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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22576687 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : - Stage : - | Confocal analysis, western blotting , immunofluorescence analysis and real time RT-PCR | Up-regulation | - | MMP-15 and 19, in colorectal cancer may lead to a re-evaluation of the use of MMP inhibitors and suggests the need of integrated translational studies on MMP . |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013] | Chromosome | 12 |
| Location | 12q14 |
| Start | 56229214 |
| End | 56236767 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 7554 |
| OMIM ID | 601807 |
| HGNC ID | HGNC:7165 |
| Unigene ID | Hs.591033 |
| Ensembl ID | - |
| PharmGKB ID | PA30876 |
mRNA Information
| mRNA ID | NM_001272101.1 |
|---|---|
| Exon | join(1..240,546..631,1748..1878,2102..2317,4250..4484, 4977..5141,5610..7554) | mRNA Sequence | Download Select all |
| Length | 3026 |
Protein Information
| Protein ID | NP_001259030.1 |
|---|---|
| Protein Name | matrix metallopeptidase 19 |
| Molecular Wt. (Da) | 90164 |
| Protein Sequence | Download Select all |
| Length | 305 |
| Uniprot ID | P14625 |
| Ensembl Protein ID | ENSP00000299767 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04278 | 103-256 | ZnMc_MMP |
| cl00064 | 103-256 | ZnMc superfamily |
| cd00094 | 286-472 | HX |
| cl02471 | 286-472 | HX superfamily |
| cd04279 | 121-256 | ZnMc_MMP_like_1 |
| cd00203 | 121-255 | ZnMc |
| cd04268 | 106-255 | ZnMc_MMP_like |
| cd04277 | 117-256 | ZnMc_serralysin_like |
| smart00120 | 431-469 | HX |
| smart00120 | 337-380 | HX |
| pfam00045 | 431-469 | Hemopexin |
| cd04327 | 121-222 | ZnMc_MMP_like_3 |
| pfam01471 | 31-80 | PG_binding_1 |
| cl18368 | 31-80 | PG_binding_1 superfamily |
| pfam11350 | 136-222 | DUF3152 |
| smart00120 | 293-335 | HX |
| pfam00045 | 337-380 | Hemopexin |
| smart00120 | 380-426 | HX |
| pfam00045 | 380-427 | Hemopexin |
| cd04280 | 126-225 | ZnMc_astacin_like |
| pfam00413 | 103-256 | Peptidase_M10 |
| smart00235 | 103-257 | ZnMc |
Ontology Information
| HPRD ID | 3537 |
|---|---|
| Molecular Class | Metallo protease |
| Molecular Function | Guanyl-nucleotide exchange factor activity (GO:0005085) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q99542 | DB00786 | Marimastat | SmallMoleculeDrug |