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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
MCM7 4176 minichromosome maintenance complex component 7  7CDC47, PPP1R104 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25075101   2014Cell line : -

Source : Kurume University Hospital in Fukuoka, Japan.

Sample Type : CRC tumor and normal tissues

No. of Sample : 145

Stage : Duke Stage A-C

Immuno-histochemistryUp-regulation-Expression of MCM7 is an independent risk factor for RFS in patients with Dukes C colorectal cancer. Dukes C, there was significantly worse OS and RFS for patients with MCM7-positive compared to those with MCM7-negative disease.


Gene Details



NC_000007.13 (99690351..99699563, complement)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]  
Chromosome 7
Location 7q21.3-q22
Start 99690351  
End 99699563  
Strand -  
Gene Sequence

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Length 9213  
OMIM ID 600592   
HGNC ID HGNC:6950   
Unigene ID Hs.438720   
Ensembl ID ENSG00000166508   
PharmGKB ID PA30697   

mRNA Information


mRNA ID NM_005916.4
Exon join(1..677,1848..1927,2188..2352,2538..2662,2738..2918, 3226..3363,3651..3800,3993..4107,4196..4327,4557..4640, 5774..6167,6471..6554,7600..7768,8540..8649,8808..9213)  
mRNA Sequence

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Length 3030  



CDS Information


   
Location647..2806
CDS Sequence

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CCDS ID CCDS5683.1



Protein Information


      
Protein IDNP_005907.3
Protein Nameminichromosome maintenance complex component 7
Molecular Wt. (Da)0
Protein Sequence

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Length 719  
Uniprot IDP37173
Ensembl Protein ID ENSP00000295754  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation549;-
SPhosphorylation373;-
SPhosphorylation121
SPhosphorylation500
SPhosphorylation324
SPhosphorylation309
TPhosphorylation320
SPhosphorylation133
TPhosphorylation144
YPhosphorylation6
SPhosphorylation365
SPhosphorylation189
SPhosphorylation113
TPhosphorylation582
TPhosphorylation406

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                      
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
990CDC64022NP_001245.1in vivo1   046   433   712   614   610   
4171MCM2303NP_004517.2in vitro;in vivo107   481   141   056   752   000   000   000   000   000   000   000   000   
4175MCM63485NP_005906.2in vitro;in vivo;yeast 2-hybrid126   945   311   261   461   000   000   000   
4331MNAT14042NP_002422.1in vitro;yeast 2-hybrid11056214   
4792NFKBIA1235NP_065390.1in vivo14743216   
5933RBL1312NP_002886.2in vitro9566894   
6117RPA11565NP_002936.1yeast 2-hybrid12614612   
9939RBM8A5609NP_005096.1yeast 2-hybrid16189514   
51562MBIP14368NP_057670.2yeast 2-hybrid16189514   
55388MCM1011297NP_877428.1in vitro15232106   


Pathway Information


            
Pathway Name Pathway ID
Cell cycle hsa04110
DNA replication hsa03030


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam1455110-165  MCM_N
cl2056310-165  MCM_N superfamily
pfam07728376-515  AAA_5
cl21455376-515  P-loop_NTPase superfamily
smart00350145-641  MCM
COG124115-708  Mcm2
pfam00493321-641  MCM
PTZ00111137-640  PTZ00111
COG0714317-632  MoxR
PRK09862363-517  PRK09862
COG1239425-636  ChlI
TIGR00368364-517  TIGR00368


Ontology Information


   
HPRD ID1765
Molecular ClassDNA helicase
Molecular FunctionExtracellular matrix structural constituent (GO:0005201)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO