Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MET | 4233 | MET proto-oncogene, receptor tyrosine kinase | 7 | HGFR, RCCP2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23996864 | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Tissue microarray and immunohistochemistry | Up-regulation | - | c-MET seems to be a valuable biomarker in colorectal adenocarcinoma; overexpression is a useful prognostic indicator for metastasis and patient outcome. c-MET was highly expressed in 138 of 230 cases (60%). Sample size: Two-hundred and thirty cases. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. | Chromosome | 7 |
| Location | 7q31 |
| Start | 116672405 |
| End | 116798386 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 125982 |
| OMIM ID | 164860 |
| HGNC ID | HGNC:7029 |
| Unigene ID | Hs.132966 |
| Ensembl ID | ENSG00000105976 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001127500.1 |
|---|---|
| Exon | join(1..173,26667..27880,59264..59455,67546..67680, 68448..68621,82951..83111,85033..85135,85234..85370, 86055..86216,86933..87086,90646..90864,97241..97387, 99094..99250,99445..99585,102477..102707,104985..105065, 106372..106553,109584..109693,110900..111065, 123251..123387,123483..125982) | mRNA Sequence | Download Select all |
| Length | 6641 |
CDS Information
| Location | join(23353..23395,26667..27880,59264..59455,67546..67680, 68448..68621,82951..83111,85033..85135,85234..85370, 86055..86216,86987..87086,90646..90864,97241..97387, 99094..99250,99445..99585,102477..102707,104985..105065, 106372..106553,109584..109693,110900..111065, 123251..123387,123483..123720) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001120972.1 |
|---|---|
| Protein Name | MET proto-oncogene, receptor tyrosine kinase |
| Molecular Wt. (Da) | 155222 |
| Protein Sequence | Download Select all |
| Length | 1408 |
| Uniprot ID | P01920 |
| Ensembl Protein ID | ENSP00000382038 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 1003 |
| Y | Phosphorylation | 1230 |
| Y | Phosphorylation | 1234 |
| Y | Phosphorylation | 1235 |
| Y | Phosphorylation | 1295 |
| S | Phosphorylation | 1331 |
| S | Phosphorylation | 1338 |
| Y | Phosphorylation | 1349 |
| Y | Phosphorylation | 1356 |
| Y | Phosphorylation | 1365 |
| Y | Dephosphorylation | 1349 |
| Y | Dephosphorylation | 1356 |
| S | Phosphorylation | 985 |
| S | Phosphorylation | 988;- |
| S | Phosphorylation | 990;- |
| T | Phosphorylation | 977;- |
| S | Phosphorylation | 1000;- |
| T | Phosphorylation | 992 |
| S | Phosphorylation | 997 |
| T | Phosphorylation | 993 |
| S | Phosphorylation | 966 |
| Y | Phosphorylation | 1233 |
Enzyme Information
| EC | 2.7.10.1 |
|---|---|
| Name | receptor protein-tyrosine kinase AATK AATYK AATYK2 AATYK3 ACH ALK anaplastic lymphoma kinase ARK ATP:protein-tyrosine O-phosphotransferase (ambiguous) AXL Bek Bfgfr BRT Bsk C-FMS CAK CCK4 CD115 CD135 CDw135 Cek1 Cek10 Cek11 Cek2 Cek3 Cek5 Cek6 Cek7 CFD1 CKIT CSF1R DAlk DDR1 DDR2 Dek DKFZp434C1418 Drosophila Eph kinase DRT DTK Ebk ECK EDDR1 Eek EGFR Ehk2 Ehk3 Elk EPH EPHA1 EPHA2 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EphB5 ephrin-B3 receptor tyrosine kinase EPHT EPHT2 EPHT3 EPHX ERBB ERBB1 ERBB2 ERBB3 ERBB4 ERK Eyk FGFR1 FGFR2 FGFR3 FGFR4 FLG FLK1 FLK2 FLT1 FLT2 