CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
MAPKAPK2	9261	Mitogen-activated protein kinase-activated protein kinase 2	1	MK2; MK-2; MAPKAP-K2

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
17640979	2007	Cell line : 18Co Source : ATCC Sample Type : - No. of Sample : - Stage : -	Cell culture, Northern blotting, Western blotting,COX-2 transcription rate analysis, PCR,	Dephosphorylation	-	HETE increase the activation of p38 and MAPKAPK-2 and the translocation of HuR into the cytosol and that the translocation of HuR is dependent on p38 activation. Since p38, MAPKAPK-2, and HuR activation are known to contribute to COX-2 mRNA stabilization. The commercially available primary human colonic subepithelial myofibrobroblast isolate (18Co) was obtained from the American Type Culture Collection.
23017941	2013	Cell line : HT 29 Source : Tissue Bank of Taipei Veterans General Hospital, Jackson Laboratory (Bar Harbor, ME) and maintained as a colony at the National Taiwan University Animal Facility, ATCC. Sample Type : - No. of Sample : - Stage : -	Cell culture, Western blotting,Immunohistochemistry	Dephosphorylation	-	CD133 cell percentage and the activation of p38MAPK-MAPKAPK2-Hsp27 pathway were increased and the PP2A activity was suppressed both in xenograft and patient tumor specimens. Activating PP2A or targeting the p38MAPK-MAPKAPK2-Hsp27 pathway sensitizes colon cancer to antiangiogenesis by suppression of their TIC population. Human tumor specimens of patients without or after several courses of Bevacizuma treatment (10 mg/kg IV infusion for 90 min every 14 days), NOD/SCID mice and human colon cancer cell line HT29 were included.
23185379	2012	Cell line : - Source : Tisssue sample from Tissue Bank of Taipei Veterans General Hospital and The human colon cancer cell line HT29 was obtained from the American Type Culture Collection (ATCC). Sample Type : - No. of Sample : - Stage : -	Flow cytometry, Western blotting, Immunohistochemistry	Dephosphorylation	-	Activation of PP2A or inactivation of the p38MAPK-MAPKAPK2-Hsp27 pathway may develop new strategies for cancer therapy by suppression of their TIC population.
15774489	2005	Cell line : MTC, DTC, NCC Source : - Sample Type : - No. of Sample : - Stage : -	Transformation of NCC cells by MCLR, Analysis of cellular proliferation activity, Genechip analysis	Up-regulation	-	In microcystin-transformed cells, PI3K, MAPKAPK2, Akt, cyclin D1 and cyclin D3 in the Akt pathway; IQGAP-2, RabGTPase, Rap1GAP, RasGAP, R-Ras, Krev-1 and TC21 of the Ras GTP/GDP protein family; andA-Raf,B-Raf and PAKin the Ras/MAPK pathway were all markedly upregulated.

