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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18678097 | 2008 | Cell line : - Source : - Sample Type : CRC Tumor No. of Sample : 17 Stage : TNM Stage II,III | Ultrasonography,Real-Time PCR,immunohistochemistry,Microarrays | Up-regulation | - | 8 genes (RB1, RBBP4, HYOUI, JUNB, MDM4, CANX, MMP2, TCF7L2) significantly upregulated in NR. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011] | Chromosome | 1 |
| Location | 1q32 |
| Start | 204485507 |
| End | 204596131 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 110625 |
| OMIM ID | 602704 |
| HGNC ID | HGNC:6974 |
| Unigene ID | Hs.497492 |
| Ensembl ID | ENSG00000198625 |
| PharmGKB ID | PA30719 |
mRNA Information
| mRNA ID | NM_002393.4 |
|---|---|
| Exon | join(1..131,9106..9218,9982..10056,14306..14439, 15813..15868,21052..21119,21831..21930,26406..26566, 28157..28306,30419..30499,32735..41742) | mRNA Sequence | Download Select all |
| Length | 10090 |
Protein Information
| Protein ID | NP_002384.2 |
|---|---|
| Protein Name | MDM4, p53 regulator |
| Molecular Wt. (Da) | 75929 |
| Protein Sequence | Download Select all |
| Length | 490 |
| Uniprot ID | P07996 |
| Ensembl Protein ID | ENSP00000260356 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| D | Proteolytic Cleavage | 361 |
| S | Phosphorylation | 342 |
| S | Phosphorylation | 342 |
| S | Phosphorylation | 367 |
| S | Phosphorylation | 367 |
| S | Phosphorylation | 342 |
| S | Phosphorylation | 161 |
| S | Phosphorylation | 391 |
| S | Phosphorylation | 403 |
| T | Phosphorylation | 365 |
| S | Phosphorylation | 367 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 375 | ARF1 | 54 | NP_001649.1 | in vitro;in vivo | 11297540 |
| 1452 | CSNK1A1 | 2739 | NP_001020276.1 | in vivo | 16511560 |
| 1869 | E2F1 | 1806 | NP_005216.1 | in vitro;yeast 2-hybrid | 12532331 |
| 2033 | EP300 | 4078 | NP_001420.2 | in vitro;in vivo | 12483531 |
| 2810 | SFN | 3185 | NP_006133.1 | in vivo | 16511572 |
| 4193 | MDM2 | 1272 | NP_002383.2 | in vitro;in vivo;yeast 2-hybrid | 1 021 857 012 393 900 000 000 000 000 000 000 000 000 |
| 5925 | RB1 | 1574 | NP_000312.2 | in vivo | 16510145 |
| 7157 | TP53 | 1859 | NP_000537.3 | in vitro;in vivo | 8 895 579 922 637 010 000 000 000 000 000 000 000 000 000 000 |
| 7161 | TP73 | 3587 | NP_005418.1 | in vitro | 11223036 |
| 7529 | YWHAB | 3184 | NP_003395.1 | in vivo | 16511560 |
| 7531 | YWHAE | 5457 | NP_006752.1 | in vivo | 1 651 156 016 511 570 |
| 7532 | YWHAG | 5639 | NP_036611.2 | in vivo | 1 651 156 016 511 570 |
| 7533 | YWHAH | 215 | NP_003396.1 | in vivo | 16511560 |
| 7534 | YWHAZ | 3183 | NP_003397.1 | in vivo | 16511560 |
| 7874 | USP7 | 3950 | NP_003461.2 | in vitro | 15916963 |
| 10971 | YWHAQ | 886 | NP_006817.1 | in vivo | 16511560 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MicroRNAs in cancer | hsa05206 |
| p53 signaling pathway | hsa04115 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam02201 | 26-76 | SWIB |
| cl02489 | 26-76 | SWIB superfamily |
| pfam00641 | 300-328 | zf-RanBP |
| cl02656 | 300-328 | zf-RanBP superfamily |
| pfam13920 | 435-482 | zf-C3HC4_3 |
| cl17238 | 435-482 | RING superfamily |
| pfam13923 | 437-477 | zf-C3HC4_2 |
Ontology Information
| HPRD ID | 2371 |
|---|---|
| Molecular Class | Ubiquitin proteasome system protein |
| Molecular Function | Extracellular matrix structural constituent (GO:0005201) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.