Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MMP11 | 4320 | matrix metallopeptidase 11 (stromelysin 3) | 22 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16733264 | 2006 | Cell line : - Source : Tissue Bank Network of the CNIO in collaboration with the following hospitals in Spain: Virgen de la Salud (Toledo), Cartagena (Murcia), Puerta de Hierro (Madrid), C?nico deSan Carlos (Madrid), Ramon y Cajal (Madrid), and Alcorcon (Madrid). Sample Type : CRC tumor and normal tissue No. of Sample : 22 Stage : - | Immunoblotting, tissue microarray | Up-regulation | - | LCN2 and MMP11 were clearly overexpressed in late Dukes' stages (B and C). |
| 17543340 | 2008 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 112 CRC, 20 normal tissues, and 11 metastatic liver lesions Stage : - | Immunohistochemistry,real time RT-PCR | Up-regulation | - | Primary cancers and metastatic lesions showed highly significant differences (P < 0.01) in MMP-1, -10, -11, and TIMP-1. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008] | Chromosome | 22 |
| Location | 22q11.23 |
| Start | 24115036 |
| End | 24126503 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 11468 |
| OMIM ID | 185261 |
| HGNC ID | HGNC:7157 |
| Unigene ID | Hs.143751 |
| Ensembl ID | ENSG00000099953 |
| PharmGKB ID | PA30869 |
mRNA Information
| mRNA ID | NM_005940.4 |
|---|---|
| Exon | join(1..130,6339..6568,7511..7654,7734..7867,8011..8252, 8345..8561,9378..9635,10563..11468) | mRNA Sequence | Download Select all |
| Length | 2306 |
Protein Information
| Protein ID | NP_005931.2 |
|---|---|
| Protein Name | matrix metallopeptidase 11 (stromelysin 3) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 488 |
| Uniprot ID | P55327 |
| Ensembl Protein ID | ENSP00000368390 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5265 | SERPINA1 | 2463 | NP_000286.3 | in vitro;in vivo | 7523394 |
| 55660 | PRPF40A | 10995 | NP_060362.3 | yeast 2-hybrid | 15231748 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04278 | 104-258 | ZnMc_MMP |
| cl00064 | 104-258 | ZnMc superfamily |
| cd00094 | 291-480 | HX |
| cl02471 | 291-480 | HX superfamily |
| cd04277 | 117-258 | ZnMc_serralysin_like |
| cd04279 | 123-258 | ZnMc_MMP_like_1 |
| cd00203 | 123-257 | ZnMc |
| cd04268 | 107-231 | ZnMc_MMP_like |
| pfam00045 | 298-341 | Hemopexin |
| smart00120 | 298-341 | HX |
| smart00120 | 436-479 | HX |
| pfam00045 | 436-479 | Hemopexin |
| smart00120 | 387-434 | HX |
| pfam00045 | 343-380 | Hemopexin |
| pfam00045 | 387-434 | Hemopexin |
| smart00120 | 343-373 | HX |
| pfam05572 | 166-226 | Peptidase_M43 |
| COG5549 | 105-260 | COG5549 |
| cd04275 | 171-226 | ZnMc_pappalysin_like |
| cd04276 | 209-238 | ZnMc_MMP_like_2 |
| pfam00413 | 104-258 | Peptidase_M10 |
| smart00235 | 104-259 | ZnMc |
| PRK12323 | Feb-86 | PRK12323 |
Ontology Information
| HPRD ID | 8927 |
|---|---|
| Molecular Class | Metallo protease |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P24347 | DB00786 | Marimastat | SmallMoleculeDrug |