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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
MBD1 4152 methyl-CpG binding domain protein 1  18PCM1, CXXC3 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
19074829   2008Cell line : Human colon carcinoma cell line HCT116, DNMT1 knockout HCT116 (HCT116.DNMT1?/?), DNMT3b knockout (HCT116.DNMT3b?/?), and DNMT1/DNMT3b double knockout (HCT116.DKO) cells.

Source : Medical College of Georgia Medical Center and Charite, Berlin.

Sample Type : CRC tumor and normal tissues

No. of Sample : -

Stage : -

Electrophoresis mobility shift assay,Bisulfite genomic DNA sequencing,Chromatin immunoprecipitation assay,Up-regulation-Data suggest that human colon carcinoma cells silence IFN-gamma-activated IRF8 expression through MBD1-dependent and PIAS1-mediated inhibition of pSTAT1 function at the methylated IRF8 promoter.


Gene Details



NC_000018.9 (47793252..47808144, complement)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011]  
Chromosome 18
Location 18q21
Start 47793252  
End 47808144  
Strand -  
Gene Sequence

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Length 14893  
OMIM ID 156535   
HGNC ID HGNC:6916   
Unigene ID Hs.405610   
Ensembl ID ENSG00000141644   
PharmGKB ID PA30659   

mRNA Information


mRNA ID XM_011525990.1
Exon join(254..412,1758..1892,4571..4685,4777..4943,5031..5113, 5357..5397,5794..5940,6047..6175,6331..6405,6530..6646, 6730..6798,7422..7589,7912..8211,8304..8441,8820..8951, 9037..9098,14112..14168,15062..15152)  
mRNA Sequence

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Length 2185  



CDS Information


   
Location 185..2170
CDS Sequence

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CCDS ID CCDS11941.1



Protein Information


      
Protein IDXP_011524292.1
Protein Namemethyl-CpG binding domain protein 1
Molecular Wt. (Da)26012
Protein Sequence

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Length 661  
Uniprot IDP01135
Ensembl Protein ID ENSP00000295400  



Post-translational Modification Information (Source : HPRD)


Residue Type site
KSumoylation489
KSumoylation450
KSumoylation489
TPhosphorylation301;-
SPhosphorylation295;-
TPhosphorylation301;-
SPhosphorylation295;-
TPhosphorylation301;-
SPhosphorylation295;-
TPhosphorylation252;-
SPhosphorylation246;-
SPhosphorylation297;-
SPhosphorylation297;-
SPhosphorylation297;-
SPhosphorylation248;-
SPhosphorylation391
SPhosphorylation399
SPhosphorylation335
SPhosphorylation343
SPhosphorylation335
SPhosphorylation343
SPhosphorylation368
SPhosphorylation376
SPhosphorylation342
SPhosphorylation350
TPhosphorylation505
TPhosphorylation449
TPhosphorylation456
KAcetylation422
KAcetylation366
KAcetylation366
KAcetylation399
KAcetylation373
SPhosphorylation393
SPhosphorylation370
SPhosphorylation344
TPhosphorylation570
TPhosphorylation468
TPhosphorylation514
TPhosphorylation501
TPhosphorylation521

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                       
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
4086SMAD13356NP_005891.1yeast 2-hybrid15231748   
4088SMAD34380NP_005893.1yeast 2-hybrid15231748   
4090SMAD54381NP_005894.3yeast 2-hybrid15231748   
4092SMAD74241NP_005895.1yeast 2-hybrid15231748   
4093SMAD94484BAA21128.1yeast 2-hybrid15231748   
8554PIAS116029NP_057250.1in vitro;in vivo;yeast 2-hybrid17066076   
9063PIAS26944NP_004662.2in vitro;in vivo;yeast 2-hybrid17066076   
9869SETDB16828NP_001138887.1in vivo17066076   
10114HIPK35111NP_005725.3yeast 2-hybrid15231748   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd01396May-75  MeCP2_MBD
cl00110May-75  MBD superfamily
smart00391Mar-76  MBD
pfam01429Feb-70  MBD
cd00122May-64  MBD
pfam02008331-377  zf-CXXC
cl03401331-377  zf-CXXC superfamily
pfam02008168-215  zf-CXXC
cl03401168-215  zf-CXXC superfamily
pfam02008217-262  zf-CXXC
cl03401217-262  zf-CXXC superfamily


Ontology Information


   
HPRD ID1829
Molecular ClassTranscription regulatory protein
Molecular FunctionGrowth factor activity (GO:0008083)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO