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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18931530 | 2008 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Knocked down by RNA interference ,silenced by methylation | Methylation | - | MBD2 in transcriptional repression of the methylated p14(ARF) tumor suppressor gene and suggest that repression by MBD2 selectively affects a subset of methylated promoters. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] | Chromosome | 18 |
| Location | 18q21 |
| Start | 51677971 |
| End | 51751158 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 73188 |
| OMIM ID | 603547 |
| HGNC ID | HGNC:6917 |
| Unigene ID | Hs.25674 |
| Ensembl ID | ENSG00000134046 |
| PharmGKB ID | PA30660 |
Protein Information
| Protein ID | NP_003918.1 |
|---|---|
| Protein Name | methyl-CpG binding domain protein 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 411 |
| Uniprot ID | Q9UN76 |
| Ensembl Protein ID | ENSP00000470801 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 407;- |
| S | Phosphorylation | 181 |
| S | Phosphorylation | 181 |
| S | Phosphorylation | 168 |
| S | Phosphorylation | 183 |
| S | Phosphorylation | 168 |
| S | Phosphorylation | 183 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1387 | CREBBP | 2534 | NP_004371.2 | in vivo | 12665568 |
| 1660 | DHX9 | 4386 | NP_001348.2 | in vitro;in vivo;yeast 2-hybrid | 12665568 |
| 3065 | HDAC1 | 3143 | NP_004955.2 | in vitro;in vivo | 10471499 |
| 5928 | RBBP4 | 4232 | NP_005601.1 | in vitro;in vivo | 10471499 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01396 | 151-214 | MeCP2_MBD |
| cl00110 | 151-214 | MBD superfamily |
| pfam14048 | 294-387 | MBD_C |
| cl16567 | 294-387 | MBD_C superfamily |
| pfam01429 | 147-215 | MBD |
| smart00391 | 147-213 | MBD |
| cd00122 | 151-208 | MBD |
| cd01397 | 155-197 | HAT_MBD |
Ontology Information
| HPRD ID | 5496 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.