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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19127118 | 2009 | Cell line : - Source : Department of Surgery at UAB, American Type Culture Collection. Sample Type : CRC tumor and normal tissue No. of Sample : 39 Stage : TNM Stage I-III | RT-PCR | Methylation & Down-regulation | - | Methylation occurs in cancer patients at higher frequencies than those found in patients without cancer. MED1 suppression seems to occur first at the level of the normal mucosa. The suppression of MED1 follows the adenoma-carcinoma sequence and is observed in normal mucosa, adenomas, and adenocarcinoma of the colon suggesting an early and detectable change. |
| 22997602 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | MSI analysis | Mutation | - | Mutation due to inactivation of DNA mismatch repair system results MSI |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains an MBD domain at the N-terminus that functions both in binding to methylated DNA and in protein interactions and a C-terminal mismatch-specific glycosylase domain that is involved in DNA repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013] | Chromosome | 3 |
| Location | 3q21.3 |
| Start | 129430944 |
| End | 129440179 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 9236 |
| OMIM ID | 603574 |
| HGNC ID | HGNC:6919 |
| Unigene ID | Hs.35947 |
| Ensembl ID | ENSG00000129071 |
| PharmGKB ID | PA30663 |
mRNA Information
| mRNA ID | NM_001276273.1 |
|---|---|
| Exon | join(1..450,2230..2372,6044..6118,6196..6330,6933..7082, 7574..7677,8602..9236) | mRNA Sequence | Download Select all |
| Length | 2642 |
CDS Information
| Location | join(347..450,2230..2372,6044..6118,6196..6330,6933..7082, 7574..7677,8602..8679) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS63769.1 |
Protein Information
| Protein ID | NP_001263199.1 |
|---|---|
| Protein Name | Methyl-CpG binding domain protein 4 |
| Molecular Wt. (Da) | 65217 |
| Protein Sequence | Download Select all |
| Length | 574 |
| Uniprot ID | P01133 |
| Ensembl Protein ID | ENSP00000265171 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 318 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1460 | CSNK2B | 278 | NP_001311.3 | yeast 2-hybrid | 14667819 |
| 4292 | MLH1 | 390 | NP_000240.1 | in vivo;yeast 2-hybrid | 10097147 |
| 8772 | FADD | 3909 | NP_003815.1 | in vitro;in vivo;yeast 2-hybrid | 12702765 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Base excision repair | hsa03410 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01396 | 87-156 | MeCP2_MBD |
| cl00110 | 87-156 | MBD superfamily |
| smart00391 | 79-155 | MBD |
| pfam01429 | 77-151 | MBD |
| cd00122 | 87-143 | MBD |
| pfam00730 | 461-574 | HhH-GPD |
| cl22429 | 461-574 | ENDO3c superfamily |
| TIGR01083 | 450-520 | nth |
| smart00478 | 468-540 | ENDO3c |
| cd00056 | 457-540 | ENDO3c |
| cd01397 | 81-143 | HAT_MBD |
| COG0177 | 453-518 | Nth |
| COG1194 | 455-540 | MutY |
Ontology Information
| HPRD ID | 3746 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Translation regulator activity (GO:0045182) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.