Gene Details

Chromosome: 1; NC_000001.10 (206858365..206907630)
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Gene Type	protein coding
Gene Family	-
Description	This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	1
Location	1q32
Start	206684912
End	206734285
Strand	+
Gene Sequence	>gi\|568815597:206684912-206734285 Homo sapiens chromosome 1, GRCh38.p2 Primary Assembly GGCCGCCGGCCCGGGGCTGGGTACATTGTCGCGCGGCCGCTTCCCCCCGGCCGGGCCCCCGCCGCCCCGC GGTCCCCAGAGCGCCAGGCCCCCGGGGGGAGGGAGGGAGGGCGCCGGGCCGGTGGGAGCCAGCGGCGCGC GGTGGGACCCACGGAGCCCCGCGACCCGCCGAGCCTGGAGCCGGGCCGGGTCGGGGAAGCCGGCTCCAGC CCGGAGCGAACTTCGCAGCCCGTCGGGGGGCGGCGGGGAGGGGGCCCGGAGCCGGAGGAGGGGGCGGCCG CGGGCACCCCCGCCTGTGCCCCGGCGTCCCCGGGCACCATGCTGTCCAACTCCCAGGGCCAGAGCCCGCC GGTGCCGTTCCCCGCCCCGGCCCCGCCGCCGCAGCCCCCCACCCCTGCCCTGCCGCACCCCCCGGCGCAG CCGCCGCCGCCGCCCCCGCAGCAGTTCCCGCAGTTCCACGTCAAGTCCGGCCTGCAGATCAAGAAGAACG CCATCATCGATGACTACAAGGTCACCAGCCAGGTCCTGGGGCTGGGCATCAACGGCAAAGTTTTGCAGAT CTTCAACAAGAGGACCCAGGAGAAATTCGCCCTCAAAGTAGGTCTGGGGCCCGGGGAGGGGAGGCGGGGC CGGTCCCGGGCCCTGGAGCTCCACGGCGTCGGGTGCCCGTCCCGGCCTGGGTCGCGGCGCGGGGCGGAGG GGTGGCCGCGGCGGGGCGGGGCGGGGCGGCCGGGCCGGCGGTGCCGAGTGCGGCGCGGGCGGCGGGTCCC AGCGCCCTCGCCTCCCTGACCGCTTCCGGCCGCTCCCGGGCGGGAGCCCTGGGACCCGCTCCTGGGGACT CAGGGGACCCTGCCATTTTGGGGTTTGAGCGGGATCCAGCCGAGTCAGAACGGTTGGCTTCGGGACTTCT GCTAATTTCACTCCATCTCAAGGAAGTGATTTTGGGGTTGGTGGTTCCCCGTCCTCTCCTCCCTCCTTTT TCTCTCTCTGCGGGCACAAAAGGCCCATTACTCATTGAGCCGGTTGGTCGGTTGGTTTGGAGAAGTCGGA TCGCAGAGGTTTATTTAGCCTCGCTCCTTATTTGGGAGCCGGAATGTGTGATTTCACTTCCCCGAGCCTC GCGAGGGCAGCCGGGCCGCCTTGGGGCGCGCCGGGCAGGAGGTGTGCGGCGGGAGGGTCCTGGGTGTCCC CCGGCTGCGGGGGCGGGATTATTTGGATCCCGGAGCTGGCCCCCTCAGCTGGCCCCCTCCCACGCCCGCG CGGGGCGGCTCCGGGGAGAGGCCGGCGGTGTCCGCGGCCCGGCTGATCATTGTGAACAGAGTCTGTAACC CGCGGCCGGGCCCGTGCTGATTCCGCCTCCTAGAGAGGGCCACTTGCTGTCCTGGACTCGCGCCGTGATG GGCAGTCTGAGGAAACATTATCCTTGAGCCGGGGGAGCCCATCCCTTTTCTTTCTTTAAGGGGTGTGGTG GTGGGGAGAATAAGGATTCAAGTGAGAATATCGACTTCAGAAGTTAAACACAATGGACTGGGAGGTCTCA TGAGATGGGTGGGTCCGCAGTGAAGTGTGAGCCGGTCTTGCAGGGTCACCAACAAGGTTTTCCTCTCACA GGGGTTTCAGGTCAAACCAATCTCTAAAGGTGACGCCTCAGGTCTGTTTCCCCTGGGGTGTCTCAATGAT TGGAGGAGGAGAAAAATACTTCCTGTGTTATATTTTTCTCTTCCCCTTCAGCCCCCACAGCGAGCTGTAT TTCAGTTGTCAAGTACAAAACTCAGAAATGTGGTATGGGTGGAACTATTGGAATATACGATCAGATGTTT TAAAAGAAACACCAGTACTTCGGGGTTGTACGGGGCAAGCATGTTCCATTTCTAGATTTTAAGGCCTCTA GAATTGTTTTCCTGCTGCTCTCATACTCAACCCTGTTACAGTGCTTTGCTTTCTACTGTAAGTTATTGCT CTGGGATCTCGGTTGTTGTTTAGTGTTGACTGTTGGAGAGGGGATAAGTATCTTCAACACTTCAACATTT GTGTCTTAGACTTCTCTTTCCCTACTCATAACTGAAGGGAAAGGAGGAGGAGGAGTTGTTTGGATTGAGC ATGGCTCTGACCTTGGGGACTGGAGTTGGGTGAATACAGTTTGACCACAGTTAACCTGTATCATTGAGGA AGTGACAGACGGTCTTTACAGGAGTGTTTGCTGTCCCCTCTGAGACACCATCTGCCTTCACCCATTAGTA GTTTGGGGACACTGGCTGTTCATTCTCTTGGATATTTGGAATATTATGTAAAGACTTCAGAACAAAAGCT CCCAACTTCTGCTCTGTATTCTGTTTAATAGACACACGCACAAAATCATCCTATAAAATGCTTTTGAGTG GCAATTCAGATTTCTCTTGTAACTAACGAGAGAGAGGTTTACATATTTTTCTACTTTGAATAGTTTTGGA AGGAAAAATCCAGCAGCGTGTTAAATAACACTCATAGTTTATCCCTCTCAGGTTAGAAGTGGGCGAAGAG TGAAGTCAGTCTGTTTTGACAGGCAGCCTGCTCCCAGATCTTTTAAGTTGACTCAACTGTTAAATTGTGG ATTTCCCACACACGTCTTTGTGTTAAAACTTAATAATGGAGGAAGAAAGGAGAGACAAGGCATTTGGAGA CTGACAGCAGTGTTAACAGCACTTCCATATCCAAATATTGGCTGAGACATAATTACAGCTGTGGGGGGAA TCTGGTTCAAAGAACGCTGTTCCAGAGACACACACCAAAGAGATTTCTAGATCTTGAATTTTGATTAACC TCAGGTGCTGAGTAGTGAAATGGTTTTCAAAACCAGAAGTCTAGTGATTATAAAGCAGGAGAGGAAGATG GAGTGGGGCAAGAGGGATTACCCCCTTGGGAAGGTGCCTGAGAAAAGGGGAGGAGACCTCTATTCTACAG TGTGCCGAGGCCAATGCTGGGGGCTAGGGCAGAGCTGGAGGGCAGGAGCCCAGCCTCTGCTGGGGTTCAG AAGTCTGCTATGTTGCAGCCCTGAGAGTTGATGGGAGCTGGCAGCTGCTTAGATGCTCTCCTCTCTGCCT ATAGTCGGTGACCTCTTAGCCCTGTTAAGTGAAATCAGCATTTGAAAAAGAGTCCCAGCTCACCCTGCTG CTTCTCTCCCTCCACCTCAGAGAGCTCCCATTTAAATGCTTTTGGTGGGTGCTTTGACCTCACCTCACCA TCTCTCCTGGCTGCTTTTGCTAAGTTCTGAGTCATGCTTCCAGTCAGAGTTGCAAGGGACTTGAAAGGTC ATTTTGTCCAGCCCCCTTATTTTGCAGAAGAGAAAACCAAGGCCCAGAGTGAGGGAGTGACTTGTTCAAG GTACCATAGCCATTCACTTGGCAGAGGCAGGATTGGAACCCAGGTTGCCTGACTCCCAGTCTCAGGCTTC TTCCCACTTACTTCCTAACTGAGCCACGGGCTCAGGCACATGGCCACCTGCTGCTCCAGGGTGCTTCCAG CCTGAGGAGCTGTTCTGTCACCTCAGGCCCTGACTGACAAGAGGGGAGGTCAGCGAAGGGGGCTGGATGG GTATTTGCTGCTCCTGAGAACAGTCCCCAAAGTTGGAGGGGAACTTCAACAGTAGCTTCATGCATTTTTT TAACCACTCCCTCCCCCTTTTAAGAGAGTATTTGATAGGCACCTTACTTACTATTTTTTGTACAAGAACA TGGGAATTCTATTATTTTTATTTTTATTTTTTTTGAGACAGAGTGTTGCTCTGTCGCCCAGGTTAGAGTG CAGTAGCACGATCTTGGCTCACTGCAAGCTCTGCTTCCCAGGTCCACGCCATTCTGCCTCAGCCTCCTGA GTAGCTGGGACTACAGGCGCCCGTCACCATGCCCGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTT CACTGTGTTATTCAGGATGGTCTTGATCTCCTGACCTCGTGATCTGCCTGCCTCAGCCTGCCTAAGTGCT GGGATTACAGGTGTGAGCTACCGCGCCCGGCCTGTATTACTTCTTTGATAAGGACACCTAGTCTCAACCC ACTTGTGTATTAATTAGTTGTATTCCCCGGGAGGGTTCCTCAGCTGCTTGCCGCTTCACTGTGTCATGGT GACCCTTAGGTGTTAGCTCAACAAATTTAATTAAAGACTGTATCGTTGTTCTCTGCTGTGCAACTCTGAT TAGGTGAAGCATGTTACTGCTTTATAAAATATAGAATGTTGTCGTAACTTATCTCTGTGTATCTTTCCAT TGCGTGGATTAGAGAAAACAAGGTCCTGTAGTTTCTTTTCCTTTCCTTTCTCCAGCATTCCTCTCTCCCT AGGTCATGGAAGTGCCACTGCGATGTGGCTTCCTTTGTTCTGGTGAAGGGGAGATGATTGGAGCCTCTCA TGATTATTCTGGATGCTGTTGGAGGGAAATGCCAGAGCTCCCACATCCCCACAGTACAGGCACCATCTCC TTTCCAACACACCTCATACTGTGTACCTGTGGAGGGCAAGACAGTTAGTGTGGCTAGGTGAGAGGCAGTG TCCCAAACTGGAGTTTGCTGGAGTTGTCACAAGGTTAGGAAAATTTCATTGACCAAGCCAGCCTCTTTTA TATGCAATATGGTTACAGGTAGGTAACAGTTTGCTGAATATCTATCATAAGCTTAGTTGCATGGAGGATA CACATGTAAAAAATGGCCTGTAAAATTTTGAGTCAAGAAACTTATTTAGAGAAGGTGAAATTAACACATG TAGGCTAGGGCTGCACTGTCCAATCTGGTAGCCACTACCCTCACATAGCTAATTAAATTAAAATTAATTA ACATGAATGGATTAAACTAAATTAAATTTGAAAAATCAGTTGCTAGCCACACTTCAAGTGTTCAGTAAAC ATGTGGCTAATGGCTATCGAATTGAACAATGCAGAAGAACATTTTCATCCTTGCAGAACGTTCTCCTAGA CTTTGTTGGTCTGGGAGCTAAATCGTGTGGCTGGGAATAGAGGAGCTTTGAAAGAGGGGAATCTGTGGTG ACTCCAGGAGCTAAGGGAGGCTCCAGCTGGGGTCAGTGGGACATGGCTGTGCCTCTGAGGAGTGAGCAAG TCTGTGAGAGGTGTGGTGACATTGGCCTGGCTAGAACTGAGGGGAGGAACAGGAGGTCAGAGTGGTCAGG GGTTGGTGGCTCCAAATTGAAGCTAACTCATCTTGTGTCAAAGCAGGCTTTAAAGTGTTTGAGGGGCATG AAGGTGTCAAAAAAGGTTAGGAATCATTGAAGATGGGCTTACAGAATTATGAGGGAAGGGTCAGGTTTGT GGTTTCAGAGATCCTGTCCCTCCTGGCCGTAGCCCTGACCCCAGCCCTGACCCCTGGCTCCTGCAGCAGG GCCCTTGGCATCCACTGAGGCAAGATTGAAGCTGGGTCAGCTCACTGTCCTTTTTTACTTGTGAATTCTG GGCTTTGACTGAGCTTGGAGACAATCTCCAGCTAAGATACGGGATCAGTGGCTGACAGGAGGGGAGAGAC AAGCAGTCCCTGGGCCTTAGGGCCAAATATTGGTGGGTGTCTAGGAAACAAAAGAACCCCTTTGTGGGAG GAGGAAGGTATTGGGACCTGTGATGTTTCTGCTACTTGGGACCTGAGAGGTTGGGCCATCCATAATTGAT GATTTTTCTTATGAAGCAGGTACAGGGGATTGGGAGGAGGGCCTGGAAGAGCCCAGCCTCAGAACTGCTG GAGGCAAACTTAATCCTTGGGCTAGGGGAGGGGCCAAAGCTCCTGTTAGCCAGAGCCCAGGAGTGTGCTG AGTGGGTGCCAGGAGGAATGTCAGCCAAGATGGGGAAGAGCAGGGCACAGTCGTCTGCATCTGAGCCATT GCCCAGTTCCCAAGCAGCCTTGCCATGCTCTGAGCTGGGGTTCTTCCTGGTGGCGTGATGTCTGTGGTGC AGGATTCACTCTATTCTCCTACCTTTCCTCTACTTCAGGCCCTGCCAAGTGTCATGTGAGGTCTCTTTTC CCCCTCTTCCCTGCACTGTATCTTTCCAGATGGTTCTGTGTCCTGGAGGGAGGTGGATGGGCAGAGAAGA GTTGTTCTTTGCAGGGACTGCAGCTTTTCTTGGTAATGGTTTGAGGCCCAGTGGCAAAGCAACCCACACT TCATAGTAACTTAGAACCCACACTCCCTGGTCATCTTTCTTGACTCCTTGCACATCACTGAGGAAGAAGC TGGCCTAGTGCAGAAATGTTCAGTGGCATGTCCAAGGTCTTACATGGTGTCAGCATCCGAGCCACATCTT GAGACCTGGTTCCCTGGGACCTGCTCTTGGTCTGGGCCCCTTTGGTTTTTGGTTGCTAGAAGACTGTAGA CCTGGTGGAGCAAAACTGAGCTCCACTAACGCATCAGCTAGGATCTTTCCACATGGGTTACCTTGTAAAT GGGGGCATTGGTGAAGAGAAGGGGCCATGTCACTGGACAGTGTAATAACGTATGGCAGTTATAGAACCCA AATCAGATTGCTGTGTACCTTTTCTAGTTTTTAGGAAAATACTGGTATTTTGTATTTTAAGATATATATA TATATATATATATACACACATACACAGATATAGATATGTAGAGATGAGCTTGTTACCATGGGTTATGTGC TAGATAAGAAAGCAAAAATAAGTGCATACATAAATAGAAAGCTTCCAGTGTTTGTATGCTGCTAACAAGT TACATGACCTTGAATAGGTCAGCTAAACTTTCCAGGCCTCATTGCACAGAGGGTCGGCTCGAGCAGCTCC TGAGCACCGGCAGGGTGAGGCAGTAGAAGGCGGTGCTGCAGGCCAGAGGTGGAGGGCAGGCAGGATAGCT TGCTGACTTGCTCCGGGTCTGACCATCAGCAGTATCTGGGTCAGCACAGATGCCCTTTCGTAAGCTTAGT GCCTGGCTCCAGGGCAGCCTGTGTCCAGTTAATGAATAATCATCACTGACCAGCTGCTCCTTCTCTTGTG TGAAGACTTAGAAAGTGTTCTATGCTGGTGACTCGGCAGAGAGGATAGACTACGTAATTTAGCAGGGTGT GCATCTTCTCTTTCCTTAAAATCAGAAGAATCATAGTGTAGTGGTGGTGCAAAGTAGAGATGAGGAACTC TATTCCCTGTTTGAGATTCCTTTCTCAAGTTATGGGGCATTTGAGGGCCACTGTGATTTCTGGTGCAGGC TGTTCCCTGTGCACAGGGATCTGGTTGAGGAGCTAAGCGAAGGCTGAAGTCCAGCCACTGTCTCCTTGCT TGGCTTTGTCTTTGTGTGTGGCTGGGTTCTTTCAAAGGAGTGCCTTCTAATTCACCAAAGGTATGGTTAT GGATTAGGGGTTGTTCTTAGGTTAGAGTTGGGGACTGATTCACAGAGCTGATGAGGAAATTAGGATTTAC ATTCAGGTGACCCTCAGCCCCTCAGACCAGGCTGAGTAAGAAGAGATATCAGGAATCCAAGGAAGCAGGA GGAAAAGGGGTTGCCTGGTGATGTCTGTTCTCTTTCCTCCTCTTCCTGCCCATGCAAGGCTAGAGCAGCT GTTTCAGCCCCGGAGGTTTAGACTGTGGGGTCCTGTGTGCTGGGCCATCAGGTTTGGTGGGAGGAGGAAG AAAGCCACAGTAGAAGGAGACATAAAGTTGGGCTGGGCCTCTGGCAGTGAAAGGTTCTTGGGGTCTTTAT TGTCTGATCAGTAAACACCTCTGTGTGCCAGAATGAGCTGGGACAAGGCCCCAAGGTCAGCCCATATTTG TATCTGGTGTTCTCCTCCAAGACCAGCCAAGCTGTGCGCTCATTCTGCTGGGAACCTGAGCCCTCCAAAA GGGTCATATGAAAGGGCATCTTATTCTTGAGGGACGTTTCCAAGCATCTCTGTGGCCAGTGTCCATCCAG GACTCATCTTAGAGGTGAAGAGTGGTGGCCAGAGGCGGAAGCTAGTGGCCACCCGATGGGAGCCTTTTCT GTTTCAGAGCATATGAGGGAGCTGAGGGAGCTGTACTGTTGATGCCTTCTCTCTGGCTCATCTCCATGAA GATTCTTTTGAACCAGAAGCAAAGGTGAAGTCTCTCTGAGGGGAGGGGCTGAACAGGAGATCTACTGACT GTCCCCCTGCCGACTCCTCCACTTTCGTCCTCCGGCGGGGCTCCTTATCCTCCTGCTTGTCTACAGGGAG AAGATCGAGTTGTTCGTTTGCTGCCATTTTAATGATCCACATTGTTAGGAGGCTCTCAGTACACACCGGA CCTTAGCAGCCTGGCCTCCTGCCCAGGGCCCAGAACTGTTACTCAGCCCCTCTGCCGAACAGCTAAAAAT AAACCTGCCACTGCTGCAGTCTCCCCTCACAGCCAGGCCCTGTTAGCTGTCCCAGTGCTTCCTGCCACAC CGCTGACCTGTTTCTCTCACTTTCTGCTGATATTCTCCCTGCTTGCCCCTTTCTCTTCCAGCCTGAGCTT GGTAGGTGATTTGGGGCTAACTCACTCTTCTGAGTGCTGGGAGACGTGCTATGGTTTTTATGTCTCCAGG TGTCTAGATTTGTGTGTATGAAAGCTCCGTGAAGCTGTCCTGCTTATTTCCCAGTAGGGAAAGGGTTAGA CAAAAAGGAGAGTGACCAAGCTCATCAGAGTGGATCAGACCTTCTACTGTGCTCGCCTCCAGCCCTGGCT TCCTCCAGTTTTACCTCCAAGCAGGCCTCTTTGCCAGAGTTACCTGGTTATGGTAACAGAGTTACCATAG TTATATGCTAGGACAGCCCCACATGGGCAGTCTGCCCCAGGCCTTCAACCCGACTGCCCTGTCACCGAGC ATGCTACCTACCGTGTACTCCTGCCCTGTTGCTACGTTATATTCTCCACCTCCGCAGTGTGAGGCTTTGG GCTACCACATTCAAAAGTGTGACCTCATCTTGTCAGCGTCCAAGAATAACTGGGCCCTGGCTCTCAGGAT CTCCTTCCTGAGTCAGGCCATGGCACCTCTGGCCCTTCCAGCTCAGCCACATGCAGAATGTCACCGAGTG CATGGGTTTCTTCTACCTCTTGACTGCAGTATTGATGTGTGTCCATGGAGGTGTGGCCTCTTCCTCTACT CCCCAGGGATCCTGGAGACTTGTGGAGCAAGATGAGGAAAGGGGCTCAGGTAGCTAGAATATTTGCTTAG CTGATAGATACTGGGCAGAGTCTGACATTGGCATTCTGTTCTTCAGCGTGGCGTTAGTATTCTTTCTGAT TTTTTCTAATCCCTAGACAGGTGTTGATACTAATCGTGGCCTAGGAGGGCTCTATGTCTGCTTTCAGGAA TTATGGTTTATTTGGGGGAAGGGGTGTATGGTGGAGAGTGATGGCAATGACAACCAAGACATAGGACTTG AGGAACCCACTGCCTTCAGCTAGAGTTACATACTCTGACCATGTGTCGATGGCCTCCTTCTCCCACCTCT CCCCTGGGGCCACATTTCCTCTGCAAGGAAAGATTTATCTGCCAAGGCCCATTGGCCTGTGCAGAGGAAG AGTTGGGCATAGTTGCTAAGTGTTTATTTTTAACTCTGACAGAAGGAGCCCCTGTCCTCAGAATAGCCAT ACCCTCTGTCTTTCCCTATCCCGACTGCCTTCCTTGGCTTCTGTGATTCCTAGAAGAAGGTTAGTAGGAT TCTAAAGGCCAGGCTTCACGGGAGCTGGAGAAGGCTAGCTTCTCTAAGTGAGGAATCTGCAGGTTGCTCG TCATGCTTGGCTTCTGCAGAGCTCAAAGGGTCCTGCGGGGAGAGCCCTGGACACTAAAGGCCGTGTGTCT GGAACTTGGAGAATTCTAGGAATGCAGGTGACCTGATGAGGAGGCTGCATGTGCCCTGCAGCTCAGAGCA GCCTGGCTGCACAGCTGAGTTGGACAGCCCAGCAAGGGGTCATCCCATACCTTCTACATCCTTACAGGCA CCCAGATCTCTGGCAGATGGGGAGGCCACAGGGAGAAAATGAGCATATGTAGTAACCTGCCCTGGAAACA CTTGCGCTTGCAGACACGCCAAGTGCTGTCATTCCCTCTGACTGCCAGGCTCACGAGCATCATGTCCTTT CCAGCAGAGCCCACCTGCGACTCTTAGTGACTTCATACCCTTTGTGTTCTCTTCCCCTGATGTGCTTTAG TGACCTGTGCTCACAGAGAGGAGGAGGAAGGGTGGCAGTGCCCCCTCTCCTGGGTCTCAGACTTTCCTGA CTTTATGCATTTGATTTGGCTACCTGGGCTCGGATACTTTAAAAGAAAATAAAATTAGGTTTGAGGTGTA ACCAGAGAGAGAAGGAATAGAGAGTAGTAGGGGGTGGGATGGGTGGTTGAAACATGTGGCTAACTCTGAG AACCCTCAGCTATGGAAGGAAGGTCTTGCCCCCATGATTCTTCGGCGTGCAGTGGGGGATTAGTTTGCCC AGAGCCCAGCTCTGATCATGTAGCTTCCCAGCTTAAGCCCTTCAGTGGGTCTCTCTGCCTGCAGAATACA TGAGATATCCACATCTTTCCCAGATCTGGCCCTGATCTGTTTTTTTTTTTTTTTTTGGAACACATGCTTT TTTTTTCTCCCCAGCTTAAGTGGCTTATATATGTTGTTTCTTTAACAGAACTGTGCTTTCCACCCCCACA CCTTAGCATCTATCCATCTGCATCTTCTCTGTACCATGCCTGTCCCCCGTCCTGTCTATATCTACCTTTT CCACCCTGCACAGATGCTGCTTTTCCAGAGCCTTTCGCACCAAAAGTGGGTCTTCCCATCCTTCCCCATC AAACTTGCTGATACACTCTTACCTTTTATTTCTCTGTTTAAGTGCATTTCTCCATGTGCAAGGCATCTCT CTCTCTCTCTCTTTTTTTTTTTAACAGGAAGGTAATTTATTAACGGAAAATATTTGAGGAGTCCTGTGCA CAGTGACCATGGCAACCCCCCTTCCTGCGGGTGCTGTCAGAGGGGTTGGGAGTGACGTCCTCAATCTGTC CGATCTTCATACCTGAGCGGGCAAGGGCCCTGAGGGCCACCTGGGCCCCAGGTCCAGGGGTCTTGGTTCT ACTTCCTCCTATGGCTCGGAGTTCGATGTGTAGGGCAGTGATACCCAGCTCTGGGCCACATCCCGGGCAG CCAACATAGCAGCATGTGGTGAGGATTCATCTCACCTGCCTTCACCTTCATCCTACCAGTCACACGGCAG ATGATTTCTTTGCCAGAAAGATCAGTGACATGGACAAAAGTGTCATTGAAGGATGCAAAGATATGGCAGA CACCAAATACATTCTCTCCTTCAGCCACCTGAGGTCTGAGGCTGATGACCTGTTCTTCCTTCTTTTCCTT CCCCTTTCAAGGTGCCATTTCTGCATGTTGTTTCCAGACTCCGCACAGGAACGCAAGGCACCTCTTTAGA TATCGGATTGGACTGTAAATCCCCTGAAAACCTACATCTTCATTATTTTTGTGTCCTCTTATTTTCATGT AGTGACCGTATGTCCTCATTAAAAAACTCAGGCCAGGCATGGTGGCTCACGCCTGTAATCTCAGTGCTTT GGAAGGACAAGTGGGAGGATCTTTTGAACTCAGGAGTTTGATATCAGCCTGGGCAACATAACAAGACCCC ATCTCTACAAAAAATTAAAAAGGTTAGCCAGCTGTGGTGGCACATACCCATAGTTTCAGCTACTCAGGAG GCTGAGGTGGGAGGATCACTTGAGCCCAGGAAGTCACGGTTACAGTGAGCTATGATCATGTCAGTGCACT CCAGCCTGGGTGACAGAGCGAGACCCCGTCTCTGAAAAAAGAATCCTAGAGTATTTTGGCACTGTGCATT ATATGCATTATACTTAGCTGCTGAATAAAGGTGTGATAACTGAGTAATAGTGGATGCCACCGATATTAAA TGTGATGTACTAGAGGTAATCCTCAGAGTCAGGGACTGTGGCAGCCCTGGGAGTGGGATAGTACTGGGCT GTGCTCTCTGAGACTGAGCTGGGGTAGAGTGATGATCTCTCACATTGTCTGTTCTCATTCTTCTGCTGCT GAAAAGCTGCTCTTAGTCTTCTGAGCATTTCTTCCCTCTACCCACTTGGATCTGCTGACTCAAGCAGGCA CCTTCTATTTCTGCTTACAGAGTTCTCATTCTTACAAGGACCCTGACCACAGTTTCTCATTGATGCCTCT CCTCCTTCTCCCTGTTCCAAGGCCCCTCCTATTCCTGTTCAGTCATGGAGATGACCCTTTTGCCCTTTGG AGAACTTTAACTGAGGGAGGGACAGATGTGGAGCTTGCCAACTTTCCTACAGCTCCTGGCATTTTCTAGT TAGCTACAGACACGGCACAGACACACAGATGCAGTCCATTGTTTTCTATCTGCTGGTCCTGCTCCTGTGT GTTGCAAGAGGGACGAGTGTTAAACACTGTATTAGTCCATTTTGTGTTGCACTAAAGGAGTATCTGAGAC TGGGTAATTTATAGAGAAAAGAGGTTTATTGCTCACAGTTCTGCAGGCTGTACAAGGATCATGGCACCAG CATCTGCTTCTGGTGAGGACCTCAGGAAGCTTTTGCTCATGGGGGAAGTTGAAGGGGGAGCAGGCATGTC ACATGTCGAGAAGAGGGAGCATGGGGGTGGGGGAGGCCCTCGACTCTTTTTAACAACCAGATCTTCTATG AACTCAGAGCGAGAACTCACTGCCACAAGGAGGGCACCAAGCCATTCATGAGGGATCTGCCCCCAAGACC CAAACATCTCCCACCGGGCCCCACCTCCAACACTGGGGATCATACTTCAACATGAGATTTGGAGGGGCCA AATATCCAAACTATATCAAGTACCCAGTTGCTGGGACTGAGGTCAAAGGTTTGAACCTCATGGGGCTGCT TAACTCCATGCCACAACAGATTTACACAAGAAAGAGAACCTGACACTAGACTGGAATCTGGGAGACCTGG CTACTAACTCTACCTGTGTGGCCCCAAGCAAGTCCTAGGACCTGTCTGGGCCTCACTCAGTTTCCTCATT GTAAATCAACAGGACTAGACTTGACCTTGAAGGACTCCTGCACCGAAAGCCTTTCATCACTGTTGTTGCA TCCGCACTGCTGGGAAAATAACCTGATGCTGGGAAACAAGTGGTCGGCCTGGGTCCCAGGGAGCCTCGGG GACTAAGAGCCATCATCTCTGTCCTCAGTTTCTGCAGGACAGTGTTACTTCACCTTTTTCCTGGCTGCAG TGTTTTTATTCATTCAGCCAATGTTTATAAATGTTTATTGTTCTCCATGCCTGCCTCCTGTCTTCCCTGC TGACTGGCCATCAGGAGGCCCAGATGGCAGGATTAGCTTGGAATGGCAGAACAGTCAAGGGTCATCCTCT TGGGTTTAGACCCCTTTAATACCTCTGCTATATGAGATGAGAAGAATTTAGAACATTGATCCTTCCAGCA GCTTAGACTAGACCCCTGCCTTTCTAAGCAGGATTTGCCTGTGGGTACCTTCTATACCCTTGAGATCCAA AGCAACTTACTACTCAAGAAAATTAATTAGCAATGCCAAGAGTGACTTGTACAGCTCCCCTAAGGATAGC TCAAAACAGCAGATAGACTTTGATACAATATAACAAATTTCTATTATTCAGATCACTGTAGGAAACTTAG CAACTCTGTGAAGGTTTCCCAGATTAATAACAAGTCTTTATTGAGCAGATACTATGTATCAGGCATTGTG TTAGGTGTTTTACTTACATTCTTGTTAATCCTTAAAATAACCCTTTTACTGCAAAGTGAAAGTCCCCATT TTACAGAAGAAACATGTTCATGTACAGAATAATTCCTTAGCAATTATTTATTGAGCACCTACTAAGTGCT AAGCATTATCTTGGGCTCTGGATATACATCAGTATATAAAACAGACAAAAAAGCTATTTGGGGGGTGGGA AGGGGGACCAGGTAGAGGAATAGCAAGTGCAAAGGCAAAAGCCTGAGGCTTATTAATAAGTGTGTCTAAC TCTAAAACCTAGGCTCCCTCCAGCTCACAGTATTGCCTCTCTAATGGTCCTTTGTGACTCCATTATAATT GGGTACTTAGATGACCTAGCAATTTTAAGTTTATCCAATATTTATGGGATACTTATTTTGTGCAAATTGC TACGATGAGATGAATAAGTTGTAGGCCCTGCCTTTGGAAACATACAGTTTAGAGGAACGAACACCCGTGT GTATAAAAATGAATGAAAGAGGACTTCCTCTCAAAATCCAGATCTTACCATTTCTTGCATTTTTGTCATT TGACCCTTGTAGGCCAGATGGTGTGGTTCCTCGTTTTGTATCTGAAGGAAGAGTTTCAGGGAGTGGGTGG GGGTAAGTGTCTGGGCACCAGGGTGGCCAATAAAGGATGCAGAGACACATGATGGGCTCTTCAAGGTGGG AGGAAGTAGAGGGTGGGATCACTGCCTGGCATGGGCAGAGGATACTTCATGGACATATACCTGTGACACA GCCAGGGGAGGGTGCAGATGAAAATACGTCCAGTGGGATGGTTTCTAAGGAGAAGTGTGAGGGACTCCAC TGGGGCTCCGTATTTTGTCTGGCTGAGGAGGGAGAGATGCTGCCTCTCCAGGAATCTGGTAATAGGCAAT GCTTGAGATTGGTGTGAACCAACGCATCACATAGAGCCAGGAGAAGTCACGAAGGAGGCAAGAAAAAGAA ATGGCTGGGCTAAAGCTGTGGCAGAGCCCTTTTTATCCTCCTTTGGGCCCTCATATGGCTTCTCTTTTGG TCTGAAGAATCTCATCCTTCTTGAGTTTAGCCTTCTAGGTGAAGGAGTGGGCAGACTGCATGCAGGGAGA CAGGGAGGCCGTGTTTGTGTCCTTCAGCTCAGGAGCTGAGAGAACAGAGGTCAGGGCTTGGGATGGAGCT GACCGTTAGTGCAGATGGGAAAGTGAAGCAATGGGTCGGGTCTGTTTGTTCCTGAGCATGTCCTGTGACA AAGGAAGTTGCAACATGTCTGTCTGTCTTTCTCTCTCTTTTTCTTTTCTCCTTTCTTTTCGTTTCTTTCT CTCTCTCTCTCTTCTTTTTTTCTCTTTCTTTCTTCTTCTTACTTTTTTTTTTTTTTTTTTTAAATAAAGA AAGAAGCAGGTAAAACCATCTTCCAGAAAATGCCAGAAAGAATATCTGGTCTGTGATGGGTGGTTCTTGC CCCTCCCGCTGCAATGCTTTTCCTGTGTAGTTTTTCTTTTGTCCTTCCTTTCCCATCCACACTTTCCACT CTCCTTTCCTCTGAGAGGTTGTGTCTCTGCAGCAGGCCAGCTATGTCTCCAAAGGGAAGTAGTCAGTGCT TGGACTGAGGGAACCTTGAGAGAGAATCCTCTCCTTTGTCCTCCAGGTGAGAGAGCTGTTGCATCCACTC ACACCTGGAAGGTTGCTGGTCTCCTCTCGCTGGACACTGAGAGCTGTTTAAATTTGACAGGTGGTTCCTG ATTCCCACCTGGCATTTTTTGCTGCTGCACAGGTCTGTGTTGTGTCTTAGAAGGCTGAGGGAATACTTAC TTCTCAACTCAGATAACCACCTTGTTGGTAGGTTCAGTGTGTGTCTGTGTCAAGGCAGATGCTGGGAAAA AAGGGCCCAGAATGTGAGTGGGAGGTAGAAATCAAGGCTAGAAGACCACACATGTTAATCTGGAGTACTT GGTCAGGTTTGATTTTGGCCTGTGTGCTATAGCTGGGCAAGAAGCCAGTTGTGTTTGGAAATGTACAGAT GATCTATTTTCCTGATGAAACCTTTTGAGGTCTGGAATAAACATAGCTTGCTTTCTCTCTTTCCCTCTTT TGAGATTCAATTTCTCTCCCTTGGACTTCTATACCCTAGTAGAGCCAAAAGTTCCAGTACAAACCAGTTT TGAGACTCCAGCATTAGTCAACTAAGGGATGTTGTAGGTCATCCCTGAGAACGAGGGCTGCTTGCTCTGG GGAAGCTGGGAAATGGCACCAGGTGTCAGGCCCTACTGCCCAGGATGGGATGACAGCTGCTGGTGTTAAT TACGTTTCTGGGCAGAACAGGGTAAAGTCCTTGGGGGTGAGAGTTTTTGTTTAGGCACTGTGTTCCCTGT ACCTGTTGCCTCTGGTACAGCTGCTGCAGAGCCCCTCCTTGCCTGCAGTCTTCTTTGAATTTAATCTCCC TGTGATCCAGTGCATCTCTTCAGACTGGAGGTGAGCCCAGAGGAGTGGTGGAGGGAGTGGGGCCAGAATT TACTTGTTTGCCTGGATCCCACTGAGAATACAGAAGCTCTCTTTCACGAGAAGCTGTGCTGGCCTCTGTG GTACCCACTGGCCATATGTGACTATTAAAATTGAAATTAAGTGTTAATAACATTTAAAATTCAGTTCCTC AGTAGTGCCAGCCACATTTTAAGTGCTCAGTGGTTAGCTAGTGGCCACGGTTTTATGTGGCACAGATAGA GAACATTTTATCATCACAGAATAGTCTCTTAGACAATGCAAGATTCTGAGATAATTTTTCTAATCCTGGT AGACACTTAGCTGGAAGGGGATTTGAGGAAGGGTACAGGGAGAGGTTTTGAAGCCCAGGTGAGAGGGCAA GTAGAAGGTATTCATTTAGAAAAGGATCTTAAAAAGTATTTAGTTTGTAGGGCCAGGTGCAGTGGCTCAT ACCTATAATCCCAGCAGTTCATGAGGCTGAGGCAGGCAAATTGCTTGAGCCCAGGAGTTCGAGACCAGCC TGAGCAACATGGGGAAACACTGTCTCTACAAAAAATACAAAAATTAGCCTGGCGTGGTGGCGTACACACA TGGTTCGATCTACTCAGGAGGCTGAGGTGGGAGGATCACTTGAGCCTGGGAGGCCAAGGCTGCAGAGAGC CGTTATTGCACTGCACTCCAACCTGGGCAACAGAATGAGACCCTGTCTCTAAAAAAAAAAAAAAAAAAAA AAAAAGAGGAGTTCACCTTGTTGAGGACTACATCCTAAGAGATGGTCACCTGGCCCAGTGGCTCCCAAAC CAGGATGATTGTTAGACTCACTTGTGGGTAGCATTTCAAGATACAGATTCCTGGGCACCACTCTTTGTGT CTAGTTGAATCCAAGACTCTTCAGAGGAGGTAACCTGGAATGTGCATTTTTAATGTGCTCCCCAAGTGAT AATTATCTGGGTTTGGCAACCACCAACCTATCATACCTGTGCTTAAATTCTTCCAATGGTAAGGAGCTTA TCCCTTTTCAAGAAAACCTTACCATTAAGGAAAAATTCGCTGTTGTTAAAGTTCTATGTTTTTCGAATCT TGAGATTTGGTTCTTTGAGGTCATGAAATCCTTTGGTGCTCATTGCATCTTTAGAGCCTCGCAGAACCGT CATCTTCATCCTTGCACTCAGTCTTCAGCAGATATTTGAGGGCAGCTGTGGTGTGGTCCCTGCCACTCCA AGTCATGGCATGCGTCAGAGTGCTTGATCTGCCAAGGGCTCTAGGGAGATGCAGAGATGCAACATCATTC CAGGATCCTTCCAATTGTCAGGCCTTGCTGAGAGCCAGAGGAAAGGTCTGAATCTCAGTGGAGCCCTACA GGGACAGCCCAAGGGCCATCCAGCCGGTGAGGGCCATGTGTGTGTCTGCCTCTCTGCATCCTGCTCCGTA GGGAAGAGTCCCTGCTTCTTTGCATGTTAGCACTTGTTAACACCGACCTGGTTTTCTTCAGAGACATTGA GAGATTCAGCCATCCATTCCCGGTAATGACAGATGTCATTTCTGTTTAGAGACCTTCAGTAGCCTCCCTT CACTTCCAGTGTAAAATTCAAACTCCTGAACGTGGCATTCAAGCAAGCTGGTTTGTCCTGCCTTCCACAC TTTGCCTTCCAGGAGAGCACTCCTTCCCGCTCTGCCTTGCATTTATCTGCTTCCACATCTTCTCTTGGAT CTTACATTTGCTTATCTTCAGTTTTTTCTGGTAGAACTGTATTTATCCTTCAAGGCTCATAATAGATTTT ACCCCCTTACTCCCCTGCCCAATTCCAGGCAGAACTGCCTCCCTCCTCTGCCCTAGTGAGGGTTCATTCT GCCTGCATGACTGCTATGCACTCAAATTACAGCCCCCTGCCAGGCCCTCCCTGCTAGACCAAGCTCCTTG CGGACAAGAACTATGTCTTACTTGGCTTGATATCCCCAAGTGCAAGCAAGCACCAGTGCTGGAGCCTCCT TTTCCTGCATTGGCATTCTTACCCTCAGTGGCCCAGAGCTCATCAGCTCCAATGAGAAAAGTGCTACTTA GCAGCTGATAATTAACAGACAGGACGTGAGGTTTGGCTACTTCAGAGGCAAAACTGGTATTTAAACAATA AGGTTTTTAAAAATCAAGCATTAAAGTGTCAGCTTCAGAAGCAGCTACTTCCAAACATAATCCTGCCCAG TTAGAGAAGACAAATGGAATAATGAGTGGAACCAAAGATTTCTCTCTAGCCTTGAGAAGAGTTCAGGGGA AAGAGGCCTGGGTGGCGTATTGGCAGGAGATTGGAAAAGGGGCCTTCATATTTCTTTTCTCTGGAATGGG GCTGGGGCTGCTTGGAGAGCAGGTGGGAGGTGCTTCCTTAGAAAGGGCTGTCTGTGTTCTCTTCCATTCC CAATTTCTATAGATTGGACTAGTTTTGCCAAGTGAGCAAGCAAGAAAAATTGGGAAACAGAGGGTAGGCA TCAACCCTGGCATTTATCCTAAGGTGATGCAGCACACACTTGTATTCAGCGATAGAGACTTTTCCGTAAT GCCTGGTAATATCTCATTGTATTTTCTTTTGATGCTCCTGGGGGCAGGAGGGGAGAGCTGACATCAGAGC CTCCTCCCTTCTAGATCACAACCAGAGCATGAGGAATTCCCCAGCCCCTTGAGGTACCCAGACACTAACC ACAATCTCCATCTCTGCTGAAGGCGTTGTAAGAAACATGCAGGCCAGGAACAGTCAGTGGCTTCAGAGCA GGGGCAGCCTGCTAAAGAGGCAGAGGCTTCTTGTGAGGGCGGGGAGCTTGAGAGTGCCCTGCACCCCATC CTGGGGGAGGTGAGCATCTGCTTCTGGGTTCAGCTGCCTGCGGAAGTCAGTGGGAGACACCCTTTCAGGG TCTGCTTCATTATGAATGAAGCAAAAAGCCTATCCCAGGAAATCACAGAGGCTGATGGGTATACCCCAGG GTACACAGGCTATATTTTTCCAATCCAAAGTGAGGGTCTATCTGATAGTTTTTCCTGGAGTTGGGGAGGG GTCCTACTTTCAGATCCAAAAGAAAATCTGAGATATGTCATTTGAATATGAACGCACTAGACTTTCTGGG AAATGTTGAAGATTTACGCCTGTCTGAGTGTCTCTCACTCGTTGTTACCTGTCCATTTGTTACCTGGCCC ACGGATGGAGGAGGTCGGATGGGGTCTCCCAGGGTCCCCTTGCTGGGCACGCTTGGCAGGCATCCTGCTT TTCCTTTCAGGTTGCTGGAATTAGTGGTGGTGGTGGCTCAGCTCACCCAGACCATGTGTGATGGTTATGG TGGTGACTTCTCACTGACTGCTGATGTGTACAGTACATTGAAAGCAGTCACCCAACTTCCTTTATAGCCG