Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MCAM | 4162 | melanoma cell adhesion molecule | 11 | MUC18, CD146 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23745687 | 2013 | Cell line : - Source : - Sample Type : Case control study No. of Sample : 1080 cases Stage : Duke stage A-D | Immunohistochemistry | Up-regulation | - | CD146 protein may be a potential biomarker for the postoperative liver metastasis of colorectal cancer. After multivariate analysis, Duke's stage and CD146 were related to liver metastasis (p=0.01 and 0.001, respectively). |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, "Immunoglobulin superfamily / V-set domain containing", "Immunoglobulin superfamily / C2-set domain containing", "Immunoglobulin superfamily / Immunoglobulin-like domain containing" |
| Description | - | Chromosome | 11 |
| Location | 11q23.3 |
| Start | 119308524 |
| End | 119317130 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 8607 |
| OMIM ID | 155735 |
| HGNC ID | HGNC:6934 |
| Unigene ID | Hs.599039 |
| Ensembl ID | ENSG00000076706 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_006500.2 |
|---|---|
| Exon | join(1..96,1868..1992,2091..2298,2382..2452,2555..2642, 4182..4361,4483..4604,4703..4865,4961..5079,5182..5323, 5480..5601,5710..5851,5946..6041,6228..6375,6665..6782, 7216..8607) | mRNA Sequence | Download Select all |
| Length | 3332 |
CDS Information
| Location | join(30..96,1868..1992,2091..2298,2382..2452,2555..2642, 4182..4361,4483..4604,4703..4865,4961..5079,5182..5323, 5480..5601,5710..5851,5946..6041,6228..6375,6665..6782, 7216..7245) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS31690.1 |
Protein Information
| Protein ID | NP_006491.2 |
|---|---|
| Protein Name | melanoma cell adhesion molecule |
| Molecular Wt. (Da) | 69258 |
| Protein Sequence | Download Select all |
| Length | 646 |
| Uniprot ID | P10321 |
| Ensembl Protein ID | ENSP00000365402 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 614;- |
| S | Phosphorylation | 606 |
| Y | Phosphorylation | 202 |
| S | Phosphorylation | 628 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2534 | FYN | 655 | NP_002028.1 | in vivo | 9756930 |
| 55729 | ATF7IP | 9811 | NP_060649.3 | yeast 2-hybrid | 15231748 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00096 | 268-321 | Ig |
| cl11960 | 268-321 | Ig superfamily |
| cd00096 | 361-410 | Ig |
| cl11960 | 361-410 | Ig superfamily |
| pfam08205 | 139-234 | C2-set_2 |
| cl11960 | 139-234 | Ig superfamily |
| cd04978 | 450-506 | Ig4_L1-NrCAM_like |
| cl11960 | 450-506 | Ig superfamily |
| cd04976 | 166-217 | Ig2_VEGFR |
| cd05874 | 450-510 | Ig6_NrCAM |
| pfam00047 | 265-322 | ig |
| cd05733 | 450-506 | Ig6_L1-CAM_like |
| pfam00047 | 358-409 | ig |
| pfam13895 | 357-425 | Ig_2 |
| pfam13927 | 448-503 | Ig_3 |
| cd05869 | 431-516 | Ig5_NCAM-1 |
| pfam13895 | 251-322 | Ig_2 |
| cd05868 | 449-506 | Ig4_NrCAM |
| cd05715 | 33-132 | Ig_P0-like |
| cl11960 | 33-132 | Ig superfamily |
| cd05867 | 450-506 | Ig4_L1-CAM_like |
| cd05875 | 450-510 | Ig6_hNeurofascin_like |
| cd05732 | 444-516 | Ig5_NCAM-1_like |
| cd00096 | 160-224 | Ig |
| cd05751 | 254-340 | Ig1_LILRB1_like |
| cd05724 | 157-190 | Ig2_Robo |
| pfam13927 | 346-410 | Ig_3 |
| pfam13895 | 149-203 | Ig_2 |
| cd05848 | 450-506 | Ig1_Contactin-5 |
| cd00096 | 448-510 | Ig |
| cd05748 | 166-204 | Ig_Titin_like |
| pfam13927 | 264-322 | Ig_3 |
| cd05859 | 167-216 | Ig4_PDGFR-alpha |
| pfam00047 | 448-501 | ig |
| pfam07686 | 344-425 | V-set |
| cd05856 | 265-321 | Ig2_FGFRL1-like |
| cd05749 | 442-510 | Ig2_Tyro3_like |
| cd05730 | 450-516 | Ig3_NCAM-1_like |
| cd05856 | 450-486 | Ig2_FGFRL1-like |
| pfam13895 | 440-510 | Ig_2 |
| cd04969 | 265-322 | Ig5_Contactin_like |
| pfam13927 | 138-203 | Ig_3 |
| smart00410 | 354-422 | IG_like |
| smart00408 | 264-322 | IGc2 |
| smart00410 | 438-515 | IG_like |
| smart00410 | 263-321 | IG_like |
| smart00409 | 263-321 | IG |
| smart00409 | 354-422 | IG |
| smart00408 | 357-410 | IGc2 |
| pfam07679 | 438-515 | I-set |
| pfam07679 | 263-321 | I-set |
| smart00408 | 160-203 | IGc2 |
| smart00409 | 438-515 | IG |
Ontology Information
| HPRD ID | 1229 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.