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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25216407 | 2014 | Cell line : SW620 Source : - Sample Type : - No. of Sample : - Stage : - | PCR,gain of function approach, and western blotting, MTT assay and Transwell assay | Down-regulation | - | miR?185 as a tumor suppressor may affect the development of colon cancer cells via inhibition of HIF?2? signaling, suggesting that miR?185 may serve as a potential therapeutic target in cancer treatment. |
Gene Details
| Gene Type | ncRNA |
|---|---|
| Gene Family | ncRNAs / Micro RNAs |
| Description | microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] | Chromosome | 22 |
| Location | 22q11.21 |
| Start | 20020662 |
| End | 20020743 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 82 |
| OMIM ID | 615576 |
| HGNC ID | HGNC:31556 |
| Unigene ID | - |
| Ensembl ID | ENSG00000208023 |
| PharmGKB ID | - |
Protein Information
| Protein ID | |
|---|---|
| Protein Name | microRNA 185 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 0 |
| Uniprot ID | |
| Ensembl Protein ID |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
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PPi Information
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Pathway Information
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Structure Information
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Domain Information
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Drug Information
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