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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MGST2 | 4258 | microsomal glutathione S-transferase 2 | 4 | MGST-II |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16369997 | 2006 | Cell line : HT29 Source : - Sample Type : - No. of Sample : - Stage : - | cDNA-microarray,real-time RT-PCR | Up-regulation | - | Enhanced transcriptional activity of GSTP1 and GSTT2 genes. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Glutathione S-transferases / Microsomal |
| Description | The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011] | Chromosome | 4 |
| Location | 4q28.3 |
| Start | 140586922 |
| End | 140661899 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 74978 |
| OMIM ID | 601733 |
| HGNC ID | HGNC:7063 |
| Unigene ID | Hs.81874 |
| Ensembl ID | ENSG00000085871 |
| PharmGKB ID | PA30792 |
mRNA Information
| mRNA ID | NM_001204366.1 |
|---|---|
| Exon | join(1..310,12776..12875,29430..29500,37688..37769, 38249..38429,74445..74978) | mRNA Sequence | Download Select all |
| Length | 1278 |
Protein Information
| Protein ID | NP_001191295.1 |
|---|---|
| Protein Name | microsomal glutathione S-transferase 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 147 |
| Uniprot ID | O60603 |
| Ensembl Protein ID | ENSP00000260010 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 84064 | HDHD2 | 13640 | NP_115500.1 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemical carcinogenesis | hsa05204 |
| Drug metabolism - cytochrome P450 | hsa00982 |
| Glutathione metabolism | hsa00480 |
| Metabolism of xenobiotics by cytochrome P450 | hsa00980 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01124 | 11-111 | MAPEG |
| cl09190 | 11-111 | MAPEG superfamily |
| COG3788 | 21-111 | YecN |
Ontology Information
| HPRD ID | 7585 |
|---|---|
| Molecular Class | Enzyme: Glutathione transferase |
| Molecular Function | Signal transducer activity (GO:0004871) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q99735 | DB01008 | Busulfan | SmallMoleculeDrug |
| Q99735 | DB00143 | Glutathione | SmallMoleculeDrug |
| Q99835 | DB01047 | Fluocinonide | SmallMoleculeDrug |
| Q99835 | DB08828 | Vismodegib | SmallMoleculeDrug |
| Q99835 | DB09143 | Sonidegib | SmallMoleculeDrug |