Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MICA | 100507436 | MHC class I polypeptide-related sequence A | 6 | PERB11.1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20533278 | 2010 | Cell line : - Source : Yangzhou in Jiangsu province were genotyped . Sample Type : CRC tumor and normal tissue No. of Sample : 117 CRC and 113 healthy individuals Stage : - | Sandwich ELISA, PCR and sequence-specific primer method and PCR based sequencing | Polymorhpism | - | There was no genetic susceptibility attributed to MICA gene polymorphism with regard to development of colorectal cancer, serum levels of soluble MICA may be a diagnostic marker of advanced stages. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Immunoglobulin superfamily / C1-set domain containing |
| Description | This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014 | Chromosome | 6 |
| Location | 6p21.3 |
| Start | 31367561 |
| End | 31383090 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 15530 |
| OMIM ID | 600169 |
| HGNC ID | HGNC:7090 |
| Unigene ID | Hs.130838 |
| Ensembl ID | ENSG00000204520 |
| PharmGKB ID | - |
Protein Information
| Protein ID | NP_000238.1 |
|---|---|
| Protein Name | MHC class I polypeptide-related sequence A |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 383 |
| Uniprot ID | Q29983 |
| Ensembl Protein ID | ENSP00000383179 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
No STRING Network could be found.
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Natural killer cell mediated cytotoxicity | hsa04650 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07698 | 205-296 | IgC_MHC_I_alpha3 |
| cl11960 | 205-296 | Ig superfamily |
| pfam00129 | 24-198 | MHC_I |
| cl08246 | 24-198 | MHC_I superfamily |
| cd00098 | 213-292 | IgC |
| pfam07654 | 212-291 | C1-set |
| smart00407 | 222-292 | IGc1 |
| cd05766 | 209-288 | IgC_MHC_II_beta |
| cd05769 | 206-305 | IgC_TCR_beta |
| cd04985 | 214-296 | IgC_CH1 |
| cd05770 | 206-289 | IgC_beta2m |
| cd07699 | 203-292 | IgC_L |
| cd05768 | 222-288 | IgC_CH4 |
| cd05847 | 219-288 | IgC_CH2_IgE |
| cd05767 | 206-288 | IgC_MHC_II_alpha |
| pfam13895 | 206-265 | Ig_2 |
Ontology Information
| HPRD ID | - |
|---|---|
| Molecular Class | MHC complex protein |
| Molecular Function | - |
| Biological Process | - |
Drug Information
No matching records could be found.