FLT3 FLT4 FMS Fv2 HBGFR HEK11 HEK2 HEK3 HEK5 HEK6 HEP HER2 HER3 HER4 HGFR HSCR1 HTK IGF1R INSR INSRR insulin receptor protein-tyrosine kinase IR IRR JTK12 JTK13 JTK14 JWS K-SAM KDR KGFR KIA0641 KIAA1079 KIAA1459 Kil Kin15 Kin16 KIT KLG LTK MCF3 Mdk1 Mdk2 Mdk5 MEhk1 MEN2A/B Mep MER MERTK MET Mlk1 Mlk2 Mrk MST1R MTC1 MUSK Myk1 N-SAM NEP NET Neu neurite outgrowth regulating kinase NGL NOK nork novel oncogene with kinase-domain Nsk2 NTRK1 NTRK2 NTRK3 NTRK4 NTRKR1 NTRKR2 NTRKR3 Nuk NYK PCL PDGFR PDGFRA PDGFRB PHB6 protein-tyrosine kinase (ambiguous) protein tyrosine kinase (ambiguous) PTK PTK3 PTK7 receptor protein tyrosine kinase RET RON ROR1 ROR2 ROS1 RSE RTK RYK SEA Sek2 Sek3 Sek4 Sfr SKY STK STK1 TEK TIE TIE1 TIE2 TIF TKT TRK TRKA TRKB TRKC TRKE TYK1 TYRO10 Tyro11 TYRO3 Tyro5 Tyro6 TYRO7 UFO VEGFR1 VEGFR2 VEGFR3 Vik YK1 Yrk |
| Class | Transferases; Transferring phosphorus-containing groups; Protein-tyrosine kinases |
| Sysname | ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type) |
| Substrate | ATP [CPD:C00002]; [protein]-L-tyrosine |
| Product | ADP [CPD:C00008]; [protein]-L-tyrosine phosphate |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 836 | CASP3 | 2799 | NP_004337.2 | in vitro;in vivo | 15542841 |
| 1268 | CNR1 | 259 | NP_057167.2 | in vitro | 11894096 |
| 1613 | DAPK3 | 4478 | NP_001339.1 | yeast 2-hybrid | 15546961 |
| 2017 | CTTN | 1268 | NP_005222.2 | in vitro;in vivo | 11439336 |
| 2549 | GAB1 | 5116 | NP_997006.1 | in vitro;in vivo | 1 099 544 210 734 310 |
| 2885 | GRB2 | 150 | NP_002077.1 | in vitro;in vivo;yeast 2-hybrid | 1 143 933 686 628 890 000 000 000 000 000 000 000 |
| 3082 | HGF | 799 | NP_000592.3 | in vitro;in vivo | 16 554 051 516 789 200 000 000 |
| 5295 | PIK3R1 | 1381 | NP_852664.1 | in vitro | 7513258 |
| 5335 | PLCG1 | 1398 | NP_002651.2 | in vitro | 75 132 588 662 733 |
| 6643 | SNX2 | 9332 | NP_003091.2 | yeast 2-hybrid | 15546961 |
| 6774 | STAT3 | 26 | NP_644805.1 | in vivo | 9440692 |
| 7409 | VAV1 | 1284 | NP_005419.2 | yeast 2-hybrid | 15546961 |
| 8243 | SMC1A | 2077 | NP_006297.2 | yeast 2-hybrid | 15546961 |
| 9093 | DNAJA3 | 9758 | NP_005138.3 | yeast 2-hybrid | 15546961 |
| 23557 | SNAPIN | 6111 | NP_036569.1 | yeast 2-hybrid | 15546961 |
| 80176 | SPSB1 | 18106 | NP_079382.2 | in vivo | 15713673 |
| 84105 | PCBD2 | 17824 | NP_115527.3 | yeast 2-hybrid | 15546961 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Adherens junction | hsa04520 |
| Axon guidance | hsa04360 |
| Bacterial invasion of epithelial cells | hsa05100 |
| Central carbon metabolism in cancer | hsa05230 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Endocytosis | hsa04144 |
| Epithelial cell signaling in Helicobacter pylori infection | hsa05120 |
| Focal adhesion | hsa04510 |
| Malaria | hsa05144 |
| Melanoma | hsa05218 |
| MicroRNAs in cancer | hsa05206 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Proteoglycans in cancer | hsa05205 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
| Renal cell carcinoma | hsa05211 |
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd11278 | 25-516 | Sema_MET |
| cl15693 | 25-516 | Sema superfamily |
| cd05058 | 1082-1343 | PTKc_Met_Ron |
| cl21453 | 1082-1343 | PKc_like superfamily |
| cd01180 | 563-656 | IPT_plexin_repeat1 |