GATACAAAACAGTGCCTGAGGTCCAGGGTCGGGGAGGACTTGATGAGGGAATAAAACCAGCCGGCTCATC TAGGGGCTGATATCTGTCCGTGGTGACATAAGCACACATGATCTGCAGTCAAGGTTGACTTGAGGGTGTG CATGGGTTCAGTCCCTTTTATGAAGTCTAATGGTCCTTCCAGAAGCTTCATCATCATTTGAACTGAATAA GTGAAGATGAGTGCACCACAAGTGTGTGTGTGCACTTCTTAATCTGTCCATTCATCTGTTCACTGCAGGC TTATTGAGGGAGAAACATGTAAGCAAGGTATTTCTTGTGTACTCCAAGTGGTAGGAGAGCTATGTTCAGG GAACTGGGTGAACTTGGAAGAAGGAGCCGCCCGTTTCTCCAAGTGCAGCGCCAGTCCCGAGACACTCTGT GATCATCTAAACTGGGGAACAGTCTGCAATGCACATTACTGAATTAAAAGCTCTGAGAAGTTCTACAGTG AAAGAATCTGTTTAACTTTGTTTAACCTGGTGCTTCTGCCATCTATATGACCCCTTTTTACTTAGCACTT ATTAACATCCTACGGAATACTATTTGAGAAATGGCAACAGCCCCCCTTCTCTGGGAGAACTGTTCAGTGA TTCAGAGCAAAAGTCACCTGACTCTGGGTCAGCACAAGTTGGAGAGGTTTGAAAAAGGTGTATGTATGTT TGCATGTGTATGTACGGTGGGTTGGGGGGAGGGGTGTGGCAGAGGAGGGGCCCCGGCAGGTGGCTTCTAT TGAAATCAGCTCTGTCTGCCTCCCTGTTGGCTTTGTGCTTCTGGAGAAGCTTTTGTCCTGGCATGAAAAC ACTGAATAGCAGCTGCATCTGTCATGCCTGGGAAGCAGCAATGTGCAGCATGGGGTTGCATGAGTAGACA CTCCTGCTGGAGGGCCAGGCTGCCGAGAGTGCCTGGGTATTGGACAAGGGAGAGGCTGGTGATTCTGAGG CAGCTGCTTGCTAATCCTGGAAGCAGAGGGGAACAAGATTTAGCTCCCTTATCTCTCTGCCTTCTCCTTT CCGATGGGTGCAATTGTGTTGACTCTTGAGGGACAGCCAGGAAGAAGCAGGTGGGCTGGATGCTTTCTCC TTTCTCCACCAACCCAAGGGCATCTGGAGGGTGGACCAGGGCAGAAAGGCGATTAGCTCTCCGTTACCCA GGGAGCTGAGACAAAGGCATTTTGGGTTAAATTCAAGGAGGAATTCAGAATTGTGAACTGGATTTATGGA AGTTTGTGGAGTTTGAAAATTCGAGAGTCCTGGCTGGACTTGTGCTTGGAACGTTGGTCGGAGGTGGATA TGAATGATGGGTCCTGCAGATGGCCGACTCCTGAGAAATGACTGGGAGGCTTTACTGGATTTTTCGCTTG GAACAAACCCAGGCTTAGGGAATTCCCGGAGCCTGTTGCAGGCCTCAACACCCTTCTGGTGCAGCTTCGC TGTGAGGCAGTGGTTATTTCTCAGGAAACTGGCAACTGGGAGTAAATGGGAGTGTGGGGTGGGAATCAGC TACTCTTCCTGAGGATTATACACTTCCAGTGTAATTAAGGCGGGGTCAGGATTTCCTATCTCTTATTTAT TTATTTATTTATTTATTTATTTATTTATTTATTTATTTGCTTAATCTTAAAAGGCTGCTTTTCCCCTCCT GGTCTTCCCACAGGGACAGGAGTTAGTCTGTTCCCAGAAGGAGCTAGGGGAGGTGTCCTTCATCTCCCAT TCCTTCTTGCCCTCTCCCTGCCTTTCCCTGGCCACAGCCACAGAGACCCAGAGTCACTCAGATGGGGGAG GAGCAAAGCCAGTCCCTCTGATCATTGCCTCTTTGTTAGTGGAGAAAGGGCAGATGCTGCTCTGCAGTTA TCCCGACCACCCTGCAGGACGTCTGGGTGGGCCGGGCTTTGGTTTGGGAATCGGGAGTATTAGCTGCAGC TGCCAACTGGGCTTGTACTTGCAGACTCCCAGGCTCCAGGCTCTCTGGAGGGGACCAGCAGCTCTGACCC CCGTGGGCTTGCTGTGGTCCCCAGGGAGCAAGCCCTTGCCAAGAACCTCTGAGCTCACCGAGGCGGGTAT GGGGTAAGGATGGAGAAGGCCTGGGGAGCAGAAGTGTGCAGATGACTCCCTCCTTCCCCTCAGCTGGGTA TGCATCACCGCTGCTGGGAAGACGTTCAGGCCACTTCTAGACAAATCGGTCATGATGGAAATTTTTTCTT GCCCGTGGGTGGGGCTTTACTTGTTCAGAAGTGGCTTCAGATGTGCTCTTTCTAGGTCCTGGCTTGAGTG CTGAGCATTTACCTGCAGCCCCTCGGGGCTAGAAGGCAGGGCAGTGTCTGAGCCCCTTCCCTACCCCTTG GGGCTAGAAGGCAGGGCAGTGTCTGAGCCCCTTCCCTACCCCTCATTCATTCTCTCCCCTCACCTGTCAT TCCATCCGTCAGCCCCGAACAGCTTGGCAGCCTTGCGGCTCCAGCTGGAGCTTAGTAGGCATGTAGTTGG AGGAGGGAACGGCACTGCAGCCGCGCTCTTCTCTCTCCCACAGGTCTTCTTCTTGTTGGGCCTCCACTTC CTGTCAGGGCCCTGCTTGCAGCTGTGGCACATCTGGACCTAGACGGGGTATCCTGTTGTCCTGCATGATG AGGATCCCAGATTTCCCCTAGGTGATGACCACAGTCATTCCAGGGTGGGAGCAGGACTTCCCCCACCCCC AGGCACTCCAGAGACTTCCTCCAGGCCCCCACTAAGTAGTCTGTTCCCAACTCCATCTCTCCCCCATGGA GAATGGTGGGAAGGAAGTTCTGCCAGAGGTTGTTTTTGGTTTGTGAGGTAATAGACTTTGGTTTGAGAAA CATACATCTCTCCCTCTTCTTTAAGATGTGAAGCCAGAAGCACCAGACTCTGGTTTCCTTGGAAACCAGA GCAGCAAAGGTAGAGAAAAAAGGGGCTGGTTGTAGGCACTGAAATTGGGGAGGATTCTCTGGATCCCAGC ACTTTTCTGGGGAATCCACATGGTCTGCCCTGGGCCCTGGGTTGTAGCCCTCACTGTGTTAATGGACTGT GTAACCTTGGTAAAATGCCTGCAACTCTCTGCACCTTAGTTTCCGCCAAGATGCCTAAGGTGGGGAACAT GTTGGCTCCACTCAGATTCTGTGCCCCAGAGACCTGCTGGGTGTGTGTGGGGGTTTGGGGGTAGGGCATG GGGCTCCTGCTCACTGATTTAGCATTTGCTGTGGCTAAACTACAAAGTGGACAGTCCACATGGAGACAGT TGAGAGCTACTTGCACCCAGGTCCTTTCTTTGAGAATACAGTGATGTAACAGGAGACTTCTTGCATTTTG CCTATGTGAAACCAGCTGGATTTTGCTGAAGCTGTAATTGTGTCTCTACATTCTTTGATTCCTGTCTAAA AAAAATGGTTTCCACAAATGCTGTGAAGAATAGACTGACAGAGCTGGAAAGCGTTAAGTAGGGATCCTTT AAACAGATCCCTACATTGTACATTGATCCCTTCAACCACAGCCAGAGAGGGGCAGGGACTTACTTGCTCT GATCACACAGTCAGAACAAGAACTAACAACAGTAAAGGTCTGGGTAGCAGCCTCACATATGCTAAGATTC CCTGTTGGCTAAGTTTGTCTGTTCCCAGGTCACCCTGGCCTTTTGCAATTCTGCCCTCCGCAGGCCCCTG TGTTGGCTGAAACCAGCCCTCTTCTTCCCCTTGCGCTTTCCTCCTGTGACCTCCCAGCCACCTCTTGTTT CCCCTGTGGTGTTCCCCACCTGTTGTTACTTCCTATTCCTCCTCACAACTTTTTATTATGAAACATTTCA GATGTGCAGCAAACTGGAAAGAATTGTACAGTGAACATGATTATACCAAACCACCTAGATTCAACCATTA GCCTTTTACTATGTTTACTTTATCATGTCTCTACGTGTTTCAATCTCTCTATCCATTGACCAGTCCATCT TATTTTGGGGATGCATTTTGTAGTAAATTGCAGACATCAATGTACTTTACCCCTAAACATCTCAGCATAC ATAGGCATTAATTTGAGTTCAATATTTGTTCATGCATTTTTTTGATGATAATATTTATATTAACAGTGAA AAATGCACAACTCTTAAGGTATCACCTGATAAGCTTTGATAAATGCCTCTATCTGTGCAACCCAAACCTC TGTCAACTATAGAACAAAAAGTTTTATTACCTAATTAATTCCCTCGTGTTGTTTCCCAATCATCCCAACA CATACCCCCTCGCAAGTGATCACAGTTCTGATGTTTTCTCACTGTAGATTAGTTTTGCTTTTTCTGGAAC CTCATATAAATGGGATAATCAGTATGAACTCTCCCTTTTGTGTGAATTTCATCTGCATGGTGACATGTAT CAGTAGTTTGTTATGCTGAGCAGTATTCCATTGTATAGATATGATAAAATTTGCTTCTCCATTCCCCTGT TGATGGACATTTGGGCTGTGTCCAGTTTTGGGCTATGATGAATAAAGCTCCTGTTAACATTCTTGCACAA ATCTTGTTGTGGATGTAATGTTTTCATTTCTCCTGGGTAAACAACGAGGAGTGTGATTGCAGAGTTACAG GAGGCTGTTACTTATTGTTCCTATCTGACTCTCTGCCCTGCCCTCTCATTGTACTGTGCACCCAATTATT TTAGGACTGTTATCACATCCAGTCCCTCAGTTGCTCCTTCAGGGTTTCTCTTCTTCCGGCAATTCACCCT AGTTTATTGAACTGTTGCTCTTATGTTATGCTCCTCAGATCTTTTATATCCTGGTTGTCCTCCTCTGGAA GTATAATACTCTTTTACAGATGTGTTGCCCAGAACTGAGTTCTCGCTGCTCGATGTGATCTACATGTGGA TTCTAGGTATGGGAGAAATATAGAGTGTGGGTGCATTTGGATCCCTGTCTTGAGCTAGGTACTTGATCTG TGAGCTGAAGGAAATATTAACTTTTTGGCAGCCACGTCATGGCATCAGATCAGATGAGTTAATGTTTGTA AAAATACCACAAATCTAAGGTCATATTAAGATATCCATTCAGCTTGAAGTCAGTCCGAGCCTCTGATACT AATGGCATTTATTATGAACTTTCTACTTGCCATTGTGTCATTTAGTTTTTGCCTACCACTTGGTGAGAAA GGTACTATTCAAATTAGCTTAATAAAAACTCCTTGATTTAAAACTAGGGTACTTAGCTTTGGCACTGTTG ACCTTTTGGACCAGATAAGCCTTTGTTTGTTGTGGGGGATTGTCCTGTGCTTTGTAGGAGTTAGCAGCAT CCCTGGCCTCTACCCACTTGATGCCAGTTGCAACCATCTATCTACCCATGCCCCCAAGTTATGACAACAG AAAATGCCTTCAGACATTGCCAAACGTCCCCTGGGGGGCAAATTAACACCAGGTTGAGAACTATTCCCAA GGTGTAGAGCTTAGTCACCGAGAAAAAATTTAAACAATATAGCTCTTCCTGAAAGGTAATCACTGCCAGC TCTTTAGCATATATACTTACAGATTATGCTCTTTCTATGGACAGTCCTCATTTTTCATGGTTCTAATCTG TGTGAATTTCAGTTACTATGGTTTGGTTAAATAACATCAGTCCTCGAAGAATTTGGCTCAAATTTGAGTT GCCAGGATATATGTATTACAAGTAACTGCATGCAGTACAAACTTTGCTGTTAGCTCTTCAGTCCACAGAT CACTATGTACATAACAGATGCTCTTCATGGTCACTGACTAATCATGTTTCTTCTTGAAGAGTCTTTTGGT GATTGGTCACTGCCTATCTGTTCACTTCACACGCAGACAGGAAAGTGTGTAGTTGTGTTGCCTCCCTGTC TCCTAGTGAGAAACTCGTGACATTTTACAAAAATGGACAATTGATGAGGGAATTGGCCAAGAAAGATGAA ATTTCAAATGAAATGTGGTAATGCTGGTAGTGAATTTCAAGCCAAACGTAATGGAATTATATAGACTAGA TAGCTGACTGTGGGAATGTCAACACTGTCACTGTTCAAGACTACATATACAGCCTGGGAAACTCAGTGAA GGTGGCATGTCAGCATAAATGAGGAAAGTGGTTTGATGAAAAGGATGAAGAGGTCCCAGAGGAGGTGACA CTGCAGAAGGAAACTTCACATTAAAGGCACCTTGAAGATATTTCACAACATCGAAAGTGCAAAGGATAAA ACGTTAGAAGCAGATCCAAACTTAGAAAGGAGTATGACAATTTGCAAAGGCATATGAAAGATACTCATTC CATATTGGATGTTAAACAACAAGAAGGCAAGTGCTGTTCAAATTACTCTGGATAAGGTTTTTACAAAGCA ATAAAACACTCATTCTCAGTGACTCTAATGTTTTAGAGTATACACAATAAATAGTTTTACTGTTTTCTCA TTTCCTTATTTATAATTTGACAGCAAGAGAGTTTTTAATGTTTTGACCGAAATTTTTAAATGTCGTGGAA AAATCATAATTTTCCTCATTGGTGATTAGGGTTGCTTTGCATGGTCATTTTTATGGTTCCGCATTACTGT GCAAAGCAAGAGCTGCCTGTATTTACAAAAAGTGTGGGTGAATACACATGCACACATGCACACACCATGC TTTTTCTCTTTTTAAAACATTTTACAAAATGGGATCAGACTATATGTATCAAATTACAACTTGCTTTTTT CATGGAAGTTTTTTTTGTTTGTTTGTTTGTTTGTTTTTGAGACACCATCTCTCTGTCGCCCAGGCTGGAG CGCAGTGGCGCTATCTCAGCCCACTGCAACCTCCACCTCTCGGAGTTCAAGTGATTCTCATGCCTCAGCC TCCCAAGTAGCTGGTACCACAGGTGCGTACCACCACACCCAGCTAATTTTTGTGTTTTTAATAGAGATGG GGTTTCGCCATGTTGGCTAGGCTGGTCTCGAACTCCTGACCTCAAGTGACCCACCCACCTCGGCCTCCCA GAGTGCTGGGATTACAGGTGTGAGCCACTGTGCCCAGCCAGAAGAATGTATTTTTGAAGAACTTTTGATT TCAGTATGTCTTAATCTACCTCATTCTTTTTTTTTTTTTTTTTTTTTATGTTTTTGAGACAGGTCTCACT CTGTCCCCCATGCTGGAGTTCAGTGGTGTGATCTCTGCTCAGTGAAACCCCTGCCTCCCAGGCTCAAGTG ATCCTCATGTCTCAGCTTCCCAAGTAGCTAGGACTACTGGCCTGTGCCACCACACCCAGCTAGTTTTTTC TGTATTTTATTCGTAGAGACAGGGTTTTGCCATGTTGCCCAGGTTGGTCTCAAACTCCTGGGCTCAAGTG ATCCATCTGCCTCGGCCTCTCAAAGTGCTGGGATTACAGGTGTGCGTCACTGTGCCTGGCCCCGTTGTCT ATTAACAGCTGTTTAGTTTATTTCCTTCTGTCCCCTAATTTGAAATAATGCTAAAGTGAATATTTTTGAT GGATACTATCATAAACTCCATTTAATCGATGAGTTCAATGGAGATTTAGAATGTGAAGTAACTGGCTAAG GTCAGGCAGCTACTAAGCTTTAGAGCTGGTGTTTGAACTTGGGGCAGTGTAATTTCAGAGCCCTTGCAAT CACAATGCTTTACACCTTCTCTTCCTTGTTCTTAGAAGCAGCTTTTAACAACGACAACAAATAATAAAAA AAAGATCTTACTGAGTCAGGTACAATTCTAAGTGCAATTATATTGTTATTATTCACTAAATAACAACCTG CGAGTTAGATAATGTTGTTATCCCTGTATTACAGTGAAGGAAACCGGAGGTATAAGAAGGTTAGGAAAGG TGCTCAGGGCCCACAGCAGTTTAATGGAGGAGCTGGGACTGCCCCCATGCAGCCTGGCTTCAGAACCTTG GCTCTCATTCATGTTATAAAGATGTGACTAGAGAAAAGTCTCTTTCATCCTGTGCTGTTGAAGATGGGTT TTTTTGTTGTTGTTGTTGTTAGTTTTGGCGTATATTTTCTCCTACTGTAATCTTTTAAAAATCTACTACC TAGCACAGACTGCCTCTCCCATTGTTTTCTTAGGGGGTGTCACTTGGAAGTTTGATAAGCTTACTGCCTA CTATGTCTTTAGTCAGCTTGTTGGTAAAATATTAATACTAGGCAAAGCCAGTCTGGTGTGGTGGCTCATG CCTGCTGTAATCCCAGTATTTTGGGAGGCCGAGGTGGGTGAATGACTTGAGGTCAGGAGTTTGAGACCAG CCTGGCCAATGTGGTGAAACCCCATCTGTACTAAAAATATAAAAATTTGCTGAGTGTGGTGGTGGGCGCC TGTAGTCCCAGCTACTCAGGAGGCTGAGGCACGAGAATCTCTTGGACCCGGGAGGTGGAGATTTCAGTGA GCTGAGATCGTGCCACTGCATTCCAGCCTGGGCGACAGAATGAGACTCCATCACACACACACACACACAC ACACACACACACACACACACACACTAATAGGTTTGCCACTGAAGTTGTTCTTTGGGTTTAGTCAACAAGT AGATACTTATTGAACACCTCCTAAATGCCATGTACCGGGTCTAGGATTTGAAATCAAAAGATGAACAAGA CATTGTCCCAGCTTCCAAGAGGTACATGGTCCACAGTGAAAAGAGAAACCGTTTTATAAATCCCACTGGT GAGTGCTGAAGTAGGAGTTTAGCAAGAGTCTGTGGGCACAGAGAGGCAGAGGGGCTGACTCTGCCTGGAA GTGGTCAGAGAGGCTTCACAGAGGAGGTGACATTGCCATGGTTCTTACAGACGTGAAGTCATGACAAGGC CTGGCTTGCCTGAGGTCAGGAAGTGCATTGTAGCTTCAATATAGGGGATGTGTTGGGAGGTTAGGGTAGC GATGATGTGGATAGGAGCTAGGGAAGACTAAGTTAGGGAATTTGGATTTTATCATGTCAGCCAGTGGAGA TGTTTAAGGAGGAAAATGTCCTGCTCAGCTTTGCCTTTCAGCATGTGACCCAAGATGTACTGGGATGGAG TACGTCTCCCTTCTAGAAACCAGTTAGAAAACACAGAAGAGTAGGCCAGGCATGGTGGCTCATGCCTGTA ATCCTAGTACTTTCGGAGGCCGAGGTGGACAGATCACTTGAGGTCAGGAGATTGAGACCAGCCTGGCCAA CATGTGAAACCCCGTTTCTACCAAAAAATAAAAAGTTAGCCAGGCGTGGTGGTGTATGTCTGTAGTCCCA GCTAGTCAGGTGCTTGAGGTGGGAGAATTGCTTGAACCCAAGAGGCGGAGTTTGCAGTGAGCTGAAATCA TGCCACTGCACTCCAGCCTGGGGGACAGAATGAGACCCTGTCTCAAAAAGAGAAAGCACACAAGAGAAAA GGGGCTGCAACCCAGTAAGCGATAGCAGGACTGGAAAAGGAAAGATGGATTTGGGAGATCTTCCCAGAGA CAAAATTGGATTGCTTCTGTGGGTGACGGAGGGAGAGAGTCTGAGGATGAGTACTCAAGATTTATATCTG GGAGCCTGGCTAGATAGTGATGTCATTGCCGTTTACTGAGATCCGGGAGCAAATTCAAAGGGGCCGTGAG TTCAGTTTGGTGCCTGTTCAGCAGCCTGTCCTAGATCCACCAAACAGCACTTTATTACTGGCCATTTATA ACAACTGCAAATATTATCTAAATGCTTTGTCATCTCACTGCCTCCTCCTTTGTCATCCCTAAGGTCTGGG CAGGAGACTGTGTTCATATACTTCATAGAGGTCCAGACCCCTTGCGTCTGGCATTCCTTTGGTCTATAAT TCAGTAAACTCTGCTAAAAAGGAAACGAGACTAGCTTGCTGTGGCCTCTTAAGCGACCCAGGGTAGCTTG TGATGGTTCAGATTATGATTTGTTCTAGAGCTTTTCCAGAGGCAGATGTTGAGGAGTTTATCCTATTTGT CCCCTTCCCTTTAAACAAACAAAAGTGCCGGCTGGACGCAGTGGCTCATGCTGGTAATCCCAGCATTTTG AGAGGCTGAGGCAGGCGGATCACCTGAGGTCAGGAGTTCGAAACTAAGCCTGGCCAGCATGGTGAAACCC TGTCTCTACTTAAAAAAAAAAAAATTAGTTGGGTGTGGTGGTGGGAGCCTATAATCCCAGCCACTCGGGA GGCTGAGGTGGGAGAATTGCTTGAATCTGGGAGGTGGAGGTTGCAGTGAGCTGAGATCACACCATTGCAC TCCAGCCTGGGTAGCAGAGTGAAACTCGGTCACAAAAAAAAAAAAAAAAAGAAGTCCCAACCCCCCAGTT TTTTATATCCTCTTAGTCATCATAGTTTATTAACAGTTTTGTTTACATATTGCTTCTTTTTCCCTCTTGG CTAGACTGTGAACCTTGAAGCCCTGTGAGCTTGGTCTAGTGCCTGGAGCATTGTGGGTACCAGGTTTCGA GAGAATGTGTGCTGCCAGAAAGCAGATCTTTGCCACCTCCTCTCCCCTCAGCTCCTGAACCACTGCCAGC AGTGGTTCTGGAATCAACCTGTACTTTCCTTCTGCATCCTGGGATGTAATTCTGGGTGATTGTAAGTTGG TTTATGGTCTAGCTTAGAATTGAGGCTTCTCTTGAGAGAGAGCATGTGTGTAAATGTTTAGCTTGTTCTA GTCTGTGGAGCATTCTCCTTCATAGAAAAGATGGGAAATACTGGAGATGAAAATTCTCCATTCTCTGTCA TTTTGTGTGTTAGAGTCTCTGTCCCCATCCCAGGGCCACTTCCTCCCTGGTTCTTCTTATGGCTTTGGAT GTAGCTTGAAGACATGCTCCTAGCATTTTCACAAGCTCTGCTTGTTGTGTTTAGTGAGCGCAGACTACTC CCTTCGGGCCTGTCCTGGCTCATGGGCAGTTGCTCGTGTCTTTGCACACATCCTTTACTGTCTCAGCTCT TCACTTCTCCCTGACATTTGTGGCTGCCTCCTCCTGGTTTCTTCTTTAAGCGATTATTGTGTTTTAGATG ATCAGAATTCACTTTTTAGAGACTTGGACCTTGTCTTTCAAAATGCATTCCCTTTTGGGATCTCTGCCCA TCATACTCCTTGGTCTCAACATCTAAATATTGGTTTTTTTTTTCTTTTTCTTTCTTTCTTTTTTTTTTTT TTTGAGATAGGGTCTCACTCTGTTGCCCAGGCTGAAGTGCAGTGGTACGATCATTGGCTCACTGCAGCCT TGACCTCCTGGGCTCAGTGATCTTCCTGCCTCAGCCTCCTGAGTAGCTGGGGCCACAGGCTAGTGCCACC ATGCCCTGCTAATTTTTTAAATTATTCATAGAGACGGGGTCTCCCTGTGTTGCCCAGGCTGGTCTTGAAC TCCTCCTTCTCCTTTTTGTATCCTCTTAGTCATCAAGCCATCCTCCTGCCTCAGCCTCCCAAAGTGCTGG GATTTCAGTGTGATCCACTGCGCCTGACCTGAATATTGGTTTTTTTGAAGTCTAGGCTAAACAACTGTTT TTGTCTCAGTTTTTTTTTTTTTAATTTCCCTCCTTTGAACTCTGAATTGACAAGCTTACTTCCTCCCAAT GTGGTGTTCTTGTTATTATTGTTTTTGCTAGCTGAAGTATTTTTTTTTTTTTTAAACATAATTTACTAGG TTTTTCTTCCTGGCCAGAAGTAAGTTCAGGGTAATAGTTCCCTTCCTTGTATCTTCAGCTGTGTGAGAGG TAATGTAGAGTGAGAATTTATTTATCAGGTGCCCTGCTCGTAGCAGAAGGCATGACCTCGACTTCTCTCT CACAGTGACCTTGTGTTTGTGTTGGTGGCTTGAACTCACTCTTGTGTCTGGGCCATTTCTCTCACTGTGT AGGAAAGAGTGGTTCCTGTCTTCTCCCTGGCCATGTAGTCTGCTGTGTGTCACCATAACAATCATCTATC TTCCGGTTCTTTTTCCTTCTCTCCTCACCCAGTTGTCTCCAGTCTTAGGCGTGTGGAATTGTGTACTGGG TGGGGGATGTGTGTGTGTGGGCCGCCCTCTTGATTTGTAGGATCCTTCTCTTCCTCCACATTCTCTGTCA ACTCTCCTCCACCCCCTGTGAGATCTGTGGACTCAGGTATACGTTGCTGTGAGTCTCATTCTGCTCAGCT GGGGTGATGAAGGTGAGATTGCTTTTGTCGCTTCAAAGTAAAATTTTAGATTTGCTTTGGCAGCCGCACA GGGTCGTATGCATGGGGGCTGCTTAGGCCAGAGGCGCAGTGTTCCTGACCTCCTTCCGTCTTACTTTCTC TTGCTAGTTTGTCCATCTCTGTGGATTTTTTAAAGTAGATACTAGATACCTAGATACTACTAAGAACATG ATCTTTCTCTTCTTGCCACTTGGATTTTAGCTTAAAGCCAACTTGGAACATTTAGGGTGTTTCCTTCCTA CCACTGTCTGCCTGGTCTCCTAGGGAAAGATGCCTTGTATCTTGTTCTGGTGTACAGTCTGCCCATTTAA TTGGTAAGTGTTTATTGTGACTCTTCTCTACTGGGCTCTGGCCCCAGGCCTGATGCGAATAGGGCAGGCC TGTGAACAGAGCAAAGACGAGTCACTTAGGAGGGGACGAGAGAGGCCAGCGGTAAACTAATATTACCAGC TCAGGGTTTATTTGTCAAAGCCTCCTTTGCTGTGAATAAAAGGTTAGATCTGAATTGGGTCTGAGTCCTG GCTTTATTACCTACTAGCCATGTGGCCTTGGGCAAATTATTAATACTTCCTTGGGCCTTGGTTGCCGCAC CTGTACGATGGAGTCAGCAATGGATCCTGTTCTGTAGGGCTGCTAGGAAGCTTAAATATAGCAATATTTG CTATATATAAAGTGCACCTGGTACATAATTGATGCGGTTGAAATGAAAATTCCTCTTTCTCTTTCAGTGC CATTTGCTGGAAGAAACAGAAGAAATATCTCTGTCCCCATCTTTCAGTTTCCTACCCAAGACTCCTGTGT GGTTGACATCACTGCTGTGTGCAGTGTTCATGTCCATATAAGTCAGAAGTGGCTTGCAGCAGTGGTTTGG GGCTTTGGGGCCTCTGCTCGCTCCTTATCAATTCTTAGGGTTACATCCTCTGGGAAGATGCCAGGCCTGG TCAAGTGTGGCCTCTGACCTAGAGTTATGCAAGGCCTCTCTTCCTCCTGTGGCCAGTGTGAAATTTCTCA TCTGTGCTCTCCTGCCTCTAGCAGGAAGGTTGGCCTACATTTGGGGCACATCTCTGTCACTGTCTCAGGC CAGGGGTTCAAATATAAGACCTGAATCATACTGCACCTCAGAACCCAAACCCTTTTACTTAATTTTTTTT AAAAAATTTCATTCAGATGGTAAAGGTTCAAACAATACATAGAGATATAAAACAGAAAGAAAAAAAAATA CACGCCTCTCTCTAGTACCTATTCCCCAGTAGTCAACACTGCTACCTTTTTTTTGCAGGGGAGGTAAATT CCTCCAGAAAAAAACTTAAACATCTACAATTTCATATATCCTCTCCCCTCTTCCCTAAAAAACAAAACAA TAACAACAAAACTATAGAAATGGGATTATGCTATATATTCTGTTCAGTACTTTTTTGTTTTTGAAAATTT AAAAAATATGCAAAAGAAGAAAATGTCATCCATATTACTACCACTTATAATTAACCACTAATTAACTTTT AGGTGTGTTTGCTTCTTGTCTTTATGAATATACTTTAAAAGCTACTTAAGTAAGGTGGAAGCAGTTCTGT TTAAAAAATTAGGATGTTGCCCGGGCGCTGTGGCTTACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGG CGGGCAGATCACGAGGTCAGGAGATCGAGCCCATCCTGAATAACATGGTGAAACCCTGTCTCTACTAAAA AATACAAAAAATTAGCCAGGCATGGTGGTGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGA GAATGACGTGAACCCGGGAGGCAGAGCTTGCAGTGAGCCAAGATCATGCCACTGCAGCTCCAGCCTGGGC GACAGAGCAAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAATAGGATGTTAAAGATAAAGCCAAAGTA TTATATCATCTTGGTCCTTATCTGCTTTCCCATTTAATAGCATCCTGCTCTCCCCGTCGCCGTGGATGGG GAGCTGCCTCTTTCTTCTACGACACCGCACGTTTTCCATTGTATGGATTTGCTGTCATTTCATTTATCTG ACCACCCTCTTATTGGTAGGCATTTAGGTTATTACCAGTTTTTTTGCCATTAAAATGCTTTATGAATATA ATGTGTAGGATGGTTTCTTGCTGGGTAATTACTGGGTCCAAGGTTTGAACATTTACAATTTTGATAGACA TGGCCAAATACCTCCCCAAAAATACTAGTTTATTTCTCTACCAACTGAATGTGTAAGAGAGTGCCTTTTC TCCCCAGATCTTTGCATAAACCTGGGAGTTTTATTTTGGTCAAACATTAAAATTTTTTTTTTGCCAGTCT GGTGAAATTATCATCTTTTTTATAAACATTTCTCTTTGAGCTACACTGAGTGTCTTCCATTCAGCCATCT GTGTTTCTCTTGCTTTGAACTGCCTGTTCTTATCGTTTGGCCATTTTTATATTAGGTTGTTGATCTTCAA CAATTGATTTGCCTGAGTTAAGTTAGCCTTTTATCCATCATGTGTTGGAAATATTTTAAAGATTTGTCAT CTACAGTGCGATTTTTAGGCCTCTTGACTTTTTGTTGAGCCCTAGGCTTTTGTGACTGCCTGTGACAGCT CTGGAGAGGGGGCCGACAGGCACAGTGGCCCGCAGTCGAGCCAGGCCCCATCTTCTGGGCAGTGACGCGT GGTTGTTTTAAGGCTTTTGGTACTGGGATTCCCCGTTGTAAGTTTTAGCTTTGTTTTGGGTAGGGACTTT TCCCCATCATATTAATGAACATTAATAACAAATAGAGACTTGCTTTTGCCTCCCAACCAAATGTTTGGGA ATGTGTGCACCCACGTGAAGGGTCTGTGTGATATCTTTATCTCATCAACCTTCTAAGGCTTTTAAAACCT GTTGTTAGATTTATGTTTAGATCATGGTTCTAGGGGAGAACCATCGTCACTCCTCATTGAGCTTTGCAGA GGCTCTGAAAGGAGGACATACTCTCTTCCCCAATCAATGTAGAGGAACGTCAGTAGTTCAGCCAAGATTG CTCTATCTGCCACCTCTTATGCTTCCAAGCTGGGCTAATTGAGAAGTGTGACATCTTGCTCCAGCCTATA AGCAGCTGTCTGTAATTTTGAGAGATGAGAAGGATTCTCCCTTAAACCATTGCTGCTTTTGTGGCAGCAT CTTATTTCTTTCCTTTGCAGCACAAATCACAGTGTATAATTAAAACTATTTTCTTTGAGCTTGTTTTTGG TGTACCTCCTGCACTAAAATGTTAAGTTCTGTGGCGGTCACGGGGCTTATTTGTCATGTTCTCTATTATA CCCTTGGCATCCTCTAAACCAGTGTGTGGCACATGCTAGGCACTCCGGGGTTTCACTGAGTGATCCATTC TGTTAGGATGGGATCAAGTGCTCATGTGTCTCCTCCTGTGTCCCTCTCTGGCTCCAGATCTTCCACCTGG CAGAGTTTCCGGAAGCCCCAGAGATATGCTCCATGGCCATAGGGCCTGAGACGTGGATGGCTGCCCTCTG ACTAAAATTTAGAGAGCTAAGCTTGTCTCTTTAAAAAGTAACATATACTAATTGTAAATCACCTAGAAAA TACAGACATAATAAAGGAAATTAAATCTGTGATTCTGTCTTTCAGAGATCATTACCATTAACAACTCATT GAGTCTTAATGCCTTTATTGTTTTTGTTTTGTTTTGTTTTGTTTTGTTTTTGAGACAGAGTCTCACTCTG TTGCCCAGGCTGGAGTGCAGGCTCACTACAACCTCCGCTTCCTGGGTTCAAGTGATTTTCCCACCTCAGC CTCCCAAGTAGCTGGGATTGCTTACAGGTGCGTGCCACCATGCCTGGCTAATTTTTTTGTATTTTTTGAT AGAGACAGGCTTTCAGCATGTTGGCCAGGCTGGTCATGAACTTCTGACTTCAAGTAATCTGCCCCCCTTG GCCTCCCAAAGTGCTGGGGTTATAGATGTGAGCCACTATGGCCAGCCCCTATGCCTTTATTTTTTTTATA TACAGATCCAATAAATATCCATAGAGCACTGAGTTTATGCTGTACATAAGGGTTTGTAACTTTCAGTTAC CATCAGACATGTTTTGATAATGAAATTTAAAGAAAGTACACATTGGGATTTGGGATGCAGAAGAAAAAAT AGGATAGTATTCTAGACAATGACAGTGATGATACCTGAGAATCTAGTAGACACTCAGGAATCCACATTTC CCCATTTAATATTCATCTGAAACACCATTTCAGTGGCTGTAGATTGTGTAGCTAAACTCACTTTTACATA AAACAACCTCTGTTACTTATCTCTGGGCCTTAAGTTTGTGATATAGTTTGGATGTTTGTTTCTCCCAAAT CTCATGTTGAAGTGTAATCCCCAGTGTGGGAGGTGGGGCCTGGTGGGAGGTGTTTGGGCCATGGGGGTAG GTCCCTCGTGAATGGCTTGGTGCTGTTCTTAAGATAGTGAGTTCTTAGGAGATCTGGTTGTTTAAAAGTG GGTGGCACCCCACCCCTGTTGCTCCTGCTCTTGCCATGTGACATCCCTGCTCCCCCTTCACCTTCCACCA TGATTGTAAGCTTCCTGAGGCCTCACCAAAAGCAGATACTAGTGCCAAGCTTGTACCAGCTGCAGAACTA TAAGCCAGTTATATCTTTTCTTTACAGATTACCCAGTCTCAGGTATTTCTTAATAGCAATGCAAAGTAGA CTAATAAGTTTGTTAGCTATTTCTAGTAAAGGTAAATAACTCTTGAGATGTATATTTTCTTAAAGATACG TCTATGATTAATACCTGAGGATGAAATTCTAAAAGTAGAATTTTAACATCAAAGGGTTTGCACTTTAAGG CATTTTCAGCCTCCATTTCTGGCTGTTGCTGTTGTGGACAGTCTTGGGCAGATTTTGAACTCTTTGCCTT ACTGTGGGGTGGTGGAAAGGAGGCTTTAGGAGCAGCCAGAGCAGGGTTCAAACTCCAGCCCTGCCAGGGA CAACTGGCCAAAAGGTCGTGAACTAATGACTCAGTGAGTTTTCTCATTTATAAAATAGGATGTTTCCTCC CAGGGTGGGGGTGAAGTGGGTGAGATGACCCATTTGAAGCACAGTGGACCCTTGAACAATGCAAAGGTTG GGCAGTCAATTCACATAAAACTTTTGATCTGAGTTGGGCAGATCACCTGAGATTAGGAGTTTGAGACCAG CGTGACCAACATGGAGAAACCCTGTCTCTACTAAAAATACAAAATTAGCCGGGCATGGTGGCACACGCCT GTAATCCCAGCTACTCGGGAGGCAGAGGCAGGAGAATCACTTGAACCCGGGAGGTGGAGGTTGCGGTGAG CCGAGATCGCACCATTGCACTCCAGCCTGGGTAATGAGAGTGAAACTCTATTTCAAAAAAAAAAAAAGGC CAGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGG AGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCCCTACTAAAAATAGAAAAAATTAGCCAGGCG TGGTGGTGGGCACCTATGGTCCCAGCTACTCGGGAAGCTGAGGCAGGAGAATGGCGTGAACCCGGGAAGC GGAGCTTGCAGTGAGCGGAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGGGCGAGACTCTGTCTCAA AAACAAAAACAAAAACAAAAAAAAACAAAGAAACAAAAGAAAACTTTTGATTCCCCTAGAACTACTATTA AATAATAGCCTACTGTTGACCCGAAGCCTTACTGATTACATAGTTGATTAACACATATTTTGTCTGTTGC GTGTATTATATCTTTATTCTTGAATAAAATAAGCTAAAGAAAATAAGCATCGTTAAGAAAATCACTTTGA GTAGGCTGAGGAAGAGGAGGAGGAAGAGGAAGGGTTGGTCTTGCTGCTGCAGGGCTGGCAGAAGTGGAAG AAAATCCCTGTATAAATGGATCCACGCAGTTCAAACCTGGGTTGTTCAAGGGCCAACAGTACTTAGCAGC CATTTAGCACAGAGCACTGCCAGCCCCCCTCGGCCTGCAGCCTGCTCCAGCACCTTGCTAAGAGGTTGCT GAGGCTCACCTGCAGCAGCTGCCCTCCCGAGTCCTCTTTCCTTTACACCCCTCAGAGCACCCGGGCCAGC CATCCTCCATGTGGTGCAGCAGAGGCGCCGGTGGTCCGGGAACCAGAGTGGGTGGCCCTGGCCTGGAGGC ACGGTGGGTTAGTGTGTGACACACGTGGCTTTCCCCCGACCCCCAGCTGCCTCCTGGGAGTGAAGAGGAG GTCTTATTTGCCAACACATACCGCACCACACACCCACAACACACTTGGTGCCAGAATCAGCCTTTTGCAT CGCTCTTGGCGCTGAATCAGAGTCTGTCTTGGGGAGGGATGTCTTCCTTCTCTCATTACATGCGCCCAGC TTAGGTGGTGTAGTGAGGGAGTGTACAGGGCTGGGATGCCACAGCCTGCTTTCCTCCCCGTGTCCTGGGG TCCCCCGTCTGTCCAGTGCCCAGAGCTATTAATAACACCTTCATTGAAATGGGTGTAATGGAATCCCAGT TGCCCCCCCCAGTGGGACTCCAACACATGGGGAGTGGGGAGCAGAATAATAATAGCAAACACGGATGCAG TACTTATTACGTGCCAAGCGTTATTCTTAGTTATTTACATCATGCACATCTATTAACTCATCTTGTATAG CAAGCCCATGAGGTGGGGACTATTACTGTCCTATTAATGGGTAAGGGAACCAAGGCACAAAGGGGTTGGA AACTTTTCCCAGTTCACATAGCTAGTGAGCAGTGGCGCTTGTGAAGGGGGTCCTCCTGAGGGCCTGGGGC CTGCTCCTTCCCAGTCTTGTCTTCATGTCCACCTTGCTGACGAGTGGCACATCAGGCCCTGGGTGCCGGC TGCTTTCCTGTCCTCTGGCTCAGCCAGGCTTCTAATGCTGACCACTCCTGAGTCTTTCCACGTGGCTCCA CAATGGCAGACTTGCAGGAGGAGATGAGGGGAACCATGCATACCTTGAATAGGGGGAGGGGTCCTGTCCT TCTTCCCCTCAGGTGCTGGAAGAGACAGAGAGGCATGGGACTGTATTTAGGCAGCTCCCGCAGCTCCCTC ACTGCCGCTGTCCTAGAGCTTCCTTCCCAGGCAATGCGCTCTGTGGCTTGGGCCCCTGCCCCTGCCACAG TTGGCAGGGGGCCTTGCCTGTGGCGTTGCAGCTGAGCACACGCAATCATTAACCTTTTCTACGTGTAAGA GAATTTCAGGCACAAACTGTGGGGCTGAGGTGAGTCACAATGTTGGACCGGGGCTTAGTTTGGGCTTAAA ATATTTCACAATTCCTCCAGGCATTCTTTGACTAATGATCTATGGCTTTTTAGTGGGAAGACCCTTCCTT CTTCTAGTCTCCAGTCCTCAGAGCATGGTTCAGGGCCTGTTGGCCTTCACTGCCCATGGCCATGCCCATG CCCAAGGAGCAGGGGCCTTGGCTTCTGGGTGGACCTGCCGCCTCGCTCTGCTGGTGGCCTCTGGCAGTGC CCTAGGAGTCCTGCTTTCCTTCCCTGTCTCTTCTTTGGCTTGGAGTGCAGGCCACCTCCCCTGCTGTTCT TTACTTAGCCCTGTACTCCAGATTAGCACATTCTTGGTTTCCTCTCTCCAGGCCTTCTGCGCTCCACACT TGTCCACAGAGCCACTTTGGCACTTCAGGGCTGTGCCCCCAGGACGTCAGCCAGCCTGCCTCGCCCATCT GAAGGGCTTTCATTGCTTGGGTTGATTTTCTTATCCAGTCAGGGATTTCTGATAAACATGTGCCTGGATG GATGTCAATGACCAGTCCTTTTTTTTTTTTTTTTTGTTAAATTTAATTTAAGTTCTGGAATACAAATGCA GGATGTGCAATGACCAGTCTTCATGGGAAATTCTTGCTAAGTTTCTCTAAGAAATTTAAAATACTACCTT TTCCAATTTATTTCAGGATGGAAAGGACAGCTCACCCTCAGTCACTGGGGGAGAGAGTTTAGTAGGGAGA AGAAGCAACAGAATGAGGGGGTGTTAGCTCAGAAGTTCCTAACCACTAGGTGAGGGAAGGAAGAGGGGAG GGAGTAAACAGAAATCAAATTAGATCTTGCCCATTAGAAACTCAGTTAGGTTGGGCAGATAAGGCATAAA TATGCAAAATGGTAAATTTTTTCAAAGTGGAAACTACCCTATATAGAGTTTCTGAAGCACCTTCAAGGAT ATTATTTCACGAAGTTGAATCTAATTTTACAGATGAGGAAACCCTTTCCAGAAAGATAGGTGGGCTTGCA TGACACAAGCTAGGAAGTGCAGAACTGGGATTCAAAATGCATGCGATTGCAAAGCCTAGGTTCACTGTGC TACATCCGTCTCCTCTAATGGGTAGAGAGTTTGTGCAAGTCTGGAAGTGTGATGTGAACCTAGCCCTTCT TGCACAAACTCTCCTTTGCCTTGTGCCACGCACTCCTAACGTGTTCAGGGCAGAAAGTGCGGAAGTTGCA GTGAGCGCTTGGAATTCAGGGGGTGCTAAGGAGCATGCATTTAGATTTGGATCTTGGTGCATCCTCACTT AGCACAGCTCTGGTTGGCAGATGTCCTGGTGGTCGTCACTGGGCTGAAGACAGAAACCCAGCCTACAATC TTGGTGATAACTTGTGCTGGTTACATCCACATGCTCCAAGCTCAACTCAGTGGTGACGGAGGAACCCCCC TGTACTGTGGCATTAATGGTACTGGTTGACAGTGATGAATGCCTTTCTGATAATAAAGCACTTTTAGAGG TATTATTTCATTAGATGCTCATAATGTTTCTATGAGGGGGAGGCTAGGCAGGTATCATCGCTCCTAAATG CATGTGGCACAGGCTCTGAAAGGTAGACCTCTCTGTGAGGCTGTGCAAGAAGAAATTGACAAATTTCAGA CTGGGCCAAGTCTTCCCTGATTGTAACTCTACAACCAGGCATTGCTTCTGAGTAAATCTGACAACTTTGA TTCTTCTCCTCTGGGCTCCAGTTCCTGTGTGCCTGTAGGGGGCGATCGAGGTTCTTTCTGCTTGGCTGCT CTGGAAACCTTGTTCCTCCTGAACCCTTTGAATTTAGCACTCTTACAGCATGTAATCTCACTGGATTTTA AGGATTTTCTGTGTCTCCCCTCATATCTTCTTCTGCCCCCCACTAGCCTAGGCTTTTCCAGATCAGGACT GCTCTATTTGGTTTTGACATTCAGTGCAATGCATGGCCCATAGTAGGAGCTCAGTAAATGCTTGCTGGAT TGAATTATATACAAAGGAAATTGGCCAGTGCCTTCTCTTGCTCCCCTTAGAGCATGGGAAAGTAAACTTT TTTCCTGGTACATCCAAATGAATGAAGTTGAAGGCTGGGCATGGTGGCTCACACCTGTAATCCCAGCACA TTGGGAGGCCAAGGTGGGGTATCACTTGAGACCAGGAGTTCGAGACCAGCCTGGCCAACATGGCGAAACC CGGTCTCTACTAAAAATACCAAAAAATTAGCCAGACGTGGTGGCTCACACCTGTAATCCCAGCTACTCAG GAGGCTGAAGTGGGAGAATTGTTTGAACCCGGGAGGCGGAGGTTACAGTGAGCCAAGATTGTGCCACTGC ACTCCAGCCTGGGCAACAGAGCGAGACCCTGTCTCAGAAACAAACAAACCCTAATGAAGTTGAAAGTGGC AGAACTCAAGACCCATGAGGTGTCCTCATATGGCCACAAGGTGGCAGTGTGACCTCCTGGGAACCTTGCC TCCTGCAACTATTGGCTCCGGCCACCTGTTACTCCATGGGAGAGACCGAGTTATCTAGTCATTGATTCCT TCTAGTCACCTGTTTGGGGAATTGCCTCTGCAAAGTCAGTCTGAGAAATCTTGGCTTCCAGCCTCCTCTA AAAGCTGGGTGGTGTGGTGGAAAGACTTGGTCTTTGGAGTCTACCAGGCCTGGATTCCAACCTTGGCTCT GCCTTTTCTCAGAAACTTAGCCTTGGGCATGCTACTTCTCTGAGCCTCAGCTTCCCCATCCTGTAAAATG GCAAATGTACAGTTAGGAAAAACCCAACATATCATGGGCCATAGCATAAATGTATGCCAGCATTCTTGTT GGAAATGCTCATTTGTCCTTCCCTTCCCTCTGCAAGCTGGCTCCATCATGGCCATCTGATCTTATTTGCA AGCTTCAGACACTTTCCAGCAGGTTCTTAGGCCTCCCTGCTGTATCACCCCAGCTCCACTCCATCTCGGT CAGTCAGCACCTGCTTCCCACGTTTCCCTCTGCCTTCATGCCTTCCCTCTGCCTGTCCATTTCCTTCCCA GCATGTCTCTTGGACACCCCAGCCCTCTGAATGTCCAAAGCAGTTGGAGTGTGGACTGTGTAGGGCTCAT CTTGACTTCCCATGAAGATGCTAAATCTGTGAGTGTCCTTGTCTTAATTATTTTGGCACCTGCGCTTGCA CTTAGACAATTGGTGATAAAAATGACAGCTATTAGTGAGTGCATGTCAGATACTCTGTGAGGTGCTTTGT GGAAATATTTCATTTAATCCTCACAACAAATCTGTGAAACAGAAGCCATTATCCATCCCCACTTTACAAA GGAAGGGTAGATCAGGATGCTTTTGGCTCCAAGCAATAGACAATTTCATGAAAAGCAGCTTAAACAGTAA GAAGAGTTTATTATCTTGTCAAAAAGAAGTACTGAGGGATCCCTGGTGATGGCAGCGAGGATCCAGGTGA TTGCCATTTCTCCTGGTTGCCTTCCTCAGTGCATTGGTTTATCCTCTTAGGCCCCCCTTACTGGTAATAA TGTGACTGTCATGGTCCCAGGTGCCATATGCAGGAGAGATGATGTACATTTCTTGTGCTCCCTTTAAGAA GCCTCTTAGCAGATTTCTTTTTTTTTTGAGATGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGC GTGATCTCGGCTCGCTGCAAGCTCCACCTCTCAGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTA GCTGGGGCTACAGTCGCCTGCCACCATGCCTGGCTAATTTTTTTTGTATTGTTAGTAGGGACGGGGTTTC ACCGTGTTAGCCAGGATGGTCTTGATCTCCTGACCTCGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTG GGATTACAGGCACGAGCCACCGTGCCCGGCAGCAGATTTCTTACAAGGCTCTTGGCCAGTTGAGTTGTAG GCTTGTTCCCAAGCCAGTCACTAGCAAAGGGACTGGAATTAATGAGACTGGCTTAGACAGGTCAAGATTG AACCCCTGAGGCTGGTGAGAAGCCAGCCTCCTTTAATACCCCTAGCCAATTGGTCCAGGGAGAAGAAGGG GCATCAGTGAGGTTCGACGAGTTAAGTAACTTGCTCAAGCTTGGAAATCTAGTAATAACTGGATTCATAC TGGCATCCGGCTGACTTCCAAGGCCATCTGTTGCCAGGTTGAAGTCAACTACAGAGGTAGAGAGAATATT GCTCTGGATTTGTTGTGCTGGGTCTGAGTAATTGCTGAGGGGCCTTTTCCTATGGACTCTGGAGTCTCTC TTCTCTCTAGCCCCCTTTCCAATACTGTATTGGTTTTTCTCAGTCTGCCTTTCTCCCCGAAGCCCCTTCA CCCCCTGCTTCCCAGTACCTGAGTGCTGCCTGCCTTCCACAGTAGACTTTATGGCCTAAGCTGGAGACAG GTCTAAGCTGGACCGAATGGCCTGAGGGCTGATCTCAGTGTAGCTGTCAAGGCCCCAAGAGAGTCATCAT GAGATTTCATATAGAGCAGATAAGGAACTGCAGAGGCCTCAGGAAATGTGCCAAGGGGGCTGGTGGGGGG GGCCAGCAGGAGTGGGGGGTTTGTGGTATGTCGGTGGCGATGTCAGGGCATGTGGGCCAGGGGCTTAGAG CAGGCCCATGTGACAGCGCAGTTACTCAGAAAGCTGTTTGGCCTGCAGATGCTTCAGGACTGCCCCAAGG CCCGCAGGGAGGTGGAGCTGCACTGGCGGGCCTCCCAGTGCCCGCACATCGTACGGATCGTGGATGTGTA CGAGAATCTGTACGCAGGGAGGAAGTGCCTGCTGATTGTCATGGAATGGTAAGCAGCCACTGTTCTAGTC CCGGCCCAGCCTGTTCCCACTCCTCACTCAGGCACCTTACCCTCTGAGGACAGCCCAGGGATGGGCCTGA AGCCTGGAATGTAAACACTTGATTTTTTGGGGGGCAGTGGAGAGTGGCGGCGGGCTGTTGTGTTCTCTGG ATCTCACTGTGGCTTCATTTCAGTTTGGACGGTGGAGAACTCTTTAGCCGAATCCAGGATCGAGGAGACC AGGCATTCACAGAAAGAGGTAGAAAGGGTCTGTTGTGGGAGCACGTGCAGGCAGGCAGGGCAGTGGGGGT CTGAAGGGGGCCTTTGCAGTGCCTGCTCTTGGGGAAGGGTGCTGAGGCTGCTGCCCCCTCCAGCATGCTG CAAGGGGTGCCTCAGCTGACCAGGGAAGCTCCTGGTGGCTTTGTTTCTGGGGTGGGTGGTGGCTGTGGGG AGCCTCAGGCTGCACAGAGGTGGGACCCGGTGCACTGGGTTTTCAAGCCTAATGATGTGTCTTTGTGACT TTCTTTCCCACTCACTCTTCCCTCCCCTCTACAGAAGCATCCGAAATCATGAAGAGCATCGGTGAGGCCA TCCAGTATCTGCATTCAATCAACATTGCCCATCGGGATGTCAAGGTGCCAGCTGTTCATAACCCTGAGCC CGAGTGCTGTGGGGGGCAACAAAGGGGCTGTGGCCACCCCAGAGATGGTTGCCAGGCCACCCTGCGTCCT TGCTGCCTGGTTCCTGAGCATGCCATTCTCTGCCTTGTAGGGCCTTGCCCTCTCTGCCCATGGGCAAACC CCTAAACCCAGTAGTGAAGCATTCTCTGGCCCCACTCAGCCCTGTGGTTCTCCTCAGGCAGAACCCCTCA GTCACACTCTTGGTTTCTCTGTTCCTGTGGTGTTTACTGCGGGTTCTGTGTGTCAGTCTGTTATCTCCAG GCACTCTGGAAACCCTGCAGAGGCAGGCACCTGCCCATAGAGAGCTGCCACTCCTCGTGGTGGGCAGTGC CCAGGATAGGCAAATGGTTGCTGGATGAGTAGAGGAAGGGAGGAACCAGGATCCTTTTCGTTTCTGATAG CCCCTCCCAGGTCCAGCAGGGTTGCTATTTTTCTGTCTCTCTTTCTGTAGCCTGAGAATCTCTTATACAC CTCCAAAAGGCCCAACGCCATCCTGAAACTCACTGACTTTGGCTTTGCCAAGGAAACCACCAGCCACAAC TCTTTGACCACTCCTTGTTATACACCGTACTATGTGGGTAAGTCCACAGGGGGCCCAGGGACCTAGGCTT TTCCCAGAACTTTTCTCAGCCCCTCCTCTTGGCTATCTGGGGGGCCGCAAATCCTAGGAGAGTTGTGTCT GTATGGCCCCTTCTGGTGCTGGTTCTGCTGGGACCTGCTGAGAAGTAGGGCTTGTCAGAGCGAAGCTACA GTTGAGAAATTGTAGGAAAGGATCTGCTGGGATCTTTCTGAGAAGAGCCATGGTTTCCATCAGATTCTCC ATGGAGTCTGGACCCAGGTCTTGTTCTGGAGCCACAGCTGATTGGCATGGAAGAAGCTTTCAAAGCATGT TCAGAGCATCTGTGAAATTAAATGAACGGCATGGGCCTGAAAGTCTCATGCAGTTCAGGATTTTTAGAAT CTTAAGCTCCTAGTTCCAGGTTCCTCATGGAGGAGGATGTTCTGTTCCAGTCCCTGGGCTGGGCTTTGGC TCTTCCTTCTGTGCCCCAACTGCTGCCACCTCATGATAGGCTGAAAGGTTGGGATGGGGAGCATCTTTCA CAGAGAAACTGAGTGGATCACAGGGTTCTGAGGGCCGGCCCACCCATGTTGACCTTTGATTTGCAGCTCC AGAAGTGCTGGGTCCAGAGAAGTATGACAAGTCCTGTGACATGTGGTCCCTGGGTGTCATCATGTACATC CTGTGAGTGTGCTGGGGAGGGGGCTGGGTGGGGCAGGGAGTCAGGGCGGCCTGTACTTCTCCAGGACAAG AGGAAGAGGCAGACGTTAGCATTCCCCTTTGTACAGGGGAGTCCCCTGCGTGCCCCTTCTCTCAGTTCCG ATAGCTAAGTGGCGGGTGTAAACCAGCTCATGGGCTGGAAAGTGTGCGCCTTAGATACTTGCTATGCTGG ATTCCCGGGCCCCGGGCTTGACTTTGTATATTGTGCCTGTGTCAATAAGCCCTGATTTCTCTGTGACCTT TACAAGGAGAAGAGCCTGTTTCTCATCCTGTTCCTGGTACAGGGCCACTAAGTGACAGCTGTTCTGTCTC CCACTTCCTTCCTCCTGTTGATGCAGGCTGTGTGGGTATCCCCCCTTCTACTCCAACCACGGCCTTGCCA TCTCTCCGGGCATGAAGACTCGCATCCGAATGGGCCAGTATGAATTTCCCAACCCAGAATGGTCAGAAGT ATCAGAGGAAGGTAAGAACCCAGGCTTTCAGGACAAGGGGAAGAGCCCGTGTGTGTGTGTGTGTGTGTAT GTGTGTACACGCAGACACATGTATGGGCCTCCATCTCATGTGCGTGGTGTAACTGTGGGTTAGCACCTAT GCCCACGCCTGCGGGGTGCGTCCTGCTTCATTTTGCCTGTGTGGAGGGCTGGAGGCAGGGCCAAGGCTGT GGGGCTGTGCAGGGCCTCTCAAGTGGTACAGCCGTAATGGTCCTTGGGGCCAGTTGCTCCGGCAGCCTGC CTCCATGCACCCCCTCTTTGAACCTGGTTTCCCCATGAAAACTGGGGAAAGGAGCAGGCCAGGGAGAGTG ACCCCTGAGCTGTCACTGCCCCCTGTCCCACCCCACAGTGAAGATGCTCATTCGGAATCTGCTGAAAACA GAGCCCACCCAGAGAATGACCATCACCGAGTTTATGAACCACCCTTGGATCATGGTAAGCTCGGCAGGCT GGGGAGCCTTGGGTCTCACGGGACTATTCCACAGGACAGAGTCTTAGCCAGGACCCTACCCCAGGCTTTC ACTCGGACCCCTTTTCTCTCTTCTCAGCAATCAACAAAGGTCCCTCAAACCCCACTGCACACCAGCCGGG TCCTGAAGGAGGACAAGGAGCGGTGGGAGGATGTCAAGGTGAGGGGCACCACTGGGTGAGAGGGGCTCCA GGTGGGGTGGGCGGCTTGCGGGGAGTGCCCAGGTGTGAGGCGTGGTGCTGGTAGGGGAGAGCTTGATTCT GCCTCTCTCATCCCAGGGGTGTCTTCATGACAAGAACAGCGACCAGGCCACTTGGCTGACCAGGTTGTGA GCAGAGGATTCTGTGTTCCTGTCCAAACTCAGTGCTGTTTCTTAGAATCCTTTTATTCCCTGGGTCTCTA ATGGGACCTTAAAGACCATCTGGTATCATCTTCTCATTTTGCAGAAGAGAAACTGAGGCCCAGAGGCGGA GGGCAGTCTGCTCAAGGTCACGCAGCTGGTGACTGGTTGGGGCAGACCGGACCCAGGTTTCCTGACTCCT GGCCCAAGTCTCTTCCTCCTATCCTGCGGGATCACTGGGGGGCTCTCAGGGAACAGCAGCAGTGCCATAG CCAGGCTCTCTGCTGCCCAGCGCTGGGGTGAGGCTGCCGTTGTCAGCGTGGACCACTAACCAGCCCGTCT TCTCTCTCTGCTCCCACCCCTGCCGCCCTCACCCTGCCCTTGTTGTCTCTGTCTCTCACGTCTCTCTTCT GCTGTCTCTCCTACCTGTCTTCTGGCTCTCTCTGTACCCTTCCTGGTGCTGCCGTGCCCCCAGGAGGAGA TGACCAGTGCCTTGGCCACAATGCGCGTTGACTACGAGCAGATCAAGATAAAAAAGATTGAAGATGCATC CAACCCTCTGCTGCTGAAGAGGCGGAAGAAAGCTCGGGCCCTGGAGGCTGCGGCTCTGGCCCACTGAGCC ACCGCGCCCTCCTGCCCACGGGAGGACAAGCAATAACTCTCTACAGGAATATATTTTTTAAACGAAGAGA CAGAACTGTCCACATCTGCCTCCTCTCCTCCTCAGCTGCATGGAGCCTGGAACTGCATCAGTGACTGAAT TCTGCCTTGGTTCTGGCCACCCCAGAGTGGGAGAGGCTGGGAGGTTGGGAGGCTGTGGAGAGAAGTGAGC AAGGTGCTCTTGAACCTGTGCTCATTTTGCAATTTTATCAGTAATTTGACTTAGAGTTTTTACGAAACCT CTTTTGTTGTCCTTGCCCCACTCCTCTCCACCAGACGCCTTCCTCTCTGGATACTGCAAAGGCTTGTGGT TTGTTAGAGGGTATTTGTGGAAACTGTCATAGGGATTGTCCCTGTGTTGTCCCATCTGCCCTCCCTGTTT CTCCACAACAGCCTGGGGTTGTCCCCGCTGGCTCACGCGTTCTGGGAGCTCAAGGCCACCTTGGAGGAGG ATGCCACGCACTTCCTCTCTCGGAGCCCTCAGACATCTCCAGTGTGCCAGACAAATAGGAGTGAGTGTAT GTGTGTGTGTGTGTGTGTGTGTGTGCACACGTGTGTATGAGTGCGCAGATCTGTGCCTGGGATCGTGCAT TTGAGGGGCCAGGGGCAGGCAGGGCTGCAGAGGGAGACGGCCCTGCTGGGGCTTAGGAACCTTCTCCCTT CTTGGGTCTGCCCTGCCCATACTGAGCCTGCCAAAGTGCCTGGGAAGCCCACCCAGATTCTGAAACAGGC CCTCTGTGGCCTGTCTCTATTAGCTGGGTTCCGGGAGGCAGAGAGGAGTGACCGGGCACTGGCACTGCGA TCAGGAAGACTGGACCCCCAGCCCCCAGGGCCCCCCTCCCCCCACTTAGTGCTGGTCCTAGGTCCTCTGA GGCACTCATCTACTGAATGACCTCTCTACTTCCCCTTCTTGCCATTATTAACCCATTTTTGTTTATTTTC CTTAAATTTTTAGCCATTTCTCCATGGGCCACCGCCCAGCTCATGTAGGTGAGCCTGGGCAGCTTCTGTT GGCAGAGCTTTTGCATTTCCTGTGTTTGTCCTGGGTTCTGGGGCATCAGCCAGCTACCCCTTGTGGGCAA AGGCAGGGCCACTTTTGAAGTCTTCCCTCAGATTTCCATTGTGTGGCCTGGTGGGTCAGGGGGAGTCTTT GCACCAAAGATGTCCTGACTTTGCCCCCTTGCCCATCAGCCATTTGCCATCACCCCAAACAACTCAGCTT CGGGGCCGGTGAGGGGAGGGGCCTCCCCCAGCACAGATGAGGAGCAGCTGGGGTAGGCTGTCTGTGCCAT GGCCCCCCACTCCCCCTTCCCTTGGAGGGAGAGGTGGCAGGAATACTTCACCTTTCCTCTCCCTCAGGGG CAGGTGGTGGAGGGGCGCCCAGGGTCGTCTTTGTGTATGGGGGAAGGCGCTGGGTGCCTGCAGCGCCTCC CTTGTCTCAGATGGTGTGTCCAGCACTCGATTGTTGTAAACTGTTGTTTTGTATGAGCGAAATTGTCTTT ACTAAACAGATTTAATAGTTGAGA Download Select all
Length	49374
OMIM ID	602006
HGNC ID	HGNC:6887
Unigene ID	Hs.643566
Ensembl ID	ENSG00000162889
PharmGKB ID	PA30631

mRNA Information

mRNA ID	XM_005273353.3
Exon	join(1..597,43799..43938,44124..44188,44485..44564, 45061..45187,45777..45852,46227..46351,46729..46814, 46928..47008,47127..47173,47664..49372)
mRNA Sequence	>9261 GGCCGCCGGCCCGGGGCTGGGTACATTGTCGCGCGGCCGCTTCCCCCCGGCCGGGCCCCCGCCG CCCCGCGGTCCCCAGAGCGCCAGGCCCCCGGGGGGAGGGAGGGAGGGCGCCGGGCCGGTGGGAG CCAGCGGCGCGCGGTGGGACCCACGGAGCCCCGCGACCCGCCGAGCCTGGAGCCGGGCCGGGTC GGGGAAGCCGGCTCCAGCCCGGAGCGAACTTCGCAGCCCGTCGGGGGGCGGCGGGGAGGGGGCC CGGAGCCGGAGGAGGGGGCGGCCGCGGGCACCCCCGCCTGTGCCCCGGCGTCCCCGGGCACCAT GCTGTCCAACTCCCAGGGCCAGAGCCCGCCGGTGCCGTTCCCCGCCCCGGCCCCGCCGCCGCAG CCCCCCACCCCTGCCCTGCCGCACCCCCCGGCGCAGCCGCCGCCGCCGCCCCCGCAGCAGTTCC CGCAGTTCCACGTCAAGTCCGGCCTGCAGATCAAGAAGAACGCCATCATCGATGACTACAAGGT CACCAGCCAGGTCCTGGGGCTGGGCATCAACGGCAAAGTTTTGCAGATCTTCAACAAGAGGACC CAGGAGAAATTCGCCCTCAAAATGCTTCAGGACTGCCCCAAGGCCCGCAGGGAGGTGGAGCTGC ACTGGCGGGCCTCCCAGTGCCCGCACATCGTACGGATCGTGGATGTGTACGAGAATCTGTACGC AGGGAGGAAGTGCCTGCTGATTGTCATGGAATGTTTGGACGGTGGAGAACTCTTTAGCCGAATC CAGGATCGAGGAGACCAGGCATTCACAGAAAGAGAAGCATCCGAAATCATGAAGAGCATCGGTG AGGCCATCCAGTATCTGCATTCAATCAACATTGCCCATCGGGATGTCAAGCCTGAGAATCTCTT ATACACCTCCAAAAGGCCCAACGCCATCCTGAAACTCACTGACTTTGGCTTTGCCAAGGAAACC ACCAGCCACAACTCTTTGACCACTCCTTGTTATACACCGTACTATGTGGCTCCAGAAGTGCTGG GTCCAGAGAAGTATGACAAGTCCTGTGACATGTGGTCCCTGGGTGTCATCATGTACATCCTGCT GTGTGGGTATCCCCCCTTCTACTCCAACCACGGCCTTGCCATCTCTCCGGGCATGAAGACTCGC ATCCGAATGGGCCAGTATGAATTTCCCAACCCAGAATGGTCAGAAGTATCAGAGGAAGTGAAGA TGCTCATTCGGAATCTGCTGAAAACAGAGCCCACCCAGAGAATGACCATCACCGAGTTTATGAA CCACCCTTGGATCATGCAATCAACAAAGGTCCCTCAAACCCCACTGCACACCAGCCGGGTCCTG AAGGAGGACAAGGAGCGGTGGGAGGATGTCAAGGGGTGTCTTCATGACAAGAACAGCGACCAGG CCACTTGGCTGACCAGGAGGAGATGACCAGTGCCTTGGCCACAATGCGCGTTGACTACGAGCAG ATCAAGATAAAAAAGATTGAAGATGCATCCAACCCTCTGCTGCTGAAGAGGCGGAAGAAAGCTC GGGCCCTGGAGGCTGCGGCTCTGGCCCACTGAGCCACCGCGCCCTCCTGCCCACGGGAGGACAA GCAATAACTCTCTACAGGAATATATTTTTTAAACGAAGAGACAGAACTGTCCACATCTGCCTCC TCTCCTCCTCAGCTGCATGGAGCCTGGAACTGCATCAGTGACTGAATTCTGCCTTGGTTCTGGC CACCCCAGAGTGGGAGAGGCTGGGAGGTTGGGAGGCTGTGGAGAGAAGTGAGCAAGGTGCTCTT GAACCTGTGCTCATTTTGCAATTTTATCAGTAATTTGACTTAGAGTTTTTACGAAACCTCTTTT GTTGTCCTTGCCCCACTCCTCTCCACCAGACGCCTTCCTCTCTGGATACTGCAAAGGCTTGTGG TTTGTTAGAGGGTATTTGTGGAAACTGTCATAGGGATTGTCCCTGTGTTGTCCCATCTGCCCTC CCTGTTTCTCCACAACAGCCTGGGGTTGTCCCCGCTGGCTCACGCGTTCTGGGAGCTCAAGGCC ACCTTGGAGGAGGATGCCACGCACTTCCTCTCTCGGAGCCCTCAGACATCTCCAGTGTGCCAGA CAAATAGGAGTGAGTGTATGTGTGTGTGTGTGTGTGTGTGTGTGCACACGTGTGTATGAGTGCG CAGATCTGTGCCTGGGATCGTGCATTTGAGGGGCCAGGGGCAGGCAGGGCTGCAGAGGGAGACG GCCCTGCTGGGGCTTAGGAACCTTCTCCCTTCTTGGGTCTGCCCTGCCCATACTGAGCCTGCCA AAGTGCCTGGGAAGCCCACCCAGATTCTGAAACAGGCCCTCTGTGGCCTGTCTCTATTAGCTGG GTTCCGGGAGGCAGAGAGGAGTGACCGGGCACTGGCACTGCGATCAGGAAGACTGGACCCCCAG CCCCCAGGGCCCCCCTCCCCCCACTTAGTGCTGGTCCTAGGTCCTCTGAGGCACTCATCTACTG AATGACCTCTCTACTTCCCCTTCTTGCCATTATTAACCCATTTTTGTTTATTTTCCTTAAATTT TTAGCCATTTCTCCATGGGCCACCGCCCAGCTCATGTAGGTGAGCCTGGGCAGCTTCTGTTGGC AGAGCTTTTGCATTTCCTGTGTTTGTCCTGGGTTCTGGGGCATCAGCCAGCTACCCCTTGTGGG CAAAGGCAGGGCCACTTTTGAAGTCTTCCCTCAGATTTCCATTGTGTGGCCTGGTGGGTCAGGG GGAGTCTTTGCACCAAAGATGTCCTGACTTTGCCCCCTTGCCCATCAGCCATTTGCCATCACCC CAAACAACTCAGCTTCGGGGCCGGTGAGGGGAGGGGCCTCCCCCAGCACAGATGAGGAGCAGCT GGGGTAGGCTGTCTGTGCCATGGCCCCCCACTCCCCCTTCCCTTGGAGGGAGAGGTGGCAGGAA TACTTCACCTTTCCTCTCCCTCAGGGGCAGGTGGTGGAGGGGCGCCCAGGGTCGTCTTTGTGTA TGGGGGAAGGCGCTGGGTGCCTGCAGCGCCTCCCTTGTCTCAGATGGTGTGTCCAGCACTCGAT TGTTGTAAACTGTTGTTTTGTATGAGCGAAATTGTCTTTACTAAACAGATTTAATAGTTGA Download Select all
Length	3133

CDS Information

Location	join(319..597,43799..43938,44124..44188,44485..44564, 45061..45187,45777..45852,46227..46351,46729..46814, 46928..47008,47664..47807)
CDS Sequence	>lcl\|XM_005273353.3_cds_XP_005273410.1_1 [gene=MAPKAPK2] [protein=MAP kinase-activated protein kinase 2 isoform X1] [protein_id=XP_005273410.1] [location=319..1434] ATGCTGTCCAACTCCCAGGGCCAGAGCCCGCCGGTGCCGTTCCCCGCCCCGGCCCCGCCGCCGCAGCCCC CCACCCCTGCCCTGCCGCACCCCCCGGCGCAGCCGCCGCCGCCGCCCCCGCAGCAGTTCCCGCAGTTCCA CGTCAAGTCCGGCCTGCAGATCAAGAAGAACGCCATCATCGATGACTACAAGGTCACCAGCCAGGTCCTG GGGCTGGGCATCAACGGCAAAGTTTTGCAGATCTTCAACAAGAGGACCCAGGAGAAATTCGCCCTCAAAA TGCTTCAGGACTGCCCCAAGGCCCGCAGGGAGGTGGAGCTGCACTGGCGGGCCTCCCAGTGCCCGCACAT CGTACGGATCGTGGATGTGTACGAGAATCTGTACGCAGGGAGGAAGTGCCTGCTGATTGTCATGGAATGT TTGGACGGTGGAGAACTCTTTAGCCGAATCCAGGATCGAGGAGACCAGGCATTCACAGAAAGAGAAGCAT CCGAAATCATGAAGAGCATCGGTGAGGCCATCCAGTATCTGCATTCAATCAACATTGCCCATCGGGATGT CAAGCCTGAGAATCTCTTATACACCTCCAAAAGGCCCAACGCCATCCTGAAACTCACTGACTTTGGCTTT GCCAAGGAAACCACCAGCCACAACTCTTTGACCACTCCTTGTTATACACCGTACTATGTGGCTCCAGAAG TGCTGGGTCCAGAGAAGTATGACAAGTCCTGTGACATGTGGTCCCTGGGTGTCATCATGTACATCCTGCT GTGTGGGTATCCCCCCTTCTACTCCAACCACGGCCTTGCCATCTCTCCGGGCATGAAGACTCGCATCCGA ATGGGCCAGTATGAATTTCCCAACCCAGAATGGTCAGAAGTATCAGAGGAAGTGAAGATGCTCATTCGGA ATCTGCTGAAAACAGAGCCCACCCAGAGAATGACCATCACCGAGTTTATGAACCACCCTTGGATCATGCA ATCAACAAAGGTCCCTCAAACCCCACTGCACACCAGCCGGGTCCTGAAGGAGGACAAGGAGCGGTGGGAG GATGTCAAGGGGTGTCTTCATGACAAGAACAGCGACCAGGCCACTTGGCTGACCAGGAGGAGATGA Download Select all
CCDS ID	CCDS31001.1

Protein Information

Protein ID	NP_004750.1
Protein Name	Mitogen-activated protein kinase-activated protein kinase 2
Molecular Wt. (Da)	42072
Protein Sequence	>9261 MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYK VTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLY AGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENL LYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYIL LCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM NHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKGCLHDKNSDQATWLTRL Download Select all
Length	370
Uniprot ID	P78545
Ensembl Protein ID	ENSP00000352673

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
T	Phosphorylation	206
T	Phosphorylation	222
S	Phosphorylation	272
T	Phosphorylation	317
T	Phosphorylation	334
T	Phosphorylation	206
T	Phosphorylation	222
T	Phosphorylation	317
T	Phosphorylation	334
T	Phosphorylation	25
T	Phosphorylation	25
T	Phosphorylation	338
T	Phosphorylation	338
Y	Phosphorylation	63
Y	Phosphorylation	63

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
207	AKT1	1261	NP_005154.2	in vitro;in vivo	11042204
240	ALOX5	1065	NP_000689.1	in vitro	1 077 954 511 844 790
1385	CREB1	442	NP_604391.1	in vitro	8887554
1912	PHC2	10340	NP_932157.1	in vivo;yeast 2-hybrid	15094067
2115	ETV1	2765	NP_004947.2	in vitro;in vivo	11551945
3315	HSPB1	9076	NP_001531.1	in vitro;in vivo	7 799 959 133 288 610 000 000
4046	LSP1	1083	NP_002330.1	in vitro	8995217
6464	SHC1	2780	NP_001123512.1	in vivo;yeast 2-hybrid	15094067
6722	SRF	2788	NP_003122.1	in vitro;in vivo	1 075 365 284 132 260 000 000 000 000 000
6929	TCF3	918	NP_003191.1	in vitro;in vivo;yeast 2-hybrid	10781029
7054	TH	1865	NP_954986.2	in vitro;in vivo	6 150 037 113 598 750 000 000
7249	TSC2	1850	NP_000539.2	in vitro;in vivo	12582162
7534	YWHAZ	3183	NP_003397.1	in vitro;in vivo	12861023
7538	ZFP36	1835	NP_003398.1	in vitro;in vivo	14688255
9532	BAG2	4859	NP_004273.1	in vitro;in vivo	15271996
10092	ARPC5	11969	NP_005708.1	in vitro	12829704
10949	HNRNPA0	17112	NP_006796.1	in vitro	12456657
29904	EEF2K	7369	NP_037434.1	in vitro	12171600

Pathway Information

Pathway Name	Pathway ID
MAPK signaling pathway	hsa04010
Neurotrophin signaling pathway	hsa04722
VEGF signaling pathway	hsa04370
Viral carcinogenesis	hsa05203

Structure Information

PDB ID	1KWP
Resolution	2.8
Method	X-RAY DIFFRACTION
Chains	A,B
Molecule	MAP Kinase Activated Protein Kinase 2
Model	View

