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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MCM5 | 4174 | minichromosome maintenance complex component 5 | 22 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 0 | 0 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Immunohistochemical analysis, | Unknown | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008] | Chromosome | 22 |
| Location | 22q13.1-q1 |
| Start | 35796116 |
| End | 35820495 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 24380 |
| OMIM ID | 602696 |
| HGNC ID | HGNC:6948 |
| Unigene ID | Hs.517582 |
| Ensembl ID | ENSG00000100297 |
| PharmGKB ID | PA30695 |
mRNA Information
| mRNA ID | XM_006724242.2 |
|---|---|
| Exon | join(1..146,369..543,3145..3271,3352..3480,6491..6663, 8346..8501,10682..10848,12448..12619,13813..13924, 15767..15910,16277..16342,16576..16752,17682..17794, 19822..19950,21256..21398,23152..23279,53937..54060, 54366..54827) | mRNA Sequence | Download Select all |
| Length | 2843 |
Protein Information
| Protein ID | XP_006724305.1 |
|---|---|
| Protein Name | minichromosome maintenance complex component 5 |
| Molecular Wt. (Da) | 81177 |
| Protein Sequence | Download Select all |
| Length | 732 |
| Uniprot ID | P36897 |
| Ensembl Protein ID | ENSP00000364129 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Acetylation | 2 |
| S | Phosphorylation | 2 |
| K | Acetylation | 392 |
| K | Acetylation | 696 |
| K | Acetylation | 396 |
| S | Phosphorylation | 130 |
| S | Phosphorylation | 159 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1029 | CDKN2A | 2542 | NP_478102.1 | in vitro | 15232106 |
| 4171 | MCM2 | 303 | NP_004517.2 | in vitro;yeast 2-hybrid | 1 261 461 215 232 100 |
| 4172 | MCM3 | 4072 | NP_002379.2 | in vitro;in vivo;yeast 2-hybrid | 1 124 802 712 614 610 |
| 4176 | MCM7 | 1154 | NP_005907.3 | in vitro | 15232106 |
| 4188 | MDFI | 7280 | NP_005577.1 | yeast 2-hybrid | 16189514 |
| 4998 | ORC1L | 3544 | NP_004144.2 | in vitro | 15232106 |
| 4999 | ORC2L | 3112 | NP_006181.1 | yeast 2-hybrid | 12614612 |
| 6118 | RPA2 | 1566 | NP_002937.1 | yeast 2-hybrid | 12614612 |
| 6772 | STAT1 | 2777 | NP_009330.1 | in vitro;in vivo | 112 480 279 843 502 |
| 23594 | ORC6L | 6237 | NP_055136.1 | yeast 2-hybrid | 12614612 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle | hsa04110 |
| DNA replication | hsa03030 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00009 | 376-520 | AAA |
| cl21455 | 376-520 | P-loop_NTPase superfamily |
| pfam14551 | 31-153 | MCM_N |
| cl20563 | 31-153 | MCM_N superfamily |
| pfam07728 | 376-449 | AAA_5 |
| smart00350 | 133-649 | MCM |
| COG1241 | 51-732 | Mcm2 |
| pfam00493 | 318-648 | MCM |
| PTZ00111 | 71-697 | PTZ00111 |
| COG0714 | 333-655 | MoxR |
Ontology Information
| HPRD ID | 1825 |
|---|---|
| Molecular Class | DNA binding protein |
| Molecular Function | Transaminase activity (GO:0008483) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.