Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MARCKS | 4082 | myristoylated alanine-rich protein kinase C substrate | 6 | PKCSL, 80K-L |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24662837 | 2015 | Cell line : SW480, SW707 Source : - Sample Type : CRC tumor No. of Sample : 926 MSI-typed CRCs Stage : - | Immunohistochemistry | Mutational inactivation | - | The finding that MARCKS acts as a mediator of apoptosis in MSS CRC cells adds a novel tumor-suppressing function. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008] | Chromosome | 6 |
| Location | 6q21 |
| Start | 114178527 |
| End | 114184652 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 6126 |
| OMIM ID | 177061 |
| HGNC ID | HGNC:6759 |
| Unigene ID | Hs.519909 |
| Ensembl ID | ENSG00000155130 |
| PharmGKB ID | PA30637 |
mRNA Information
| mRNA ID | NM_002356.6 |
|---|---|
| Exon | join(1..513,2349..6141) | mRNA Sequence | Download Select all |
| Length | 4322 |
Protein Information
| Protein ID | NP_002347.5 |
|---|---|
| Protein Name | myristoylated alanine-rich protein kinase C substrate |
| Molecular Wt. (Da) | 23379 |
| Protein Sequence | Download Select all |
| Length | 332 |
| Uniprot ID | P04155 |
| Ensembl Protein ID | ENSP00000291527 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 135 |
| T | Phosphorylation | 150 |
| S | Phosphorylation | 262 |
| G | Myristoylation | 2 |
| S | Phosphorylation | 101 |
| S | Phosphorylation | 118 |
| S | Phosphorylation | 159 |
| S | Phosphorylation | 163 |
| S | Phosphorylation | 167 |
| S | Phosphorylation | 170 |
| S | Phosphorylation | 27 |
| S | Phosphorylation | 46 |
| S | Phosphorylation | 81 |
| S | Phosphorylation | 159 |
| S | Phosphorylation | 163 |
| S | Phosphorylation | 170 |
| S | Phosphorylation | 159 |
| S | Phosphorylation | 163 |
| S | Phosphorylation | 170 |
| S | Phosphorylation | 145;- |
| T | Phosphorylation | 150;- |
| S | Phosphorylation | 27;- |
| S | Phosphorylation | 101;- |
| S | Phosphorylation | 170;- |
| T | Phosphorylation | 143;- |
| S | Phosphorylation | 147;- |
| S | Phosphorylation | 26;- |
| S | Phosphorylation | 29;- |
| S | Phosphorylation | 77 |
| T | Phosphorylation | 120 |
| S | Phosphorylation | 131 |
| S | Phosphorylation | 132 |
| S | Phosphorylation | 134 |
| S | Phosphorylation | 63 |
| S | Phosphorylation | 83 |
| S | Phosphorylation | 128 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 805 | CALM2 | 242 | NP_001734.1 | in vitro | 12577052 |
| 1508 | CTSB | 287 | NP_680090.1 | in vitro | 9295331 |
| 4836 | NMT1 | 1187 | NP_066565.1 | in vitro | 10734119 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Fc gamma R-mediated phagocytosis | hsa04666 |
| MicroRNAs in cancer | hsa05206 |
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 1064 |
|---|---|
| Molecular Class | Cytoskeletal protein |
| Molecular Function | Protease inhibitor activity (GO:0030414) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.