| cl15674 | 563-656 | IPT superfamily |
| cd01179 | 657-740 | IPT_plexin_repeat2 |
| cl15674 | 657-740 | IPT superfamily |
| cd01181 | 742-837 | IPT_plexin_repeat3 |
| cl15674 | 742-837 | IPT superfamily |
| cd00603 | 839-932 | IPT_PCSR |
| cl15674 | 839-932 | IPT superfamily |
| cd11248 | 43-516 | Sema_MET_like |
| cd00192 | 1082-1337 | PTKc |
| pfam01403 | 57-500 | Sema |
| cd11236 | 51-515 | Sema_plexin_like |
| cd11279 | 24-515 | Sema_RON |
| smart00630 | 52-487 | Sema |
| cd05035 | 1082-1340 | PTKc_TAM |
| cd05032 | 1084-1339 | PTKc_InsR_like |
| cd05074 | 1083-1340 | PTKc_Tyro3 |
| cd05075 | 1078-1333 | PTKc_Axl |
| cd05044 | 1084-1331 | PTKc_c-ros |
| cd14204 | 1069-1340 | PTKc_Mer |
| cd05043 | 1082-1335 | PTK_Ryk |
| cd05053 | 1082-1342 | PTKc_FGFR |
| cd05039 | 1078-1340 | PTKc_Csk_like |
| cd05057 | 1083-1338 | PTKc_EGFR_like |
| cd05036 | 1084-1339 | PTKc_ALK_LTK |
| cd05060 | 1084-1340 | PTKc_Syk_like |
| cd05034 | 1084-1336 | PTKc_Src_like |
| cd05059 | 1071-1337 | PTKc_Tec_like |
| cd05041 | 1082-1333 | PTKc_Fes_like |
| cd13999 | 1084-1337 | STKc_MAP3K-like |
| cd05056 | 1078-1340 | PTKc_FAK |
| cd05048 | 1078-1339 | PTKc_Ror |
| cd05052 | 1084-1341 | PTKc_Abl |
| cd05033 | 1078-1339 | PTKc_EphR |
| cd05054 | 1080-1338 | PTKc_VEGFR |
| cd05049 | 1078-1339 | PTKc_Trk |
| cd05051 | 1079-1333 | PTKc_DDR |
| cd05061 | 1084-1334 | PTKc_InsR |
| cd05038 | 1084-1340 | PTKc_Jak_rpt2 |
| cd05068 | 1084-1343 | PTKc_Frk_like |
| cd05148 | 1084-1340 | PTKc_Srm_Brk |
| cd05084 | 1082-1333 | PTKc_Fes |
| cd05046 | 1083-1338 | PTK_CCK4 |
| cd05055 | 1080-1337 | PTKc_PDGFR |
| cd05045 | 1080-1335 | PTKc_RET |
| cd05062 | 1084-1337 | PTKc_IGF-1R |
| cd05112 | 1071-1338 | PTKc_Itk |
| cd05113 | 1084-1337 | PTKc_Btk_Bmx |
| cd05109 | 1083-1340 | PTKc_HER2 |
| cd05085 | 1082-1339 | PTKc_Fer |
| cd05108 | 1082-1338 | PTKc_EGFR |
| cd05066 | 1078-1335 | PTKc_EphR_A |
| cd05098 | 1084-1342 | PTKc_FGFR1 |
| cd05110 | 1082-1338 | PTKc_HER4 |
| cd05114 | 1071-1340 | PTKc_Tec_Rlk |
| cd05065 | 1078-1335 | PTKc_EphR_B |
| cd05099 | 1084-1356 | PTKc_FGFR4 |
| cd05092 | 1084-1339 | PTKc_TrkA |
| cd05082 | 1082-1340 | PTKc_Csk |
| cd05072 | 1084-1348 | PTKc_Lyn |
| cd05100 | 1084-1375 | PTKc_FGFR3 |
| cd05097 | 1080-1333 | PTKc_DDR_like |
| cd05096 | 1080-1338 | PTKc_DDR1 |
| cd05050 | 1084-1333 | PTKc_Musk |
| cd05040 | 1082-1335 | PTKc_Ack_like |
| cd05063 | 1071-1335 | PTKc_EphR_A2 |
| cd05095 | 1080-1333 | PTKc_DDR2 |
| cd05102 | 1078-1334 | PTKc_VEGFR3 |
| cd05083 | 1082-1337 | PTKc_Chk |
| cd05101 | 1084-1347 | PTKc_FGFR2 |
| cd05047 | 1082-1338 | PTKc_Tie |
| cd05103 | 1084-1337 | PTKc_VEGFR2 |
| cd05089 | 1078-1338 | PTKc_Tie1 |
| cd05067 | 1082-1342 | PTKc_Lck_Blk |
| cd14207 | 1084-1337 | PTKc_VEGFR1 |
| cd05093 | 1084-1333 | PTKc_TrkB |
| cd05111 | 1082-1338 | PTK_HER3 |
| cd14203 | 1084-1335 | PTKc_Src_Fyn_like |
| cd05115 | 1084-1341 | PTKc_Zap-70 |
| cd05094 | 1084-1340 | PTKc_TrkC |
| cd05073 | 1084-1335 | PTKc_Hck |
| cd05116 | 1084-1337 | PTKc_Syk |
| cd05090 | 1078-1339 | PTKc_Ror1 |
| cd05088 | 1078-1361 | PTKc_Tie2 |
| cd05107 | 1157-1334 | PTKc_PDGFR_beta |
| cd14205 | 1080-1340 | PTKc_Jak2_rpt2 |
| cd05071 | 1084-1343 | PTKc_Src |
| cd05091 | 1078-1339 | PTKc_Ror2 |
| cd05081 | 1083-1340 | PTKc_Jak3_rpt2 |
| cd00180 | 1084-1337 | PKc |
| cd05070 | 1084-1342 | PTKc_Fyn |
| cd05064 | 1078-1338 | PTKc_EphR_A10 |
| cd05105 | 1163-1341 | PTKc_PDGFR_alpha |
| cd05079 | 1084-1340 | PTKc_Jak1_rpt2 |
| cd05106 | 1080-1338 | PTKc_CSF-1R |
| cd05069 | 1084-1342 | PTKc_Yes |
| cd05104 | 1080-1337 | PTKc_Kit |
| cd11272 | 62-551 | Sema_plexin_A2 |
| cd05080 | 1082-1334 | PTKc_Tyk2_rpt2 |
| cd14061 | 1083-1340 | STKc_MLK |
| cd11244 | 46-372 | Sema_plexin_A |
| cd11276 | 46-514 | Sema_plexin_B2 |
| cd14066 | 1084-1337 | STKc_IRAK |
| cd11245 | 62-515 | Sema_plexin_B |
| cd14058 | 1084-1344 | STKc_TAK1 |
| cd11271 | 52-515 | Sema_plexin_A1 |
| cd05042 | 1084-1333 | PTKc_Aatyk |
| cd06606 | 1082-1333 | STKc_MAPKKK |
| cd11274 | 61-372 | Sema_plexin_A4 |
| cd14148 | 1083-1340 | STKc_MLK2 |
| cd14146 | 1083-1340 | STKc_MLK4 |
| cd14145 | 1082-1340 | STKc_MLK1 |
| cd14014 | 1082-1339 | STKc_PknB_like |
| cd14206 | 1084-1333 | PTKc_Aatyk3 |
| cd14147 | 1080-1340 | STKc_MLK3 |
| cd14059 | 1084-1337 | STKc_MAP3K12_13 |
| cd11273 | 62-371 | Sema_plexin_A3 |
| cd14065 | 1084-1334 | PKc_LIMK_like |
| cd05122 | 1082-1333 | PKc_STE |
| cd05087 | 1084-1333 | PTKc_Aatyk1 |
| cd13978 | 1084-1332 | STKc_RIP |
| cd14060 | 1085-1340 | STKc_MLTK |
| cd14062 | 1084-1337 | STKc_Raf |
| cd05086 | 1084-1337 | PTKc_Aatyk2 |
| cd14155 | 1125-1342 | PKc_TESK |
| cd14154 | 1084-1333 | STKc_LIMK |
| cd14151 | 1084-1340 | STKc_B-Raf |
| cd14027 | 1125-1336 | STKc_RIP1 |
| cd14150 | 1084-1340 | STKc_A-Raf |
| cd14221 | 1124-1333 | STKc_LIMK1 |
| cd11275 | 62-515 | Sema_plexin_B1 |
| cd14664 | 1084-1340 | STK_BAK1_like |
| cd06627 | 1082-1335 | STKc_Cdc7_like |
| cd14156 | 1130-1343 | PKc_LIMK_like_unk |
| cd14064 | 1084-1339 | PKc_TNNI3K |
| cd14009 | 1084-1284 | STKc_ATG1_ULK_like |
| cd14222 | 1124-1340 | STKc_LIMK2 |
| cd14158 | 1084-1340 | STKc_IRAK4 |
| cd11277 | 58-367 | Sema_plexin_B3 |
| cd14149 | 1084-1337 | STKc_C-Raf |
| cd06612 | 1080-1288 | STKc_MST1_2 |
| cd06629 | 1082-1335 | STKc_Bck1_like |
| cd06614 | 1082-1335 | STKc_PAK |
| cd05117 | 1079-1283 | STKc_CAMK |
| cd14003 | 1082-1288 | STKc_AMPK-like |
| cd07866 | 1079-1279 | STKc_BUR1 |
| cd06628 | 1083-1335 | STKc_Byr2_like |
| cd13992 | 1131-1330 | PK_GC |
| cd14080 | 1079-1288 | STKc_TSSK-like |
| cd14007 | 1084-1293 | STKc_Aurora |
| cd05118 | 1083-1333 | STKc_CMGC |
| cd05037 | 1080-1337 | PTK_Jak_rpt1 |
| cd08215 | 1082-1337 | STKc_Nek |
| cd14063 | 1078-1333 | PK_KSR |
| cd14042 | 1107-1337 | PK_GC-A_B |
| cd06642 | 1082-1334 | STKc_STK25 |
| cd06609 | 1082-1287 | STKc_MST3_like |
| cd00603 | 657-740 | IPT_PCSR |
| cd05581 | 1079-1311 | STKc_PDK1 |
| cd06610 | 1082-1299 | STKc_OSR1_SPAK |
| cd14002 | 1079-1284 | STKc_STK36 |
| cd14025 | 1082-1335 | STKc_RIP4_like |
| cd05123 | 1084-1289 | STKc_AGC |
| cd08225 | 1079-1336 | STKc_Nek5 |
| cd13994 | 1084-1335 | STKc_HAL4_like |
| cd06632 | 1082-1333 | STKc_MEKK1_plant |
| cd14010 | 1079-1284 | STKc_ULK4 |
| cd08530 | 1083-1333 | STKc_CNK2-like |
| cd14120 | 1084-1282 | STKc_ULK1_2-like |
| cd14057 | 1114-1334 | PK_ILK |
| cd07840 | 1084-1285 | STKc_CDK9_like |
| cd14053 | 1082-1338 | STKc_ACVR2 |
| cd14000 | 1083-1339 | STKc_LRRK |
| cd06641 | 1082-1334 | STKc_MST3 |
| cd06640 | 1082-1334 | STKc_MST4 |
| cd08217 | 1082-1333 | STKc_Nek2 |
| cd14159 | 1084-1278 | STKc_IRAK1 |
| cd06611 | 1084-1333 | STKc_SLK_like |
| cd14202 | 1082-1333 | STKc_ULK1 |
| cd14069 | 1084-1335 | STKc_Chk1 |
| cd06625 | 1083-1335 | STKc_MEKK3_like |
| cd06623 | 1083-1335 | PKc_MAPKK_plant_like |
| cd13998 | 1082-1344 | STKc_TGFbR-like |
| cd08228 | 1084-1331 | STKc_Nek6 |
| cd08528 | 1082-1338 | STKc_Nek10 |
| cd14054 | 1082-1327 | STKc_BMPR2_AMHR2 |
| cd14026 | 1084-1344 | STKc_RIP2 |
| cd05612 | 1084-1300 | STKc_PRKX_like |
| cd07829 | 1082-1279 | STKc_CDK_like |
| cd07834 | 1080-1279 | STKc_MAPK |
| cd14043 | 1131-1333 | PK_GC-2D |
| cd07841 | 1084-1279 | STKc_CDK7 |
| smart00429 | 656-739 | IPT |
| cd08224 | 1084-1333 | STKc_Nek6_7 |
| cd06638 | 1082-1334 | STKc_myosinIIIA_N |
| cd14162 | 1082-1288 | STKc_TSSK4-like |
| cd14161 | 1080-1284 | STKc_NUAK2 |
| cd14137 | 1081-1278 | STKc_GSK3 |
| cd14084 | 1079-1289 | STKc_Chk2 |
| cd06917 | 1082-1333 | STKc_NAK1_like |
| cd08529 | 1084-1282 | STKc_FA2-like |
| cd14099 | 1082-1335 | STKc_PLK |
| cd05616 | 1079-1284 | STKc_cPKC_beta |
| cd06608 | 1082-1335 | STKc_myosinIII_N_like |
| cd14201 | 1082-1303 | STKc_ULK2 |
| cd13979 | 1080-1332 | STKc_Mos |
| cd13996 | 1079-1276 | STKc_EIF2AK |
| cd05572 | 1084-1295 | STKc_cGK |
| cd14121 | 1082-1284 | STKc_ULK3 |
| cd13986 | 1080-1337 | STKc_16 |
| cd14663 | 1083-1288 | STKc_SnRK3 |
| cd13983 | 1080-1335 | STKc_WNK |
| cd07838 | 1084-1279 | STKc_CDK4_6_like |
| cd14045 | 1131-1333 | PK_GC_unk |
| cd00102 | 657-740 | IPT |
| cd14008 | 1084-1333 | STKc_LKB1_CaMKK |
| cd14165 | 1104-1288 | STKc_TSSK1_2-like |
| cd06648 | 1073-1284 | STKc_PAK_II |
| cd06631 | 1082-1335 | STKc_YSK4 |
| cd07871 | 1084-1285 | STKc_PCTAIRE3 |
| cd05589 | 1083-1285 | STKc_PKN |
| cd08222 | 1084-1334 | STKc_Nek11 |
| cd05580 | 1080-1292 | STKc_PKA_like |
| cd13993 | 1080-1337 | STKc_Pat1_like |
| cd07873 | 1084-1285 | STKc_PCTAIRE1 |
| cd07843 | 1084-1279 | STKc_CDC2L1 |
| cd14096 | 1084-1286 | STKc_RCK1-like |
| cd06630 | 1082-1335 | STKc_MEKK1 |
| cd06605 | 1083-1333 | PKc_MAPKK |
| cd07860 | 1082-1281 | STKc_CDK2_3 |
| cd05578 | 1079-1285 | STKc_Yank1 |
| cd14019 | 1082-1284 | STKc_Cdc7 |
| cd14068 | 1083-1339 | STKc_LRRK2 |
| cd07832 | 1084-1285 | STKc_CCRK |
| smart00429 | 741-836 | IPT |
| cd05570 | 1083-1284 | STKc_PKC |
| cd07862 | 1084-1279 | STKc_CDK6 |
| cd08229 | 1084-1331 | STKc_Nek7 |
| cd05577 | 1084-1310 | STKc_GRK |
| cd07845 | 1084-1297 | STKc_CDK10 |
| cd06655 | 1082-1334 | STKc_PAK2 |
| cd14193 | 1078-1284 | STKc_MLCK4 |
| cd13975 | 1079-1342 | PKc_Dusty |
| cd14038 | 1084-1286 | STKc_IKK_beta |
| cd07863 | 1084-1279 | STKc_CDK4 |
| cd14081 | 1084-1304 | STKc_BRSK1_2 |
| cd14079 | 1082-1312 | STKc_AMPK_alpha |
| cd08219 | 1083-1336 | STKc_Nek3 |
| cd05631 | 1083-1284 | STKc_GRK4 |
| cd05592 | 1083-1284 | STKc_nPKC_theta_like |
| cd06620 | 1103-1282 | PKc_Byr1_like |
| cd06613 | 1084-1287 | STKc_MAP4K3_like |
| cd07872 | 1082-1285 | STKc_PCTAIRE2 |
| cd13987 | 1135-1284 | STKc_SBK1 |
| cd06647 | 1082-1334 | STKc_PAK_I |
| cd07855 | 1082-1279 | STKc_ERK5 |
| cd14073 | 1080-1284 | STKc_NUAK |
| cd14186 | 1083-1284 | STKc_PLK4 |
| cd06633 | 1073-1334 | STKc_TAO3 |
| cd00603 | 563-656 | IPT_PCSR |
| smart00429 | 562-655 | IPT |
| cd14072 | 1084-1300 | STKc_MARK |
| cd06652 | 1082-1334 | STKc_MEKK2 |
| cd06624 | 1083-1333 | STKc_ASK |
| cd05595 | 1082-1284 | STKc_PKB_beta |
| cd14098 | 1082-1314 | STKc_Rad53_Cds1 |
| cd14153 | 1078-1334 | PK_KSR2 |
| cd05620 | 1082-1286 | STKc_nPKC_delta |
| cd14044 | 1156-1342 | PK_GC-C |
| cd14056 | 1082-1329 | STKc_TGFbR_I |
| cd06656 | 1059-1334 | STKc_PAK3 |
| cd14192 | 1082-1284 | STKc_MLCK3 |
| cd05593 | 1082-1284 | STKc_PKB_gamma |
| cd14185 | 1083-1284 | STKc_DCKL3 |
| cd06651 | 1082-1335 | STKc_MEKK3 |
| cd06636 | 1077-1288 | STKc_MAP4K4_6_N |
| cd06654 | 1059-1334 | STKc_PAK1 |
| cd06616 | 1084-1335 | PKc_MKK4 |
| cd14001 | 1108-1334 | PKc_TOPK |
| cd13985 | 1083-1337 | STKc_GAK_like |
| cd14208 | 1080-1283 | PTK_Jak3_rpt1 |
| cd14078 | 1082-1289 | STKc_MELK |
| cd05582 | 1083-1284 | STKc_RSK_N |
| cd14105 | 1082-1284 | STKc_DAPK |
| cd14077 | 1080-1288 | STKc_Kin1_2 |
| cd05077 | 1082-1337 | PTK_Jak1_rpt1 |
| cd07836 | 1082-1291 | STKc_Pho85 |
| cd05619 | 1074-1282 | STKc_nPKC_theta |
| cd06643 | 1080-1334 | STKc_SLK |
| cd14067 | 1122-1336 | STKc_LRRK1 |
| cd05615 | 1080-1284 | STKc_cPKC_alpha |
| cd07864 | 1083-1279 | STKc_CDK12 |
| cd06653 | 1082-1286 | STKc_MEKK3_like_u1 |
| cd14006 | 1084-1284 | STKc_MLCK-like |
| cd14070 | 1084-1292 | STKc_HUNK |
| cd07835 | 1082-1285 | STKc_CDK1_CdkB_like |
| cd14190 | 1074-1284 | STKc_MLCK2 |
| cd14167 | 1077-1313 | STKc_CaMKI_alpha |
| cd07839 | 1082-1285 | STKc_CDK5 |
| cd08223 | 1080-1335 | STKc_Nek4 |
| cd05602 | 1079-1305 | STKc_SGK1 |
| cd14082 | 1081-1274 | STKc_PKD |
| cd06644 | 1084-1334 | STKc_STK10 |
| cd06637 | 1077-1288 | STKc_TNIK |
| cd06639 | 1082-1334 | STKc_myosinIIIB_N |
| cd14160 | 1123-1337 | PK_IRAK3 |
| cd05607 | 1083-1286 | STKc_GRK7 |
| cd14095 | 1083-1284 | STKc_DCKL |
| cd06659 | 1124-1284 | STKc_PAK6 |
| cd07830 | 1082-1278 | STKc_MAK_like |
| cd05632 | 1083-1284 | STKc_GRK5 |
| cd14116 | 1084-1293 | STKc_Aurora-A |
| cd14097 | 1076-1284 | STKc_STK33 |
| cd14209 | 1083-1284 | STKc_PKA |
| cd07842 | 1084-1278 | STKc_CDK8_like |
| cd06621 | 1102-1276 | PKc_Pek1_like |
| cd07877 | 1084-1291 | STKc_p38alpha |
| cd07856 | 1130-1297 | STKc_Sty1_Hog1 |
| cd14004 | 1082-1284 | STKc_PASK |
| cd07853 | 1084-1279 | STKc_NLK |
| cd05579 | 1084-1284 | STKc_MAST_like |
| cd14012 | 1135-1335 | PK_eIF2AK_GCN2_rpt1 |
| cd14164 | 1080-1306 | STKc_TSSK6-like |
| cd14152 | 1078-1333 | STKc_KSR1 |
| cd05605 | 1156-1284 | STKc_GRK4_like |
| cd06618 | 1078-1333 | PKc_MKK7 |
| cd14076 | 1084-1286 | STKc_Kin4 |
| cd06658 | 1084-1284 | STKc_PAK5 |
| cd05630 | 1083-1284 | STKc_GRK6 |
| cd07859 | 1082-1288 | STKc_TDY_MAPK |
| cd06635 | 1073-1337 | STKc_TAO1 |
| cd05078 | 1078-1334 | PTK_Jak2_rpt1 |
| cd14071 | 1130-1300 | STKc_SIK |
| cd05076 | 1084-1330 | PTK_Tyk2_rpt1 |
| cd14113 | 1080-1286 | STKc_Trio_C |
| cd00102 | 563-656 | IPT |
| cd05608 | 1083-1282 | STKc_GRK1 |
| cd06634 | 1073-1329 | STKc_TAO2 |
| cd06607 | 1084-1335 | STKc_TAO |
| cd05587 | 1083-1284 | STKc_cPKC |
| cd14194 | 1130-1284 | STKc_DAPK1 |
| cd14199 | 1119-1274 | STKc_CaMKK2 |
| cd07870 | 1082-1287 | STKc_PFTAIRE2 |
| cd05585 | 1083-1312 | STKc_YPK1_like |
| cd05621 | 1041-1286 | STKc_ROCK2 |
| cd07861 | 1082-1279 | STKc_CDK1_euk |
| cd06626 | 1084-1333 | STKc_MEKK4 |
| cd14039 | 1084-1275 | STKc_IKK_alpha |
| cd13997 | 1079-1334 | PKc_Wee1_like |
| cd05611 | 1084-1284 | STKc_Rim15_like |
| cd14140 | 1082-1340 | STKc_ACVR2b |
| cd14189 | 1187-1284 | STKc_PLK3 |
| cd13989 | 1084-1290 | STKc_IKK |
| cd05604 | 1082-1305 | STKc_SGK3 |
| cd14187 | 1187-1335 | STKc_PLK1 |
| cd08221 | 1083-1336 | STKc_Nek9 |
| cd06650 | 1103-1286 | PKc_MEK1 |
| cd14184 | 1082-1290 | STKc_DCKL2 |
| cd14048 | 1082-1277 | STKc_EIF2AK3_PERK |
| cd06657 | 1073-1284 | STKc_PAK4 |
| cd07854 | 1084-1285 | STKc_MAPK4_6 |
| cd14191 | 1082-1284 | STKc_MLCK1 |
| cd14144 | 1084-1327 | STKc_BMPR1 |
| cd08220 | 1083-1276 | STKc_Nek8 |
| cd05584 | 1083-1310 | STKc_p70S6K |
| cd05603 | 1082-1284 | STKc_SGK2 |
| cd14011 | 1131-1328 | PK_SCY1_like |
| cd07852 | 1124-1291 | STKc_MAPK15-like |
| cd08218 | 1084-1278 | STKc_Nek1 |
| cd07878 | 1084-1318 | STKc_p38beta |
| cd13995 | 1084-1295 | STKc_MAP3K8 |
| cd07831 | 1108-1291 | STKc_MOK |
| cd05594 | 1082-1284 | STKc_PKB_alpha |
| cd05573 | 1083-1284 | STKc_ROCK_NDR_like |
| cd14188 | 1187-1334 | STKc_PLK2 |
| cd14141 | 1082-1279 | STKc_ACVR2a |
| cd14093 | 1082-1284 | STKc_PhKG |
| cd06649 | 1103-1291 | PKc_MEK2 |
| pfam01833 | 657-738 | TIG |
| cd14183 | 1073-1284 | STKc_DCKL1 |
| cd14033 | 1080-1315 | STKc_WNK4 |
| cd05622 | 1082-1286 | STKc_ROCK1 |
| cd14083 | 1080-1288 | STKc_CaMKI |
| cd14103 | 1084-1271 | STKc_MLCK |
| cd14031 | 1069-1335 | STKc_WNK3 |
| cd07858 | 1084-1285 | STKc_TEY_MAPK |
| cd08216 | 1106-1305 | PK_STRAD |
| cd14142 | 1082-1327 | STKc_ACVR1_ALK1 |
| cd14101 | 1083-1334 | STKc_PIM2 |
| cd14118 | 1130-1288 | STKc_CAMKK |
| cd14196 | 1130-1284 | STKc_DAPK2 |
| cd14166 | 1080-1284 | STKc_CaMKI_gamma |
| cd14055 | 1082-1279 | STKc_TGFbR2_like |
| cd07844 | 1116-1285 | STKc_PCTAIRE_like |
| pfam01437 | 519-562 | PSI |
| cl02601 | 519-562 | PSI superfamily |
| cd14075 | 1084-1335 | STKc_NIM1 |
| cd07851 | 1130-1318 | STKc_p38 |
| cd14117 | 1084-1284 | STKc_Aurora-B_like |
| cd05617 | 1083-1298 | STKc_aPKC_zeta |
| cd06617 | 1082-1284 | PKc_MKK3_6 |
| cd14111 | 1180-1300 | STKc_SPEG_rpt2 |
| pfam01833 | 563-654 | TIG |
| cd13990 | 1084-1284 | STKc_TLK |
| cd07879 | 1084-1278 | STKc_p38delta |
| cd14115 | 1084-1286 | STKc_Kalirin_C |
| cd05575 | 1083-1284 | STKc_SGK |
| cd06619 | 1078-1337 | PKc_MKK5 |
| cd14195 | 1130-1284 | STKc_DAPK3 |
| cd07833 | 1082-1335 | STKc_CDKL |
| cd07880 | 1130-1282 | STKc_p38gamma |
| cd05590 | 1082-1282 | STKc_nPKC_eta |
| cd06615 | 1103-1286 | PKc_MEK |
| cd14665 | 1084-1337 | STKc_SnRK2-3 |
| cd14074 | 1080-1300 | STKc_SNRK |
| cd09295 | 58-386 | Sema |
| cd14163 | 1108-1322 | STKc_TSSK3-like |
| cd14047 | 1163-1277 | STKc_EIF2AK2_PKR |
| cd00603 | 742-805 | IPT_PCSR |
| cd07869 | 1082-1285 | STKc_PFTAIRE1 |
| cd07865 | 1084-1279 | STKc_CDK9 |
| cd14157 | 1084-1278 | STKc_IRAK2 |
| cd06645 | 1084-1288 | STKc_MAP4K3 |
| cd14102 | 1083-1333 | STKc_PIM3 |
| cd06622 | 1078-1333 | PKc_PBS2_like |
| cd07837 | 1082-1285 | STKc_CdkB_plant |
| cd14169 | 1075-1313 | STKc_CaMKI_beta |
| cd05596 | 1083-1286 | STKc_ROCK |
| cd14100 | 1083-1335 | STKc_PIM1 |
| cd13968 | 1084-1224 | PKc_like |
| cd07867 | 1084-1278 | STKc_CDC2L6 |
| cd14046 | 1082-1276 | STKc_EIF2AK4_GCN2_rpt2 |
| cd14131 | 1082-1333 | PKc_Mps1 |
| cd07849 | 1125-1285 | STKc_ERK1_2_like |
| cd14110 | 1125-1288 | STKc_obscurin_rpt2 |
| cd14086 | 1082-1286 | STKc_CaMKII |
| cd05591 | 1082-1292 | STKc_nPKC_epsilon |
| cd07868 | 1084-1278 | STKc_CDK8 |
| cd14182 | 1082-1284 | STKc_PhKG1 |
| smart00423 | 519-561 | PSI |
| cd14168 | 1077-1288 | STKc_CaMKI_delta |
| cd14106 | 1156-1282 | STKc_DRAK |
| cd14143 | 1082-1327 | STKc_TGFbR1_ACVR1b_ACVR1c |
| cd05618 | 1073-1298 | STKc_aPKC_iota |
| cd14050 | 1080-1336 | PKc_Myt1 |
| cd14049 | 1080-1277 | STKc_EIF2AK1_HRI |
| cd14114 | 1130-1284 | STKc_Twitchin_like |
| cd14181 | 1082-1284 | STKc_PhKG2 |
| cd14133 | 1082-1329 | PKc_DYRK_like |
| cd14005 | 1083-1335 | STKc_PIM |
| cd05571 | 1082-1284 | STKc_PKB |
| cd05601 | 1083-1289 | STKc_CRIK |
| cd14119 | 1130-1333 | STKc_LKB1 |
| cd01180 | 657-713 | IPT_plexin_repeat1 |
| cd13977 | 1084-1326 | STKc_PDIK1L |
| cd14088 | 1097-1337 | STKc_CaMK_like |
| cd14032 | 1078-1335 | STKc_WNK2_like |
| cd05598 | 1200-1284 | STKc_LATS |
| cd14087 | 1083-1310 | STKc_PSKH1 |
| cd14220 | 1084-1331 | STKc_BMPR1a |
| cd13988 | 1084-1285 | STKc_TBK1 |
| cd14052 | 1082-1275 | PTKc_Wee1_fungi |
| cd13982 | 1187-1329 | STKc_IRE1 |
| cd05606 | 1083-1291 | STKc_beta_ARK |
| cd14223 | 1081-1291 | STKc_GRK2 |
| cd14089 | 1135-1284 | STKc_MAPKAPK |
| cd05614 | 1184-1284 | STKc_MSK2_N |
| cd14030 | 1073-1282 | STKc_WNK1 |
| cd14091 | 1082-1285 | STKc_RSK_C |
| cd14176 | 1129-1286 | STKc_RSK2_C |
| cd05633 | 1081-1291 | STKc_GRK3 |
| cd14175 | 1082-1286 | STKc_RSK1_C |
| cd14198 | 1135-1282 | STKc_DRAK2 |
| cd14094 | 1082-1284 | STKc_CASK |
| cd14104 | 1080-1284 | STKc_Titin |
| cd08226 | 1134-1310 | PK_STRAD_beta |
| cd14170 | 1154-1311 | STKc_MAPKAPK2 |
| cd14662 | 1084-1286 | STKc_SnRK2 |
| cd07857 | 1084-1279 | STKc_MPK1 |
| cd14132 | 1084-1282 | STKc_CK2_alpha |
| cd07874 | 1084-1333 | STKc_JNK3 |
| cd14178 | 1129-1286 | STKc_RSK3_C |
| cd05583 | 1192-1284 | STKc_MSK_N |
| cd14200 | 1130-1286 | STKc_CaMKK1 |
| cd05613 | 1082-1282 | STKc_MSK1_N |
| cd14219 | 1084-1330 | STKc_BMPR1b |
| cd07875 | 1084-1291 | STKc_JNK1 |
| cd14177 | 1129-1286 | STKc_RSK4_C |
| cd11247 | 62-370 | Sema_plexin_D1 |
| cd14041 | 1068-1284 | STKc_TLK2 |
| cd00102 | 742-805 | IPT |
| smart00429 | 838-934 | IPT |
| cd01179 | 742-805 | IPT_plexin_repeat2 |
| pfam01833 | 742-805 | TIG |
| pfam07714 | 1078-1337 | Pkinase_Tyr |
| smart00219 | 1078-1337 | TyrKc |
| smart00221 | 1078-1337 | STYKc |
| smart00220 | 1082-1333 | S_TKc |
| pfam00069 | 1079-1334 | Pkinase |
| COG0515 | 1082-1337 | SPS1 |
| PTZ00024 | 1084-1291 | PTZ00024 |
| PTZ00263 | 1082-1300 | PTZ00263 |
| PHA03209 | 1118-1277 | PHA03209 |
| PTZ00036 | 1083-1298 | PTZ00036 |
| PTZ00283 | 1155-1334 | PTZ00283 |
| PRK13184 | 1084-1340 | pknD |
| PTZ00267 | 1147-1332 | PTZ00267 |
| PLN00034 | 1123-1275 | PLN00034 |
| PTZ00426 | 1079-1284 | PTZ00426 |
| PHA03212 | 1113-1278 | PHA03212 |
| PHA02988 | 1103-1338 | PHA02988 |
| PLN00113 | 1081-1282 | PLN00113 |
| PLN00009 | 1082-1285 | PLN00009 |
| PHA03390 | 1129-1282 | pk1 |
| PHA03207 | 979-1282 | PHA03207 |
| TIGR03903 | 1116-1278 | TOMM_kin_cyc |
Ontology Information
| HPRD ID | 2181 |
|---|---|
| Molecular Class | Receptor tyrosine kinase |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P08581 | DB08865 | Crizotinib | SmallMoleculeDrug |
| P08581 | DB08875 | Cabozantinib | SmallMoleculeDrug |