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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MEG3 | 55384 | maternally expressed 3 (non-protein coding) | 14 | GTL2, NCRNA00023, LINC00023 |
- Evidence
- Gene
- mRNA
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25636452 | 2015 | Cell line : - Source : - Sample Type : CRC tumor and adjacent normal tissue No. of Sample : 62 Stage : - | real time RT-PCR,Multivariate analyses | Up-regulation | - | MEG3 is involved in the development and progression of colorectal cancer by regulating cell proliferation and shows that MEG3 may be a potential diagnostic and prognostic target in patients with colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Long non-coding RNAs, "-" |
| Description | This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene expression. Its deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is a lncRNA tumor suppressor. [provided by RefSeq, Mar 2012] | Chromosome | 14 |
| Location | 14q32.2 |
| Start | 101292445 |
| End | 101327363 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 34919 |
| OMIM ID | 605636 |
| HGNC ID | HGNC:14575 |
| Unigene ID | - |
| Ensembl ID | ENSG00000214548 |
| PharmGKB ID | - |
Protein Information
| Protein ID | |
|---|---|
| Protein Name | maternally expressed 3 (non-protein coding) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 0 |
| Uniprot ID | |
| Ensembl Protein ID |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
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PPi Information
No STRING Network could be found.
No matching records from HPRD source could be found.
Pathway Information
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Structure Information
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Domain Information
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Drug Information
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