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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MBL2 | 4153 | mannose-binding lectin (protein C) 2, soluble | 10 | COLEC1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15370690 | 2004 | Cell line : - Source : - Sample Type : Serum samples No. of Sample : 193 CRC and serum 150 healthy Stage : - | Immunofluorometric assays | Up-regulation | - | MBL/MASP activity was significantly (P < 0.0002) increased in patients (584 (202-914) mU/mL) compared with in blood donors. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Collectins |
| Description | This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008] | Chromosome | 10 |
| Location | 10q11.2 |
| Start | 54525140 |
| End | 54532578 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 7439 |
| OMIM ID | 154545 |
| HGNC ID | HGNC:6922 |
| Unigene ID | Hs.499674 |
| Ensembl ID | ENSG00000165471 |
| PharmGKB ID | PA30665 |
mRNA Information
| mRNA ID | XM_011539816.1 |
|---|---|
| Exon | join(1..105,1198..1393,2056..2172,3527..3595,4332..7462) | mRNA Sequence | Download Select all |
| Length | 3618 |
Protein Information
| Protein ID | XP_011538118.1 |
|---|---|
| Protein Name | mannose-binding lectin (protein C) 2, soluble |
| Molecular Wt. (Da) | 21095 |
| Protein Sequence | Download Select all |
| Length | 248 |
| Uniprot ID | P01137 |
| Ensembl Protein ID | ENSP00000221930 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 799 | CALCR | 239 | NP_001733.1 | in vivo | 11560994 |
| 811 | CALR | 169 | NP_004334.1 | in vitro;in vivo | 8062452 |
| 3848 | KRT1 | 763 | NP_006112.3 | in vivo | 11549596 |
| 5788 | PTPRC | 1050 | NP_002829.2 | in vitro;in vivo | 11564800 |
| 10747 | MASP2 | 5484 | NP_006601.2 | in vitro | 10878362 |
| 22918 | CD93 | 396 | NP_036204.2 | in vitro | 9476117 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Complement and coagulation cascades | hsa04610 |
| Phagosome | hsa04145 |
| Staphylococcus aureus infection | hsa05150 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03591 | 136-246 | CLECT_collectin_like |
| cl02432 | 136-246 | CLECT superfamily |
| smart00034 | 132-245 | CLECT |
| pfam00059 | 146-246 | Lectin_C |
| cd00037 | 137-246 | CLECT |
| cd03590 | 132-245 | CLECT_DC-SIGN_like |
| cd03596 | 131-246 | CLECT_tetranectin_like |
| cd03592 | 141-245 | CLECT_selectins_like |
| cd03603 | 146-235 | CLECT_VCBS |
| cd03589 | 137-244 | CLECT_CEL-1_like |
| cd03588 | 147-237 | CLECT_CSPGs |
| cd03602 | 136-237 | CLECT_1 |
| cd03601 | 183-245 | CLECT_TC14_like |
| cd03594 | 147-246 | CLECT_REG-1_like |
| cd03598 | 194-246 | CLECT_EMBP_like |
Ontology Information
| HPRD ID | 3409 |
|---|---|
| Molecular Class | Transport/cargo protein |
| Molecular Function | Receptor binding (GO:0005102) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.