Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
MCM2 4171 minichromosome maintenance complex component 2  3D3S3194, KIAA0030, BM28, cdc19 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
19077563   2009Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

 Immunohistochemistry and real-time reverse transcription-PCR.Up-regulation-Potential value of MCM2 in early diagnosis of colorectal cancer.The expression of MCM2 mRNA in adenocarcinomas was significantly higher than in adenomas (P=0.001).

23770000   2013Cell line : HCT116

Source : -

Sample Type : -

No. of Sample : -

Stage : -

RT-PCR,Western blottingUp-regulation-MCM-2 is a noval therapeutic target of TSA in colon cancer cells.


Gene Details



NC_000003.11 (127317200..127341279)

View Larger Image
   
Gene Type protein coding
Gene Family -
Description The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012]  
Chromosome 3
Location 3q21
Start 127317200  
End 127341279  
Strand +  
Gene Sequence

   Download   Select all

Length 24080  
OMIM ID 116945   
HGNC ID HGNC:6944   
Unigene ID Hs.477481   
Ensembl ID ENSG00000073111   
PharmGKB ID PA164742061   

mRNA Information


mRNA ID NM_004526.3
Exon join(1..116,962..1191,6252..6427,6540..6800,7762..7981, 8254..8461,10026..10160,10476..10667,17506..17599, 18512..18762,18923..19049,19613..19725,20671..20922, 22342..22524,22717..22872,23307..24080)  
mRNA Sequence

   Download   Select all

Length 3504  



CDS Information


   
Location111..2825
CDS Sequence

   Download   Select all

CCDS ID CCDS3043.1



Protein Information


      
Protein IDNP_004517.2
Protein Nameminichromosome maintenance complex component 2
Molecular Wt. (Da)96427
Protein Sequence

   Download   Select all

Length 904  
Uniprot IDP10600
Ensembl Protein ID ENSP00000238682  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation106
SPhosphorylation139
SPhosphorylation27
SPhosphorylation41
SPhosphorylation26
SPhosphorylation139;-
SPhosphorylation26;-
SPhosphorylation41;-
SPhosphorylation27;-
SPhosphorylation108;-
SPhosphorylation13;-
YPhosphorylation137;-
TPhosphorylation25;-
SPhosphorylation40;-
TPhosphorylation35;-
TPhosphorylation39;-
TPhosphorylation59;-
SPhosphorylation53;-
SPhosphorylation31
SPhosphorylation32
SPhosphorylation381
SPhosphorylation4
SPhosphorylation5
SPhosphorylation7
KAcetylation216
KAcetylation896
SPhosphorylation754
SPhosphorylation566

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                            
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
4356MPP33069NP_001923.2yeast 2-hybrid16169070   
6191RPS4X2427NP_000998.1yeast 2-hybrid16169070   
10681GNB59191NP_057278.2yeast 2-hybrid16169070   
25843MOBKL310165NP_056202.2yeast 2-hybrid16169070   


Pathway Information


            
Pathway Name Pathway ID
Cell cycle hsa04110
DNA replication hsa03030


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00009518-664  AAA
cl21455518-664  P-loop_NTPase superfamily
pfam1261973-182  MCM2_N
cl1399173-182  MCM2_N superfamily
pfam14551195-310  MCM_N
cl20563195-310  MCM_N superfamily
pfam01078485-659  Mg_chelatase
pfam07728518-657  AAA_5
smart00350291-803  MCM
COG1241213-840  Mcm2
pfam00493460-803  MCM
PTZ00111194-804  PTZ00111
COG0714475-791  MoxR
PRK09862485-659  PRK09862
TIGR00368485-659  TIGR00368
COG1239570-674  ChlI
COG0606485-632  YifB
smart00382518-632  AAA


Ontology Information


   
HPRD ID1823
Molecular ClassDNA binding protein
Molecular FunctionReceptor signaling protein serine/threonine kinase activity (GO:0004702)
Biological ProcessSignal transduction (GO:0007165); Regulation of cell proliferation (GO:0042127); Regulation of immune response (GO:0050776)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO