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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
MID1 4281 midline 1  XOS; FXY; OSX; OGS1; XPRF; BBBG1; GBBB1; MIDIN; RNF59; ZNFXY; TRIM18 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20077526   2010Cell line : -

Source : -

Sample Type : CRC tumor and normal tissues

No. of Sample : 181

Stage : -

Gene annotation enrichment analysis of DAVID,ImmunohistochemistryUp-regulation-CRC clinical samples showed that the individual expression of LYN, MAP4K4, and MID1, as well as the five-gene signature, was closely correlated with lymph node metastasis in CRC patients.


Gene Details



NC_000023.10 (10413350..10851829, complement)

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Gene Type protein coding
Gene Family Tripartite motif-containing
Description The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Multiple different transcript variants are generated by alternate splicing; however, the full-length nature of some of the variants has not been determined. [provided by RefSeq, Jul 2010]  
Chromosome X
Location Xp22
Start 10413350  
End 10851829  
Strand -  
Gene Sequence

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Length 438480  
OMIM ID 300552   
HGNC ID HGNC:7095   
Unigene ID Hs.27695   
Ensembl ID ENSG00000101871   
PharmGKB ID PA30816   

mRNA Information


mRNA ID ?NM_000381.3
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS14138.1



Protein Information


      
Protein ID
Protein Namemidline 1
Molecular Wt. (Da)58032
Protein Sequence

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Length 0  
Uniprot IDO00206
Ensembl Protein ID ENSP00000363089  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation96
SDephosphorylation96
SPhosphorylation98;-
SPhosphorylation92;-
SPhosphorylation98;-
SPhosphorylation92;-
SPhosphorylation98;-
SPhosphorylation92;-
SPhosphorylation98;-
SPhosphorylation92;-
SPhosphorylation96
SPhosphorylation96
SPhosphorylation96
SPhosphorylation90
SPhosphorylation90
SPhosphorylation90
SPhosphorylation90

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


      
Pathway Name Pathway ID
Ubiquitin mediated proteolysis hsa04120


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd12892485-661  SPRY_PRY_TRIM18
cl02614485-661  SPRY superfamily
cd00063381-481  FN3
cl21522381-481  FN3 superfamily
cd00162Sep-63  RING
cl17238Sep-63  RING superfamily
cd00021174-212  BBOX
cl00034174-212  BBOX superfamily
cd13739486-653  SPRY_PRY_TRIM1
cd13734486-653  SPRY_PRY_C-I
cd12891488-650  SPRY_PRY_C-IV_2
cd12901486-657  SPRY_PRY_FSD1
cd12874486-650  SPRY_PRY
cd12900488-650  SPRY_PRY_Btn_TRIMs
smart00449538-656  SPRY
cd12897485-643  SPRY_PRY_TRIM50_62_72
cd12888488-650  SPRY_PRY_TRIM7_like
cd12905488-641  SPRY_PRY_TRIM_Bty_69_NF7
cd12893485-647  SPRY_PRY_TRIM35
cd12903486-645  SPRY_PRY_SPRYD4
cd13733485-643  SPRY_PRY_C-IV_1
cd12899486-654  SPRY_PRY_TRIM76_like
cd13738488-650  SPRY_PRY_TRIM14
cd12896478-641  SPRY_PRY_TRIM65
cd13741488-646  SPRY_PRY_TRIM41
cd12898486-641  SPRY_PRY_TRIM76
smart00502219-344  BBC
cl17972219-344  BBC superfamily
cd12904487-651  SPRY_BSPRY
cd13736488-645  SPRY_PRY_TRIM25
pfam00622538-650  SPRY
cd13740488-643  SPRY_PRY_TRIM7
cd12902489-641  SPRY_PRY_RNF135
cd12890488-641  SPRY_PRY_TRIM16
cd13745488-641  SPRY_PRY_TRIM39
cd13744488-642  SPRY_PRY_TRIM62
cd13737539-643  SPRY_PRY_TRIM25-like
cd12889486-657  SPRY_PRY_TRIM67_9
cd13743486-644  SPRY_PRY_TRIM50
cd13742488-645  SPRY_PRY_TRIM72
smart00060382-471  FN3
cd11709539-651  SPRY
smart00336171-212  BBOX
pfam00041381-470  fn3
pfam13765486-524  PRY
cl02686486-524  PRY superfamily
cd12876524-633  SPRY_SOCS3
pfam13920Jun-64  zf-C3HC4_3
cd12875489-617  SPRY_SOCS_Fbox
smart00184Oct-59  RING
smart00589488-525  PRY
pfam15227Oct-59  zf-C3HC4_4
pfam00643171-209  zf-B_box
cd12907486-617  SPRY_Fbox
pfam00097Oct-59  zf-C3HC4
pfam13639Sep-60  zf-RING_2
pfam13923Oct-38  zf-C3HC4_2
cd12895593-641  SPRY_PRY_TRIM46
pfam13445Oct-57  zf-RING_UBOX
cd12880526-618  SPRYD7
smart00336114-160  BBOX
cl00034114-160  BBOX superfamily
TIGR00599Apr-89  rad18
PLN03208Jul-98  PLN03208
COG5432Apr-60  RAD18
COG1196208-338  Smc
COG0419206-323  SbcC
COG5574Oct-60  PEX10
COG1196205-338  Smc


Ontology Information


   
HPRD ID1777
Molecular ClassNot Available
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessNuclear organization and biogenesis (GO:0006997)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO