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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MME | 4311 | membrane metallo-endopeptidase | 3 | CALLA, CD10, NEP |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21814804 | 2012 | Cell line : Murine CT-26 Source : - Sample Type : - No. of Sample : - Stage : - | RT-PCR, immunoblotting, immunohistochemistry | Down-regulation | - | Expression of MME inversely correlates with the expression of bFGF and tumor angiogenesis in a model of murine colon cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules |
| Description | This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008] | Chromosome | 3 |
| Location | 3q25.2 |
| Start | 154797436 |
| End | 154901518 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 104083 |
| OMIM ID | 120520 |
| HGNC ID | HGNC:7154 |
| Unigene ID | Hs.307734 |
| Ensembl ID | ENSG00000196549 |
| PharmGKB ID | PA30864 |
mRNA Information
| mRNA ID | XM_011512855.1 |
|---|---|
| Exon | join(1..201,60035..60204,60936..60971,90871..91032, 92356..92436,92541..92636,92745..92863,94623..94688, 113979..114113,116068..116169,117868..118004, 118114..118207,119320..119448,120236..120334, 123021..123101,124427..124530,136267..136325, 142779..142898,144369..144502,144609..144674, 147994..148089,148413..148489,156237..159581) | mRNA Sequence | Download Select all |
| Length | 5709 |
Protein Information
| Protein ID | XP_011511157.1 |
|---|---|
| Protein Name | membrane metallo-endopeptidase |
| Molecular Wt. (Da) | 46135 |
| Protein Sequence | Download Select all |
| Length | 750 |
| Uniprot ID | P11387 |
| Ensembl Protein ID | ENSP00000354522 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 6 |
| S | Phosphorylation | 6 |
| S | Phosphorylation | 6 |
| S | Phosphorylation | 6 |
| S | Phosphorylation | 4 |
| S | Phosphorylation | 4 |
| S | Phosphorylation | 4 |
| S | Phosphorylation | 4 |
| Y | Phosphorylation | 399 |
| T | Phosphorylation | 407 |
| Y | Phosphorylation | 399 |
| T | Phosphorylation | 407 |
| Y | Phosphorylation | 399 |
| T | Phosphorylation | 407 |
| Y | Phosphorylation | 399 |
| T | Phosphorylation | 407 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 116 | ADCYAP1 | 2369 | NP_001108.2 | in vitro | 9313778 |
| 133 | ADM | 61 | NP_001115.1 | in vitro | 8687431 |
| 1906 | EDN1 | 7030 | NP_001946.3 | in vitro | 2201681 |
| 1907 | EDN2 | 7173 | NP_001947.1 | in vitro | 2201681 |
| 2520 | GAST | 671 | NP_000796.1 | in vitro | 2736261 |
| 4878 | NPPA | 164 | NP_006163.1 | in vitro | 253 137 792 321 962 000 000 |
| 4880 | NPPC | 8975 | NP_077720.1 | in vitro | 9232196 |
| 7432 | VIP | 15950 | NP_003372.1 | in vitro | 9313778 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Alzheimer's disease | hsa05010 |
| Hematopoietic cell lineage | hsa04640 |
| Protein digestion and absorption | hsa04974 |
| Renin-angiotensin system | hsa04614 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd08662 | 79-748 | M13 |
| cl14813 | 79-748 | GluZincin superfamily |
| pfam05649 | 80-483 | Peptidase_M13_N |
| cl14911 | 80-483 | Peptidase_M13_N superfamily |
| pfam01431 | 543-749 | Peptidase_M13 |
| cd09594 | 538-601 | GluZincin |
| COG3590 | 72-750 | PepO |
Ontology Information
| HPRD ID | 3587 |
|---|---|
| Molecular Class | Metallo protease |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P08473 | DB06655 | Liraglutide | BiotechDrug |
| P08473 | DB00616 | Candoxatril | SmallMoleculeDrug |
| P08473 | DB09292 | Sacubitril | SmallMoleculeDrug |