Domain Information

ID	Location	Description
cd14170	61-363	STKc_MAPKAPK2
cl21453	61-363	PKc_like superfamily
cd14089	62-324	STKc_MAPKAPK
cd14172	59-325	STKc_MAPKAPK3
cd05117	62-324	STKc_CAMK
cd14171	58-325	STKc_MAPKAPK5
cd14092	83-346	STKc_MSK_C
cd14091	62-340	STKc_RSK_C
cd14083	59-324	STKc_CaMKI
cd14003	62-324	STKc_AMPK-like
cd14090	61-325	STKc_Mnk
cd14166	68-329	STKc_CaMKI_gamma
cd14167	68-325	STKc_CaMKI_alpha
cd14095	68-324	STKc_DCKL
cd14175	62-337	STKc_RSK1_C
cd14093	68-324	STKc_PhKG
cd14007	68-325	STKc_Aurora
cd14085	60-344	STKc_CaMKIV
cd14084	58-325	STKc_Chk2
cd14179	62-342	STKc_MSK1_C
cd14178	61-336	STKc_RSK3_C
cd14096	103-325	STKc_RCK1-like
cd14169	110-325	STKc_CaMKI_beta
cd14086	61-331	STKc_CaMKII
cd14180	84-343	STKc_MSK2_C
cd14087	69-325	STKc_PSKH1
cd14176	53-337	STKc_RSK2_C
cd14174	61-325	STKc_Mnk1
cd05123	70-324	STKc_AGC
cd14006	70-324	STKc_MLCK-like
cd14103	70-325	STKc_MLCK
cd14106	55-325	STKc_DRAK
cd14168	68-329	STKc_CaMKI_delta
cd14177	70-333	STKc_RSK4_C
cd14088	80-325	STKc_CaMK_like
cd14184	61-324	STKc_DCKL2
cd14173	61-325	STKc_Mnk2
cd14009	115-324	STKc_ATG1_ULK_like
cd14181	68-324	STKc_PhKG2
cd14183	58-325	STKc_DCKL1
cd14097	70-325	STKc_STK33
cd14182	68-327	STKc_PhKG1
cd00180	70-323	PKc
cd14081	70-325	STKc_BRSK1_2
cd08215	68-325	STKc_Nek
cd14008	70-325	STKc_LKB1_CaMKK
cd14080	68-325	STKc_TSSK-like
cd14094	68-337	STKc_CASK
cd14185	115-324	STKc_DCKL3
cd14099	70-325	STKc_PLK
cd05580	61-324	STKc_PKA_like
cd14098	103-324	STKc_Rad53_Cds1
cd14014	63-315	STKc_PknB_like
cd05122	69-325	PKc_STE
cd05579	76-324	STKc_MAST_like
cd14075	86-325	STKc_NIM1
cd14105	60-325	STKc_DAPK
cd06606	68-325	STKc_MAPKKK
cd14194	60-325	STKc_DAPK1
cd14078	60-325	STKc_MELK
cd14079	70-324	STKc_AMPK_alpha
cd14073	68-325	STKc_NUAK
cd14002	61-325	STKc_STK36
cd05572	70-324	STKc_cGK
cd14191	61-325	STKc_MLCK1
cd14074	113-325	STKc_SNRK
cd14663	62-324	STKc_SnRK3
cd14195	60-325	STKc_DAPK3
cd14209	61-324	STKc_PKA
cd14077	70-325	STKc_Kin1_2
cd14196	60-325	STKc_DAPK2
cd14121	115-324	STKc_ULK3
cd14198	63-325	STKc_DRAK2
cd14197	70-325	STKc_DRAK1
cd14193	66-325	STKc_MLCK4
cd14114	61-325	STKc_Twitchin_like
cd14662	83-324	STKc_SnRK2
cd05571	68-324	STKc_PKB
cd06623	69-325	PKc_MAPKK_plant_like
cd14069	62-324	STKc_Chk1
cd05575	69-323	STKc_SGK
cd05573	61-324	STKc_ROCK_NDR_like
cd14190	66-325	STKc_MLCK2
cd14116	60-325	STKc_Aurora-A
cd14109	61-325	PK_Unc-89_rpt1
cd05118	63-325	STKc_CMGC
cd14665	83-324	STKc_SnRK2-3
cd13994	70-325	STKc_HAL4_like
cd14165	70-325	STKc_TSSK1_2-like
cd13985	69-321	STKc_GAK_like
cd06614	68-325	STKc_PAK
cd05595	68-363	STKc_PKB_beta
cd14071	100-325	STKc_SIK
cd05612	61-324	STKc_PRKX_like
cd14192	68-325	STKc_MLCK3
cd13999	77-318	STKc_MAP3K-like
cd05581	61-324	STKc_PDK1
cd05599	69-324	STKc_NDR_like
cd07832	62-324	STKc_CCRK
cd14082	68-324	STKc_PKD
cd14072	115-325	STKc_MARK
cd05584	68-314	STKc_p70S6K
cd14004	62-325	STKc_PASK
cd05570	69-323	STKc_PKC
cd14104	70-340	STKc_Titin
cd08217	62-325	STKc_Nek2
cd14005	63-324	STKc_PIM
cd06609	68-349	STKc_MST3_like
cd06627	70-325	STKc_Cdc7_like
cd07829	68-325	STKc_CDK_like
cd05604	68-324	STKc_SGK3
cd05602	68-322	STKc_SGK1
cd14161	68-325	STKc_NUAK2
cd08530	62-323	STKc_CNK2-like
cd14107	63-324	STKc_obscurin_rpt1
cd14163	68-325	STKc_TSSK3-like
cd14118	115-325	STKc_CAMKK
cd05578	68-325	STKc_Yank1
cd05585	69-327	STKc_YPK1_like
cd07830	63-324	STKc_MAK_like
cd13993	63-321	STKc_Pat1_like
cd14120	117-323	STKc_ULK1_2-like
cd14164	115-325	STKc_TSSK6-like
cd08220	101-325	STKc_Nek8
cd05592	68-318	STKc_nPKC_theta_like
cd05603	68-265	STKc_SGK2
cd14133	63-325	PKc_DYRK_like
cd14117	60-330	STKc_Aurora-B_like
cd13989	70-349	STKc_IKK
cd13987	70-324	STKc_SBK1
cd14186	61-325	STKc_PLK4
cd07833	63-324	STKc_CDKL
cd14115	70-324	STKc_Kalirin_C
cd13996	68-321	STKc_EIF2AK
cd05583	69-324	STKc_MSK_N
cd05620	68-324	STKc_nPKC_delta
cd14137	63-323	STKc_GSK3
cd05611	73-324	STKc_Rim15_like
cd06648	70-325	STKc_PAK_II
cd05586	70-382	STKc_Sck1_like
cd14162	136-324	STKc_TSSK4-like
cd14201	113-325	STKc_ULK2
cd05596	60-358	STKc_ROCK
cd14202	133-325	STKc_ULK1
cd08218	70-325	STKc_Nek1
cd14113	113-325	STKc_Trio_C
cd07834	63-324	STKc_MAPK
cd05601	125-323	STKc_CRIK
cd06612	69-325	STKc_MST1_2
cd06917	68-336	STKc_NAK1_like
cd07841	70-337	STKc_CDK7
cd14076	115-325	STKc_Kin4
cd05594	53-363	STKc_PKB_alpha
cd06625	69-325	STKc_MEKK3_like
cd05593	68-314	STKc_PKB_gamma
cd06632	68-325	STKc_MEKK1_plant
cd05613	68-314	STKc_MSK1_N
cd08219	62-320	STKc_Nek3
cd05598	68-324	STKc_LATS
cd05582	68-323	STKc_RSK_N
cd14134	52-324	PKc_CLK
cd14187	65-321	STKc_PLK1
cd13997	70-323	PKc_Wee1_like
cd06659	70-328	STKc_PAK6
cd06605	69-328	PKc_MAPKK
cd06639	68-325	STKc_myosinIIIB_N
cd06611	70-330	STKc_SLK_like
cd08225	68-325	STKc_Nek5
cd06626	71-325	STKc_MEKK4
cd14119	70-324	STKc_LKB1
cd07840	63-324	STKc_CDK9_like
cd05619	60-324	STKc_nPKC_theta
cd06608	68-325	STKc_myosinIII_N_like
cd14200	116-325	STKc_CaMKK1
cd14070	70-325	STKc_HUNK
cd05609	131-326	STKc_MAST
cd05597	61-324	STKc_DMPK_like
cd06610	61-325	STKc_OSR1_SPAK
cd06621	70-332	PKc_Pek1_like
cd07831	63-324	STKc_MOK
cd13976	86-325	PK_TRB
cd05621	51-377	STKc_ROCK2
cd08221	124-325	STKc_Nek9
cd05590	68-314	STKc_nPKC_eta
cd06647	70-325	STKc_PAK_I
cd08224	63-318	STKc_Nek6_7
cd06638	61-325	STKc_myosinIIIA_N
cd13990	101-324	STKc_TLK
cd05589	69-263	STKc_PKN
cd06643	70-336	STKc_SLK
cd07838	70-254	STKc_CDK4_6_like
cd14189	68-322	STKc_PLK3
cd06613	68-325	STKc_MAP4K3_like
cd14108	62-324	STKc_SPEG_rpt1
cd14131	70-323	PKc_Mps1
cd08528	115-318	STKc_Nek10
cd05587	69-263	STKc_cPKC
cd05622	61-377	STKc_ROCK1
cd05600	62-368	STKc_Sid2p_like
cd05591	68-267	STKc_nPKC_epsilon
cd14037	85-327	STKc_NAK_like
cd05614	68-324	STKc_MSK2_N
cd13974	158-322	STKc_SHIK
cd07843	73-325	STKc_CDC2L1
cd06656	70-336	STKc_PAK3
cd14199	115-325	STKc_CaMKK2
cd14023	90-324	PK_TRB1
cd06644	70-344	STKc_STK10
cd07852	70-327	STKc_MAPK15-like
cd05624	61-324	STKc_MRCK_beta
cd06658	70-325	STKc_PAK5
cd14112	97-325	STKc_Unc-89_rpt2
cd05616	69-263	STKc_cPKC_beta
cd14010	84-324	STKc_ULK4
cd13979	67-318	STKc_Mos
cd06631	136-325	STKc_YSK4
cd14188	68-322	STKc_PLK2
cd14038	70-266	STKc_IKK_beta
cd08223	68-325	STKc_Nek4
cd14210	57-325	PKc_DYRK
cd14101	80-326	STKc_PIM2
cd05627	60-380	STKc_NDR2
cd07845	70-324	STKc_CDK10
cd13986	63-322	STKc_16
cd06654	70-325	STKc_PAK1
cd06640	70-330	STKc_MST4
cd08529	70-323	STKc_FA2-like
cd05623	61-324	STKc_MRCK_alpha
cd06641	70-330	STKc_MST3
cd06655	70-336	STKc_PAK2
cd14111	84-325	STKc_SPEG_rpt2
cd14022	160-324	PK_TRB2
cd05617	51-384	STKc_aPKC_zeta
cd14110	78-325	STKc_obscurin_rpt2
cd05618	68-314	STKc_aPKC_iota
cd08222	68-325	STKc_Nek11
cd14046	68-322	STKc_EIF2AK4_GCN2_rpt2
cd14039	70-313	STKc_IKK_alpha
cd08228	77-316	STKc_Nek6
cd05588	68-263	STKc_aPKC
cd13982	64-323	STKc_IRE1
cd06642	70-350	STKc_STK25
cd06624	69-325	STKc_ASK
cd05615	60-263	STKc_cPKC_alpha
cd06652	68-325	STKc_MEKK2
cd07848	69-323	STKc_CDKL5
cd05631	68-318	STKc_GRK4
cd14100	117-325	STKc_PIM1
cd07837	70-324	STKc_CdkB_plant
cd14102	117-325	STKc_PIM3
cd06651	68-324	STKc_MEKK3
cd14000	79-323	STKc_LRRK
cd05577	88-314	STKc_GRK
cd07866	60-324	STKc_BUR1
cd05630	68-323	STKc_GRK6
cd05607	61-314	STKc_GRK7
cd06607	70-327	STKc_TAO
cd05628	68-302	STKc_NDR1
cd05605	128-324	STKc_GRK4_like
cd05574	69-324	STKc_phototropin_like
cd07855	61-363	STKc_ERK5
cd14059	70-322	STKc_MAP3K12_13
cd14047	62-257	STKc_EIF2AK2_PKR
cd07854	70-269	STKc_MAPK4_6
cd06657	120-328	STKc_PAK4
cd05629	61-324	STKc_NDR_like_fungal
cd07857	63-325	STKc_MPK1
cd07836	70-324	STKc_Pho85
cd07863	103-325	STKc_CDK4
cd07865	70-324	STKc_CDK9
cd06628	102-325	STKc_Byr2_like
cd14050	68-323	PKc_Myt1
cd06633	124-356	STKc_TAO3
cd07849	59-327	STKc_ERK1_2_like
cd06653	68-325	STKc_MEKK3_like_u1
cd05632	68-318	STKc_GRK5
cd06630	102-323	STKc_MEKK1
cd14212	63-267	PKc_YAK1
cd14058	115-328	STKc_TAK1
cd05610	120-323	STKc_MASTL
cd07858	70-337	STKc_TEY_MAPK
cd14068	127-315	STKc_LRRK2
cd06646	62-320	STKc_MAP4K5
cd14061	69-318	STKc_MLK
cd07835	70-324	STKc_CDK1_CdkB_like
cd14041	60-326	STKc_TLK2
cd06645	51-327	STKc_MAP4K3
cd06620	61-330	PKc_Byr1_like
cd14019	167-323	STKc_Cdc7
cd07853	174-325	STKc_NLK
cd08229	53-317	STKc_Nek7
cd07864	60-325	STKc_CDK12
cd14154	70-258	STKc_LIMK
cd13977	133-257	STKc_PDIK1L
cd06635	70-336	STKc_TAO1
cd14145	65-322	STKc_MLK1
cd05608	134-314	STKc_GRK1
cd14024	144-325	PK_TRB3
cd14052	70-253	PTKc_Wee1_fungi
cd05576	72-324	STKc_RPK118_like
cd06618	55-325	PKc_MKK7
cd07839	70-324	STKc_CDK5
cd14040	68-326	STKc_TLK1
cd14033	104-322	STKc_WNK4
cd07846	69-263	STKc_CDKL2_3
cd07862	70-266	STKc_CDK6
cd06616	70-302	PKc_MKK4
cd06629	65-325	STKc_Bck1_like
cd13988	70-263	STKc_TBK1
cd07847	166-324	STKc_CDKL1_4
cd14146	134-313	STKc_MLK4
cd14065	70-253	PKc_LIMK_like
cd06637	134-325	STKc_TNIK
cd06619	68-328	PKc_MKK5
cd00192	91-318	PTKc
cd14031	102-329	STKc_WNK3
cd06617	110-327	PKc_MKK3_6
cd14132	60-323	STKc_CK2_alpha
cd07851	68-324	STKc_p38
cd14213	70-324	PKc_CLK1_4
cd07850	68-325	STKc_JNK
cd06615	61-328	PKc_MEK
cd05606	134-324	STKc_beta_ARK
cd14215	63-324	PKc_CLK2
cd14214	70-324	PKc_CLK3
cd06634	124-334	STKc_TAO2
cd07876	173-325	STKc_JNK2
cd05626	65-305	STKc_LATS2
cd07878	70-357	STKc_p38beta
cd14148	69-289	STKc_MLK2
cd14225	68-325	PKc_DYRK4
cd06636	68-325	STKc_MAP4K4_6_N
cd05038	67-313	PTKc_Jak_rpt2
cd14224	68-263	PKc_DYRK2_3
cd07877	61-358	STKc_p38alpha
cd07871	70-312	STKc_PCTAIRE3
cd14012	58-323	PK_eIF2AK_GCN2_rpt1
cd13978	70-263	STKc_RIP
cd14066	102-266	STKc_IRAK
cd07859	63-263	STKc_TDY_MAPK
cd14222	70-253	STKc_LIMK2
cd07880	61-327	STKc_p38gamma
cd14036	86-321	STKc_GAK
cd14051	101-323	PTKc_Wee1
cd07842	63-324	STKc_CDK8_like
cd07856	68-325	STKc_Sty1_Hog1
cd05041	115-313	PTKc_Fes_like
cd07860	70-324	STKc_CDK2_3
cd14229	70-261	STKc_HIPK3
cd06622	70-327	PKc_PBS2_like
cd07879	70-259	STKc_p38delta
cd14221	64-253	STKc_LIMK1
cd13995	73-322	STKc_MAP3K8
cd07844	176-324	STKc_PCTAIRE_like
cd07875	134-325	STKc_JNK1
cd14138	84-323	PTKc_Wee1a
cd05625	65-324	STKc_LATS1
cd13983	115-325	STKc_WNK
cd14067	165-323	STKc_LRRK1
cd14049	70-315	STKc_EIF2AK1_HRI
cd07861	70-324	STKc_CDK1_euk
cd14147	134-313	STKc_MLK3
cd14227	58-263	STKc_HIPK2
cd14030	113-329	STKc_WNK1
cd05033	68-254	PTKc_EphR
cd13975	105-259	PKc_Dusty
cd07873	70-324	STKc_PCTAIRE1
cd05063	65-282	PTKc_EphR_A2
cd14205	68-257	PTKc_Jak2_rpt2
cd07874	136-325	STKc_JNK3
cd14011	115-324	PK_SCY1_like
cd05116	70-254	PTKc_Syk
cd14048	68-322	STKc_EIF2AK3_PERK
cd14155	70-253	PKc_TESK
cd14063	134-320	PK_KSR
cd13991	63-318	STKc_NIK
cd05084	115-313	PTKc_Fes
cd14211	68-261	STKc_HIPK
cd14228	58-263	STKc_HIPK1
cd14139	84-323	PTKc_Wee1b
cd05085	115-261	PTKc_Fer
cd06650	61-328	PKc_MEK1
cd14018	161-313	STKc_PINK1
cd14156	70-253	PKc_LIMK_like_unk
cd07872	70-324	STKc_PCTAIRE2
cd05065	68-264	PTKc_EphR_B
cd05044	115-315	PTKc_c-ros
cd13968	70-209	PKc_like
cd05081	86-257	PTKc_Jak3_rpt2
cd14060	136-272	STKc_MLTK
cd14226	59-263	PKc_DYRK1
cd14136	165-325	STKc_SRPK
cd05039	134-254	PTKc_Csk_like
cd05080	68-315	PTKc_Tyk2_rpt2
cd05115	55-254	PTKc_Zap-70
cd05633	134-314	STKc_GRK3
cd05066	115-264	PTKc_EphR_A
cd07870	174-324	STKc_PFTAIRE2
cd14032	102-329	STKc_WNK2_like
cd05082	134-254	PTKc_Csk
cd05059	131-333	PTKc_Tec_like
cd14135	173-259	STKc_PRP4
cd05112	136-332	PTKc_Itk
cd14013	146-324	STKc_SNT7_plant
cd14062	165-268	STKc_Raf
cd05056	115-263	PTKc_FAK
cd05060	70-254	PTKc_Syk_like
cd05032	70-254	PTKc_InsR_like
cd07869	173-276	STKc_PFTAIRE1
cd14223	134-314	STKc_GRK2
cd05092	70-321	PTKc_TrkA
cd05083	134-313	PTKc_Chk
cd05045	142-318	PTKc_RET
cd07867	166-264	STKc_CDC2L6
cd05105	144-313	PTKc_PDGFR_alpha
cd07868	166-264	STKc_CDK8
cd14152	134-256	STKc_KSR1
cd06649	61-328	PKc_MEK2
cd05099	65-319	PTKc_FGFR4
cd14158	134-263	STKc_IRAK4
cd14150	131-266	STKc_A-Raf
cd05101	155-320	PTKc_FGFR2
cd13992	164-316	PK_GC
cd05103	170-322	PTKc_VEGFR2
cd05071	134-315	PTKc_Src
cd14203	127-315	PTKc_Src_Fyn_like
cd05148	136-313	PTKc_Srm_Brk
cd05048	68-266	PTKc_Ror
cd05069	134-315	PTKc_Yes
cd13980	173-321	STKc_Vps15
cd05113	134-254	PTKc_Btk_Bmx
cd05072	170-315	PTKc_Lyn
cd05070	127-315	PTKc_Fyn
cd05098	155-320	PTKc_FGFR1
cd05061	70-254	PTKc_InsR
cd05074	56-332	PTKc_Tyro3
cd05036	115-263	PTKc_ALK_LTK
cd05100	170-320	PTKc_FGFR3
cd05034	115-322	PTKc_Src_like
cd14017	63-212	STKc_TTBK
cd05053	174-318	PTKc_FGFR
cd14016	63-213	STKc_CK1
cd05073	70-320	PTKc_Hck
cd14207	170-320	PTKc_VEGFR1
cd05114	131-267	PTKc_Tec_Rlk
cd05079	170-315	PTKc_Jak1_rpt2
cd14149	128-263	STKc_C-Raf
cd05089	69-313	PTKc_Tie1
cd14153	76-283	PK_KSR2
cd05037	165-313	PTK_Jak_rpt1
cd05054	68-322	PTKc_VEGFR
cd05055	68-315	PTKc_PDGFR
cd05067	70-320	PTKc_Lck_Blk
cd05093	70-264	PTKc_TrkB
cd14054	113-254	STKc_BMPR2_AMHR2
cd14151	128-266	STKc_B-Raf
cd05109	91-263	PTKc_HER2
cd14664	174-318	STK_BAK1_like
cd05068	134-289	PTKc_Frk_like
cd05047	69-263	PTKc_Tie
cd14127	63-261	STKc_CK1_fungal
cd05049	69-319	PTKc_Trk
cd05035	86-318	PTKc_TAM
smart00750	155-326	KIND
cd05075	68-332	PTKc_Axl
cd14125	174-261	STKc_CK1_delta_epsilon
cd14142	133-316	STKc_ACVR1_ALK1
cd05106	170-315	PTKc_CSF-1R
cd05108	68-335	PTKc_EGFR
cd05102	170-320	PTKc_VEGFR3
cd14027	166-318	STKc_RIP1
cd14204	68-322	PTKc_Mer
cd14056	144-258	STKc_TGFbR_I
cd14130	63-263	STKc_TTBK1
cd14064	136-263	PKc_TNNI3K
TIGR03724	120-214	arch_bud32
COG3642	119-212	Bud32
smart00220	68-325	S_TKc
pfam00069	65-325	Pkinase
COG0515	62-386	SPS1
PTZ00263	70-324	PTZ00263
PTZ00267	94-348	PTZ00267
PTZ00283	67-365	PTZ00283
PTZ00426	126-359	PTZ00426
PTZ00266	60-313	PTZ00266
PHA03390	115-325	pk1
PLN00034	70-334	PLN00034
PTZ00024	70-337	PTZ00024
smart00221	83-318	STYKc
smart00219	83-318	TyrKc
PTZ00036	63-324	PTZ00036
pfam07714	68-318	Pkinase_Tyr
PLN00009	60-252	PLN00009
TIGR03903	86-261	TOMM_kin_cyc
PTZ00284	63-259	PTZ00284
PHA03207	103-299	PHA03207
PHA03209	161-261	PHA03209
PHA03212	73-269	PHA03212
PRK13184	166-350	pknD
PHA03211	173-254	PHA03211
PHA03210	166-305	PHA03210
PLN03225	146-240	PLN03225
PLN03224	166-235	PLN03224

Ontology Information

HPRD ID	8835
Molecular Class	Serine/threonine kinase
Molecular Function	Transcription factor activity (GO:0003700)
Biological Process	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO