGTACAGGTAAGCAGGGGAGACAAGCCTGAGTGGGAAG GTGGGGACTGGACCCAGCGCCCTCGTCCCCAGCACTTGCCTGGGCCGCTCCTGCTGACCCCGGGCTCCCT CCCTCAGCACCTGTGGTTCAGCTCCTGGAACTCACCCAGGCTTTCCTGGCTGAGCCGCTCTCTCAGCCAA ATAAGCTTTTCAAAGGCTTTTCACAGCTTGTGGCTGACTGCCTCTGGGCCACATCAACTTGACATTTTAT TTTTATTCTCCTCAGAGTCCTTAATGCACCCCCTCGTTTCCCATCAACAGGGAGGGTGCTGGGAACAGAA GCTGCTTCCCACTCTTGCGTGACCGTGAGCGCAGGCCGGGTTGGTGGGGGGGGCCTTCCACTGTCCTCTA TGGGAGAAACCTGCTGGTGCCTTTTCTCCTGGGAGATGCACCGAGTAGGGATGCGGGCGGTAGAAAAGGA GGGGACAGATAGACTTGGTGGCCCGGTAGAAAGGAAGCCAGGGTGGGGCTGAGTCTGTTCCCAGGCTCTG CATTCCCCCACAGATGATTTTTTGAAACAAGAGTTCAAGTGCTGGGCACAATGGCTCTCACCTATAATCC CAGCACTTTCTGAGGCCGAGGCAGGTGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCCAACATGGT GAAACCCCGTCTCTGCTAAAAATACAAAAATTCCCTGGGCATGGTAGCGCATGCCTGTAACCTCAGCTAC TCAGGAGGCTGAGGCAGGAGAATCGCTTGAATCCAGGAGTCGAAGGTTGCAGTGAGCCGAGATTGTGCCA CTGCACTCCAGCCTGGTGACAGAGTAAGATTCTGTCTCAAAAAAAAAAAAAAAAACAAGAGTTCAAGCTA GAAACAGCTCCTTCCCCTATCACCAGGCAGGTTTTGTATCATTGGAGTTTGGAACCTGCTAGTGATAAGA TTGTGGGGAGGGCAGCTGGCTGCCTTGGAACCAAGAAATGCTCAGTTTGGTGGGATTCCTTCTGCTGTCC TGGGTGCCTTTTGGCCCAGGGTAGGAGCCTCTGATAGACACACTTCTTTCAGCTGTCCAAGAGAAGCCTG TAGGCCTCCAGTGGTCCCCAGGACTGCCATGAGTCTGCCTTCTCCATGGGGGCAGAAGATGAGGCCAAGG GAGGGTGGCTGAGGCCATGATCTGCTCCACAGCTGTTCTGCAGCAACCCATCTGTTGCCGGGTCCTTTAA TACTTGGCAGGGATCCCAGTCCAGTTAGAGCCATGGCAGTGATGAGCCCCGAGGCCAGCAGAGAAGGGCA GGCTCCCCAGTACCAGGCAGCAGCCCAGGCTGTTCACCTTCAACAGCAGCCAGGGACCCCCAGGAACTGT GAGAATGGAGGTGACCAGCCTTACCTGTTCCTCCATCCGGAGGCAACAGAAACAAGCTCTGCTCAGTCAG AGCTGAGAGGCCTGCCATGAGCGTGGCCCCCTCCTAGGAACTCTCCAGGGGCAGCTCACCTTGGAGAGCA GTGAGCGAACCGTGTCTGCTCCCCTGACTCTCCCCAAGAAGTGCTGAGTCTGTACCCCATCACCATAGTA ACAAGCACAGCTTCTCGGCAGCTTGCCTTGGGGCCAGACACTGAGCTGGGCTTTTTAAATGAACTAAATT ATTGAAACTTCATTTCCACCCTGTATGGCAGAAAATACCAAACCCATTTTATAAGTGAGATAAGTGAGAA AACAGGTTCCTTGGGATTTAGAAACCTTGCCGCATTCACACAAGGAATGGCAACCTGGGATTTGACCTTG GATCTGCAGGAGTCCAGATACAAGTGTCTGGACCAGTCCATCTTCCTGCTTCCTCGTGCTCAATATGCAA ATCTGTCCCTTTTGTGACAGCCAGTCCGAGAGTCTTGATCAGATCCCCAACAATGTGGCCCATGCTACAG AGGGCAAAATGGCCCGTGTGTGTTGGAAGGGAAAGCGTCGCAGCAAAGCCCGGAAGAAACGGAAGAAGAA GAGCTCAAAGTCCCTGGCTCATGCAGGAGTGGCCTTGGCCAAACCCCTCCCCAGGACCCCTGAGCAGGAG AGCTGCACCATCCCAGTGCAGGTGAGACCCTCCACCCACTGCCCAGACCCCAGGTTCATGGGGCCTTGAA ATTGGAGCCTGTCCCTGGGCCCTGGCCCTCTGTGCTGATAGCTGTGTTTCCCCCCGCAGGAGGATGAGTC TCCACTCGGCGCCCCATATGTTAGAAACACCCCGCAGTTCACCAAGCCTCTGAAGGAACCAGGCCTTGGG CAACTCTGTTTTAAGCAGCTTGGCGAGGGCCTACGGCCGGCTCTGCCTCGATCAGAACTCCACAAACTGA TCAGCCCCTTGCAATGTCTGAACCACGTGTGGAAACTGCACCACCCCCAGGACGGAGGCCCCCTGCCCCT GCCCACGCACCCCTTCCCCTATAGCAGACTGCCTCATCCCTTCCCATTCCACCCTCTCCAGCCCTGGAAA CCTCACCCTCTGGAGTCCTTCCTGGGCAAACTGGCCTGTGTAGACAGCCAGAAACCCTTGCCTGACCCAC ACCTGAGCAAACTGGCCTGTGTAGACAGTCCAAAGCCCCTGCCTGGCCCACACCTGGAGCCCAGCTGCCT GTCTCGTGGTGCCCATGAGAAGTTTTCTGTGGAGGAATACCTAGTGCATGCTCTGCAAGGCAGCGTGAGC TCAGGCCAGGCCCACAGCCTGACCAGCCTGGCCAAGACCTGGGCAGCAAGGGGCTCCAGATCCCGGGAGC CCAGCCCCAAAACTGAGGACAACGAGGGTGTCCTGCTCACTGAGGTAACTAATCCCCCGGCACCTGTATA TGTCCCTCTACCAGCAACCTGGGGGATGCTTTTCTCTCTTTATCAGAGTCACTCTTGCCTGTGGTGACAA ATCAAACAGTAGGACAGTGCTCATTGTGGATGAAAAGTATCATCTCTTATTCCGCCAATCTCACTTCTCA CAGCCTTTTTAGCGTCTTCTGTTCTGAGTTCTTCTGGTTGGTCACCTCCTGCTTGCTGAATGTGGGCACT GCATTAATAGTACACATGCTGAGGACAAGGGGAATCAGCCAGGAGCCACTGGAGATGTTATCATGGCCCC CAGAGACGGAAGATGAGGATGGGACCTGTTTTCACCACCCACCTCCTTCCCTTTTTCCTCTTGTTAACTT CCCAAATAATTTTATAACTTTAAATGATTTTATCAAACTTTGATTTCCGGGTTTTATTCCATCCATCCAC TTTTTTTTTTTTTTTTTAATAAATGTGTTTTTTGAGACAGAGTCTCACTCTGTCACCCAGGCTGGAGTGC AGTCGTACAATCATAGCTCACTACAGCCTCCGTCTCCTGGGTTCAAGCAATCCTCCTGCCTCAGCCCCCC GAGTAGCTGGGACTACAAGCGTGTACCACCACGCCCAGCTATATTTTTTTTAATAGAGATGAGGTCTTGC TATGTTGCCCAGGCTGGTCTCAAACTCCTGGGCTAAAGCAATCCTCACACATTGGCCTCCAAAAGTGCTC GGATTATAGGTGTGAGCCACTGCACTGTCTTATTCCATCCACTTTTTAATTTTTTAATTTTTTTGTTTTG TTTTGTTTTGAGACAGAGTCTTACTCTGTCGCCCAGGCTGGAGTGTAGTGGCACTATAACAGCTCACTGC AACCTCCCCCTTCCAAGTTCAAGTGATTCTCCCACCTCAGCCTCCCGAGTAGCTGAGACTACAGGTGTGC ACTACCATGCCTGGCTAATTTTGTGTTTTTTGGTAGAGACAGGGTTTCACCATGTTGGCCAGGGTGGTCT CAAACTCCTGACCTCAAGTGATCTGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCAC CATGCCTGGCCCCTCCATCCACTTTTAACATCATCCTTGACCCCCGCCCCTCTTCACTGTTCCTCCCTTC CCTCCACCTTCTAGCTCCTGAGTTTTGTTTTTTCATTGTCAAGGTGATTGGCAGTTCTGTTTCTGTCTCA CCATCACAAGTCTGGGATGTTTTTCATCACAAGGATCAGTGGCCGCAGCCCATGAACCCTTCCCTCGCCT TCACTTCATTCCTCTGCCCCCTCTCTGGTGCTGCCCGGCTCAGATCCCTGCCTTCGCCCCAGGGCTGCCT GGTTGTGAGGGCTCAGCTCAGCAGCCCTGGCAAGGTCACCAGCTGGAGAGTCTTCCTCACTGTAGCCCTG TAGCCCTCTGCTGCCCTGGCCACTGAAACTGTCCTCTCTCTCCTGCCAACCCCAGAAACTCAAGCCAGTG GATTATGAGTACCGAGAAGAAGTCCACTGGGCCACGCACCAGCTCCGCCTGGGCAGAGGCTCCTTCGGAG AGGTGCACAGGATGGAGGACAAGCAGACTGGCTTCCAGTGCGCTGTCAAAAAGGTACGCCAGGGCTCAGG GGCTGAGTGAAGAGGGAAGCCAGGAAGGGGGCCTGGTGTGTTCCCTCTGCTTTCTGTCCAGGACAGTCGC AGGGTGGCCGTGGGTCTGACTTGTGAACAGAACTTGGCTATCACTAGCCACCTGAGGTCGGCTGGAACTG GAAGGGAGCAGCCTGTCACGTGTCCTGGCCTGGCTGCTGCCCCTGGCATGTGTGTATGTGAGAGGCAGTG TGAGAGGACACACGTGGCCTCGGTGTCTCAATACAGCCAGGGCCTGAGGGGCAAGTCCCAACGTGGAAGA TGGTTGGAGCGTCATGAAATTCACACTGAGGTAAAACCCCTGAACCACATAGGAGGCCGCCCCTGACCTG GGCCAGATGATAGGAAAGCAGTAGCCTCCACCTGTGGGGTGCTTCTAGGAGGAAGCCAGCCTCAGTGGGA GTGGGCAGATCTGCCAGAGTCGGAGCTGTGCCCCCTGTTGGCCAGGCGTGCCACAGTCCTGCAAGACAGA CATGTTGGGGACATGAAGCTTGGCAAGACAGGAAGTCACTGGCCGGGTGGCAAGAGCCCTGAATCAGACC AGGTCTGTCTGACCTGAGAGTTCGGCTTTCAACCACTCTTCAGGAAGAAGAGGGAAGAAGATAGACTTCT TGTCCTAGAGTTTTGAGTAGAGACAGAAGACAGGAATCACCCCTCCCACCCCTTCATCTCACTGATGTTA GAAGTGGAGAGCAGAGAGGACAGTGTGGCATGCTGGGCCTGGAGCTGAGGCCTCCTCCTGTCAGATCACA CTATCCGGGCCCAGAGGGAGCATCGGTGGCGGCTGCAGACCGACAGACCTTACAGGTGTCGGTCCTTCTC CCTGTCACCAACCTTTCCCCCACCCCCAACTCTCAGATCATCTTGATTGGAAGCCACCTTGTCCCCAGTC AAAGCTCTCGGCCTCAAAGCCAGCACCAGGACCTAAGGCGCGTTTCTGTGGACCATCCCCTTGGCCCTCT GGGCAGGGTGAAGTAAGCTCTGAGATATACCTTGTTTCAAGTGGCTTATGTCAGAGACACTCCAATCCCC GAAAGAAAAGCAACAAATACAGGTAGAGCATCCGCAATCTGAAAACCCAAAATCTGAAGTGCTCCAAAAT CCAAAACTTTTGGAGCACCAACCTGACACAGGAAATGCTCACTGTAGCCAGAGCACAAAAGCCTGGCACA CGCTGGCTCCATTCAGAGCAGACGCTGCCACCACCGTCCAGGGTGCCTGTGGCCTTAAGGGGAGAGGAGA CAGCTGGGATGTGAATAAACCCGGCTTCCCTGGTGTGTACTTGGGCTGGATGGTGAGACCAGTGAGGGGA CTATCTGCAGGTACCACCCCAAACTTCAGACACACTGTGTCGAATACGAAAACTCCGCCCTCACCACCCC TGACTGGCAACACGTGCTGAGTGCGTGCTGAGTTCTTGCCGAGTTCTTGCCAGTGTGGATCATCGTCTTC CACTGGGGGAGGCCAAGGCCACGTGCCTGACCTGCTCAGCTGCAATTCCCCTCCCCAGGCTACCGGAGAA GGCTCAGCTGTCCCTCTTGAGAGGTGGTGGGAGGAGAGTGTGAGAGTGTGAAGAGACGCGCACCCAGTGC TGGGAGCTTAGTCACTGGGCTTCTCAGCTGTTCCCCTGCTGAGGGCCTCAAGAGTCCTCCCAGGCAACAA GGTAAACAACCCTAATATAGTGGAAGAGGATAAATACTCCATGTCTCGCCCCTCGCATCCACTGCAAGGC AGTTGGAAAAGCTCCAAGCACAAGGCATGGACTTCTCAGCACCAGAGCTGCAGCTCAAGCCCACCAGAGC TGCCACTCACAGAACCACTTCCTTCCCACCCCGGAGAATGCAGTGGGGATGGCTCTTTGGCAGCCTGCAC AGCTGCCATTGGTTGGGCAGACAGCCCCTGCTTTCCCTCAAGGCAGTGGTGTCCTTTAGGGTTTTCAGCT GGAAGAGCAGGAGAAACAGTTCCCTGATTAGGAGATGGGGACCGGGAGGTGGATCAGGCATCAGAGGTCA GGCTGCACATCGGATCAGAGCAAGTCTGTGCCCCCCTGATGCTCCTTGGGGAGAATCCAGTGTGTAAGGT GTCACGTGGCAGTGCCAGCACTCCCTTCATCCTCCTGATCTAGATGCTGATTGGCCATAGGTCCAGGGTT TGATGCAGTTGTTTTTATTTTTAAGGTTTTGTTTGATCTTTTTTCTTTTCTTTCTTTTTTTTTTTTTTTT GAGACAGGATCTCGCTCTGTTGTCCAGGCTAGTATGCAGTGGCATGATCACAGCTCACTGCAGCCTCAGC CCCACAGACCCAAACAACCCTGTTGCCTCAGCTTCCCACATAGCTGGGACTTTAGGCACGCACCACCACA CCCAGCTAATTTTTTATTTTTTGTAGAAACAGGATCTCACTATGTTGCCCAGGCTGGACTCAAACTCCTG GGCAACCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGTGCCCCACCAGGATCCCATTTTAATAGA AGAAACAACTACTTGTTTATACACGCATAAAAAGTCCAGGCTGGGTACAGTGGCTCACGCTTGTAATCCC AGTACTTTGGGAGGCTGAGGTGGGAGGATTGCTTGAGGCCAAGAGGTGGAGACCAGCCTGGGCAACATAG CGAGATCGCATGTCTACAAAAGAGTAAAAAATAGAAATAAAAAAGAAATTTCAAAAGTCTAAAAAGATAT CTGTCAAAGGGCAGTTACCTCTGAGAATAGGACTGGGGAATGGAGACTTTTGCTTTTTTTGGTATCATTT GCATTCTTTTATAATGAGCCTATATTTGTTTGCAATTAAAAGTAAGATCAGGGCCGAGCACGGTGGCTCA CACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGATCACAAGGTTAGGAGTTCAAGACCAGCCT CTGGCCAAGATGGTGAAACCCCATCTCTACTAAAAATACAAATATTAGCCGGGTGTGGTGGCAGGTGCCT GTAATCCCAGCTACTCAGGAGGCTGAGGCAGAGAATTGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGC CAAGATCACGCCACAGCACTCCAGCCTGGGTGACAGAGCAAGACTCAGTCTCAAAAAAAAAAAAAAAAAA AAAAGAAGTAAGATCAGGCCAGGCCTGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGACCAAGGGTG GTGGATCACAAGGTCAGGAGATCTGGCCAACACAGTGAAACCCCATCTCTACTAAAAATACAAAAATTAG CCAGGTGTGGTGGCGGGTGCCTGTAGTCCCAGGTACTTGGGAGGCTGAGGCAGAATTGCTTGAACCCAGG AGGCAGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAGCCTGGCAACACCAGAGTGAGACTCTG CCTCAAAAAAAAAAAAAAAAAGAAAGATCAGGCGGTGCGGCACTTATACCTATAATCCTAGCACTTCTTT GTAGAGACCCCATCTCTACAAAGAAAAAAAATTAGCCAGGCATGGTGGCATACACCTGTGGTCCTAGCTA CTCGGGAGACTGAGGTGGGAGGATCGCTTGAGCCCAGGAAGTAGAGGCTGCAGTGAGCCAAGATCGTACC ACTGCACTCCAGCCTGGACAACAGAGTGAGACCCTGTCCCCCAACCCCACAAGAAATGGGATCCTACTCT AGGGACTATTCTGTACCATGTTTTTTTCATGCAATAATATGACAGATTTCCTTATTGGCATATATACAAC TCTCTTATGCTTTTTAACGGCCATGTAGAAGTTCTTATCCTAGTCAGTGGATGGATTGATAGGATCCATG AATTCTAGGAAATTTATTCAAAAGAGTGTTTGTCGGCCAGGCGCAGTAGCTCACGCCTGTAATCCCAGCA CTTTGGAAGGCCAAAGCGGGCAGATCACTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAA ACCCCGTCTCTACCAAAAATATAAAAAATTAGCTGGGTGTGGTAGCGCATGCCTGTAATACTAACTACTC GGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCAAGATCACACCACT GCACTCCAGCCTGGGCAACAGAATGAGACTCCGTCTCAAAAATAAAAGAATACCAAAGAAGGCCGGGTGT GGTGGCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCGAGGCGGGTGAATCACCTGAGGTCGGGAGTTC GAGACCAGCCTGACCAACATGGAGAAACCCTGTCTCTATTAAAAATACAAAAAGTTAGCCAGGCGTGGTG GCGCATGCCTGTAATCTCAGCTACTCAGGAGGCTGAAGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGG TTGCGGTGAGCCAAGATCATGCCACTGCAGTCCAGCCTGGGCGACAGAGCAAGACTCTGTCTCAAAAAAA AAAAAAAAAAAAAAAGTGTTTCTGTGTTGCATGTATGGGCAATCACACATTTTTAAAGAATAATTCATAT CATTTCCCAGATCCTCATAGGGGTCTGTAGCCCAAAAAGGGTTAAGAATCACTCCTTTTAGAACATCTGG CTCAAGTGTGGAGTTCTGGGAGCTTTGCTTTGGCTCTGCTGCTGATCTGGGATAATGTGGCCCTGGCCAA GTCAACCCAGCTGTCACCAAACACCTGCTCTGTGCCAGACAATGTGCAGGGGCTGGGGACAGAGATGTGA AATCCACAGGCCTGACCTGAAGGAACCCGAGTTGTAATGGGGGATAGACATTTATATTGGGGTAAAGGTG AGCAGCCTTCAGTCCTGGACACGTGTTTAGAAGGAAAATAGCACAAGGATCAGAGGAAAATACCTCGATA GAGGTGAGAAAATAAGGCGGGACCCTCTAATATTCATTGGACATCTGTGCACAGTACTGTGGTAGCCCCT TTCACATAGTTTACATTCCTGGAATCTTCAAAAGAATTTATAGAATTGCTCTTACGCCTTTTTTTATTGA TGGAATAAAACAGATAAGAATACCAAAGAAGAGGCTGGGTGCGGTGGCTCACGTCTGTAATCCCAGCACT TTGGGAGGCCGAGGTGGGCAGATCATGAGGTCAGGAGAGCGAGACCATCCTGGCTAACACAGTGAAACCC CGTATCTACTAAAAATACCAAAAAATTAGCCAGGCATGATGGCGCCACCAGCTACTCGGGAGGCCGAGGC AGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCCAGCCTG GGCGACAGAATGAGACTCCGTCTCAAAAAAAAAAAGAATACCAAAGAAGGCTGGGTGTGGTGGCTCACGC CTGTAATCCCAGCACTTTGAGAGGCCGAGGCGGGTGAATCACCTGAGGTCGGGAGTTCGAGACCAGCCTG ACCAACATGGAGAAACCCCATCTCTATTAAAAATACAAAAAGCCGGGCGTGGTGGCGCATGCCTGTAATC TCAGCTACTCAGGAGGCTGAAGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGTTGCGGTGAGCCGAGA TCACGCCATTGCACTCCAGCCCGGGCAACAAGAGCGAAACTCCGTTTCAAAAAAAAGAATACCAAAGAAA ACAAGAGGGAAGTTCAAGGAGGAAAAAGTGATCCCCAGTGTTCAGTGTGCAGGCAATTGAGGGGAAGGAA GTGGCTTCTGTATCAGGCAGTAGGCTCATTGCTGACAGTGCTTCCACCTGGGGATGCTCAGTCCTAAGTG TATTTTAAAACATTAGCATGGATGCCAGGCACAGTGGCTCACACTTGTAATCTCAACATGTTGGAGGCCG AGGTGGGAGAATCACTTGAGCCTAGGAGTTCAAGACTAGCCTGGGCAATATGGCGAAACCCCATCTCTAC AAAAATTAGCTGGGCATGGCACCTATAGTCTCAGCTACTTGGGAGGCTGAGATGGGAGGATCGCTTGAGC CCGGGAAGGTCGAGGCTGCAGTGAGCTGTGATTGTGCCACTGCACTCCAGCCTGGCCAACCAAGGGAGAC CTTGTCTCAAAAAAAAAAAAAAAAAGTTCAGCATGGAAAGGCCTTCAGGAGGCAGAGTAGCTGGCAGCTC TGGAGTCAGGCTTGCCCGAGTAAAAGCGCTGCTGTGATCTCTTATACCCAGTGACCTTGGGCAAATTACT TGCCCAGGCTTCAGCTTCTTCATCTATAAAATGGGGATAATGATCCCACCAGCTTACAGGCTATTGTAAG ATCTGAATAACTAATGCTTAGAAAGGGCTTTACCGGTGCCTGGGAAATGATAAGTGGGCATTAGATCTTA GTTCTCATGAATATCCTCATCGCAGTCCAGCCCCCTCATTTTACGGATGAGGAACACGGAAGTTCAGAGA GGAGGGGTGGCCAGACGGGCAGCCAGCTTGGCCTGGAAGGCTGGGCTGCTTTCTCCTCTGGCACCGACTT CTAAAGCACCTTGTATTTTGAAGTATCTCCTCCCACCTCTTTGGTCTGGGTGGTTGGAAATATTTTTAGC ATGGACGGGACACTCTAAGAGGACTTACAGATTTCTGCAAAGTTAAAGCCAAGTTTCCCCAACTCTTTTG GATCACAGCCCTGTTAATATCTCAGTCATTGTTTCAGGGCAACCCAGGCCAAAACAAATACCCAACAGTT CTGTTTATGAAGCAGTGAGGTCGAATAATAAGTCTTTATCCTAACAACTTAGTAGCCATTTGAAAAGCGT GACATAAGTTGAAAGAAAAAGGGTCCTTCCATTTCCAAACCGCCAGATTATTAACGGGATGTATGCCTTG TTGCACATCTCAACCCTTGAAATCAGATAGGACACCACCACCTTCATATCCCACATTTTCTCCTTGAAGT ACTTTTAATCACAGTGACCTGCAAAAACATAGCTTCATAGAGATACATTATCAAAGGGAATGTCACGTGC GTGATCGTACTTTGAAGCTGAACTGTCTCGAGCGAGTAGTTCACGCGGTGTCCTGCAGATACTGCGGTGG CCGTTTCCCTCAAATGTCAGATATCCATTTGGCGCCCTTCTGAGTTATCTGCAGTGCCCCGGGGTGCCTC AGCTCAGTTTGGGGGTGGTTAGGCTGAAGACATTTGCTAACAAGTCCTGTTGTTGAATTAGTTCCAACTC AGGTTCAGAGGCTTTTTAGAGCTGGAAACACTGGCAGAGTCAAAGTTCATGGGAGGTGATTAACCAAACC AGATATTAGGGAACCAGAAGGGCGACATTTTCCACTGATAGGCAAAAGTCCAAAAACCCCACAGTGTCAG GGCTGTTTGCCAAGTCAGCAAGTCTGTGAAGATCGCTTCCAAGCTGGTTCTGTTACTGCCAGCGCCCCCT GGCGATGCTACTCAAGGCTTACTTGAGAACCATCAGCAGCTAGGAAGGAGGACAAGTCTACTAAGCGGGG AGGGGGGAGGAATAGCATTAGGAGATATACCTAATGCTAAATGACAAGTTAATGGGTGCAGCACACCAAC ATGGCACATGTATACATATGTAACAAACCTGCACATTGTGCACATGTACCCTAAAACTTAAAGTATAATA ATAAATAAAATTAAAAAAAAGAAGAAGAAGCCTAAGAGGCCGTGCGCAGTGGCTCACGCCTGTAATCCCA GCACTTTGGGAGGCTGAGGTGGGCGGATCATGAGGCCAGGAGTTCAAGACCAGCCTGGCCAACGTGGTGA AACTCTGTCTCTACTAAAAATACAAAAATTAGCTGGATGTGGTGGCACGTGCCTGTAATCCCAGCTACTC AGGAGGCTGAGGCACAAGAATCGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCTGAGATATCACACCA CTGCACTCCAGCCTGGTGACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAGAAGTCTAA GAGGCCGGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTAGGCGGATCACCTGA GGTCAGGAGTTTAAGACCAGCCTGACCAACATGGTGAAACCCTGCCTCTACTAAAAATATGAAAAATTAG CTGTGCATAGTGGCAGGTGCCTGTAATCCCAGCTACTGGGGAGGCTGAGGCAGGAGAATTGCTTGAACCC AGGAGGCGGAGGTTGTAATTAGCTGAGATTGCGCCACTGCACTCCAGCCTGGGCGACACAGCGAGACTCT GTCTCAAAAAAAAAAAAGGTCTAAGTCAGTCTAAGTATCAGCTTCTCTGATGTGAGCTGGAGGAATTGGG GAGCTAGCACTTCCTGAGTGCCCACTGGTTGCCAGGCCTGGTGTCAGTTACCATCCTTCCAAATCCTTGC TCTACCCAGGAGCAGATACCACCGTCCCTGCTGTTTGCATGTGGAAATATGTGGATGGGAAGTCTGCTGC CTTGTTTTAAAAGGCGGAGCCAGGATCTAAGCCCAAGATGTTTATATCCAAGGCCTATTTCCTCCCACCA AGTTGCTGGTCCCTGCAGAAAGGAGTGGATGATCCCGGACCTGCCATTTGGCAGTGGGAGTGGCCTTGGC CACTCCCCAGAAGCCTCCTCAGAAGCCTCCTTAAGTTCCCAGATGCTGGGAGACAGCTGCAAACAGAATA AACACTGCTCTGTCTATGTGGATGTTTTAGTCCTCCGGGAAAGAAAAGTGTTGAGGCCGGGCATGGTGGC TCACGCCTGTAATCCTAGCACTTTGGGAGGCCAACGCAGGCAAATCACAAGGTTAGGAGTTTGAGACCAG CCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAAATACAAAAATTATCTGGGCCTGGTGGCGCACAC TTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCGGGAGGCAGAGGTTGCAATG AATAGAGATCACGTCACTGTACTCCAGCCTGGGCGACAGAGCAAGACCTCTGTCTCAAAAAAAAAAAAAA AAAAGAAAAGAAAAGAAAAAAAAATGCACCCGATGGAGTCCAAATCTTGGTTCTTGACAGTCAGATAAGT CAAAAACCCAGCTTCTGAGAGTAGACATGGATGTTGATAAGCAAAAGGTCCCACATCCTAGAAATTGCCC AGAAATTTAGCTGGAGGAAAAAATGTTCTGCGTTTGGCAGATTTGAGGGCGGACAGCGTGCCAGCAGCCA GGATGACGAATGTAGGGGGTTTTTTGTTTTTTTGTTTGTTTTTTTGTGGGTTTTTTTTTGTTTTTTTTTT TTGAGATGGAGTCTCACTCTGTCGCCAGACTGGAGCGCAGTGGTGCGACCTCGGCTTATTGCGACCTTGG CTCATTGCAACCTCCGACTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTAC AGCCACGTGCCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCGCCATGTTGGCCAA GATGGTCTTGATCTCCCGACCTCGATCTCCTTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGAGATTAC AGCCATGAGCCACCGCGCCCGGCTGGAATGTAGTGTTTTGTTTTGTTTTTTTAATTTTTTTTTTTTGAGA CGGAGTCTCACTTTGTTGCCCAGGCTGGAGTGCACTGGCGCAATCTCAGCTCACTGCAAGCTCCGCCTCC TGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCGCCACGCCCA GCTAATTTTTTTGTATTTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTG ACCTCGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTATAGGCATGAGCCACTGCGCCCGGTGC GGATGTAGTTTTTATGTGGCTGTTTTTGCACACAGGCAGCACTCCAGAACTTTAATTAAGTACAAGAAGT TGCTCCTGATACCAAGGGCACGGGATACACAATTTAGCCTCTGAGGGTCCAGCAGGCCCCCCAGGCCCCT GCATCACCACTGGAAACAGCAGCAGCCTCTGTGTGTGGAGCACTAGGGTGCTGACAGGATGCCAGGGACC CAGCTCTGGTCCCCTCACCCTGTCTTAACAGCTGCCTCTGGGCCCTTGCAGGTGCGGCTGGAAGTATTTC GGGCAGAGGAGCTGATGGCATGTGCAGGATTGACCTCACCCAGAATTGTCCCTTTGTATGGAGCTGTGAG AGAAGGGCCTTGGGTCAACATCTTCATGGAGCTGCTGGAAGGTAAGGAGCCAGGTCCCACTCTTTCTCCA AATTCAGGGCCAAGAGTTCCCCCCTGAGTCTTGCCCAAGTTGGCCTTGGTCACTGATCTATCCATTGTTA ACCTCTTGACCCTGTGACCCTGCTTTCCACTGCCTGCCCTGTGCTCTTGCCCTTGGCTGGCATGGAGGCT CGGGCAAGTCCCATGTATAGCCTGGCCTTTGGTCTCCTAGGTGGCTCCCTGGGCCAGCTGGTCAAGGAGC AGGGCTGTCTCCCAGAGGACCGGGCCCTGTACTACCTGGGCCAGGCCCTGGAGGGTCTGGAATACCTCCA CTCACGAAGGATTCTGCATGGGGACGTCAAAGGTAAGGCCCAGGCCCCACGGCCCTGATCCCCAGCAGGC TCTTCTCTCACACCATCCTGTCTGATCTCCTCTCAGTTCTGGGCTAGCCTGGTCATCCCCAGTAGCAGGC CCTGAGTCAGGCTGACAGGACTGTGCCTGTAGGAAGGGGAATGATGTTCTCCAACCCCTTAGCCAAGCAC TGTAGTTTCTGGTAGACGGTGGCCACAGAGAACCGAAGGTCAAGCTCCCACCCACTGGTGACCCCTGGTA TGGGGTCGGCGCAGGCGAGCAGAGTGGCAGCGTTCCCGAGTAAACCCTGCTCCTGTCCCTTTGCCCTCAG AGATCCTGCCTACCTCTAGCCTGAATTGATACCCTCCTCCCTTCCTCCACGATTAATGAAACTAATCAGA AGCAGCAGCTGCCACGTAGGGTCAGCCAGAAAATTACATCACTGGAGGGCAGGCCAAACCGAGCCAGGGT GGGCTGGGACCCGGCATGACTCACCTGTTCCTCTTCCTCCCCGGGGCGGCCTGGCAGCTGACAACGTGCT CCTGTCCAGCGATGGGAGCCACGCAGCCCTCTGTGACTTTGGCCATGCTGTGTGTCTTCAACCTGATGGC CTGGGAAAGTCCTTGCTCACAGGTAAGGCCCCCCACCAACTGCCGTGCCCCCCAATGCATTCATTCGCCA AATGCCTTCCATGCTTTCCAGAATGGGAATTGAGGTGTGAACACTTAGGTCCACCTGTGTGTTTAAGCCC CGCAACCAGCCTGGATGATTATCAGGGGTTTCTTTGTTACGCGTAAATGTGATAATAGATGTCAGGTGCT CATTGTCGATGCTCCTGTACACAGGGAAGAGAAGGGAAAGGCTGGTTGACTCTCCGTAGGTCCCAGGCCT TCTGCCTTGGAGTCCCCGTGGCTCCTACCTCTTGTCTGGCCTTTGCAGGGGAGTGCACTGCCAGCCTGTG ACCCCAGCTCTCCTGCGCCTCTGAGCACGGTTGGCTGGAAGCACAGTGGGCAGGCTGACCAAGGGGCCTG GGCTCTAAAGTCAGTGAAATATCTTTCTTTAACTCCTCTGATTATTGAAATAATCCATGCCCACTGTGAA GTATAGAGTTAAGCATATAAAAGAGGCAGAGAACAGAATTCTCACCATGTCTCTTACCCAGAGAGAGAAT CACAAATTTTTTTGTTGTTTTCATTGAGACAGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCAC AATCTCAGCTCACTGCAACCTCCTCCTCCCGGGTTCAAGTAATTCTCCTGCCTCAGCCTCCTGAGTAGCT GGGATTACAGGCGCCTTCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGGGACGGGGTTTTGCCATA TTGGCCAGGCCAGTCTCAAACTCCAGACCTTAGGTGATCCGCCCCACTCAGCCTCCCAAAGTGCTGGAAT TACAGGCATGAGCCTCCGTGCCCGGCCGAATCATGAATATTTTAAATAACTCCTTCCAGGCTGTTGTTTT CCCTGTGCCTAGTTAGGGCCATTATAACACAATTTTGTGCCCTGCGTTTTTCATGTATAGCCTTAAGGAT AAAATGATTTCATTTTGACCAACGGAAAAAGAATCTTTGGAAGTATATGATTGTGTGTTGTTAAAGGACT ATGTTGGCAATTCTGAAGATGTAAATTGAATGTGGACACTTGACCTCCACCCGTGTTGTTTTAAGCCCTT TTAAAATAACTGTAGTGGGCTTTTTCTTGTTACAAAAAAAAATGTATCTTTTCTGATTCTTTTTAACTTT TATTTTTTAGAGACAGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTAGCTCACTCATAGCTCACTGC AGCCTCAAGCTCCTTGGTTCAAGCGATCCTCCCACCTCAGCCTCCTGAGTAGCTGGGACCACAGCATGTA CCACCATGTCCGGCTCAATTTTTATGTTTTTTGTAGATATACATGGGGTCTCAGTATGTTGCCCAGGCTG GTCTTAAATTCCTGGATTTAAGCATTCCTCCCACCTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAG CCACTGCCTGACCCTTTTTTCTAATATCTGTTGAAGAAAGTAGAGCTAAGCAAAAATTACAAATACAAAT CACCAGGAAAAAAACCACTGTTCACATCTGCCATCTATCCTTTCAGTCTTTTACGCATATAAGTTTTCTA TTACAATTTTTAAATTTCACTTACTAGTATTTCTTACTAGTAAGAAGTATTACTTACTGGTATTACTTAC TAGCCTTCTACAACCTAATTTGTAATGTCCAGCCCCTGCCCCATTTTTAAAAAACACTTTAAGGGTTTGG TCCAAAGGGCAGAGTCCACATCATGGATGCTCTGTTACTTTGTACAAGTTCCCAGCAGAGTCCCCGCCTA GCTCCTCCCTACAAGTCTGACTTGGAGACTTTATTTCTATATTTAAAGTATTTTAACATGTCCGGGCACA GTGGCTCATGCCTGTAATCTCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACCTGAGGTCAGGAGTTCG AGACCAGCCTGGCCAACATGGGTGAAACCCCATCTCTACAAAAACATAAAAATTAGCTGGGCATGGTGGC TCATGCCTGTAATTCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCTCTTGAACCCGGGAGGTGGAGGTT GCAGTGAGCCAAGATCGCGCCATTGTACTCCAGCCTGGGTGACAGAGCAAGACTCCATCTCAAAGAACTA AAAAGATAATAAAATAAAAAGTACTTTAACAGTGACAAATGTAAGATACCCCGAGGATTAACCAGGGTGG CCATTGCCTAGGCTCCTGCCCATCAGCATTCCAGGTAACTTTATGTCTCATCCCCCTTCTCAGGGGACTA CATCCCTGGCACAGAGACCCACATGGCTCCGGAGGTGGTGCTGGGCAGGAGCTGCGACGCCAAGGTGGAT GTCTGGAGCAGCTGCTGTATGATGCTGCACATGCTCAACGGCTGCCACCCCTGGACTCAGTTCTTCCGAG GGCCGCTCTGCCTCAAGGTCGGTGACGGCACCCAGCATGGCCAACAGGGGGAGCTGCAGGGCCCTGGGGC CCAGGCTGCAGGCTGGAGGGGCTGCTCTGCGGTGGCAGATGGAGCAAGGGGAGGCCTGGTCATCCATGTG GGATCCTAATTCAAATACTTGCCACCCAAATCTGGGGGTACAAGGGGAGATCCAGCTGCGGAGGCTCACC AAGTTCATGGCAGGTGAGAACTCTCTTCTGTCCATACCCTGGGCCCCATCCACCTGCCTCCTAACGGGCC GGGCCTGGAGGCTGTGGGCGTCTTGCTGCCTGGCTCTGGCCTGTTTTACTGGCTCCATTTGTCCCTTTCC TGGGAAAAGTGCCCTCACTGTAGCCCAGACCCCTCCATTCCTTGTGGTAGACCCCAGCACAGCGGGAACA GGGGCCGGCGGGAGTTGCGCAAAGAGCAATAACAGCCGGGTATCAGGAAATGAGGGAAGGCAGGCCTCAC CTGTTGTCTTTTGCCCCCCAGATTGCCAGCGAGCCTCCGCCTGTGAGGGAGATCCCACCCTCCTGCGCCC CTCTCACAGCCCAGGCCATCCAAGAGGGGCTGAGGAAAGAGCCCATCCACCGCGTGTCTGCAGCGGAGCT GGGAGGGAAGGTGAACCGGGCACTACAGCAAGGTAGGAAGAGCCCCACGCTGGCTGACCCGGGGGGCAGA AGACAGAGGTGGACAGAGGAGGCAGGTGGGCGCAGGTCCAGAGCAAGGCACCCCTCAGAGCCTTAGTTTC CCCCTCTGGATTATGGGGGTGCAGCAGCCTCAGGGTTGTTGGGAGATTGCGACAGTGCCACGCCTGGACC CAGAGGCAGCGCTCAGGAGATGGGAAAGAGAAAACTCACACGCAAACTCGAAGTGCTTTTTCCATTCTCC CACTCAACTACAATCAACCCAGAAGACTCCTGTGACCACATGTGTGGGGATTTCCACCCCACCAAGCCAG CAATCAGTTCTGCAGCAGACACTAGCTTGGTGTCCTCTAATTCAGTTCTGTTCCAACACTATCTACCTGG AGGTAGCATCAGATCCCACAGCAGGAGGGCTCGATCCCCAAGACTGCACCCCCTAGCCATGCCAGTCTCA GGCCCACGTGTTTACCTGTGCTTCTGACCAACTGGCTATAAGTCAGGGACCCCATGACCCCCTCCTTGGG ATTGATTAATTTGCTGGAGTGGCTCACAGAACTCAGAGAAACACTTCCTTACATTTACCAGTTTATTAGA AAGGATATTACAAAGGATACAAATGAAGAGATGCATAGGGCAAGGCATGTGGGAGGGAGCACAGAGCTTC CAGGGCTTGGCACCCTCCAGGAACCTCCATGTGCCCAGCTACCAGAAGTTCTCTGAACCCGGTCTTCTTG GGTTTTTGTGTAGGCTTCATTACGTAGGCATGATTGAATAAATCACTGGCCATTGGCGAACCGCTTAACC TTTAGCCCCCTTCCCTCCCAGTACGTGGGATGGTGGGATGAAAGTCCCAACCCTCTAATCCTGCCTATGT CTCTCTGATGACCAGCCCCCATCTTGAAGCTACCTAGGGGCTGCCAGCCTTCAGTCAATCCATTAGTACA CAGAAAGAGATCATTTTGGAGAGTAAGGCTTTTAGGAGTTCTGTGCCAGAAATGGGGTTAAAGATAAAAT ATATGTTTACTAGTATCATAAGGGTTATGATGTATAGAGGGGGCTCAAACTCACTAGGAATCCAAGAATA CAAAATAAAGACAGGCCGGGAGCAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGGGGCAGGA GGATCGCTTGAGGCCAGGAGTTCAAGATCAGCCTGGGCAACATAGCAAGACCCTTTCTCTGCAAAAAAAT TTAAAAATTAGCCAGGCATGGTGGCACATGCGTGTAGTCCTAGCTACTCAGGAGGTGAGAGGATTGTTTG AGCCTGGAAGGTCGAGGCTGCAGTGAGCCATGATTGCACCACTGCACTCCAGCCTGCGCAACAGAGACCC GACTCAAAAAATAAATAAATAAATAAAGCCAGGTAACACTCAAGAGCCATTTGACTGGAAAAAAGCAGAA AGTTGGTGGGATGTAGGGCTGTTGGGACCCCTCAGGTGCTGCTGATGGGCATGTGGACAAGGCTACCCAC TCTGGGGGGGCACCTGGCTGCACTCAGGCAGACGTCTGCAGACTGAGACCAAGGACTTCTACCCCTGGGT GCACTGACAAACGAATGCCAGCAGATCCATATGGGGACACGCCTGAGGACGCGCACTACAGCTTCCTTTG TGGGAGGGGAGTAGGGTACGATGGGGTCCCTCACTGGGAGGACAGAGACACAAAAGGGGATGCCTCATGG AGCACCAAGCAGTTAAAGCAACTCGGCGTTCACAGAGCAGCATGGATGGATCCTAAAGCCATGGTGCCGA GTGAAAAGAGAACCCGACACAGAATGGGACCCAGAACATAATGCCTGTTTGGTAAACTAAAAATTGATCA ATAGCCAGGTATGGTGGCGCACATCTGTAGTCCCAGCCACTCAGAAGATTGAGGTGGAAGGATCGCTTGA GCCCAGGAGTTGGAGTCCAGCCTGGGCAACATGATGAGACCTCATCTCTTTAAAAAAATAAAAATAAAAA TAAATTGATAAATAAAACAACGCACATTTTGCAAGGACACAACCAAATCAAAAATGACACATCAAACATA ATAGAATGTCACCTGAGGGATGGGCACAAAAAAGGCTGTGATTATAGGAATGAAAATGAAATAAAGAAAA CCAGAGAGATCTTGCACCTCACCAAAGACAGCTGGTAGTTATAAGGATGAGGGTGGTCCCAGGGCTGAAC TAGCCCCATGCCAGAACAAACGGTGCCTGGGGAAGTACCGACTGAGGATGGGGTAGGAGAGATGGTGGGT CCAGGATGCCACTTTGCCTGGGAGCTCTTGAGTTGGTGTAGCCCCAGGGCTGTTTTCAATCTTCTCTTTC TTGTTAACAAAGTCCTCTGGAGCTGATTCTGTAGTTTTTGAATTTGCTACTGATACCTAGAAGAAAAACA GAATCAAAGACAGAAATCCAGTCCTATCCCTGTCATATTGGGACCATTTTATTGAGGAAGTCTCCTGTGG AGACCACCATGCTGCCCTCTGGAGCCACCTCCCATGGTGGCCCGGGGCAGTGTCCTCCCCTTTGTTTGCC TCTAGCCCTTCTGCACTCAGGAGAGGCCGCTCCTGCCTGGACCGCTGTCTGTGCACAGCACGCTTCCCCT CACCATTGTACTCTCTGTTTTCTAGTGGGAGGTCTGAAGAGCCCTTGGAGGGGAGAATATAAAGAACCAA GACATCCACCGCCAAATCAAGCCAATTACCACCAGACCCTCCATGCCCAGCCGAGAGAGCTTTCGCCAAG GGCCCCAGGGCCCCGGCCAGCTGAGGAGACAACAGGCAGAGCCCCTAAGCTCCAGCCTCCTCTCCCACCA GAGCCCCCAGAGCCAAACAAGTCTCCTCCCTTGACTTTGAGCAAGGAGGAGTCTGGGATGTGGGAACCCT TACCTCTGTCCTCCCTGGAGCCAGCCCCTGCCAGAAACCCCAGCTCACCAGAGCGGAAAGCAACCGTCCC GGAGCAGGAACTGCAGCAGCTGGAAATAGGTACGGGCAGCCGTGGCTGCAGTGGGGCCCTGAGCACTGGC CCTGGGCCACCCGCGGAGGCCGGTGTTTCTCTTTACCTGCGGTGTGGGCTTTCTTCCAGCCCCTTCCCCA GCAGCTCAGCTTCTACCGACTGTGCAGGAAGAACCCCTGAAAACACAGCCAGCCTCCTCCCAGTCTTTCA CAGCCATCTTCCACTTTTCCCTGCAGAATTATTCCTCAACAGCCTGTCCCAGCCATTTTCTCTGGAGGAG CAGGAGCAAATTCTCTCGTGCCTCAGCATCGACAGCCTCTCCCTGTCGGATGACAGTGAGAAGGTGAGTC GGTTGTGGCCCCGGAGCCATGGCTCCAGGGGTGTGGTTTTCCCGGCCCTGGCACAGAGCAAGTAGCTTTG CGTCCAGCTAGTGAATGGACACTGTGCAAGTAGTGGGTAAAGGGAGGGTGATGGGGGTCACCCCTTCCTT CTGGTGGGGGTCCTCACTAGGTTGGGGGAGGTGGTCATGGTTCAGAGTCAGAGAAACCATGGGAATCTAC CCTTCTGGGATTAGGGAATGTGTTTTGCCACCAGAGATAATGGGGAGGCAGGCCTTCGTCCCCCATGGAG GCAACCCTTACCCTCCTCCAGCTGAGGGCATGAGCAGTGCCCCTTTTCCCCAAATGAGACCCAAGCCGGA GATGGATCCTGGAGCCCAGGGCCCTGAGCCCGTACCCAATCCTGTTGTTTCAGAACCCATCAAAGGCCTC TCAAAGCTCGCGGGACACCCTGAGCTCAGGCGTACACTCCTGGAGCAGCCAGGCCGAGGCTCGAAGCTCC AGCTGGAACATGGTGCTGGCCCGGGGGCGGCCCACCGACACCCCAAGCTATTTCAATGGTACAGTCCAAT TCCCACCTGCTCAGCAGTCCCCGTGGCAGCTGATCTGCCTGGAGCTAGACAGCCATTGAGGGATTTTGTC TCCCCTCCTCTGGCACAGTGGGAGGGAGGAAGGCGCCTGGTCCCAGAACTTGAGGTTCCTGGCCAGTAAG TTGGGTTTCAAGCAAAGGTCCCAATCACCCATGAGCCTTTCCTGATGGGGCAGTGAGGGACCATTATCCC CTCATTGTCAGTTGATGGAGTCCCAGAAGGTTCCCCTAGCTTGGGGAGGAGAGCAGTCTCTTGACCTGGA GTCAGGAAAATGAGCAATTAATCTCTTCTAAAGGGAAAAGGAACAGGACCCATGAGCATTTTAATCAAAA ACTCAGCAAAAGGAATCCCCCTCTGGGATTTGAGGTCAGATGAGAAAGACAACATAAAATTCCTTCGTTT TCAAGCTTGATTGCATAGGTTATGATGTGGCTTTGCTACAACAAGGGCATCATCAGCTTGGAGTTCCCTG GCCCTCTCCAGGGCAAGTGTGACTCATGGCATCAGGGCCCCATGGCTGGCCAAAGGCCACTTCAACTCAG GCAACAATCTAAATTGCCCATAATCTAATTTAAGAATCCTTGTGTTCAGTTCCTTTCTGCTTTGCATCCA AGTTGAAATACTACTTCCCCATAGGAGCCAGCCCCAGCTCTTAGCAATGCACAGGCCAAATCCCAGGTGC TGACGGCCAGGAAGAACTAGCAGGTGTATATAATATGAGGGCTGTTCCAGCCTGAATTTTTTTTTTCTTA TAAAAATGCAGCTTTGTGACCAGGTGTGGTGGCCCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGC AGGTGGATTACATGAGGTCAGGGGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAA AATACAAAAATTAGCTGGGTATAGTGGCGCATGCCTGTAATCCCAGCTACTTGAGAGGCTGAGGCAGGAG AATCACTTGAACCCGGGAGGTAAAGGTTGCAGTGAACTGAGATCACGCCACTGCACTCCAGCCAGGGCGA CACAGTGAGACTCTGTCTCAAAAACAAAAAAATGCAGCTGTGCTTAGACCAGCCTAAATTTTATCTCTGC TGCTCCATCACAGCCAGACCTGCTCCCCCTACATAGGGCAGAGTGACTTTTAACAAAAACGTTCCCCCAG CCCCTGCCAGGACCCTGGTCCTTGGGGAGCCAGCAGCCGCTCTCCTGACTATCACCTTGTCCGCCTTCTA GGTGTGAAAGTCCAAATACAGTCTCTTAATGGTGAACACCTGCACATCCGGGAGTTCCACCGGGTCAAAG TGGGAGACATCGCCACTGGCATCAGCAGCCAGGTAAGGGGGGCAGGTACACTCTGACGGGCAGAGTCCCA GAAGCCAATGCAGCTGGCCCCACCCTCCAGGAGGAAAGCTTTCAAAGAAGTAGAATGGCACTCTAGGGAA TACTTGGAATTGGCCTTCAACGTCCCCCAGGACCTCAAAGCATTTCCCAGGGCCTCAAAGCAAGGCTGGC AGTGGTGACAAAGAGGTCCTCCAGACCTACACTTGAGCCGGGTGGGATTCTCTGAGTCCCGTGGAATGAC AGACAGGCAGTGCCCTTAGGGCTGCCGGTCTGGCTGGAAGGAGATGTCTTTACCTTTCTACATGGCTTGA GCCCTATGCCATGATCTCAGCCCACTGGTTTGCTCCACCCTTAGATCCCAGCTGCAGCCTTCAGCTTGGT CACCAAAGACGGGCAGCCTGTTCGCTACGACATGGAGGTGCCAGACTCGGGCATCGACCTGCAGTGCACA CTGGCCCCTGATGGCAGCTTCGCCTGGAGCTGGAGGGTCAAGCATGGCCAGCTGGAGAACAGGCCCTAAC CCTGCCCTCCACCGCCGGCTCCACACTGCCGGAAGCAGCCTTCCTGCTCGGTGCACGATGCTGCCCTGAA ACACAGGCTCAGCCGTTCCCAGGGATCTGCCAGCCCCCGGCTCAGCAGTGGGACCAGGGCCTCGCAGCAG CAAGGTGGGGGCAAGCAGAATGCCTCCCAGGATTTCACACCTGAGCCCTGCCCCACCCTGCTGAGAAAAC ACTCCGCCACGTGAAGAGACAGAGGAGGATGGCAGGAGTTACCTCGGGAAACAAACAGGATCTTCTCTGC CCTGCTCCAGTCGAGTTGGCCTGACCCGCTTGGATCAGTGACCATTTGCTGGCAGACAGGGGAGAGCAGC TTCCAGCCTGGGTCAGAAGGGGTGGGCGAGCCCCTCGGCCCCTCACCCTCCAGGCTGCTGTGAGAGTGTC AAGTGTGTAAGGGCCCAAACTCAGGTTCAGTGCAGAACCAGGTCAGCAGGTATGCCCGCCCGTAGGTTAA GGGGGCCCTCTAAACCCCTTGCCTGGCCTCACCTGGCCAGCTCACCCCTTTTGGGTGTAGGGGAAAAGAA TGCCTGACCCTGGGAAGGCTCCCTGGTAGAATACACCACACTTTTCAGGTTGTTGCAACACAGGTCCTGA GTTGACCTCTGGTTCAGCCAAGGACCAAAGAAGGTGTGTAAGTGAAGTGGTTCTCAGTCCCCAGACATGT GCCCCTTTGCTGCTGGCTACCACTCTTCCCCAGAGCAGCAGGCCCCGAGCCCCTTCAGGCCCAGCACTGC CCCAGACTCGCTGGCACTCAGTTCCCTCATCTGTAAAGGTGAAGGGTGATGCAGGATATGCCTGACAGGA ACAGTCTGTGGATGGACATGATCAGTGCTAAGGAAAGCAGCAGAGAGAGACGCTCCGGCGCCCCAGCCCC ACTATCAGTGTCCAGCGTGCTGGTTCCCCAGAGCACAGCTCAGCATCACACTGACACTCACCCTGCCCTG CCCCTGGCCAGAGGGTACTGCCGACGGCACTTTGCACTCTGATGACCTCAAAGCACTTTCATGGCTGCCC TCTGGCAGGGCAGGGCAGGGCAGTGACACTGTAGGAGCATAGCAAGCCAGGAGATGGGGTGAAGGGACAC AGTCTTGAGCTGTCCACATGCATGTGACTCCTCAAACCTCTTCCAGATTTCTCTAAGAATAGCACCCCCT TCCCCATTGCCCCAGCTTAGCCTCTTCTCCCAGGGGAGCTACTCAGGACTCACGTAGCATTAAATCAGCT GTGAATCGTCAGGGGGTGTCTGCTAGCCTCAACCTCCTGGGGCAGGGGACGCCGAGACTCCGTGGGAGAA GCTCATTCCCACATCTTGCCAAGACAGCCTTTGTCCAGCTGTCCACATTGAGTCAGACTGCTCCCGGGGA GAGAGCCCCGGCCCCCAGCACATAAAGAACTGCAGCCTTGGTACTGCAGAGTCTGGGTTGTAGAGAACTC TTTGTAAGCAATAAAGTTTGGGGTGATGACAAATGTTTCCAGGCCA    Download   Select all
Length	53946
OMIM ID	604655
HGNC ID	HGNC:6853
Unigene ID	Hs.404183
Ensembl ID	ENSG00000143627
PharmGKB ID	-

mRNA Information

mRNA ID	NM_003954.4
Exon	join(1..105,26300..26575,27760..27829,29701..29911, 30020..30634,32116..32253,42472..42601,42811..42942, 43458..43562,45844..46007,46502..46652,49306..49659, 49867..49973,50384..50528,51802..51902,52265..53946)
mRNA Sequence	>9020 GGGGCGACCACGGGCCGGGAGCTCAGCGGTCGGCGGCCGGCGGCGGGAGATCGCGGGCGAGCGG AGCGCAACACTCGCTTGGTTGGGGAGATCGGCGCTTGGCCGGATGAGCACAAGCCTGGGAGATG GCAGTGATGGAAATGGCCTGCCCAGGTGCCCCTGGCTCAGCAGTGGGGCAGCAGAAGGAACTCC CCAAAGCCAAGGAGAAGACGCCGCCACTGGGGAAGAAACAGAGCTCCGTCTACAAGCTTGAGGC CGTGGAGAAGAGCCCTGTGTTCTGCGGAAAGTGGGAGATCCTGAATGACGTGATTACCAAGGGC ACAGCCAAGGAAGGCTCCGAGGCAGGGCCAGCTGCCATCTCTATCATCGCCCAGGCTGAGTGTG AGAATAGCCAAGAGTTCAGCCCCACCTTTTCAGAACGCATTTTCATCGCTGGGTCCAAACAGTA CAGCCAGTCCGAGAGTCTTGATCAGATCCCCAACAATGTGGCCCATGCTACAGAGGGCAAAATG GCCCGTGTGTGTTGGAAGGGAAAGCGTCGCAGCAAAGCCCGGAAGAAACGGAAGAAGAAGAGCT CAAAGTCCCTGGCTCATGCAGGAGTGGCCTTGGCCAAACCCCTCCCCAGGACCCCTGAGCAGGA GAGCTGCACCATCCCAGTGCAGGAGGATGAGTCTCCACTCGGCGCCCCATATGTTAGAAACACC CCGCAGTTCACCAAGCCTCTGAAGGAACCAGGCCTTGGGCAACTCTGTTTTAAGCAGCTTGGCG AGGGCCTACGGCCGGCTCTGCCTCGATCAGAACTCCACAAACTGATCAGCCCCTTGCAATGTCT GAACCACGTGTGGAAACTGCACCACCCCCAGGACGGAGGCCCCCTGCCCCTGCCCACGCACCCC TTCCCCTATAGCAGACTGCCTCATCCCTTCCCATTCCACCCTCTCCAGCCCTGGAAACCTCACC CTCTGGAGTCCTTCCTGGGCAAACTGGCCTGTGTAGACAGCCAGAAACCCTTGCCTGACCCACA CCTGAGCAAACTGGCCTGTGTAGACAGTCCAAAGCCCCTGCCTGGCCCACACCTGGAGCCCAGC TGCCTGTCTCGTGGTGCCCATGAGAAGTTTTCTGTGGAGGAATACCTAGTGCATGCTCTGCAAG GCAGCGTGAGCTCAGGCCAGGCCCACAGCCTGACCAGCCTGGCCAAGACCTGGGCAGCAAGGGG CTCCAGATCCCGGGAGCCCAGCCCCAAAACTGAGGACAACGAGGGTGTCCTGCTCACTGAGAAA CTCAAGCCAGTGGATTATGAGTACCGAGAAGAAGTCCACTGGGCCACGCACCAGCTCCGCCTGG GCAGAGGCTCCTTCGGAGAGGTGCACAGGATGGAGGACAAGCAGACTGGCTTCCAGTGCGCTGT CAAAAAGGTGCGGCTGGAAGTATTTCGGGCAGAGGAGCTGATGGCATGTGCAGGATTGACCTCA CCCAGAATTGTCCCTTTGTATGGAGCTGTGAGAGAAGGGCCTTGGGTCAACATCTTCATGGAGC TGCTGGAAGGTGGCTCCCTGGGCCAGCTGGTCAAGGAGCAGGGCTGTCTCCCAGAGGACCGGGC CCTGTACTACCTGGGCCAGGCCCTGGAGGGTCTGGAATACCTCCACTCACGAAGGATTCTGCAT GGGGACGTCAAAGCTGACAACGTGCTCCTGTCCAGCGATGGGAGCCACGCAGCCCTCTGTGACT TTGGCCATGCTGTGTGTCTTCAACCTGATGGCCTGGGAAAGTCCTTGCTCACAGGGGACTACAT CCCTGGCACAGAGACCCACATGGCTCCGGAGGTGGTGCTGGGCAGGAGCTGCGACGCCAAGGTG GATGTCTGGAGCAGCTGCTGTATGATGCTGCACATGCTCAACGGCTGCCACCCCTGGACTCAGT TCTTCCGAGGGCCGCTCTGCCTCAAGATTGCCAGCGAGCCTCCGCCTGTGAGGGAGATCCCACC CTCCTGCGCCCCTCTCACAGCCCAGGCCATCCAAGAGGGGCTGAGGAAAGAGCCCATCCACCGC GTGTCTGCAGCGGAGCTGGGAGGGAAGGTGAACCGGGCACTACAGCAAGTGGGAGGTCTGAAGA GCCCTTGGAGGGGAGAATATAAAGAACCAAGACATCCACCGCCAAATCAAGCCAATTACCACCA GACCCTCCATGCCCAGCCGAGAGAGCTTTCGCCAAGGGCCCCAGGGCCCCGGCCAGCTGAGGAG ACAACAGGCAGAGCCCCTAAGCTCCAGCCTCCTCTCCCACCAGAGCCCCCAGAGCCAAACAAGT CTCCTCCCTTGACTTTGAGCAAGGAGGAGTCTGGGATGTGGGAACCCTTACCTCTGTCCTCCCT GGAGCCAGCCCCTGCCAGAAACCCCAGCTCACCAGAGCGGAAAGCAACCGTCCCGGAGCAGGAA CTGCAGCAGCTGGAAATAGAATTATTCCTCAACAGCCTGTCCCAGCCATTTTCTCTGGAGGAGC AGGAGCAAATTCTCTCGTGCCTCAGCATCGACAGCCTCTCCCTGTCGGATGACAGTGAGAAGAA CCCATCAAAGGCCTCTCAAAGCTCGCGGGACACCCTGAGCTCAGGCGTACACTCCTGGAGCAGC CAGGCCGAGGCTCGAAGCTCCAGCTGGAACATGGTGCTGGCCCGGGGGCGGCCCACCGACACCC CAAGCTATTTCAATGGTGTGAAAGTCCAAATACAGTCTCTTAATGGTGAACACCTGCACATCCG GGAGTTCCACCGGGTCAAAGTGGGAGACATCGCCACTGGCATCAGCAGCCAGATCCCAGCTGCA GCCTTCAGCTTGGTCACCAAAGACGGGCAGCCTGTTCGCTACGACATGGAGGTGCCAGACTCGG GCATCGACCTGCAGTGCACACTGGCCCCTGATGGCAGCTTCGCCTGGAGCTGGAGGGTCAAGCA TGGCCAGCTGGAGAACAGGCCCTAACCCTGCCCTCCACCGCCGGCTCCACACTGCCGGAAGCAG CCTTCCTGCTCGGTGCACGATGCTGCCCTGAAACACAGGCTCAGCCGTTCCCAGGGATCTGCCA GCCCCCGGCTCAGCAGTGGGACCAGGGCCTCGCAGCAGCAAGGTGGGGGCAAGCAGAATGCCTC CCAGGATTTCACACCTGAGCCCTGCCCCACCCTGCTGAGAAAACACTCCGCCACGTGAAGAGAC AGAGGAGGATGGCAGGAGTTACCTCGGGAAACAAACAGGATCTTCTCTGCCCTGCTCCAGTCGA GTTGGCCTGACCCGCTTGGATCAGTGACCATTTGCTGGCAGACAGGGGAGAGCAGCTTCCAGCC TGGGTCAGAAGGGGTGGGCGAGCCCCTCGGCCCCTCACCCTCCAGGCTGCTGTGAGAGTGTCAA GTGTGTAAGGGCCCAAACTCAGGTTCAGTGCAGAACCAGGTCAGCAGGTATGCCCGCCCGTAGG TTAAGGGGGCCCTCTAAACCCCTTGCCTGGCCTCACCTGGCCAGCTCACCCCTTTTGGGTGTAG GGGAAAAGAATGCCTGACCCTGGGAAGGCTCCCTGGTAGAATACACCACACTTTTCAGGTTGTT GCAACACAGGTCCTGAGTTGACCTCTGGTTCAGCCAAGGACCAAAGAAGGTGTGTAAGTGAAGT GGTTCTCAGTCCCCAGACATGTGCCCCTTTGCTGCTGGCTACCACTCTTCCCCAGAGCAGCAGG CCCCGAGCCCCTTCAGGCCCAGCACTGCCCCAGACTCGCTGGCACTCAGTTCCCTCATCTGTAA AGGTGAAGGGTGATGCAGGATATGCCTGACAGGAACAGTCTGTGGATGGACATGATCAGTGCTA AGGAAAGCAGCAGAGAGAGACGCTCCGGCGCCCCAGCCCCACTATCAGTGTCCAGCGTGCTGGT TCCCCAGAGCACAGCTCAGCATCACACTGACACTCACCCTGCCCTGCCCCTGGCCAGAGGGTAC TGCCGACGGCACTTTGCACTCTGATGACCTCAAAGCACTTTCATGGCTGCCCTCTGGCAGGGCA GGGCAGGGCAGTGACACTGTAGGAGCATAGCAAGCCAGGAGATGGGGTGAAGGGACACAGTCTT GAGCTGTCCACATGCATGTGACTCCTCAAACCTCTTCCAGATTTCTCTAAGAATAGCACCCCCT TCCCCATTGCCCCAGCTTAGCCTCTTCTCCCAGGGGAGCTACTCAGGACTCACGTAGCATTAAA TCAGCTGTGAATCGTCAGGGGGTGTCTGCTAGCCTCAACCTCCTGGGGCAGGGGACGCCGAGAC TCCGTGGGAGAAGCTCATTCCCACATCTTGCCAAGACAGCCTTTGTCCAGCTGTCCACATTGAG TCAGACTGCTCCCGGGGAGAGAGCCCCGGCCCCCAGCACATAAAGAACTGCAGCCTTGGTACTG CAGAGTCTGGGTTGTAGAGAACTCTTTGTAAGCAATAAAGTTTGGGGTGATGACAAATGTTTCC AGGCCAAAAAAAAAAAAAA    Download   Select all
Length	4499

CDS Information

   

Location	join(26320..26575,27760..27829,29701..29911,30020..30634, 32116..32253,42472..42601,42811..42942,43458..43562, 45844..46007,46502..46652,49306..49659,49867..49973, 50384..50528,51802..51902,52265..52429)
CDS Sequence	>lcl|NM_003954.4_cds_NP_003945.2_1 [gene=MAP3K14] [protein=mitogen-activated protein kinase kinase kinase 14] [protein_id=NP_003945.2] [location=126..2969] ATGGCAGTGATGGAAATGGCCTGCCCAGGTGCCCCTGGCTCAGCAGTGGGGCAGCAGAAGGAACTCCCCA AAGCCAAGGAGAAGACGCCGCCACTGGGGAAGAAACAGAGCTCCGTCTACAAGCTTGAGGCCGTGGAGAA GAGCCCTGTGTTCTGCGGAAAGTGGGAGATCCTGAATGACGTGATTACCAAGGGCACAGCCAAGGAAGGC TCCGAGGCAGGGCCAGCTGCCATCTCTATCATCGCCCAGGCTGAGTGTGAGAATAGCCAAGAGTTCAGCC CCACCTTTTCAGAACGCATTTTCATCGCTGGGTCCAAACAGTACAGCCAGTCCGAGAGTCTTGATCAGAT CCCCAACAATGTGGCCCATGCTACAGAGGGCAAAATGGCCCGTGTGTGTTGGAAGGGAAAGCGTCGCAGC AAAGCCCGGAAGAAACGGAAGAAGAAGAGCTCAAAGTCCCTGGCTCATGCAGGAGTGGCCTTGGCCAAAC CCCTCCCCAGGACCCCTGAGCAGGAGAGCTGCACCATCCCAGTGCAGGAGGATGAGTCTCCACTCGGCGC CCCATATGTTAGAAACACCCCGCAGTTCACCAAGCCTCTGAAGGAACCAGGCCTTGGGCAACTCTGTTTT AAGCAGCTTGGCGAGGGCCTACGGCCGGCTCTGCCTCGATCAGAACTCCACAAACTGATCAGCCCCTTGC AATGTCTGAACCACGTGTGGAAACTGCACCACCCCCAGGACGGAGGCCCCCTGCCCCTGCCCACGCACCC CTTCCCCTATAGCAGACTGCCTCATCCCTTCCCATTCCACCCTCTCCAGCCCTGGAAACCTCACCCTCTG GAGTCCTTCCTGGGCAAACTGGCCTGTGTAGACAGCCAGAAACCCTTGCCTGACCCACACCTGAGCAAAC TGGCCTGTGTAGACAGTCCAAAGCCCCTGCCTGGCCCACACCTGGAGCCCAGCTGCCTGTCTCGTGGTGC CCATGAGAAGTTTTCTGTGGAGGAATACCTAGTGCATGCTCTGCAAGGCAGCGTGAGCTCAGGCCAGGCC CACAGCCTGACCAGCCTGGCCAAGACCTGGGCAGCAAGGGGCTCCAGATCCCGGGAGCCCAGCCCCAAAA CTGAGGACAACGAGGGTGTCCTGCTCACTGAGAAACTCAAGCCAGTGGATTATGAGTACCGAGAAGAAGT CCACTGGGCCACGCACCAGCTCCGCCTGGGCAGAGGCTCCTTCGGAGAGGTGCACAGGATGGAGGACAAG CAGACTGGCTTCCAGTGCGCTGTCAAAAAGGTGCGGCTGGAAGTATTTCGGGCAGAGGAGCTGATGGCAT GTGCAGGATTGACCTCACCCAGAATTGTCCCTTTGTATGGAGCTGTGAGAGAAGGGCCTTGGGTCAACAT CTTCATGGAGCTGCTGGAAGGTGGCTCCCTGGGCCAGCTGGTCAAGGAGCAGGGCTGTCTCCCAGAGGAC CGGGCCCTGTACTACCTGGGCCAGGCCCTGGAGGGTCTGGAATACCTCCACTCACGAAGGATTCTGCATG GGGACGTCAAAGCTGACAACGTGCTCCTGTCCAGCGATGGGAGCCACGCAGCCCTCTGTGACTTTGGCCA TGCTGTGTGTCTTCAACCTGATGGCCTGGGAAAGTCCTTGCTCACAGGGGACTACATCCCTGGCACAGAG ACCCACATGGCTCCGGAGGTGGTGCTGGGCAGGAGCTGCGACGCCAAGGTGGATGTCTGGAGCAGCTGCT GTATGATGCTGCACATGCTCAACGGCTGCCACCCCTGGACTCAGTTCTTCCGAGGGCCGCTCTGCCTCAA GATTGCCAGCGAGCCTCCGCCTGTGAGGGAGATCCCACCCTCCTGCGCCCCTCTCACAGCCCAGGCCATC CAAGAGGGGCTGAGGAAAGAGCCCATCCACCGCGTGTCTGCAGCGGAGCTGGGAGGGAAGGTGAACCGGG CACTACAGCAAGTGGGAGGTCTGAAGAGCCCTTGGAGGGGAGAATATAAAGAACCAAGACATCCACCGCC AAATCAAGCCAATTACCACCAGACCCTCCATGCCCAGCCGAGAGAGCTTTCGCCAAGGGCCCCAGGGCCC CGGCCAGCTGAGGAGACAACAGGCAGAGCCCCTAAGCTCCAGCCTCCTCTCCCACCAGAGCCCCCAGAGC CAAACAAGTCTCCTCCCTTGACTTTGAGCAAGGAGGAGTCTGGGATGTGGGAACCCTTACCTCTGTCCTC CCTGGAGCCAGCCCCTGCCAGAAACCCCAGCTCACCAGAGCGGAAAGCAACCGTCCCGGAGCAGGAACTG CAGCAGCTGGAAATAGAATTATTCCTCAACAGCCTGTCCCAGCCATTTTCTCTGGAGGAGCAGGAGCAAA TTCTCTCGTGCCTCAGCATCGACAGCCTCTCCCTGTCGGATGACAGTGAGAAGAACCCATCAAAGGCCTC TCAAAGCTCGCGGGACACCCTGAGCTCAGGCGTACACTCCTGGAGCAGCCAGGCCGAGGCTCGAAGCTCC AGCTGGAACATGGTGCTGGCCCGGGGGCGGCCCACCGACACCCCAAGCTATTTCAATGGTGTGAAAGTCC AAATACAGTCTCTTAATGGTGAACACCTGCACATCCGGGAGTTCCACCGGGTCAAAGTGGGAGACATCGC CACTGGCATCAGCAGCCAGATCCCAGCTGCAGCCTTCAGCTTGGTCACCAAAGACGGGCAGCCTGTTCGC TACGACATGGAGGTGCCAGACTCGGGCATCGACCTGCAGTGCACACTGGCCCCTGATGGCAGCTTCGCCT GGAGCTGGAGGGTCAAGCATGGCCAGCTGGAGAACAGGCCCTAA    Download   Select all
CCDS ID	CCDS74079.1

Protein Information

      

Protein ID	NP_003945.2
Protein Name	Mitogen-activated protein kinase kinase kinase 14
Molecular Wt. (Da)	103911
Protein Sequence	>9020 MAVMEMACPGAPGSAVGQQKELPKAKEKTPPLGKKQSSVYKLEAVEKSPVFCGKWEILNDVITK GTAKEGSEAGPAAISIIAQAECENSQEFSPTFSERIFIAGSKQYSQSESLDQIPNNVAHATEGK MARVCWKGKRRSKARKKRKKKSSKSLAHAGVALAKPLPRTPEQESCTIPVQEDESPLGAPYVRN TPQFTKPLKEPGLGQLCFKQLGEGLRPALPRSELHKLISPLQCLNHVWKLHHPQDGGPLPLPTH PFPYSRLPHPFPFHPLQPWKPHPLESFLGKLACVDSQKPLPDPHLSKLACVDSPKPLPGPHLEP SCLSRGAHEKFSVEEYLVHALQGSVSSGQAHSLTSLAKTWAARGSRSREPSPKTEDNEGVLLTE KLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMACAGLT SPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRIL HGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAK VDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIH RVSAAELGGKVNRALQQVGGLKSPWRGEYKEPRHPPPNQANYHQTLHAQPRELSPRAPGPRPAE ETTGRAPKLQPPLPPEPPEPNKSPPLTLSKEESGMWEPLPLSSLEPAPARNPSSPERKATVPEQ ELQQLEIELFLNSLSQPFSLEEQEQILSCLSIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSWS SQAEARSSSWNMVLARGRPTDTPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPA AAFSLVTKDGQPVRYDMEVPDSGIDLQCTLAPDGSFAWSWRVKHGQLENRP    Download   Select all
Length	947
Uniprot ID	P00533
Ensembl Protein ID	ENSP00000275493

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
T	Phosphorylation	559

Enzyme Information

No matching records could be found.

PPi Information

No STRING Network could be found.

                                                                                                                                                                                                                                                                                                            

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
330	BIRC3	3426	NP_001156.1	in vivo	18997792
841	CASP8	3459	NP_001073594.1	in vivo	11002417
1147	CHUK	2811	NP_001269.3	in vivo	9   244   310   952   044   610   000   000
1956	EGFR	579	NP_005219.2	in vivo	11116146
3326	HSP90AB1	6763	NP_031381.2	in vitro	14743216
3551	IKBKB	4462	NP_001547.1	in vivo	101   958   949   346   485
4791	NFKB2	1239	NP_001070962.1	in vitro;in vivo	11239468
5037	PEBP1	6850	NP_002558.1	in vivo	11585904
5595	MAPK3	3479	NP_002737.2	in vitro	12049732
6125	RPL5	4699	NP_000960.2	in vivo	14743126
6885	MAP3K7	4011	NP_663304.1	in vitro;in vivo	10094049
7185	TRAF1	3418	NP_005649.1	in vitro;in vivo	1   127   826   815   084   600
7186	TRAF2	3538	NP_066961.2	in vitro;in vivo	9   020   361   112   782   680   000   000   000   000   000
7188	TRAF5	3834	NP_004610.1	in vitro;in vivo	9275204
7189	TRAF6	3833	NP_665802.1	in vitro;in vivo	1   127   826   816   286   460
8517	IKBKG	2217	NP_001093326.2	in vitro;in vivo	9927690
8518	IKBKAP	4763	NP_003631.2	in vitro;in vivo	9751059
8737	RIPK1	4583	NP_003795.2	in vivo	11116146
10913	EDAR	4974	NP_071731.1	in vivo	11035039
11140	CDC37	5456	NP_008996.1	in vitro	14743216

Pathway Information

                                                            

Pathway Name	Pathway ID
Apoptosis	hsa04210
Epithelial cell signaling in Helicobacter pylori infection	hsa05120
Epstein-Barr virus infection	hsa05169
HTLV-I infection	hsa05166
Intestinal immune network for IgA production	hsa04672
MAPK signaling pathway	hsa04010
NF-kappa B signaling pathway	hsa04064
Osteoclast differentiation	hsa04380
T cell receptor signaling pathway	hsa04660
TNF signaling pathway	hsa04668

Structure Information

PDB ID	1LIU
Resolution	2.73
Method	X-RAY DIFFRACTION
Chains	A,B,C
Molecule	PYRUVATE KINASE ISOZYMES R/L
Model	View

Domain Information

ID	Location	Description
cd13991	393-660	STKc_NIK
cl21453	393-660	PKc_like superfamily
cd00180	406-589	PKc
cd14014	405-647	STKc_PknB_like
cd06606	406-647	STKc_MAPKKK
cd06627	406-665	STKc_Cdc7_like
cd05122	405-647	PKc_STE
cd06630	398-647	STKc_MEKK1
cd06625	406-647	STKc_MEKK3_like
cd13995	408-647	STKc_MAP3K8
cd06632	399-647	STKc_MEKK1_plant
cd08215	406-647	STKc_Nek
cd06626	405-647	STKc_MEKK4
cd14003	406-665	STKc_AMPK-like
cd14007	406-647	STKc_Aurora
cd06614	405-647	STKc_PAK
cd05117	406-595	STKc_CAMK
cd14009	406-647	STKc_ATG1_ULK_like
cd06609	405-647	STKc_MST3_like
cd06652	398-647	STKc_MEKK2
cd06653	397-612	STKc_MEKK3_like_u1
cd05123	406-657	STKc_AGC
cd06623	406-647	PKc_MAPKK_plant_like
cd06605	406-647	PKc_MAPKK
cd06628	406-647	STKc_Byr2_like
cd06610	390-647	STKc_OSR1_SPAK
cd13999	406-624	STKc_MAP3K-like
cd06631	397-647	STKc_YSK4
cd14069	406-598	STKc_Chk1
cd08529	405-647	STKc_FA2-like
cd14008	406-647	STKc_LKB1_CaMKK
cd06629	397-647	STKc_Bck1_like
cd14099	406-647	STKc_PLK
cd05581	406-649	STKc_PDK1
cd06612	406-647	STKc_MST1_2
cd05118	405-592	STKc_CMGC
cd13994	406-597	STKc_HAL4_like
cd06624	390-595	STKc_ASK
cd06917	406-647	STKc_NAK1_like
cd07832	405-646	STKc_CCRK
cd06648	401-647	STKc_PAK_II
cd14006	406-603	STKc_MLCK-like
cd06651	397-647	STKc_MEKK3
cd05611	408-596	STKc_Rim15_like
cd14080	405-665	STKc_TSSK-like
cd06647	405-647	STKc_PAK_I
cd14103	406-587	STKc_MLCK
cd08225	406-608	STKc_Nek5
cd05579	408-641	STKc_MAST_like
cd14091	390-687	STKc_RSK_C
cd05572	406-598	STKc_cGK
cd06644	406-647	STKc_STK10
cd06613	405-647	STKc_MAP4K3_like
cd14002	402-647	STKc_STK36
cd06611	406-647	STKc_SLK_like
cd14098	405-646	STKc_Rad53_Cds1
cd06655	405-647	STKc_PAK2
cd14084	392-665	STKc_Chk2
cd05570	406-641	STKc_PKC
cd06654	405-647	STKc_PAK1
cd06641	405-647	STKc_MST3
cd14187	406-647	STKc_PLK1
cd08217	405-647	STKc_Nek2
cd13996	406-647	STKc_EIF2AK
cd06642	405-647	STKc_STK25
cd00192	406-581	PTKc
cd05580	406-600	STKc_PKA_like
cd06656	405-647	STKc_PAK3
cd05573	406-592	STKc_ROCK_NDR_like
cd06659	404-647	STKc_PAK6
cd06621	405-598	PKc_Pek1_like
cd06615	406-595	PKc_MEK
cd06640	405-647	STKc_MST4
cd05592	406-597	STKc_nPKC_theta_like
cd14058	406-619	STKc_TAK1
cd07829	405-602	STKc_CDK_like
cd06643	406-647	STKc_SLK
cd06608	407-647	STKc_myosinIII_N_like
cd13987	406-596	STKc_SBK1
cd05601	406-597	STKc_CRIK
cd14663	406-665	STKc_SnRK3
cd06617	406-647	PKc_MKK3_6
cd14106	406-595	STKc_DRAK
cd05577	406-598	STKc_GRK
cd05578	407-643	STKc_Yank1
cd06620	406-647	PKc_Byr1_like
cd14094	406-646	STKc_CASK
cd14665	406-647	STKc_SnRK2-3
cd05609	401-600	STKc_MAST
cd05596	406-595	STKc_ROCK
cd14165	406-596	STKc_TSSK1_2-like
cd14190	406-596	STKc_MLCK2
cd06639	406-614	STKc_myosinIIIB_N
cd14121	405-646	STKc_ULK3
cd14662	406-596	STKc_SnRK2
cd14079	406-647	STKc_AMPK_alpha
cd14105	405-596	STKc_DAPK
cd05586	406-600	STKc_Sck1_like
cd06638	406-619	STKc_myosinIIIA_N
cd14116	406-596	STKc_Aurora-A
cd13997	405-647	PKc_Wee1_like
cd14074	406-647	STKc_SNRK
cd06650	385-595	PKc_MEK1
cd05595	406-654	STKc_PKB_beta
cd14119	406-647	STKc_LKB1
cd08224	403-589	STKc_Nek6_7
cd08530	406-647	STKc_CNK2-like
cd05608	406-596	STKc_GRK1
cd14162	406-592	STKc_TSSK4-like
cd07833	405-592	STKc_CDKL
cd07830	405-647	STKc_MAK_like
cd13979	403-597	STKc_Mos
cd14046	405-647	STKc_EIF2AK4_GCN2_rpt2
cd06622	406-672	PKc_PBS2_like
cd14111	405-596	STKc_SPEG_rpt2
cd05585	406-612	STKc_YPK1_like
cd14202	406-596	STKc_ULK1
cd05584	450-597	STKc_p70S6K
cd07840	406-602	STKc_CDK9_like
cd05619	406-596	STKc_nPKC_theta
cd06658	404-649	STKc_PAK5
cd08218	405-657	STKc_Nek1
cd06616	406-599	PKc_MKK4
cd05620	406-596	STKc_nPKC_delta
cd05614	449-650	STKc_MSK2_N
cd14082	406-598	STKc_PKD
cd14097	405-647	STKc_STK33
cd05599	407-592	STKc_NDR_like
cd14113	406-608	STKc_Trio_C
cd05604	406-646	STKc_SGK3
cd05590	406-650	STKc_nPKC_eta
cd05612	405-596	STKc_PRKX_like
cd14186	406-643	STKc_PLK4
cd14201	390-596	STKc_ULK2
cd08222	403-647	STKc_Nek11
cd14081	406-646	STKc_BRSK1_2
cd14189	406-647	STKc_PLK3
cd14192	406-596	STKc_MLCK3
cd05583	449-656	STKc_MSK_N
cd05587	406-596	STKc_cPKC
cd14050	405-574	PKc_Myt1
cd05616	406-695	STKc_cPKC_beta
cd08220	406-586	STKc_Nek8
cd14086	390-590	STKc_CaMKII
cd07834	406-602	STKc_MAPK
cd08219	406-647	STKc_Nek3
cd14195	391-596	STKc_DAPK3
cd05630	406-598	STKc_GRK6
cd06649	406-595	PKc_MEK2
cd14175	406-603	STKc_RSK1_C
cd14164	406-631	STKc_TSSK6-like
cd14178	391-603	STKc_RSK3_C
cd14177	391-603	STKc_RSK4_C
cd14137	394-602	STKc_GSK3
cd06619	402-647	PKc_MKK5
cd05621	406-596	STKc_ROCK2
cd14193	406-596	STKc_MLCK4
cd14120	406-643	STKc_ULK1_2-like
cd08228	405-589	STKc_Nek6
cd05574	406-602	STKc_phototropin_like
cd05589	406-595	STKc_PKN
cd05613	449-642	STKc_MSK1_N
cd05588	406-596	STKc_aPKC
cd05617	406-642	STKc_aPKC_zeta
cd05603	406-708	STKc_SGK2
cd14087	406-665	STKc_PSKH1
cd05622	406-596	STKc_ROCK1
cd14059	406-596	STKc_MAP3K12_13
cd07847	405-647	STKc_CDKL1_4
cd14161	406-596	STKc_NUAK2
cd14196	406-596	STKc_DAPK2
cd07852	405-592	STKc_MAPK15-like
cd14047	405-647	STKc_EIF2AK2_PKR
cd14114	406-596	STKc_Twitchin_like
cd14070	405-646	STKc_HUNK
cd13978	406-581	STKc_RIP
cd14083	391-581	STKc_CaMKI
cd14191	405-596	STKc_MLCK1
cd05607	406-599	STKc_GRK7
cd14010	469-647	STKc_ULK4
cd14095	406-603	STKc_DCKL
cd14092	406-592	STKc_MSK_C
cd06657	402-647	STKc_PAK4
cd07846	406-647	STKc_CDKL2_3
cd05602	387-596	STKc_SGK1
cd07841	406-586	STKc_CDK7
cd07845	405-592	STKc_CDK10
cd05618	406-596	STKc_aPKC_iota
cd08528	406-589	STKc_Nek10
cd14012	440-647	PK_eIF2AK_GCN2_rpt1
cd05606	406-598	STKc_beta_ARK
cd14078	391-647	STKc_MELK
cd14194	406-596	STKc_DAPK1
cd14072	406-596	STKc_MARK
cd14110	403-595	STKc_obscurin_rpt2
cd06646	405-647	STKc_MAP4K5
cd07855	406-590	STKc_ERK5
cd14107	391-581	STKc_obscurin_rpt1
cd07835	405-644	STKc_CDK1_CdkB_like
cd08229	384-589	STKc_Nek7
cd05610	406-596	STKc_MASTL
cd05591	406-596	STKc_nPKC_epsilon
cd07838	405-646	STKc_CDK4_6_like
cd07831	405-590	STKc_MOK
cd14167	391-596	STKc_CaMKI_alpha
cd14176	391-603	STKc_RSK2_C
cd14066	406-592	STKc_IRAK
cd05582	406-596	STKc_RSK_N
cd05624	406-596	STKc_MRCK_beta
cd14089	406-595	STKc_MAPKAPK
cd14065	406-581	PKc_LIMK_like
cd07857	406-602	STKc_MPK1
cd07866	405-592	STKc_BUR1
cd05594	367-676	STKc_PKB_alpha
cd05593	406-596	STKc_PKB_gamma
cd05632	406-602	STKc_GRK5
cd13993	406-598	STKc_Pat1_like
cd07860	405-590	STKc_CDK2_3
cd14071	406-581	STKc_SIK
cd05056	406-657	PTKc_FAK
cd14179	406-596	STKc_MSK1_C
cd05600	406-597	STKc_Sid2p_like
cd05571	406-710	STKc_PKB
cd06636	406-614	STKc_MAP4K4_6_N
cd14223	399-677	STKc_GRK2
cd05633	399-598	STKc_GRK3
cd05605	406-601	STKc_GRK4_like
cd06645	405-567	STKc_MAP4K3
cd07864	406-586	STKc_CDK12
cd05615	406-596	STKc_cPKC_alpha
cd14108	402-596	STKc_SPEG_rpt1
cd14085	406-596	STKc_CaMKIV
cd14131	406-647	PKc_Mps1
cd05597	406-595	STKc_DMPK_like
cd14049	405-590	STKc_EIF2AK1_HRI
cd14188	406-647	STKc_PLK2
cd06607	404-647	STKc_TAO
cd05631	402-596	STKc_GRK4
cd14039	406-596	STKc_IKK_alpha
cd07856	406-676	STKc_Sty1_Hog1
cd14118	466-647	STKc_CAMKK
cd07843	405-592	STKc_CDC2L1
cd14093	406-596	STKc_PhKG
cd14090	406-595	STKc_Mnk
cd05040	405-596	PTKc_Ack_like
cd08221	406-590	STKc_Nek9
cd07865	388-604	STKc_CDK9
cd07850	465-592	STKc_JNK
cd13985	406-647	STKc_GAK_like
cd14117	406-596	STKc_Aurora-B_like
cd14073	406-581	STKc_NUAK
cd07836	405-646	STKc_Pho85
cd13983	402-596	STKc_WNK
cd07849	406-592	STKc_ERK1_2_like
cd05629	406-536	STKc_NDR_like_fungal
cd14185	406-603	STKc_DCKL3
cd05060	405-648	PTKc_Syk_like
cd14181	406-596	STKc_PhKG2
cd14221	406-581	STKc_LIMK1
cd14076	406-596	STKc_Kin4
cd05575	406-646	STKc_SGK
cd14180	406-596	STKc_MSK2_C
cd06633	395-615	STKc_TAO3
cd14060	407-652	STKc_MLTK
cd14048	406-581	STKc_EIF2AK3_PERK
cd14169	405-581	STKc_CaMKI_beta
cd05598	406-595	STKc_LATS
cd05041	405-581	PTKc_Fes_like
cd07880	393-592	STKc_p38gamma
cd14038	405-596	STKc_IKK_beta
cd13990	406-595	STKc_TLK
cd14016	405-538	STKc_CK1
cd07861	405-591	STKc_CDK1_euk
cd05623	406-596	STKc_MRCK_alpha
cd14168	406-596	STKc_CaMKI_delta
cd05038	406-653	PTKc_Jak_rpt2
cd14198	406-645	STKc_DRAK2
cd08223	406-647	STKc_Nek4
cd14209	406-596	STKc_PKA
cd14172	390-596	STKc_MAPKAPK3
cd05034	405-581	PTKc_Src_like
cd14033	404-598	STKc_WNK4
cd14133	406-647	PKc_DYRK_like
cd14154	406-625	STKc_LIMK
cd14075	406-603	STKc_NIM1
cd13986	403-647	STKc_16
cd13982	496-646	STKc_IRE1
cd14109	406-596	PK_Unc-89_rpt1
cd06618	406-647	PKc_MKK7
cd05115	403-624	PTKc_Zap-70
cd14200	466-647	STKc_CaMKK1
cd14052	406-647	PTKc_Wee1_fungi
cd07877	406-693	STKc_p38alpha
cd14115	406-608	STKc_Kalirin_C
cd14104	406-596	STKc_Titin
cd14166	406-665	STKc_CaMKI_gamma
cd07853	406-592	STKc_NLK
cd07859	406-592	STKc_TDY_MAPK
cd14001	469-581	PKc_TOPK
cd05628	406-596	STKc_NDR1
cd14146	406-645	STKc_MLK4
cd14032	404-622	STKc_WNK2_like
cd07848	406-592	STKc_CDKL5
cd14664	406-600	STK_BAK1_like
cd14064	406-646	PKc_TNNI3K
cd05039	406-581	PTKc_Csk_like
cd14163	406-596	STKc_TSSK3-like
cd14000	406-638	STKc_LRRK
cd14136	498-592	STKc_SRPK
cd14155	406-581	PKc_TESK
cd07854	406-592	STKc_MAPK4_6
cd05032	406-581	PTKc_InsR_like
cd14019	405-600	STKc_Cdc7
cd05083	405-581	PTKc_Chk
cd14031	404-598	STKc_WNK3
cd05627	406-596	STKc_NDR2
cd05057	406-581	PTKc_EGFR_like
cd14222	406-606	STKc_LIMK2
cd14212	405-585	PKc_YAK1
cd13988	406-599	STKc_TBK1
cd14017	405-596	STKc_TTBK
cd14183	406-602	STKc_DCKL1
cd07851	406-592	STKc_p38
cd07858	406-591	STKc_TEY_MAPK
cd07871	405-592	STKc_PCTAIRE3
cd07844	405-592	STKc_PCTAIRE_like
cd08216	406-599	PK_STRAD
cd07869	405-592	STKc_PFTAIRE1
cd14145	406-641	STKc_MLK1
cd06634	406-581	STKc_TAO2
cd14063	405-568	PK_KSR
cd05112	406-586	PTKc_Itk
cd06635	406-615	STKc_TAO1
cd07878	393-693	STKc_p38beta
cd14174	406-597	STKc_Mnk1
cd14182	406-596	STKc_PhKG1
cd07870	405-592	STKc_PFTAIRE2
cd05148	405-581	PTKc_Srm_Brk
cd13968	406-536	PKc_like
cd13989	406-596	STKc_IKK
cd14197	406-596	STKc_DRAK1
cd07839	405-595	STKc_CDK5
cd07863	406-604	STKc_CDK4
cd06637	406-614	STKc_TNIK
cd14173	391-638	STKc_Mnk2
cd14184	406-596	STKc_DCKL2
cd05114	406-618	PTKc_Tec_Rlk
cd07873	405-592	STKc_PCTAIRE1
cd14170	406-596	STKc_MAPKAPK2
cd14025	405-581	STKc_RIP4_like
cd14102	406-625	STKc_PIM3
cd07874	465-590	STKc_JNK3
cd14077	406-596	STKc_Kin1_2
cd05059	406-586	PTKc_Tec_like
cd07875	465-592	STKc_JNK1
cd07872	405-592	STKc_PCTAIRE2
cd05111	406-597	PTK_HER3
cd14096	405-596	STKc_RCK1-like
cd14199	439-647	STKc_CaMKK2
cd14135	406-593	STKc_PRP4
cd14147	406-641	STKc_MLK3
cd14037	406-586	STKc_NAK_like
cd07879	393-592	STKc_p38delta
cd13975	406-581	PKc_Dusty
cd14101	406-598	STKc_PIM2
cd07876	402-592	STKc_JNK2
cd14061	406-609	STKc_MLK
cd14088	411-646	STKc_CaMK_like
cd05067	405-581	PTKc_Lck_Blk
cd14156	406-647	PKc_LIMK_like_unk
cd14030	404-598	STKc_WNK1
cd14132	405-602	STKc_CK2_alpha
cd05084	405-581	PTKc_Fes
cd07862	406-590	STKc_CDK6
cd14210	406-595	PKc_DYRK
cd05626	406-596	STKc_LATS2
cd05072	405-581	PTKc_Lyn
cd05036	406-581	PTKc_ALK_LTK
cd05081	406-651	PTKc_Jak3_rpt2
cd14148	406-641	STKc_MLK2
cd07842	407-591	STKc_CDK8_like
cd14004	406-581	STKc_PASK
cd14158	405-595	STKc_IRAK4
cd05079	406-603	PTKc_Jak1_rpt2
cd05625	406-596	STKc_LATS1
cd14055	405-593	STKc_TGFbR2_like
cd14068	406-654	STKc_LRRK2
cd05113	406-610	PTKc_Btk_Bmx
cd05116	406-624	PTKc_Syk
cd14159	406-592	STKc_IRAK1
cd05082	406-581	PTKc_Csk
cd14005	406-592	STKc_PIM
cd05073	405-581	PTKc_Hck
cd05048	406-581	PTKc_Ror
cd14018	476-644	STKc_PINK1
cd14011	494-595	PK_SCY1_like
cd14100	477-598	STKc_PIM1
cd14026	406-596	STKc_RIP2
cd07837	405-589	STKc_CdkB_plant
cd14171	396-596	STKc_MAPKAPK5
cd05055	388-581	PTKc_PDGFR
cd05085	406-581	PTKc_Fer
cd14112	406-597	STKc_Unc-89_rpt2
cd05049	406-599	PTKc_Trk
cd05063	401-590	PTKc_EphR_A2
cd05109	406-619	PTKc_HER2
cd14224	393-592	PKc_DYRK2_3
cd13998	502-581	STKc_TGFbR-like
cd14054	406-581	STKc_BMPR2_AMHR2
cd05037	433-643	PTK_Jak_rpt1
cd05068	405-581	PTKc_Frk_like
cd05103	495-596	PTKc_VEGFR2
cd05099	406-581	PTKc_FGFR4
cd05051	403-581	PTKc_DDR
cd14207	495-596	PTKc_VEGFR1
cd05092	406-653	PTKc_TrkA
cd13973	434-536	PK_MviN-like
cd05097	405-622	PTKc_DDR_like
cd05054	495-581	PTKc_VEGFR
cd14204	406-581	PTKc_Mer
cd14203	405-581	PTKc_Src_Fyn_like
cd05066	406-591	PTKc_EphR_A
cd14053	502-570	STKc_ACVR2
cd14027	406-646	STKc_RIP1
cd14036	403-596	STKc_GAK
cd08226	403-619	PK_STRAD_beta
cd14040	406-596	STKc_TLK1
cd14225	406-592	PKc_DYRK4
cd05108	406-581	PTKc_EGFR
cd14125	405-538	STKc_CK1_delta_epsilon
cd13981	406-592	STKc_Bub1_BubR1
cd14205	395-601	PTKc_Jak2_rpt2
cd05110	406-619	PTKc_HER4
cd05053	405-581	PTKc_FGFR
cd05069	403-581	PTKc_Yes
cd05107	461-581	PTKc_PDGFR_beta
cd14216	498-592	STKc_SRPK1
cd14041	406-596	STKc_TLK2
cd14141	440-593	STKc_ACVR2a
cd14218	405-592	STKc_SRPK3
cd05065	406-586	PTKc_EphR_B
smart00750	475-647	KIND
cd14151	405-597	STKc_B-Raf
cd05052	405-581	PTKc_Abl
cd14062	498-598	STKc_Raf
cd05074	406-555	PTKc_Tyro3
cd05090	439-638	PTKc_Ror1
cd14149	405-598	STKc_C-Raf
cd05075	406-581	PTKc_Axl
cd14124	476-598	PK_VRK3
cd05044	406-581	PTKc_c-ros
cd14213	406-587	PKc_CLK1_4
cd05102	495-581	PTKc_VEGFR3
cd07867	405-590	STKc_CDC2L6
cd05047	406-656	PTKc_Tie
cd14226	406-592	PKc_DYRK1
cd14140	408-593	STKc_ACVR2b
cd05095	401-599	PTKc_DDR2
cd14015	487-545	STKc_VRK
cd13977	406-581	STKc_PDIK1L
cd14150	405-597	STKc_A-Raf
cd14157	409-526	STKc_IRAK2
cd05033	406-581	PTKc_EphR
cd14067	436-595	STKc_LRRK1
cd05071	403-581	PTKc_Src
cd07868	487-590	STKc_CDK8
cd14020	403-592	STKc_KIS
cd14138	402-524	PTKc_Wee1a
cd05106	493-581	PTKc_CSF-1R
cd05061	406-581	PTKc_InsR
cd05080	406-595	PTKc_Tyk2_rpt2
cd14153	406-536	PK_KSR2
cd05105	493-581	PTKc_PDGFR_alpha
cd14051	402-524	PTKc_Wee1
cd05091	406-581	PTKc_Ror2
cd05093	406-599	PTKc_TrkB
cd05070	405-581	PTKc_Fyn
cd05058	406-581	PTKc_Met_Ron
smart00220	406-665	S_TKc
pfam00069	405-665	Pkinase
COG0515	406-647	SPS1
pfam07714	406-581	Pkinase_Tyr
smart00219	406-581	TyrKc
smart00221	406-581	STYKc
PRK13184	406-630	pknD
PTZ00263	383-596	PTZ00263
PHA03209	480-603	PHA03209
TIGR03903	421-662	TOMM_kin_cyc
PLN00009	405-591	PLN00009
PTZ00024	406-592	PTZ00024
PTZ00426	406-596	PTZ00426
PTZ00036	406-592	PTZ00036
PHA03390	403-595	pk1
PLN00034	405-647	PLN00034
PHA03210	482-622	PHA03210
PTZ00267	432-682	PTZ00267
PHA03207	452-590	PHA03207
PHA03212	500-592	PHA03212
PTZ00283	498-647	PTZ00283
PTZ00266	467-603	PTZ00266
PHA03211	498-582	PHA03211

Ontology Information

   

HPRD ID	2555
Molecular Class	Serine/threonine kinase
Molecular Function	Translation factor activity, nucleic acid binding (GO:0008135)
Biological Process	Protein metabolism (GO:0019538)

SNP Information

View SNP Geneview Report   

Drug Information

No matching records could be found.

External Links

                                 

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO