Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MAT2A | 4144 | methionine adenosyltransferase II, alpha | 2 | SAMS2, MATA2, MATII |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17631143 | 2007 | Cell line : RKO, HT 29 Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 13 Stage : - | real time RT-PCR,diphenyltetrazolium bromide assay | Up-regulation | - | up-regulation of MAT2A also provides a growth advantage and SAMe and MTA can block mitogenic signaling in colon cancer cells. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011] | Chromosome | 2 |
| Location | 2p11.2 |
| Start | 85766101 |
| End | 85772403 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 6303 |
| OMIM ID | 601468 |
| HGNC ID | HGNC:6904 |
| Unigene ID | Hs.516157 |
| Ensembl ID | ENSG00000168906 |
| PharmGKB ID | PA30647 |
mRNA Information
| mRNA ID | NM_005911.5 |
|---|---|
| Exon | join(1..401,2106..2183,2278..2400,2656..2768,2852..2995, 3178..3396,3588..3770,3924..4057,4693..6303) | mRNA Sequence | Download Select all |
| Length | 3022 |
Protein Information
| Protein ID | NP_005902.1 |
|---|---|
| Protein Name | methionine adenosyltransferase II, alpha |
| Molecular Wt. (Da) | 73028 |
| Protein Sequence | Download Select all |
| Length | 395 |
| Uniprot ID | P02786 |
| Ensembl Protein ID | ENSP00000353224 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 114 |
| K | Acetylation | 81 |
| S | Phosphorylation | 384 |
| T | Phosphorylation | 262 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Biosynthesis of amino acids | hsa01230 |
| Cysteine and methionine metabolism | hsa00270 |
| Metabolic pathways | hsa01100 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam02773 | 252-388 | S-AdoMet_synt_C |
| cl03707 | 252-388 | S-AdoMet_synt_C superfamily |
| pfam02772 | 128-250 | S-AdoMet_synt_M |
| cl03706 | 128-250 | S-AdoMet_synt_M superfamily |
| pfam00438 | 16-115 | S-AdoMet_synt_N |
| cl02868 | 16-115 | S-AdoMet_synt_N superfamily |
| PTZ00104 | 16-395 | PTZ00104 |
| TIGR01034 | 19-394 | metK |
| PRK05250 | 18-388 | PRK05250 |
| COG0192 | 17-394 | MetK |
| PLN02243 | 17-393 | PLN02243 |
| PRK12459 | 16-388 | PRK12459 |
Ontology Information
| HPRD ID | 1828 |
|---|---|
| Molecular Class | Enzyme: Adenosyltransferase |
| Molecular Function | Growth factor activity (GO:0008083) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P31153 | DB00134 | L-Methionine | SmallMoleculeDrug |
| P31153 | DB00118 | S-Adenosylmethionine | SmallMoleculeDrug |