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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21858198 | 2011 | Cell line : Hct116 Source : ATCC, The Jackson Laboratory (Bar Harbor, ME). Sample Type : - No. of Sample : Mouse model Stage : - | Western blotting,RT-PCR,Immunohistochemistry | Down-regulation | - | The decreased expression of MEIS1D in colon tumors also suggests that this conserved homeodomain-less isoform may act as a tumor suppressor in human colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Homeoboxes / TALE class |
| Description | Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008] | Chromosome | 2 |
| Location | 2p14 |
| Start | 66662257 |
| End | 66799891 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 137635 |
| OMIM ID | 601739 |
| HGNC ID | HGNC:7000 |
| Unigene ID | Hs.526754 |
| Ensembl ID | ENSG00000143995 |
| PharmGKB ID | PA30740 |
mRNA Information
| mRNA ID | XM_005264323.1 |
|---|---|
| Exon | join(1..744,1772..1819,2613..2839,4719..4860,5438..5488, 6290..6340,7778..7924,28985..29096,77025..77170, 112819..112895,132329..132387,133543..133632, 133926..134021,136122..137635) | mRNA Sequence | Download Select all |
| Length | 3504 |
Protein Information
| Protein ID | XP_005264380.1 |
|---|---|
| Protein Name | Meis homeobox 1 |
| Molecular Wt. (Da) | 164340 |
| Protein Sequence | Download Select all |
| Length | 406 |
| Uniprot ID | Q13009 |
| Ensembl Protein ID | ENSP00000286827 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Sumoylation | 72 |
| S | Phosphorylation | 196;- |
| S | Phosphorylation | 198;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3199 | HOXA2 | 5252 | NP_006726.1 | yeast 2-hybrid | 15617687 |
| 3202 | HOXA5 | 840 | NP_061975.2 | yeast 2-hybrid | 15617687 |
| 3204 | HOXA7 | 838 | NP_008827.2 | in vivo | 9405651 |
| 3206 | HOXA10 | 845 | NP_061824.3 | in vitro | 9343407 |
| 3207 | HOXA11 | 846 | NP_005514.1 | yeast 2-hybrid | 1 561 768 716 087 730 |
| 3209 | HOXA13 | 847 | NP_000513.2 | in vivo;yeast 2-hybrid | 1 608 773 415 617 680 |
| 3211 | HOXB1 | 855 | NP_002135.2 | in vitro | 10373562 |
| 3214 | HOXB4 | 7032 | NP_076920.1 | yeast 2-hybrid | 15617687 |
| 3218 | HOXB8 | 851 | NP_076921.1 | yeast 2-hybrid | 15617687 |
| 3229 | HOXC13 | 862 | NP_059106.2 | yeast 2-hybrid | 15617687 |
| 3233 | HOXD4 | 864 | NP_055436.2 | in vitro;in vivo | 10523646 |
| 3237 | HOXD11 | 869 | NP_067015.2 | in vitro | 9343407 |
| 3238 | HOXD12 | 871 | NP_067016.3 | in vitro | 9343407 |
| 3239 | HOXD13 | 872 | BAB11690.1 | in vivo;yeast 2-hybrid | 1 561 768 716 087 730 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00086 | 276-329 | homeodomain |
| cl00084 | 276-329 | homeodomain superfamily |
| pfam05920 | 290-329 | Homeobox_KN |
| smart00389 | 276-329 | HOX |
| pfam00046 | 291-329 | Homeobox |
Ontology Information
| HPRD ID | 1785 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Extracellular matrix structural constituent (GO:0005201) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.