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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MCM4 | 4173 | minichromosome maintenance complex component 4 | 8 | CDC54, hCdc21, P1-Cdc21, MGC33310 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22351690 | 2012 | Cell line : - Source : - Sample Type : Mice tumor No. of Sample : Colon tumors were dissected in one piece from FabplCre;Apc15lox/� C57Bl/6 mice. Stage : - | In-depth proteome profiling by tandem mass spectrometry,ELISA,Immunohistochemistry | Unknown | - | S100A9, MCM4, and four other proteins that have been proposed as candidate biomarkers for human CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008] | Chromosome | 8 |
| Location | 8q12-q13 |
| Start | 48872763 |
| End | 48890720 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 17958 |
| OMIM ID | 602638 |
| HGNC ID | HGNC:6947 |
| Unigene ID | Hs.460184 |
| Ensembl ID | ENSG00000104738 |
| PharmGKB ID | PA30694 |
mRNA Information
| mRNA ID | NM_005914.3 |
|---|---|
| Exon | join(1..1012,1314..1478,1851..2014,2103..2204,2562..2657, 2743..2838,4372..4510,5985..6205,7163..7283,9596..9855, 10309..10674,11139..11266,12655..12862,14532..14760, 15513..15646,16484..17958) | mRNA Sequence | Download Select all |
| Length | 4928 |
Protein Information
| Protein ID | NP_005905.2 |
|---|---|
| Protein Name | minichromosome maintenance complex component 4 |
| Molecular Wt. (Da) | 81477 |
| Protein Sequence | Download Select all |
| Length | 863 |
| Uniprot ID | Q15582 |
| Ensembl Protein ID | ENSP00000416330 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 326 |
| S | Phosphorylation | 326 |
| T | Phosphorylation | 7 |
| T | Phosphorylation | 19 |
| S | Phosphorylation | 32 |
| S | Phosphorylation | 54 |
| T | Phosphorylation | 110 |
| T | Phosphorylation | 7 |
| T | Phosphorylation | 19 |
| S | Phosphorylation | 32 |
| S | Phosphorylation | 54 |
| T | Phosphorylation | 110 |
| S | Phosphorylation | 3 |
| S | Phosphorylation | 3 |
| T | Phosphorylation | 7 |
| S | Phosphorylation | 3 |
| T | Phosphorylation | 19 |
| S | Phosphorylation | 32 |
| T | Phosphorylation | 110 |
| S | Phosphorylation | 54 |
| T | Phosphorylation | 7 |
| T | Phosphorylation | 19 |
| S | Phosphorylation | 32 |
| S | Phosphorylation | 54 |
| T | Phosphorylation | 110 |
| T | Phosphorylation | 7 |
| T | Phosphorylation | 19 |
| S | Phosphorylation | 32 |
| S | Phosphorylation | 88 |
| T | Phosphorylation | 110 |
| T | Phosphorylation | 7 |
| T | Phosphorylation | 19 |
| S | Phosphorylation | 32 |
| S | Phosphorylation | 88 |
| T | Phosphorylation | 110 |
| T | Phosphorylation | 110;- |
| T | Phosphorylation | 110;- |
| S | Phosphorylation | 145;- |
| S | Phosphorylation | 131;- |
| S | Phosphorylation | 142;- |
| S | Phosphorylation | 145;- |
| S | Phosphorylation | 131;- |
| S | Phosphorylation | 142;- |
| S | Phosphorylation | 120;- |
| S | Phosphorylation | 120;- |
| S | Phosphorylation | 31;- |
| S | Phosphorylation | 31;- |
| S | Phosphorylation | 34;- |
| S | Phosphorylation | 34;- |
| S | Phosphorylation | 26 |
| S | Phosphorylation | 26 |
| T | Phosphorylation | 102 |
| S | Phosphorylation | 105 |
| T | Phosphorylation | 102 |
| S | Phosphorylation | 105 |
| K | Acetylation | 220 |
| K | Acetylation | 220 |
| K | Acetylation | 450 |
| K | Acetylation | 450 |
| S | Phosphorylation | 2 |
| S | Phosphorylation | 2 |
| S | Phosphorylation | 6 |
| S | Phosphorylation | 6 |
| T | Phosphorylation | 23 |
| T | Phosphorylation | 23 |
| Y | Phosphorylation | 394 |
| Y | Phosphorylation | 394 |
| S | Phosphorylation | 406 |
| S | Phosphorylation | 406 |
| S | Phosphorylation | 736 |
| S | Phosphorylation | 736 |
| T | Phosphorylation | 53 |
| T | Phosphorylation | 53 |
| Y | Phosphorylation | 193 |
| Y | Phosphorylation | 193 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4171 | MCM2 | 303 | NP_004517.2 | in vivo | 16902406 |
| 4172 | MCM3 | 4072 | NP_002379.2 | in vitro;in vivo;yeast 2-hybrid | 1 261 461 216 902 400 |
| 4175 | MCM6 | 3485 | NP_005906.2 | in vitro;in vivo;yeast 2-hybrid | 126 146 121 269 453 000 000 000 |
| 4176 | MCM7 | 1154 | NP_005907.3 | in vitro;in vivo;yeast 2-hybrid | 1 074 811 487 986 500 000 000 000 000 000 000 000 000 000 000 000 000 000 000 000 |
| 4999 | ORC2L | 3112 | NP_006181.1 | in vitro;yeast 2-hybrid | 12614612 |
| 8900 | CCNA1 | 4946 | NP_003905.1 | in vitro | 15232106 |
| 11198 | SUPT16H | 16088 | NP_009123.1 | in vivo | 16902406 |
| 23594 | ORC6L | 6237 | NP_055136.1 | in vitro | 15232106 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle | hsa04110 |
| DNA replication | hsa03030 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00009 | 505-650 | AAA |
| cl21455 | 505-650 | P-loop_NTPase superfamily |
| pfam14551 | 162-287 | MCM_N |
| cl20563 | 162-287 | MCM_N superfamily |
| pfam07728 | 505-644 | AAA_5 |
| smart00350 | 267-770 | MCM |
| COG1241 | 187-853 | Mcm2 |
| pfam00493 | 445-770 | MCM |
| PTZ00111 | 156-847 | PTZ00111 |
| COG0714 | 445-783 | MoxR |
| COG1239 | 557-829 | ChlI |
| TIGR02031 | 551-764 | BchD-ChlD |
| COG0457 | 621-850 | TPR |
Ontology Information
| HPRD ID | 2846 |
|---|---|
| Molecular Class | DNA binding protein |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.