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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16127744 | 2005 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 6 Stage : - | RT-PCR,microarray. | Up-regulation | - | MEF2b expression in UC which increase in accordance with inflammation may be induced by the inflammatory mediator. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Myocyte enhancer factors |
| Description | The product of this gene is a member of the MADS/MEF2 family of DNA binding proteins. The protein is thought to regulate gene expression, including expression of the smooth muscle myosin heavy chain gene. This region undergoes considerable alternative splicing, with transcripts supporting two non-overlapping loci (GeneID 729991 and 100271849) as well as numerous read-through transcripts that span both loci (annotated as GeneID 4207). Several isoforms of this protein are expressed from either this locus or from some of the read-through transcripts annotated on GeneID 4207. [provided by RefSeq, Jan 2014] | Chromosome | 19 |
| Location | 19p13.11 |
| Start | 19256376 |
| End | 19281098 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 24723 |
| OMIM ID | 600661 |
| HGNC ID | HGNC:6995 |
| Unigene ID | Hs.153629 |
| Ensembl ID | - |
| PharmGKB ID | - |
Protein Information
| Protein ID | NP_001139257.1 |
|---|---|
| Protein Name | myocyte enhancer factor 2B |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 365 |
| Uniprot ID | Q02080 |
| Ensembl Protein ID | ENSP00000402154 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 9759 | HDAC4 | 5610 | NP_006028.2 | in vitro | 15567413 |
| 23523 | CABIN1 | 10369 | NP_036427.1 | in vitro | 12700764 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| cGMP-PKG signaling pathway | hsa04022 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00265 | Feb-78 | MADS_MEF2_like |
| cl00109 | Feb-78 | MADS superfamily |
| smart00432 | Feb-60 | MADS |
| cd00120 | Feb-60 | MADS |
| cd00266 | Feb-83 | MADS_SRF_like |
| pfam00319 | Sep-59 | SRF-TF |
| COG5068 | Jan-66 | ARG80 |
| PHA03247 | 123-364 | PHA03247 |
| PHA03247 | 102-355 | PHA03247 |
| PRK14086 | 104-246 | dnaA |
| PHA03247 | 98-360 | PHA03247 |
| PRK07764 | 148-361 | PRK07764 |
| PHA03307 | 90-365 | PHA03307 |
| PRK14965 | 110-180 | PRK14965 |
| PHA03247 | 98-247 | PHA03247 |
| PRK12323 | 115-340 | PRK12323 |
| PHA03247 | 130-359 | PHA03247 |
Ontology Information
| HPRD ID | 19467 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Transcription (GO:0006350) |
Drug Information
No matching records could be found.