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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
MMP1 4312 matrix metallopeptidase 1 (interstitial collagenase)  11- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21538057   2011Cell line : -

Source : PubMed, Embase, ISI Web of Knowledge, and Medline .

Sample Type : -

No. of Sample : -

Stage : -

Meta analysis,Crude odds ratiosPolymorhpism-Polymorphisms of MMP1 (-1607) and MMP3 (-1612) increased the risk of colorectal cancer; these two polymorphic sites could be used as markers for early diagnosis of colorectal cancer.

25391421   2015Cell line : -

Source : Asian population and hospital-based studies and PubMed and EMBASE database

Sample Type : Population based case control study

No. of Sample : 10,640 CRC and 10,915 controls

Stage : -

Meta analysis,Crude odds ratios .Polymorhpism- Polymorphism MMP1 -1607 1G>2G is significantly associated with a significantly increased risk of cancers


Gene Details



NC_000011.9 (102660641..102668966, complement)

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Gene Type protein coding
Gene Family Endogenous ligands
Description This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]  
Chromosome 11
Location 11q21-q22
Start 102660641  
End 102668966  
Strand -  
Gene Sequence

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Length 8326  
OMIM ID 120353   
HGNC ID HGNC:7155   
Unigene ID Hs.83169   
Ensembl ID ENSG00000196611   
PharmGKB ID PA30867   

mRNA Information


mRNA ID NM_001145938.1
Exon join(1..137,777..980,1074..1222,1447..1572,2629..2784, 2945..3062,5498..5631,6741..6903,7430..7533,7715..8326)  
mRNA Sequence

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Length 1903  



CDS Information


   
Location 190..1401
CDS Sequence

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CCDS ID CCDS8322.1



Protein Information


      
Protein IDNP_001139410.1
Protein Namematrix metallopeptidase 1 (interstitial collagenase)
Molecular Wt. (Da)0
Protein Sequence

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Length 403  
Uniprot IDP11388
Ensembl Protein ID ENSP00000411532  



Post-translational Modification Information (Source : HPRD)


Residue Type site
LProteolytic Cleavage102
SPhosphorylation280
TPhosphorylation288
TPhosphorylation289
KAcetylation276
YPhosphorylation360

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                      
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
12SERPINA3120NP_001076.2in vitro;in vivo1311327   
682BSG176NP_001719.2in vitro;in vivo10706100   
960CD44115NP_000601.3in vitro11381077   
1280COL2A1361NP_001835.3in vitro8609233   
3486IGFBP3899NP_001013416.1in vitro7523391   
6347CCL21149NP_002973.1in vitro;in vivo121   491   929   558   113   
6354CCL71150CAA50405.1in vitro;in vivo1   214   919   210   947   980   
6357CCL133230NP_005399.1in vitro;in vivo12149192   
7035TFPI1064NP_006278.1in vitro10859319   
8600TNFSF114031NP_003692.1in vivo10224132   


Pathway Information


                        
Pathway Name Pathway ID
Bladder cancer hsa05219
Pathways in cancer hsa05200
PPAR signaling pathway hsa03320
Rheumatoid arthritis hsa05323


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00094275-466  HX
cl02471275-466  HX superfamily
cd04278108-261  ZnMc_MMP
cl00064108-261  ZnMc superfamily
cd04279133-261  ZnMc_MMP_like_1
cd00203124-260  ZnMc
cd04277132-261  ZnMc_serralysin_like
cd04268114-260  ZnMc_MMP_like
pfam0147127-87  PG_binding_1
cl1836827-87  PG_binding_1 superfamily
smart00120377-424  HX
pfam00045377-424  Hemopexin
smart00120330-372  HX
pfam00045328-371  Hemopexin
pfam00045284-326  Hemopexin
smart00120284-325  HX
cd11375197-241  Peptidase_M54
cd04327126-228  ZnMc_MMP_like_3
pfam13688165-245  Reprolysin_5
cd04267214-261  ZnMc_ADAM_like
smart00120426-451  HX
pfam00045426-451  Hemopexin
cd04275210-228  ZnMc_pappalysin_like
pfam00413108-261  Peptidase_M10
smart00235105-261  ZnMc


Ontology Information


   
HPRD ID4963
Molecular ClassMetallo protease
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessCell proliferation (GO:0008283)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P03956DB00786MarimastatSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO