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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26352605 | 2015 | Cell line : HT29, SW480,HCT116 Source : - Sample Type : - No. of Sample : - Stage : - | MTT assay,Hoechst staining,Flow cytometry,Western blotting and immunoprecipitation | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010] | Chromosome | 1 |
| Location | 1q21 |
| Start | 150547027 |
| End | 150552214 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 5188 |
| OMIM ID | 159552 |
| HGNC ID | HGNC:6943 |
| Unigene ID | Hs.632486 |
| Ensembl ID | ENSG00000143384 |
| PharmGKB ID | PA30688 |
mRNA Information
| mRNA ID | NM_001197320.1 |
|---|---|
| Exon | join(1..316,776..896,1248..1495,2248..5188) | mRNA Sequence | Download Select all |
| Length | 3648 |
Protein Information
| Protein ID | NP_001184249.1 |
|---|---|
| Protein Name | myeloid cell leukemia 1 |
| Molecular Wt. (Da) | 101765 |
| Protein Sequence | Download Select all |
| Length | 197 |
| Uniprot ID | P61812 |
| Ensembl Protein ID | ENSP00000355896 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 163 |
| T | Phosphorylation | 163 |
| S | Phosphorylation | 159 |
| T | Phosphorylation | 163 |
| S | Phosphorylation | 159 |
| T | Phosphorylation | 163 |
| S | Phosphorylation | 159 |
| T | Phosphorylation | 163 |
| S | Phosphorylation | 159 |
| T | Phosphorylation | 163 |
| S | Phosphorylation | 121 |
| S | Phosphorylation | 121 |
| Y | Phosphorylation | 347 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 572 | BAD | 4409 | NP_004313.1 | in vitro;in vivo;yeast 2-hybrid | 114 838 551 057 930 000 000 000 |
| 578 | BAK1 | 2744 | NP_001179.1 | in vitro;in vivo;yeast 2-hybrid | 10 837 489 105 793 000 000 000 000 000 000 |
| 581 | BAX | 2498 | NP_004315.1 | in vitro | 1 083 748 915 077 110 |
| 598 | BCL2L1 | 2497 | NP_612815.1 | in vivo | 15077116 |
| 638 | BIK | 4547 | NP_001188.1 | in vitro | 16697956 |
| 666 | BOK | 5657 | NP_115904.1 | yeast 2-hybrid | 935 646 110 579 309 |
| 1603 | DAD1 | 2589 | NP_001335.1 | in vivo | 10965038 |
| 5111 | PCNA | 1456 | NP_002583.1 | in vitro;in vivo;yeast 2-hybrid | 10978339 |
| 8658 | TNKS | 4490 | NP_003738.2 | in vitro;in vivo;yeast 2-hybrid | 12475993 |
| 10018 | BCL2L11 | 4828 | NP_619527.1 | in vivo;yeast 2-hybrid | 1 083 748 916 213 500 |
| 10075 | HUWE1 | 6608 | NP_113584.3 | in vitro;in vivo | 16213503 |
| 27113 | BBC3 | 16165 | NP_001120712.1 | in vitro | 16697956 |
| 90427 | BMF | 5881 | NP_277038.1 | in vitro;yeast 2-hybrid | 1 154 687 216 697 950 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Jak-STAT signaling pathway | hsa04630 |
| MicroRNAs in cancer | hsa05206 |
| PI3K-Akt signaling pathway | hsa04151 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd06845 | 175-318 | Bcl-2_like |
| cl02575 | 175-318 | Bcl-2_like superfamily |
| smart00337 | 213-312 | BCL |
| pfam00452 | 213-312 | Bcl-2 |
| PHA03159 | 228-318 | PHA03159 |
| TIGR00865 | 208-350 | bcl-2 |
| PRK12323 | 31-131 | PRK12323 |
| PTZ00436 | 31-122 | PTZ00436 |
Ontology Information
| HPRD ID | 1822 |
|---|---|
| Molecular Class | Chaperone |
| Molecular Function | Receptor signaling protein serine/threonine kinase activity (GO:0004702) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.