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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MMP13 | 4322 | matrix metallopeptidase 13 (collagenase 3) | 11 | CLG3 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24563279 | 2014 | Cell line : - Source : Mansoura Gastroenterology Center Sample Type : - No. of Sample : 40 Stage : - | immunohistochemistry, tissue microarray | Up-regulation | - | MMP-13 may be a potential biological marker of early tumorigenesis in the adenoma-carcinoma sequence. |
| 25880591 | 2015 | Cell line : MC38, HCT116 Source : ATCC and mice from Jackson Research Laboratories (Bar Harbor, ME) and a breeding pair of MMP13 null mice was obtained (Laboratory of Dr. Zena Werb, UCSF). Sample Type : Mice tumor No. of Sample : - Stage : - | real time RT-PCR,western blotting,whole organ confocal microscopy,MTT, migration and invasion assays | Up-regulation | - | Stromal as well as tumor derived MMP13 contribute to tumor cell extravasation and establishment of metastases in the liver microenvironment. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Mutations in this gene are associated with metaphyseal anadysplasia. This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016] | Chromosome | 11 |
| Location | 11q22.3 |
| Start | 102813721 |
| End | 102826463 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 12743 |
| OMIM ID | 600108 |
| HGNC ID | HGNC:7159 |
| Unigene ID | Hs.2936 |
| Ensembl ID | ENSG00000137745 |
| PharmGKB ID | PA30871 |
mRNA Information
| mRNA ID | NM_002427.3 |
|---|---|
| Exon | join(1..149,242..483,1129..1277,1454..1579,3562..3723, 5508..5625,6577..6710,7685..7844,9986..10089,11369..12743) | mRNA Sequence | Download Select all |
| Length | 2735 |
Protein Information
| Protein ID | NP_002418.1 |
|---|---|
| Protein Name | matrix metallopeptidase 13 (collagenase 3) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 471 |
| Uniprot ID | P06753 |
| Ensembl Protein ID | ENSP00000307712 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| E | Proteolytic Cleavage | 103 |
| G | Proteolytic Cleavage | 54 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1280 | COL2A1 | 361 | NP_001835.3 | in vitro | 8609233 |
| 2161 | F12 | 1992 | NP_000496.2 | in vivo | 10930399 |
| 4035 | LRP1 | 138 | NP_002323.2 | in vitro;in vivo | 10514495 |
| 6354 | CCL7 | 1150 | CAA50405.1 | in vitro;in vivo | 1 214 919 210 947 980 |
| 7078 | TIMP3 | 1785 | NP_000353.1 | in vitro | 9065415 |
| 63827 | BCAN | 2644 | NP_068767.3 | in vitro | 10986281 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04278 | 112-267 | ZnMc_MMP |
| cl00064 | 112-267 | ZnMc superfamily |
| cd00094 | 281-471 | HX |
| cl02471 | 281-471 | HX superfamily |
| cd04277 | 120-267 | ZnMc_serralysin_like |
| cd04279 | 131-267 | ZnMc_MMP_like_1 |
| cd00203 | 118-266 | ZnMc |
| pfam01471 | 32-91 | PG_binding_1 |
| cl18368 | 32-91 | PG_binding_1 superfamily |
| smart00120 | 382-428 | HX |
| pfam00045 | 382-428 | Hemopexin |
| cd04268 | 118-233 | ZnMc_MMP_like |
| pfam00045 | 334-376 | Hemopexin |
| smart00120 | 334-376 | HX |
| pfam00045 | 290-332 | Hemopexin |
| smart00120 | 290-331 | HX |
| cd04327 | 133-232 | ZnMc_MMP_like_3 |
| pfam13582 | 145-233 | Reprolysin_3 |
| pfam00413 | 112-267 | Peptidase_M10 |
| smart00235 | 111-268 | ZnMc |
Ontology Information
| HPRD ID | 3418 |
|---|---|
| Molecular Class | Metallo protease |
| Molecular Function | Receptor signaling complex scaffold activity (GO:0030159) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P45452 | DB00786 | Marimastat | SmallMoleculeDrug |