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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25015560 | 2014 | Cell line : - Source : Puerta del Mar Hospital, C?diz; Puerto Real Hospital, C?diz; and San Cecilio Hospital, Granada Sample Type : - No. of Sample : - Stage : - | Tissue microarray, immunohistochemistry and sanger sequencing | Up-regulation | - | MGMT expression may be an OS biomarker as useful as tumor stage or differentiation grade. MGMT and CD133 may both be useful for determining the prognosis of colorectal cancer patients and to identify those requiring more aggressive adjuvant therapies. Sample size:123 paraffin-embedded colorectal adenocarcinoma samples. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | - | Chromosome | 10 |
| Location | 10q26 |
| Start | 129467190 |
| End | 129768042 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 300853 |
| OMIM ID | 156569 |
| HGNC ID | HGNC:7059 |
| Unigene ID | Hs.501522 |
| Ensembl ID | ENSG00000170430 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_002412.3 |
|---|---|
| Exon | join(1..107,69052..69188,240706..240854,292013..292152, 299599..300330) | mRNA Sequence | Download Select all |
| Length | 1265 |
CDS Information
| Location | join(27..107,69052..69188,240706..240854,292013..292152, 299599..299808) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS7660.2 |
Protein Information
| Protein ID | NP_002403.2 |
|---|---|
| Protein Name | O-6-methylguanine-DNA methyltransferase |
| Molecular Wt. (Da) | 24919 |
| Protein Sequence | Download Select all |
| Length | 238 |
| Uniprot ID | P13747 |
| Ensembl Protein ID | ENSP00000373091 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 232 |
Enzyme Information
| EC | 2.1.1.63 |
|---|---|
| Name | methylated-DNA---[protein]-cysteine S-methyltransferase |
| Class | Transferases; Transferring one-carbon groups; Methyltransferases |
| Sysname | DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase |
| Substrate | DNA containing 6-O-methylguanine [CPD:C04250]; protein L-cysteine [CPD:C02743] |
| Product | DNA [CPD:C00039]; protein S-methyl-L-cysteine [CPD:C03800] |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1457 | CSNK2A1 | 277 | NP_001886.1 | in vitro;in vivo | 10667577 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd06445 | 94-173 | ATase |
| cl01497 | 94-173 | ATase superfamily |
| TIGR00589 | 93-172 | ogt |
| pfam01035 | 92-176 | DNA_binding_1 |
| pfam02870 | Jun-90 | Methyltransf_1N |
| cl03751 | Jun-90 | Methyltransf_1N superfamily |
| COG3695 | 96-173 | Atl1 |
| COG0350 | 7-173 | AdaB |
| PRK00901 | 66-173 | PRK00901 |
| PRK10286 | 94-176 | PRK10286 |
| PRK15435 | 90-172 | PRK15435 |
| PRK03887 | 93-173 | PRK03887 |
Ontology Information
| HPRD ID | 1231 |
|---|---|
| Molecular Class | DNA repair protein |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P16455 | DB00151 | L-Cysteine | SmallMoleculeDrug |